Analysis of the Flow Field and Impact Force in High-Pressure Water Descaling

This study aims to improve the performances of the high-pressure water descaling technology used in steel hot rolling processes.In particular,a 2050 mm hot rolling line is considered,and the problem is investigated by means of a fluid–structure interaction(FSI)method by which the descaling effect produced by rolling coils with different section sizes is examined.Assuming a flat fan-shaped nozzle at the entrance of the R1R2 roughing mill,the outflow field characteristics and the velocity distribution curve on the strike line(at a target distance of 30–120 mm)are determined.It is found that the velocity in the center region of the water jet with different target distances is higher than that in the boundary region.As the target distance increases,the velocity of the water jet in the central region decreases.Through comparison with experimental results,it is shown that the simulation model can accurately predict the impact position of the high-pressure water on the impact plate,thereby providing a computational scheme that can be used to optimize the nozzle space layout and improve the slabs’descent effect for different rolling specifications.

Analysis on the Changes of Research Hotspots in the Prevention and Treatment of COVID-19 by Traditional Chinese Medicine Based on Knowledge Graph

Objective: To grasp the changing trend of research hotspots of traditional Chinese medicine in the prevention and treatment of COVID-19, and to better play the role of traditional Chinese medicine in the prevention and treatment of COVID-19 and other diseases. Methods: The research literature from 2020 to 2022 was searched in the CNKI database, and CiteSpace software was used for visual analysis. Results: The papers on the prevention and treatment of COVID-19 by traditional Chinese medicine changed from cases, overviews, reports, and efficacy studies to more in-depth mechanism research, theoretical exploration, and social impact analysis, and finally formed a theory-clinical-society Influence-institutional change and other multi-dimensional achievement systems. Conclusion: Analyzing the changing trends of TCM hotspots in the prevention and treatment of COVID-19 can fully understand the important value of TCM, take the coordination of TCM and Western medicine as an important means to deal with public health security incidents, and promote the exploration of the potential efficacy of TCM, so as to enhance the role of TCM in Applications in social stability, emergency security, clinical practice, etc.

In vitro study of emodin-induced nephrotoxicity in human renal glomerular endothelial cells on a microfluidic chip

Emodin is an effective component of rhubarb with positive pharmacological effects on human health.However,it is also toxic to different cells or tissues to varying degrees.The effects of emodin on glomerular endothelial cells(GECs)remain to be tested,and the documented works were always performed in vitro and hardly reflect the real physiological situation.To study the effects of emodin on GECs in a biomimetic environment,we utilized a microfluidic chip to assess the physiological reaction of human renal glomerular endothelial cells to various concentrations of emodin in this work.The results showed that emodin caused cytotoxicity,impaired glomerular filtration barrier integrity to macromolecules,and increased barrier permeability in a dose-dependent manner.With the increase in emodin concentration,the concentration of the pro-inflammatory cytokine tumor necrosis factor-α,interleukin(IL)-6,transforming growth factor-β1,and monocyte chemoattractant protein(MCP-1)increased while the production of inflammatory cytokine IL-6 first increased and then decreased with the increase in emodin concentration.Our findings shed new light on emodin-induced nephrotoxicity and provide insights for the application of microfluidic chip devices to reveal drug-cell interactions.

Analysis and Optimization of Flow-Guided Structure Based on Fluid-Structure Interaction

Gases containing sulfur oxides can cause corrosion and failure of bellows used as furnace blowers in high-temperature environments.In order to mitigate this issue,the behavior of an effective blast furnace blower has been examined in detail.Firstly,the Sereda corrosion model has been introduced to simulate the corrosion rate of the related bellows taking into account the effects of temperature and SO_(2) gas;such results have been compared with effective measurements;then,the average gas velocity in the pipeline and the von Mises stress distribution of the inner draft tube have been analyzed using a Fluid-Structure Interaction model.Finally,the semi-closed internal corrosion environment caused by a 5 mm radial gap between the inner draft tube and the bellows has been considered.The gas flow rate in the residential space has been found to be low(0.5 ms–this value leads to a stable semi-closed internal corrosion environment for exhaust gas exchange);water phase in the exhaust gas is prone to accelerate the corrosion rate.On this basis,a bellows with an optimized inner draft tube has proposed,which includes corrosion-resistant honeycomb buffer rings.

