Oceanic vertical mixing of the lower halocline water(LHW)in the Chukchi Borderland and Mendeleyev Ridge was studied based on in situ hydrographic and turbulent observations.The depth-averaged turbulent dissipation rat...Oceanic vertical mixing of the lower halocline water(LHW)in the Chukchi Borderland and Mendeleyev Ridge was studied based on in situ hydrographic and turbulent observations.The depth-averaged turbulent dissipation rate of LHW demonstrates a clear topographic dependence,with a mean value of 1.2×10^(-9) W/kg in the southwest of Canada Basin,1.5×10^(-9) W/kg in the Mendeleyev Abyssal Plain,2.4×10^(-9) W/kg on the Mendeleyev Ridge,and2.7×10^(-9) W/kg on the Chukchi Cap.Correspondingly,the mean depth-averaged vertical heat flux of the LHW is0.21 W/m^(2) in the southwest Canada Basin,0.30 W/m^(2) in the Mendeleyev Abyssal Plain,0.39 W/m^(2) on the Mendeleyev Ridge,and 0.46 W/m^(2) on the Chukchi Cap.However,in the presence of Pacific Winter Water,the upward heat released from Atlantic Water through the lower halocline can hardly contribute to the surface ocean.Further,the underlying mechanisms of diapycnal mixing in LHW—double diffusion and shear instability—was investigated.The mixing in LHW where double diffusion were observed is always relatively weaker,with corresponding dissipation rate ranging from 1.01×10^(-9) W/kg to 1.57×10^(-9) W/kg.The results also show a strong correlation between the depth-average dissipation rate and strain variance in the LHW,which indicates a close physical linkage between the turbulent mixing and internal wave activities.In addition,both surface wind forcing and semidiurnal tides significantly contribute to the turbulent mixing in the LHW.展开更多
Recurrent oral ulcer is a painful oral mucosal disorder that affects 20%of the world’s population.The lack of a radical cure due to its unknown underlying cause calls for innovative symptomatic treatments.This work r...Recurrent oral ulcer is a painful oral mucosal disorder that affects 20%of the world’s population.The lack of a radical cure due to its unknown underlying cause calls for innovative symptomatic treatments.This work reports a hyaluronic acid-based dissolvablemicroneedle patch(ROUMNpatch,short for recurrent oral ulcer microneedle)loaded with dexamethasone acetate,vitamin C and tetracaine hydrochloride for the treatment of recurrent oral ulcers.The ROUMN patch shows enhancement in both the anti-inflammatory effect elicited by dexamethasone and the pro-proliferation effect of vitamin C.In vitro experiments show that ROUMN has a higher efficiency in suppressing lipopolysaccharide(LPS)-induced interleukin-6(IL-6)expression than dexamethasone alone.Cell proliferation and migrationwere also significantly promoted byROUMNcompared to vitamin C alone.The healing-promoting effect of ROUMN was also verified in vivo using an acetic acid-cauterized oral ulcer model in rats.ROUMN as a treatment accelerated the healing process of oral ulcers,shortening the total healing time to 5 days compared with the 7 days required by treatment using watermelon frost,a commonly used over-the-counter(OTC)drug for oral ulcers.The rapid dissolution of the hyaluronic acid-based microneedles and the superior healing-promoting effect of the drug combination could lead to a broad application prospect of the ROUMN patch in the treatment of recurrent oral ulcers.展开更多
基金The National Natural Science Foundation of China under contract No.42006037the Chinese Polar Environmental Comprehensive Investigation&Assessment Programs,Grant from the Scientific Research Fund of the Second Institute of Oceanography,MNR under contract No.JB904the National Key R&D Program of China under contract No.2019YFC1509102。
文摘Oceanic vertical mixing of the lower halocline water(LHW)in the Chukchi Borderland and Mendeleyev Ridge was studied based on in situ hydrographic and turbulent observations.The depth-averaged turbulent dissipation rate of LHW demonstrates a clear topographic dependence,with a mean value of 1.2×10^(-9) W/kg in the southwest of Canada Basin,1.5×10^(-9) W/kg in the Mendeleyev Abyssal Plain,2.4×10^(-9) W/kg on the Mendeleyev Ridge,and2.7×10^(-9) W/kg on the Chukchi Cap.Correspondingly,the mean depth-averaged vertical heat flux of the LHW is0.21 W/m^(2) in the southwest Canada Basin,0.30 W/m^(2) in the Mendeleyev Abyssal Plain,0.39 W/m^(2) on the Mendeleyev Ridge,and 0.46 W/m^(2) on the Chukchi Cap.However,in the presence of Pacific Winter Water,the upward heat released from Atlantic Water through the lower halocline can hardly contribute to the surface ocean.Further,the underlying mechanisms of diapycnal mixing in LHW—double diffusion and shear instability—was investigated.The mixing in LHW where double diffusion were observed is always relatively weaker,with corresponding dissipation rate ranging from 1.01×10^(-9) W/kg to 1.57×10^(-9) W/kg.The results also show a strong correlation between the depth-average dissipation rate and strain variance in the LHW,which indicates a close physical linkage between the turbulent mixing and internal wave activities.In addition,both surface wind forcing and semidiurnal tides significantly contribute to the turbulent mixing in the LHW.
基金the National Natural Science Foundation of China(Nos.62003023,32071407,52073138,52003018 and 52003019)Beijing Natural Science Foundation(No.7212204)Beijing Advanced Innovation Center for Biomedical Engineering and Beihang University.
文摘Recurrent oral ulcer is a painful oral mucosal disorder that affects 20%of the world’s population.The lack of a radical cure due to its unknown underlying cause calls for innovative symptomatic treatments.This work reports a hyaluronic acid-based dissolvablemicroneedle patch(ROUMNpatch,short for recurrent oral ulcer microneedle)loaded with dexamethasone acetate,vitamin C and tetracaine hydrochloride for the treatment of recurrent oral ulcers.The ROUMN patch shows enhancement in both the anti-inflammatory effect elicited by dexamethasone and the pro-proliferation effect of vitamin C.In vitro experiments show that ROUMN has a higher efficiency in suppressing lipopolysaccharide(LPS)-induced interleukin-6(IL-6)expression than dexamethasone alone.Cell proliferation and migrationwere also significantly promoted byROUMNcompared to vitamin C alone.The healing-promoting effect of ROUMN was also verified in vivo using an acetic acid-cauterized oral ulcer model in rats.ROUMN as a treatment accelerated the healing process of oral ulcers,shortening the total healing time to 5 days compared with the 7 days required by treatment using watermelon frost,a commonly used over-the-counter(OTC)drug for oral ulcers.The rapid dissolution of the hyaluronic acid-based microneedles and the superior healing-promoting effect of the drug combination could lead to a broad application prospect of the ROUMN patch in the treatment of recurrent oral ulcers.
