With drilling and seismic data of Transtensional(strike-slip)Fault System in the Ziyang area of the central Sichuan Basin,SW China plane-section integrated structural interpretation,3-D fault framework model building,...With drilling and seismic data of Transtensional(strike-slip)Fault System in the Ziyang area of the central Sichuan Basin,SW China plane-section integrated structural interpretation,3-D fault framework model building,fault throw analyzing,and balanced profile restoration,it is pointed out that the transtensional fault system in the Ziyang 3-D seismic survey consists of the northeast-trending F_(I)19 and F_(I)20 fault zones dominated by extensional deformation,as well as 3 sets of northwest-trending en echelon normal faults experienced dextral shear deformation.Among them,the F_(I)19 and F_(I)20 fault zones cut through the Neoproterozoic to Lower Triassic Jialingjiang Formation,presenting a 3-D structure of an“S”-shaped ribbon.And before Permian and during the Early Triassic,the F_(I)19 and F_(I)20 fault zones underwent at least two periods of structural superimposition.Besides,the 3 sets of northwest-trending en echelon normal faults are composed of small normal faults arranged in pairs,with opposite dip directions and partially left-stepped arrangement.And before Permian,they had formed almost,restricting the eastward growth and propagation of the F_(I)19 fault zone.The F_(I)19 and F_(I)20 fault zones communicate multiple sets of source rocks and reservoirs from deep to shallow,and the timing of fault activity matches well with oil and gas generation peaks.If there were favorable Cambrian-Triassic sedimentary facies and reservoirs developing on the local anticlinal belts of both sides of the F_(I)19 and F_(I)20 fault zones,the major reservoirs in this area are expected to achieve breakthroughs in oil and gas exploration.展开更多
BACKGROUND Circulating tumor cell(CTC)count and neutrophil-to-lymphocyte ratio(NLR)are both closely associated with the prognosis of hepatocellular carcinoma(HCC).AIM To investigate the prognostic value of combining t...BACKGROUND Circulating tumor cell(CTC)count and neutrophil-to-lymphocyte ratio(NLR)are both closely associated with the prognosis of hepatocellular carcinoma(HCC).AIM To investigate the prognostic value of combining these two indicators in HCC.METHODS Clinical data were collected from patients with advanced HCC who received im-mune therapy combined with targeted therapy at the Department of Oncology,the Affiliated Hospital of Southwest Medical University,Sichuan,China,from 2021 to 2023.The optimal cutoff values for CTC programmed death-ligand 1(PD-L1)(+)>1 or CTC PD-L1(+)≤1 and NLR>3.89 or NLR≤3.89 were evaluated using X-Tile software.Patients were categorized into three groups based on CTC PD-L1(+)counts and NLR:CTC-NLR(0),CTC-NLR(1),and CTC-NLR(2).The relationship between CTC-NLR and clinical variables as well as survival rates was assessed.RESULTS Patients with high CTC PD-L1(+)expression or NLR at baseline had shorter median progression-free survival(m-PFS)and median overall survival(mOS)than those with low levels of CTC PD-L1(+)or NLR(P<0.001).Mean-while,patients in the CTC-NLR(2)group showed a significant decrease in mPFS and mOS.Cox regression analysis revealed that alpha-fetoprotein(AFP),CTC PD-L1(+),and CTC-NLR were independent predictors of OS.The time-dependent receiver operating characteristic curve showed that the area under the curve of CTC-NLR at 12 months(0.821)and 18 months(0.821)was superior to that of AFP and CTC PD-L1(+).CONCLUSION HCC patients with high CTC PD-L1(+)or NLR expression tend to exhibit poor prognosis,and a high baseline CTC-NLR score may indicate low survival.CTC-NLR may serve as an effective prognostic indicator for patients with advanced HCC receiving immunotherapy combined with targeted therapy.展开更多
