BACKGROUND At present,the clinical mechanisms underlying precocious puberty remain unclear,making effective intervention for children experiencing this condition and rapidly progressive puberty essential.AIM To explor...BACKGROUND At present,the clinical mechanisms underlying precocious puberty remain unclear,making effective intervention for children experiencing this condition and rapidly progressive puberty essential.AIM To explore the effects of Zhibai dihuang pills and gonadotropin-releasing hormone analogue(GnRHa)on growth and ovarian function in girls with precocious puberty.METHODS The clinical data of 84 adolescent girls with precocious puberty and rapidly progressive puberty from February 2017 to August 2023 were retrospectively analyzed.Girls were divided into a control group and an observation group,with 42 cases in each group.The control group received diet intervention combined with GnRHa treatment,while the observation group received diet intervention combined with Zhibai dihuang pills+GnRHa treatment.Outcomes such as clinical efficacy,growth indicators,ovarian function,and adverse reactions were compared between the two groups.RESULTS The observation group showed superior clinical efficacy compared to the control group(P<0.05).Prior to the intervention,no significant differences were found in growth or ovarian function between the groups(P>0.05).Post-intervention,the observation group exhibited significantly lower rates in growth,height,and bone age,along with reduced levels of progesterone,testosterone,estradiol,prolactin,luteinizing hormone,and follicle-stimulating hormone compared to the control group(P<0.05).The incidence of adverse reactions was similar across both groups(P>0.05).CONCLUSION Combining Zhibai dihuang pills with GnRHa and dietary intervention effectively improves growth,enhances ovarian function,and minimizes adverse reactions in adolescent girls with precocious and rapidly progressive puberty.展开更多
Objective To evaluate left univentricular (LUV) pacing for cardiac resynchronization therapy (CRT) using a rate-adaptive atrioven- tricular delay (RAAVD) algorithm to track physiological atrioventricular delay ...Objective To evaluate left univentricular (LUV) pacing for cardiac resynchronization therapy (CRT) using a rate-adaptive atrioven- tricular delay (RAAVD) algorithm to track physiological atrioventricular delay (AVD). Methods A total of 72 patients with congestive heart failure (CHF) were randomized to RAAVD LUV pacing versus standard biventricular (BiV) pacing in a 1 : 1 ratio. Echocardiography was used to optimize AVD for both groups. The effects of sequential BiV pacing and LUV pacing with optimized A-V (right atrio-LV) delay using an RAAVD algorithm were compared. The standard deviation (SD) of the S/R ratio in lead VI at five heart rate (HR) segments (Rs/R-SD5), defined as the "tracking index," was used to evaluate the accuracy of the RAAVD algorithm for tracking physiological AVD. Results TheQRS complex duration (132 ± 9.8 vs. 138± 10ms, P 〈 0.05), the time required for optimization (21 ±5 vs. 50±8min, P〈 0.001), the mitral regurgitant area (1.9 ± 1.1 vs. 2.5 ± 1.3 em2, P 〈 0.05), the interventricular mechanical delay time (60.7 ± 13.3 ms vs. 68.3 ± 14.2 ms, P 〈 0.05), and the average annual cost (13,200 ± 1000 vs. 21,600 ± 2000 RMB, P 〈 0.001) in the RAAVD LUV pacing group were significantly less than those in the standard BiV pacing group. The aortic valve velocity-time integral in the RAAVD LUV pacing group was greater than that in the standard BiV pacing group (22.7 ± 2.2 vs. 21.4 ± 2.1 cm, P 〈 0.05). The Rs/R-SD5 was 4.08 ± 1.91 in the RAAVD LUV pacing group, and was significantly negatively correlated with improved left ventricular ejection fraction (LVEF) (ALVEF, Pearson's r = -0.427, P = 0.009), and positively correlated with New York Heart Association class (Spearman's r - 0.348, P 0.037). Conclusions RAAVD LUV pacing is as effective as standard BiV pacing, can be more physiological than standard BiV pacing, and can de- crease the average annual cost of CRT.展开更多