Construction of Industrialization Development Model for"1+4+X"Community-Based Elderly Care in Gannan Old Revolutionary Base Area in the Context of Population Aging

In the context of controlling population development in a planned way,China entered an aging society in the early 21 st century.In this context,how to meet the needs of the elderly care and form an effective elderly care model has become a key problem to be solved urgently by local government departments.With the continuous advancement of the elderly care policy,the community-based elderly care has gradually become the mainstream and is in the stage of vigorous promotion.Taking the Gannan old revolutionary base area in Jiangxi Province as an example,this study puts forward"1+4+X"community-based elderly care model based on the policy system of community-based elderly care,the physical and mental health of the elderly,the material space and the construction of evaluation system,and explores how to promote the application of this community model efficiently in the form of industrialization,so as to drive the economic growth of the Gannan old revolutionary base area,promote the employment development and improve the community-based elderly care service.

Petal-assisted artificial pollination method enhanced the fruit setting ratios in tea plant(Camellia sinensis)

Pollination methods play an important role in developing F1 populations.Our study presents an improved method of petal-assisted artificial pollination in tea plants.The field operation using this method exhibited high efficiency in which more than 500 pistillate flowers per day can be pollinated per capita,and the pollen amount from only one staminate flower was sufficient to pollinate more than five pistillate flowers.Additionally,we surveyed the fruit-setting ratio in three F1 groups,which were established using this method and the influence of rainfall on the fruit-setting ratio.The results indicate that the fruit-setting ratio was superior among the tested F1 population with an average value of 12.90%,and a significant negative correlation was observed between rainfall and fruit-setting ratio.By analyzing the growth states of each F1 population,both a high germination rate and survival rate were observed.Furthermore,the purity for 184 individuals in the F1 population of'Jiaming 1'×'Longjing 43'(J×L)were analyzed with 32 selected simple sequence repeats(SSRs).The purposes of this paper are(1)to demonstrate that this method is beneficial to establish high purity F1 populations and(2)to identify the number of SSR markers that are suitable for identification.The parentage analysis detected nine false-hybrid individuals,and the rate of false-hybrid was only 4.89%at 95%confidence,demonstrating that a low false-hybrid rate can be achieved using the method.Furthermore,one to two SSR markers randomly selected from each linkage group or chromosome were recommended as a sufficient quantity for SSR identification.

Nano-Contact Problem with Surface Effects on Triangle Distribution Loading

This work presents a theoretical study of contact problem. The Fourier integral transform method based on the surface elasticity theory is adopted to derive the fundamental solution for the contact problem with surface effects, in which both the surface tension and the surface elasticity are considered. As a special case, the deformation induced by a triangle distribution force is discussed in detail. The results are compared with those of the classical contact problem. At nano-scale, the contributions of the surface tension and the surface elasticity to the stress and displacement are not equal at the contact surface. The surface tension plays a major role to the normal stress, whereas the shear stress is mainly affected by the surface elasticity. In addition, the hardness of material depends strongly on the surface effects. This study is helpful to characterize and measure the mechanical properties of soft materials through nanoindentation.

血细胞参数NLR和RPR预测急性ST段抬高心肌梗死的价值分析

目的探讨血细胞参数NLR和RPR对急性ST段抬高心肌梗死(STEMI)的预测价值。方法选取急性STEMI患者110例,对照人群109例,收集这些研究对象的中性粒细胞、淋巴细胞及RDW、PLT数据,根据公式NLR=N/L,RPR=RDW(%)/PLT(109/L),计算所有研究对象的NLR和RPR。结果急性STEMI患者组和对照组人群的NLR及RPR结果比较均具有统计学差异(P<0.05)。NLR和RPR对急性STEMI患者的诊断价值大小用ROC曲线下面积(AUC)表示为0.914、0.724;当NLR的诊断最佳截点值为4.002时,灵敏度为0.809,特异度为0.543,阳性预测值为0.899,阴性预测值为0.825;当RPR的诊断最佳截点值为0.056时,灵敏度为0.800,特异度为0.578,阳性预测值为0.652,阴性预测值为0.738。结论 NLR和RPR对于急性STEMI均具有一定预测价值,但参数NLR的价值更高。

Spatial Distribution of Carbon, Nitrogen and Phosphorus within Surface Sediments in the Lower Lancang River: Pollution Assessment Related to Dams