The Tongnan secondary negative structure in central Sichuan Basin has controls and influences on the structural framework and petroleum geological conditions in the Gaoshiti-Moxi area.To clarify the controls and influ...The Tongnan secondary negative structure in central Sichuan Basin has controls and influences on the structural framework and petroleum geological conditions in the Gaoshiti-Moxi area.To clarify the controls and influences,the deformation characteristics,structural attributes and evolution process of the Tongnan negative structure were investigated through a series of qualitative and quantitative methods such as balanced profile restoration,area-depth-strain(ADS)analysis,and structural geometric forward numerical simulation,after comprehensive structural interpretation of high-precision 3D seismic data.The results are obtained in three aspects.First,above and below the P/AnP(Permian/pre-Permian)unconformity,the Tongnan negative structure demonstrates vertical differential structural deformation.It experiences two stages of structural stacking and reworking:extensional depression(from the Sinian Dengying Formation to the Permian),and compressional syncline deformation(after the Jurassic).The multi-phase trishear deformation of the preexisting deep normal faults dominated the extensional depression.The primary depression episodes occurred in the periods from the end of Late Proterozoic to the deposition of the 1st–2nd members of the Dengying Formation,and from the deposition of Lower Cambrian Longwangmiao Formation–Middle–Upper Cambrian until the Ordovician.Second,the multi-stage evolution process of the Tongnan negative structure controlled the oil and gas migration and adjustment and present-day differential gas and water distribution between the Tongnan negative structure and the Gaoshiti and Moxi-Longnüsi structural highs.Third,the Ordovician,which is limitedly distributed in the Tongnan negative structure and is truncated by the P/AnP unconformity on the top,has basic geological conditions for the formation of weathering karst carbonate reservoirs.It is a new petroleum target deserving attention.展开更多
It is shown that the flux motion in high-T_(c) superconductors can be well consistently analysed by a unified materials equation.The different models of U(J)so far suggested can be shown as specific forms or limits of...It is shown that the flux motion in high-T_(c) superconductors can be well consistently analysed by a unified materials equation.The different models of U(J)so far suggested can be shown as specific forms or limits of this unified materials equation.The scaling law of flux pinning derived from this equation agrees with recent experimental observations on high-Jc NdBa2Gu3O7-δsingle crystal.The amplitude dependence of ac susceptibility derived from this equation is compared with several experimental results of high-T_(c) superconductors and a general power law is found.展开更多
随着物联网的快速发展,物联网生态系统逐步形成,通过设计与物联网云平台的数据交互,可以增加设计的灵活性以及降低硬件成本。本文提出了基于Arduino和Android平台实现语音交互的声控智能小车,该小车以Arduino UNO R3开发板为控制系统、...随着物联网的快速发展,物联网生态系统逐步形成,通过设计与物联网云平台的数据交互,可以增加设计的灵活性以及降低硬件成本。本文提出了基于Arduino和Android平台实现语音交互的声控智能小车,该小车以Arduino UNO R3开发板为控制系统、通过Android Studio编写手机终端语音识别App、阿里云平台提供云语音识别技术。通过ESP8266 WiFi模块的中继功能,阿里云平台与手机终端App的数据交互发送到Arduino中。此外,L298N直流电机驱动模块通过Arduino IDE编程驱动L298N模块控制直流电机转动速度和方向,最终实现非特定语音对智能小车前进、后退、转弯、加减速等控制。展开更多
Objective:To establish an efficacious and efficient fermentation method of enhancing the anti-adipogenesis effect of mulberry(Morus alba) leaves using Cordyceps militais.Methods:Dried mulberry leaves,dried mulberry le...Objective:To establish an efficacious and efficient fermentation method of enhancing the anti-adipogenesis effect of mulberry(Morus alba) leaves using Cordyceps militais.Methods:Dried mulberry leaves,dried mulberry leaves with50% raw silkworm pupa and raw silkworm pupa were fermented with Cordyceps militais for 4 weeks at 25℃,after which the dried mulberry leaves and fermented product were extracted with 70%ethanol and subjected to high performance liquid chromatography(HPLC).The contents of cordycepin,pelargonidin,chlorogenic acid,iso-quercetin and caffeic acid were determined.We then used the 3 T3-L1 cells to investigate whether extracts of fermentation enhanced anti-adipogenesis activity in vitro.Results:HPLC showed that fermentation changed the contents of cordycepin,pelargonidin,chlorogenic acid,iso-quercetin and caffeic acid.Furthermore,fermented dried mulberry leaves with 50% raw silkworm pupa had a better efficacy of anti-adipogenesis than dried mulberry leaves,fermented dried mulberry leaves and fermented silkworm pupa and inhibited triglycerides accumulation and glucose consumption.Additionally,fermented dried mulberry leaves with50% raw silkworm pupa inhibited PPAR-γ signaling.Conclusions:Fermentation with Cordyceps militaris enhanced antiadipogenesis efficacy of mulberry leaves.展开更多
基金Supported by the Key Project of National Natural Science Foundation of China(42330810).