Objective:To explore the effect of self-ligating bracket appliance on the periodontal tissues in patients with chronic periodontitis after orthodontic treatment.Methods:A total of 56 patients with chronic periodontiti...Objective:To explore the effect of self-ligating bracket appliance on the periodontal tissues in patients with chronic periodontitis after orthodontic treatment.Methods:A total of 56 patients with chronic periodontitis who were admitted in our hospital were included in the study and divided into the observation group and the control group according to different treatment protocols. The patients in the observation group were given self-ligating brackets, while the patients in the control group were given traditional brackets. The periodontal tissues and tooth motility (TM) before and after treatment in the two groups were observed and recorded. IL-1βand TNF-α levels in the gingival crervicular fluid (GCF) before and after treatment in the two groups were detected.Results:PD, CAL, SBI, and PLI after treatment in the two groups were significantly reduced, while GR was significantly elevated when compared with the control group. PD, CAL, SBI, and PLI after treatment in the observation group were significantly lower than those in the control group, while GR was significantly higher than that in the control group. TM after treatment in the two groups was significantly improved, among which the number of 0° TM was significantly increased, while the number ofⅠ°-Ⅲ°TM was significantly reduced. IL-1β and TNF-α levels in GCF after treatment in the two groups were significantly reduced when compared with before treatment. IL-1β and TNF-α levels in GCF after treatment in the observation group were significantly lower than those in the control group.Conclusions:The self-ligating brackets can effectively improve the periodontal tissues and TM in patients with chronic periodontitis, and reduce the levels of inflammatory cytokines in periodontal tissues, with an accurate efficacy.展开更多
Herein, we present a novel way for the production of self-healing hydrogels with stretch beyond 4200% than their initial length and relatively high tensile strength (0.1-0.25 MPa). Furthermore, the hydrogel was inse...Herein, we present a novel way for the production of self-healing hydrogels with stretch beyond 4200% than their initial length and relatively high tensile strength (0.1-0.25 MPa). Furthermore, the hydrogel was insensitive to notch. Even for the samples containing V-notches, a stretch of 2300% was demonstrated. The hydrogels were developed by in situ crosslinking of the self-assembled colloidal poly(acrylic acid) (PAA)/functionalized polyhedral oligomeric silsesquioxane (POSS) micelles. This was achieved by the addition of functionalized polyhedral oligomeric silsesquioxane with tertiary amines and hydroxyls (POSS-AH) into the PAA reaction solution. The POSS-AH led to micellar growth, then the dual- crosslinked network was constructed. One type of crosslink was formed by hydrogen-bonding and ionic interactions between PAA chains and POSS-AH, the other type of crosslink was formed by covalent bonds between PAA and bis(N,N'-methylene- bis-acrylamide).展开更多
The electrochemiluminescence(ECL)properties of many carbon materials have been reported with glassy carbon(GC),Pt,Au or indium tin oxide(ITO)as the working electrode(WE).As one type of carbon materials,GC itself can g...The electrochemiluminescence(ECL)properties of many carbon materials have been reported with glassy carbon(GC),Pt,Au or indium tin oxide(ITO)as the working electrode(WE).As one type of carbon materials,GC itself can generate ECL signal.Some research groups have already noticed the ECL signal from GC WE and reported the results of GC WE with respect to their luminophores.However,comprehensive analyses of ECL properties of GC WE are rare.Herein,the ECL properties of GC WE in organic electrolyte with benzoyl peroxide as the coreactant are reported.Our results are of great importance to distinguish the true ECL data of luminophores from that of GC.展开更多
Dear Editor,A common reason for drug failure during long-term treatment of chronic hepatitis B with nucleot(s)ide analogues(NUCs)is the emergence of drug resistance(Das et al.,2001).Most primary NUCs-resistant mutatio...Dear Editor,A common reason for drug failure during long-term treatment of chronic hepatitis B with nucleot(s)ide analogues(NUCs)is the emergence of drug resistance(Das et al.,2001).Most primary NUCs-resistant mutations identified in clinical samples have been limited to a minority of amino acids(usually less展开更多