Surface sediment is one of the main sources of nutrients in overlying water environments, and these can also indirectly reflect the degree of eutrophication. In this paper, the spatial distribution characteristics of total organic carbon (TOC), total nitrogen (TN) and total phosphorus (TP) in the surface sediments of 11 sections in the lower Lancang River during flood season are analyzed, as well as the distribution of phosphorus in different forms. The main sources of TOC and its correlation with TN and TP are discussed and, finally, the pollution levels of the surface sediments are evaluated. The results show that the average content of TOC in the surface sediments of the lower Lancang River is 9003.75 mg/kg. The average TN content is 893.79 mg/kg, while the average TP content is 521.35 mg/kg. The TOC in the surface sediments of the lower Lancang River is derived mainly from algae and plankton in the river, and the TN and TP have similar sources. The total phosphorus in the surface sediments of the lower Lancang River is composed mainly of calcium-bound phosphorus (Ca-P). The evaluations of the organic pollution index and comprehensive pollution index show that the surface sediment pollution degree at the upper sections of the Nuozhadu and Jinghong Dams are more serious than those below the dams. Furthermore, the tributary sections are all slightly polluted, with the exception of the Mengyang River, which is considered moderately polluted.

Effect of raw material variability of glipizide on the in vitro dissolution rate and in vivo bioavailability performance: The importance of particle size

The objective of this study was to understand the impact of active pharmaceutical ingredients(API) particle size on a re-developed generic product of glipizide and to improve its formulation so that it exhibits bioequivalent to that of the reference listed drug(RLD). Two commercial batches of APIs(API-1 and API-2) with the same polymorphism and one batch of home-made APIs(API-3) with super-small particle size were used in the present study.The in vitro dissolution profiles of the tested formulations were compared with the RLD in a series of dissolution media. Then, the impact of particle size on in vivo absorption was evaluated in Beagle dogs. Compared with the RLD, formulation A with larger API size showed slower dissolution in p H 6.0 and 7.4 medium, resulting bioinequivalent with the RLD. Conversely, formulation B with smaller API size demonstrated similar in vitro dissolution profiles with the RLD and thus exhibited bioequivalent in the present study. Furthermore, formulation C with super small particle size still exhibited identical oral absorption although rapid dissolution was observed in the tested condition. Herein, it indicated that 2–5 μm might be defined as the "inert size range" of glipizide for ensuring the bioequivalence with the RLD. The results in the present study might help to obtain a better understanding of the variability in raw materials for oral absorption, develop a bioequivalent product and thus post-market quality control.

Sampled-Data Consensus Control of MUSV Systems with Channel Fading and Transmission Delay

This paper studies sampled-data consensus control of a collection of unmanned surface vehicles(USV)operating in network environments with fading channels and time-varying transmission delay.The channel fading is modeled as each independent stochastic process whose probability distribution is known.By considering the effects of channel fading and transmission delay from sampler to the controller,a new MUSV system model is formulated in the framework of network.With the novel established model,stability analysis is given at first,then the sampled-data consensus controller is designed,which also extends to the robust control with wave-induced disturbance.The effectiveness of the presented method is demonstrated by numerical simulation.

An integrative analysis of metabolomics,DNA methylation and RNASeq data reveals key genes involved in albino tea'Haishun 2'

Albino tea,a type of tea closely associated with the chlorophyll-deficient phenotype is of great interest due to its multiple benefits to human health.To explore the potential mechanisms involved in albino tea,we performed metabolomics,DNA methylation and RNA-Seq analysis of green and albino leaves in a special tea mutant'Haishun 2'.The albino leaves accumulated significantly less catechins compared with the green leaves,which is closely associated with their difference in chlorophyll formation.A total of 385 candidate genes were identified by the integrative analysis.Two NAC transcription factors were less methylated and highly up regulated in the albino leaves of'Haishun 2',which was the first identification of the key roles of NAC transcription factors in albino tea and worth further study.Many genes involved in catechin biosynthesis were down regulated in albino leaves,such as 4-coumarate-CoA ligase,flavonol synthase and leucoanthocyanidin reductase genes,suggesting chlorophyll formation is important for catechin biosynthesis.Furthermore,CsMYB5 and CsGSTF11 were found to be differentially methylated and expressed in albino and green leaves,indicating their potential roles in catechin accumulation.This was the first report of the integrative analysis of transcriptome and DNA methylation data in tea plants and the results suggest that the integrative analysis is useful for exploring key genes associated with epigenetic changes in tea plants.