文摘With drilling and seismic data of Transtensional(strike-slip)Fault System in the Ziyang area of the central Sichuan Basin,SW China plane-section integrated structural interpretation,3-D fault framework model building,fault throw analyzing,and balanced profile restoration,it is pointed out that the transtensional fault system in the Ziyang 3-D seismic survey consists of the northeast-trending F_(I)19 and F_(I)20 fault zones dominated by extensional deformation,as well as 3 sets of northwest-trending en echelon normal faults experienced dextral shear deformation.Among them,the F_(I)19 and F_(I)20 fault zones cut through the Neoproterozoic to Lower Triassic Jialingjiang Formation,presenting a 3-D structure of an“S”-shaped ribbon.And before Permian and during the Early Triassic,the F_(I)19 and F_(I)20 fault zones underwent at least two periods of structural superimposition.Besides,the 3 sets of northwest-trending en echelon normal faults are composed of small normal faults arranged in pairs,with opposite dip directions and partially left-stepped arrangement.And before Permian,they had formed almost,restricting the eastward growth and propagation of the F_(I)19 fault zone.The F_(I)19 and F_(I)20 fault zones communicate multiple sets of source rocks and reservoirs from deep to shallow,and the timing of fault activity matches well with oil and gas generation peaks.If there were favorable Cambrian-Triassic sedimentary facies and reservoirs developing on the local anticlinal belts of both sides of the F_(I)19 and F_(I)20 fault zones,the major reservoirs in this area are expected to achieve breakthroughs in oil and gas exploration.
基金The research protocol was approved by the Clinical Trial Ethics Committee of the Affiliated Hospital of Southwest Medical University(approval number:KY2021063)registered in the Chinese Clinical Trial Registry(registration number:ChiCTR2100044198).
文摘BACKGROUND Circulating tumor cell(CTC)count and neutrophil-to-lymphocyte ratio(NLR)are both closely associated with the prognosis of hepatocellular carcinoma(HCC).AIM To investigate the prognostic value of combining these two indicators in HCC.METHODS Clinical data were collected from patients with advanced HCC who received im-mune therapy combined with targeted therapy at the Department of Oncology,the Affiliated Hospital of Southwest Medical University,Sichuan,China,from 2021 to 2023.The optimal cutoff values for CTC programmed death-ligand 1(PD-L1)(+)>1 or CTC PD-L1(+)≤1 and NLR>3.89 or NLR≤3.89 were evaluated using X-Tile software.Patients were categorized into three groups based on CTC PD-L1(+)counts and NLR:CTC-NLR(0),CTC-NLR(1),and CTC-NLR(2).The relationship between CTC-NLR and clinical variables as well as survival rates was assessed.RESULTS Patients with high CTC PD-L1(+)expression or NLR at baseline had shorter median progression-free survival(m-PFS)and median overall survival(mOS)than those with low levels of CTC PD-L1(+)or NLR(P<0.001).Mean-while,patients in the CTC-NLR(2)group showed a significant decrease in mPFS and mOS.Cox regression analysis revealed that alpha-fetoprotein(AFP),CTC PD-L1(+),and CTC-NLR were independent predictors of OS.The time-dependent receiver operating characteristic curve showed that the area under the curve of CTC-NLR at 12 months(0.821)and 18 months(0.821)was superior to that of AFP and CTC PD-L1(+).CONCLUSION HCC patients with high CTC PD-L1(+)or NLR expression tend to exhibit poor prognosis,and a high baseline CTC-NLR score may indicate low survival.CTC-NLR may serve as an effective prognostic indicator for patients with advanced HCC receiving immunotherapy combined with targeted therapy.