This article is focused on secure relay beamformer design with a correlated channel model in the relay-eavesdropper network. In this network, a single-antenna source-destination pair transmits secure information with ...This article is focused on secure relay beamformer design with a correlated channel model in the relay-eavesdropper network. In this network, a single-antenna source-destination pair transmits secure information with the help of an amplify-and-forward (AF) relay equipped with multiple antennas, and the legitimate and eavesdropping channels are correlated. The relay cannot obtain the instantaneous channel state information (CSI) of the eavesdropper, and has only the knowledge of correlation information between the legitimate and eavesdropping channels. Depending on this information, we derive the conditional distribution of the eavesdropping channel. Two beamformers at the relay are studied for the approximate ergodic secrecy rate:(1) the generalized match-andforward (GMF) beamformer to maximize the legitimate channel rate, and (2) the general-rank beamformer (GRBF).In addition, one lower-bound-maximizing (LBM) beamformer at the relay is discussed for maximizing the lower bound of the ergodic secrecy rate. We find that the GMF beamformer is the optimal rank-one beamformer, that the GRBF is the iteratively optimal beamformer, and that the performance of the LBM beamformer for the ergodic secrecy rate gets close to that of the GRBF for the approximate secrecy rate. It can also be observed that when the relay has lower power or the channel gain of the second hop is low, the performance of the GMF beamformer surpasses that of the GRBF. Numerical results are presented to illustrate the beamformers' performance.展开更多
We investigate the problem of resource allocation in a downlink orthogonal frequency-division multiple access (OFDMA) broadband network with an eavesdropper under the condition that both legitimate users and the eav...We investigate the problem of resource allocation in a downlink orthogonal frequency-division multiple access (OFDMA) broadband network with an eavesdropper under the condition that both legitimate users and the eavesdropper are with imperfect channel state information (CSI). We consider three kinds of imperfect CSI: (1) noise and channel estimation errors, (2) feedback delay and channel prediction, and (3) limited feedback channel capacity, where quantized CSI is studied using rate-distortion theory because it can be used to establish an information-theoretic lower bound on the capacity of the feedback channel. The problem is formulated as joint power and subcarrier allocation to optimize the maximum-minimum (max-min) fairness criterion over the users' secrecy rate. The problem considered is a mixed integer nonlinear programming problem. To reduce the complexity, we propose a two-step suboptimal algorithm that separately performs power and subcarrier allocation. For a given subcarrier assignment, optimal power allocation is achieved by developing an algorithm of polynomial computational complexity. Numerical results show that our proposed algorithm can approximate the optimal solution.展开更多
文摘BACKGROUND At present,the clinical mechanisms underlying precocious puberty remain unclear,making effective intervention for children experiencing this condition and rapidly progressive puberty essential.AIM To explore the effects of Zhibai dihuang pills and gonadotropin-releasing hormone analogue(GnRHa)on growth and ovarian function in girls with precocious puberty.METHODS The clinical data of 84 adolescent girls with precocious puberty and rapidly progressive puberty from February 2017 to August 2023 were retrospectively analyzed.Girls were divided into a control group and an observation group,with 42 cases in each group.The control group received diet intervention combined with GnRHa treatment,while the observation group received diet intervention combined with Zhibai dihuang pills+GnRHa treatment.Outcomes such as clinical efficacy,growth indicators,ovarian function,and adverse reactions were compared between the two groups.RESULTS The observation group showed superior clinical efficacy compared to the control group(P<0.05).Prior to the intervention,no significant differences were found in growth or ovarian function between the groups(P>0.05).Post-intervention,the observation group exhibited significantly lower rates in growth,height,and bone age,along with reduced levels of progesterone,testosterone,estradiol,prolactin,luteinizing hormone,and follicle-stimulating hormone compared to the control group(P<0.05).The incidence of adverse reactions was similar across both groups(P>0.05).CONCLUSION Combining Zhibai dihuang pills with GnRHa and dietary intervention effectively improves growth,enhances ovarian function,and minimizes adverse reactions in adolescent girls with precocious and rapidly progressive puberty.