Analysis on Occupational Well-being Status and Influencing Factors of Medical Staff in Tuberculosis Departments

Objective:To investigate the status of occupational well-being of medical staff in tuberculosis department and analyze its influencing factors,so as to provide a basis for improving the occupational well-being of medical staff in tuberculosis department.Methods:In May 2020,we adopted the method of cluster sampling to select staff members from the tuberculosis departments of the Affiliated Hospital of Hebei University and infectious disease hospital.A total of 139 medical staff were recruited as the research subjects,and were investigated using medical staff occupational well-being scale.Results:The total score of occupational well-being was 76.4697 points,There were statistically significant differences(P<0.05)in occupational well-being score among tuberculosis medical staff with different age,years of work,job title,night shift,marital status,and occupational type.The influencing factors of occupational well-being were the night shift,years of work,occupational type,and marital status(P<0.05).Conclusion:The overall level of occupational well-being of tuberculosis medical staffs is moderate,and occupational well-being is affected by night shift,years of work,occupational type and marital status.It is recommended that managers take targeted measures to improve the occupational well-being of tuberculosis medical staff.

南岭哺乳类和鸟类物种丰富度空间分布格局及其影响因子

作为华南地区的最大山脉和重要自然地理界线,南岭是物种丰富度研究的热点区域之一。但是已有的物种丰富度相关研究集中在局部区域和单个生物类群,缺乏对于整个南岭区域哺乳类和鸟类物种丰富度空间分布格局及其影响因子的研究。本研究利用南岭区域123种哺乳类和524种鸟类的地理分布数据,构建了整个南岭山脉的哺乳类和鸟类的物种丰富度空间分布格局。此外,我们利用路径分析和空间误差模型,探讨多种环境因子(气候、生产力、人类活动、生境异质性和海拔)对南岭哺乳类和鸟类物种丰富度空间分布格局的影响。南岭地区哺乳类和鸟类物种丰富度空间分布格局差异较大:哺乳类物种丰富度热点区域在南岭地区的西南部山地,丰富度空间分布格局总体自西向东递减;鸟类物种丰富度热点区域在南岭地区的东南部低地,丰富度空间分布格局总体自东南向西北递减。路径分析和空间误差模型显示,温度相关因子对于南岭哺乳类和鸟类物种丰富度空间分布格局影响最大。在温度相关的两个因子中,年均温与哺乳类物种丰富度呈负相关,与鸟类却呈正相关;气温年较差与哺乳类呈正相关,与鸟类却呈负相关。年均温和气温年较差对哺乳类和鸟类影响的差异可能是由哺乳类和鸟类在生理适应性和行为策略上的差异所导致。

Microstructure and Mechanical Properties of the Ti_(62)Nb_(12)Mo_(12)Ta_(12)W_(2)Refractory High Entropy Alloy Prepared through Spark Plasma Sintering

A refractory high entropy alloy Ti_(62)Nb_(12)Mo_(12)Ta_(12)W_(2)was prepared by mechanical alloying and spark plasma sintering.The microstructure and mechanical properties of the Ti_(62)Nb_(12)Mo_(12)Ta_(12)W_(2)alloy were analyzed.The experimental results show that the microstructure of the alloy is composed of two BCC phases,an FCC precipitated phase,and the precipitated phase which is a mixture of TiC,TiN and TiO.The alloy exhibits good room temperature compressive properties.The plasticity of the sample sintered at 1550℃can reach 10.8%,and for the sample sintered at 1600℃,the yield strength can be up to 2032 MPa,in the meantime the plasticity is 9.4%.The alloy also shows high strength at elevated temperature.The yield strength of the alloy exceeds 420 MPa at 900℃,and value of which is still above 200 MPa when the test temperature reaches 1000℃.Finally,the compressive yield strength model at room temperature is constructed.The prediction error of the model ranges from−7.9%to−12.4%,expressing fair performance.

Candy or poison: Plant metabolites as swing factors against microbes

Plant metabolites play crucial roles in plant-microbe interactions,influencing compatibility with different microbial species and modulating both symbiotic and pathogenic relationships.Plants synthesize two categories of metabolites:primary and secondary metabolites,each serving specific functions in plant physiology and defense.Primary metabolites,including sugars,lipids,nucleotides,amino acids,and organic acids,are essential for plant growth and development.However,these metabolites also serve as nutrient sources for microbes.Successful invasion of devastating pathogens relies heavily on their ability to effectively acquire primary metabolites from host plants.For instance,transcriptional activator-like effectors from Xanthomonas and Ralstonia are known to trigger the transcription of OsSWEET genes,which encode sugar transporters.