基金Supported by the National Natural Science Foundation of China(U19B6003-01).
文摘The Tongnan secondary negative structure in central Sichuan Basin has controls and influences on the structural framework and petroleum geological conditions in the Gaoshiti-Moxi area.To clarify the controls and influences,the deformation characteristics,structural attributes and evolution process of the Tongnan negative structure were investigated through a series of qualitative and quantitative methods such as balanced profile restoration,area-depth-strain(ADS)analysis,and structural geometric forward numerical simulation,after comprehensive structural interpretation of high-precision 3D seismic data.The results are obtained in three aspects.First,above and below the P/AnP(Permian/pre-Permian)unconformity,the Tongnan negative structure demonstrates vertical differential structural deformation.It experiences two stages of structural stacking and reworking:extensional depression(from the Sinian Dengying Formation to the Permian),and compressional syncline deformation(after the Jurassic).The multi-phase trishear deformation of the preexisting deep normal faults dominated the extensional depression.The primary depression episodes occurred in the periods from the end of Late Proterozoic to the deposition of the 1st–2nd members of the Dengying Formation,and from the deposition of Lower Cambrian Longwangmiao Formation–Middle–Upper Cambrian until the Ordovician.Second,the multi-stage evolution process of the Tongnan negative structure controlled the oil and gas migration and adjustment and present-day differential gas and water distribution between the Tongnan negative structure and the Gaoshiti and Moxi-Longnüsi structural highs.Third,the Ordovician,which is limitedly distributed in the Tongnan negative structure and is truncated by the P/AnP unconformity on the top,has basic geological conditions for the formation of weathering karst carbonate reservoirs.It is a new petroleum target deserving attention.
基金Supported by the National Natural Sciences Foundation of China under Grant No.19571006the National Center for Research and Development on Superconductivity of China.
文摘It is shown that the flux motion in high-T_(c) superconductors can be well consistently analysed by a unified materials equation.The different models of U(J)so far suggested can be shown as specific forms or limits of this unified materials equation.The scaling law of flux pinning derived from this equation agrees with recent experimental observations on high-Jc NdBa2Gu3O7-δsingle crystal.The amplitude dependence of ac susceptibility derived from this equation is compared with several experimental results of high-T_(c) superconductors and a general power law is found.
基金This work was supported by Korea Institute of Planning and Evaluation for Technology in Food,Agriculture,Forestry and Fisheries(IPET)through High Value-added Food Technology Development Program,funded by Ministry of Agriculture,Food and Rural Affairs(MAFRA)(116027032HD020).
文摘Objective:To establish an efficacious and efficient fermentation method of enhancing the anti-adipogenesis effect of mulberry(Morus alba) leaves using Cordyceps militais.Methods:Dried mulberry leaves,dried mulberry leaves with50% raw silkworm pupa and raw silkworm pupa were fermented with Cordyceps militais for 4 weeks at 25℃,after which the dried mulberry leaves and fermented product were extracted with 70%ethanol and subjected to high performance liquid chromatography(HPLC).The contents of cordycepin,pelargonidin,chlorogenic acid,iso-quercetin and caffeic acid were determined.We then used the 3 T3-L1 cells to investigate whether extracts of fermentation enhanced anti-adipogenesis activity in vitro.Results:HPLC showed that fermentation changed the contents of cordycepin,pelargonidin,chlorogenic acid,iso-quercetin and caffeic acid.Furthermore,fermented dried mulberry leaves with 50% raw silkworm pupa had a better efficacy of anti-adipogenesis than dried mulberry leaves,fermented dried mulberry leaves and fermented silkworm pupa and inhibited triglycerides accumulation and glucose consumption.Additionally,fermented dried mulberry leaves with50% raw silkworm pupa inhibited PPAR-γ signaling.Conclusions:Fermentation with Cordyceps militaris enhanced antiadipogenesis efficacy of mulberry leaves.