文摘Objective To evaluate left univentricular (LUV) pacing for cardiac resynchronization therapy (CRT) using a rate-adaptive atrioven- tricular delay (RAAVD) algorithm to track physiological atrioventricular delay (AVD). Methods A total of 72 patients with congestive heart failure (CHF) were randomized to RAAVD LUV pacing versus standard biventricular (BiV) pacing in a 1 : 1 ratio. Echocardiography was used to optimize AVD for both groups. The effects of sequential BiV pacing and LUV pacing with optimized A-V (right atrio-LV) delay using an RAAVD algorithm were compared. The standard deviation (SD) of the S/R ratio in lead VI at five heart rate (HR) segments (Rs/R-SD5), defined as the "tracking index," was used to evaluate the accuracy of the RAAVD algorithm for tracking physiological AVD. Results TheQRS complex duration (132 ± 9.8 vs. 138± 10ms, P 〈 0.05), the time required for optimization (21 ±5 vs. 50±8min, P〈 0.001), the mitral regurgitant area (1.9 ± 1.1 vs. 2.5 ± 1.3 em2, P 〈 0.05), the interventricular mechanical delay time (60.7 ± 13.3 ms vs. 68.3 ± 14.2 ms, P 〈 0.05), and the average annual cost (13,200 ± 1000 vs. 21,600 ± 2000 RMB, P 〈 0.001) in the RAAVD LUV pacing group were significantly less than those in the standard BiV pacing group. The aortic valve velocity-time integral in the RAAVD LUV pacing group was greater than that in the standard BiV pacing group (22.7 ± 2.2 vs. 21.4 ± 2.1 cm, P 〈 0.05). The Rs/R-SD5 was 4.08 ± 1.91 in the RAAVD LUV pacing group, and was significantly negatively correlated with improved left ventricular ejection fraction (LVEF) (ALVEF, Pearson's r = -0.427, P = 0.009), and positively correlated with New York Heart Association class (Spearman's r - 0.348, P 0.037). Conclusions RAAVD LUV pacing is as effective as standard BiV pacing, can be more physiological than standard BiV pacing, and can de- crease the average annual cost of CRT.
文摘Objective:To explore the effect of self-ligating bracket appliance on the periodontal tissues in patients with chronic periodontitis after orthodontic treatment.Methods:A total of 56 patients with chronic periodontitis who were admitted in our hospital were included in the study and divided into the observation group and the control group according to different treatment protocols. The patients in the observation group were given self-ligating brackets, while the patients in the control group were given traditional brackets. The periodontal tissues and tooth motility (TM) before and after treatment in the two groups were observed and recorded. IL-1βand TNF-α levels in the gingival crervicular fluid (GCF) before and after treatment in the two groups were detected.Results:PD, CAL, SBI, and PLI after treatment in the two groups were significantly reduced, while GR was significantly elevated when compared with the control group. PD, CAL, SBI, and PLI after treatment in the observation group were significantly lower than those in the control group, while GR was significantly higher than that in the control group. TM after treatment in the two groups was significantly improved, among which the number of 0° TM was significantly increased, while the number ofⅠ°-Ⅲ°TM was significantly reduced. IL-1β and TNF-α levels in GCF after treatment in the two groups were significantly reduced when compared with before treatment. IL-1β and TNF-α levels in GCF after treatment in the observation group were significantly lower than those in the control group.Conclusions:The self-ligating brackets can effectively improve the periodontal tissues and TM in patients with chronic periodontitis, and reduce the levels of inflammatory cytokines in periodontal tissues, with an accurate efficacy.
基金financially supported by the Natural Science Foundation of Guangdong Province(No.2014A030313379)the National Natural Science Foundation of China(Nos.81171459 and 31400824)
文摘Herein, we present a novel way for the production of self-healing hydrogels with stretch beyond 4200% than their initial length and relatively high tensile strength (0.1-0.25 MPa). Furthermore, the hydrogel was insensitive to notch. Even for the samples containing V-notches, a stretch of 2300% was demonstrated. The hydrogels were developed by in situ crosslinking of the self-assembled colloidal poly(acrylic acid) (PAA)/functionalized polyhedral oligomeric silsesquioxane (POSS) micelles. This was achieved by the addition of functionalized polyhedral oligomeric silsesquioxane with tertiary amines and hydroxyls (POSS-AH) into the PAA reaction solution. The POSS-AH led to micellar growth, then the dual- crosslinked network was constructed. One type of crosslink was formed by hydrogen-bonding and ionic interactions between PAA chains and POSS-AH, the other type of crosslink was formed by covalent bonds between PAA and bis(N,N'-methylene- bis-acrylamide).