老年高尿酸血症患者血清白细胞介素-23、尿酸、单核细胞趋化蛋白-1与肾功能损伤的相关性研究

目的探讨老年高尿酸血症(HUA)患者白细胞介素-23(IL-23)、尿酸(UA)、单核细胞趋化蛋白-1(MCP-1)与肾功能损伤的相关性。方法选取2020年3月至2021年10月我院老年HUA患者112例。收集患者住院期间的临床资料及IL-23、MCP-1水平等实验室指标。通过Logistic多因素回归分析血清指标与肾功能损伤的关联性,采用Spearman相关系数模型分析血清指标水平与不同程度肾功能损伤的关系。通过受试者工作特征(ROC)曲线评价血清指标预测肾功能损伤的价值。结果与肾功能正常患者相比,肾功能损伤患者的病程更长,合并高血压比例更高,血清的IL-23、UA、MCP-1水平增高,GFR减低(P<0.05)。校正后的血清IL-23、UA、MCP-1水平与肾功能损伤的发生存在关联性(P<0.05)。血清IL-23、UA、MCP-1水平与肾功能损伤的程度亦呈正相关(P<0.05),重度肾功能损伤患者的血清IL-23、UA、MCP-1水平最高(P<0.05)。血清IL-23、UA、MCP-1联合预测肾功能损伤的曲线下面积(AUC)为0.892,大于各单独指标。结论老年HUA患者的血清IL-23、UA、MCP-1水平与肾功能损伤的发生以及损伤程度均呈正相关,3个指标联合对老年HUA患者肾功能损伤的预测价值更大。

Single-cell analysis reveals the lncRNA-MEG3/miRNA-133a-3p/PRRT2 axis regulates skeletal muscle regeneration and myogenesis

Skeletal muscle is the largest motor and metabolic organ of the body, which has a robust capacity for regeneration following injury or disease. Delayed regeneration after skeletal muscle injury reduces muscle contractility and leads to dysfunction of innervation. Therefore, identifying the regulation components in skeletal muscle regeneration and determining their molecular mechanisms are important to discover novel therapeutic markers for muscular diseases. Long non-coding RNA (LncRNA) has been implicated in skeletal muscle regeneration. Recent developed single-cell RNA sequencing (scRNA-seq) provides a higher resolution of cellular differences than bulk RNA-seq. Here, we re-analyzed single-cell transcriptomes data of skeletal muscle regeneration and identified lncRNA maternally expressed gene 3 (lncRNA-MEG3) was highly expressed in muscle satellite cells (MuSCs). Further study showed that lncRNA-MEG3 regulates skeletal muscle regeneration via sponging miR-133a-3p to regulate proline-rich transmembrane protein 2 (PRRT2) expression level. These results suggested that lncRNA-MEG3 might be a potential target for skeletal muscle diseases.

自振荡凝胶的仿生运动

定向运动是生命体最基本的功能,是其进化、生存和繁衍的前提。近年来为了研究生命体的运动机制,许多人工系统被相继开发并用于模拟部分生命体的运动行为。在诸多人工仿生系统里,自振荡凝胶由于同时具有内部驱动产生动能、运动定向性、无缆化和环境自适应等性能而备受瞩目。本文介绍了自振荡凝胶仿生运动的化学-机械能转换的理论根源并综述了仿生运动模式研究近期的进展,在此基础上展望了自振荡凝胶运动研究面临的机遇、挑战和未来发展方向。

Fiber-shaped organic electrochemical transistors for biochemical detections with high sensitivity and stability

Precise and continuous monitoring of biochemicals by biosensors assists to understand physiological functions for various diagnostics and therapeutic applications.For implanted biosensors,small size and flexibility are essential for minimizing tissue damage and achieving accurate detection.However,the active surface area of sensor decreases as the sensor becomes smaller,which will increase the impedance and decrease the signal to noise ratio,resulting in a poor detection limit.Taking advantages of local amplification effect,organic electrochemical transistors(OECTs)constitute promising candidates for high-sensitive monitoring.However,their detections in deep tissues are rarely reported.Herein,we report a family of implantable,fiber-shaped all-in-one OECTs based on carbon nanotube fibers for versatile biochemical detection including H2O2,glucose,dopamine and glutamate.These fiber-shaped OECTs demonstrated high sensitivity,dynamical stability in physiological environment and antiinterference capability.After implantation in mouse brain,7-day dopamine monitoring in vivo was realized for the first time.These fiber-shaped OECTs could be great additions to the"life science"tool box and represent promising avenue for biomedical monitoring.