基金support from Natural Sciences and Engineering Research Council Canada(NSERC,DG RGPIN-2013-201697,DG RGPIN-2018-06556 and SPG STPGP-2016-493924)Canada Foundation of Innovation,Ontario Innovation Trust(CFI/OIT,9040)+1 种基金Premier’s Research Excellence Award(PREA,2003)Western University.
文摘The electrochemiluminescence(ECL)properties of many carbon materials have been reported with glassy carbon(GC),Pt,Au or indium tin oxide(ITO)as the working electrode(WE).As one type of carbon materials,GC itself can generate ECL signal.Some research groups have already noticed the ECL signal from GC WE and reported the results of GC WE with respect to their luminophores.However,comprehensive analyses of ECL properties of GC WE are rare.Herein,the ECL properties of GC WE in organic electrolyte with benzoyl peroxide as the coreactant are reported.Our results are of great importance to distinguish the true ECL data of luminophores from that of GC.
基金supported in part by grants from the National Natural Science Foundation of China(81671997)Chongqing Science&Technology Commission(cstc2015jcyj A10023)+1 种基金Chongqing Education Commission(CYB15099)the Program for Innovation Team of Higher Education in Chongqing(CXTDX 201601015)
文摘Dear Editor,A common reason for drug failure during long-term treatment of chronic hepatitis B with nucleot(s)ide analogues(NUCs)is the emergence of drug resistance(Das et al.,2001).Most primary NUCs-resistant mutations identified in clinical samples have been limited to a minority of amino acids(usually less
基金supported by the National Natural Science Foundation of China(Nos.61471008,61571020,and 61622101)the National Key Research and Development Project of China(No.2016YFE0123100)
文摘This article is focused on secure relay beamformer design with a correlated channel model in the relay-eavesdropper network. In this network, a single-antenna source-destination pair transmits secure information with the help of an amplify-and-forward (AF) relay equipped with multiple antennas, and the legitimate and eavesdropping channels are correlated. The relay cannot obtain the instantaneous channel state information (CSI) of the eavesdropper, and has only the knowledge of correlation information between the legitimate and eavesdropping channels. Depending on this information, we derive the conditional distribution of the eavesdropping channel. Two beamformers at the relay are studied for the approximate ergodic secrecy rate:(1) the generalized match-andforward (GMF) beamformer to maximize the legitimate channel rate, and (2) the general-rank beamformer (GRBF).In addition, one lower-bound-maximizing (LBM) beamformer at the relay is discussed for maximizing the lower bound of the ergodic secrecy rate. We find that the GMF beamformer is the optimal rank-one beamformer, that the GRBF is the iteratively optimal beamformer, and that the performance of the LBM beamformer for the ergodic secrecy rate gets close to that of the GRBF for the approximate secrecy rate. It can also be observed that when the relay has lower power or the channel gain of the second hop is low, the performance of the GMF beamformer surpasses that of the GRBF. Numerical results are presented to illustrate the beamformers' performance.
基金Project supported by the National Natural Science Foundation of China(Nos.61471008,61622101,and 61571020)the National Key Research and Development Program of China(No.2016YFE0123100)
文摘We investigate the problem of resource allocation in a downlink orthogonal frequency-division multiple access (OFDMA) broadband network with an eavesdropper under the condition that both legitimate users and the eavesdropper are with imperfect channel state information (CSI). We consider three kinds of imperfect CSI: (1) noise and channel estimation errors, (2) feedback delay and channel prediction, and (3) limited feedback channel capacity, where quantized CSI is studied using rate-distortion theory because it can be used to establish an information-theoretic lower bound on the capacity of the feedback channel. The problem is formulated as joint power and subcarrier allocation to optimize the maximum-minimum (max-min) fairness criterion over the users' secrecy rate. The problem considered is a mixed integer nonlinear programming problem. To reduce the complexity, we propose a two-step suboptimal algorithm that separately performs power and subcarrier allocation. For a given subcarrier assignment, optimal power allocation is achieved by developing an algorithm of polynomial computational complexity. Numerical results show that our proposed algorithm can approximate the optimal solution.