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DEAON: dynamically-evolving active overlay networks for scalable information retrieval
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作者 黄新力 ma fanyuan 《High Technology Letters》 EI CAS 2007年第4期413-417,共5页
In this paper, we propose the dynamically-evolving active overlay network (DEAON), which is an efficient, scalable yet simple protocol to facilitate applications of decentralized information retrieval in P2P network... In this paper, we propose the dynamically-evolving active overlay network (DEAON), which is an efficient, scalable yet simple protocol to facilitate applications of decentralized information retrieval in P2P networks. DEAON consists of three novel components : a Desirable Topology Construction and Adaptation algorithm to guide the evolution of the overlay topology towards a small-world-like graph; a Semantic-based Neighbor Selection scheme to conduct an online neighbor ranking; a Topology-aware Intelligent Search mechanism to forward incoming queries to deliberately selected neighbors. We deploy and compare DEAON with other several existing distributed search techniques over static and dynamic environments. The results indicate that DEAON outperforms its competitors by achieving higher recall rate while using much less network resources, in both of the above environments. 展开更多
关键词 active overlay networks information retrieval SEARCH topological properties small world
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基于舒缓医疗理念的老年医学教育探究
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作者 张华 马藩源 +1 位作者 张红梅 史娟 《国际老年医学杂志》 2024年第3期381-384,共4页
舒缓医疗的目标是帮助患者和家属改善生活质量,体现医护职业道德核心内容,尊重患者的生命价值和人格尊严,方式包括通过镇痛和缓解症状,减轻身体、精神、心理痛苦,满足患者延长生命的需求。本文通过阐述将舒缓医疗理念融入老年医学教育,... 舒缓医疗的目标是帮助患者和家属改善生活质量,体现医护职业道德核心内容,尊重患者的生命价值和人格尊严,方式包括通过镇痛和缓解症状,减轻身体、精神、心理痛苦,满足患者延长生命的需求。本文通过阐述将舒缓医疗理念融入老年医学教育,为老年医学医务工作者的培养工作提供了一种可持续性发展的教学模式和实践经验,提高老年医学教育的质量,提升老年专科医师的岗位胜任力,为建立全面且规范的老年医学教育提供了一定思路。 展开更多
关键词 舒缓医疗 医学教育 老年医学 临终关怀
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脑梗死合并2型糖尿病的认知障碍危险因素
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作者 马藩源 陈垂雄 +1 位作者 吴利平 张华 《重庆医科大学学报》 CAS CSCD 北大核心 2023年第10期1238-1242,共5页
目的:探讨脑梗死合并2型糖尿病(type 2 diabetes,T2D)患者发生认知障碍的危险因素,为认知障碍的临床诊疗提供一定思路。方法:回顾性收集2010年1月至2021年12月于空军军医大学西京医院入院的脑梗死合并T2D的患者资料,将符合入组条件的19... 目的:探讨脑梗死合并2型糖尿病(type 2 diabetes,T2D)患者发生认知障碍的危险因素,为认知障碍的临床诊疗提供一定思路。方法:回顾性收集2010年1月至2021年12月于空军军医大学西京医院入院的脑梗死合并T2D的患者资料,将符合入组条件的191例患者根据简易精神状态检查分为认知障碍组(CD组)和认知正常组(Non-CD组),对患者的一般特征、临床特征和生化检验资料进行分析。结果:单因素分析显示,年龄、教育程度、依赖程度、糖尿病病程、D-二聚体、纤维蛋白原降解产物与认知障碍显著相关(P<0.05)。多因素logistic回归和ROC曲线分析显示,年龄(OR=2.249,95%CI=1.172~4.319,P=0.015)和教育程度(OR=0.587,95%CI=0.352~0.978,P=0.041)与脑梗死合并T2D发生认知障碍的显著危险因素。结论:年龄和教育程度与脑梗死合并T2D密切相关,也是其发生认知障碍的有效危险因素。 展开更多
关键词 认知障碍 2型糖尿病 脑梗死 危险因素
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A Chord-based resource scheduling approach in drug discovery grid
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作者 陈曙东 Zhang Wenju  +2 位作者 Zhang Jun   ma fanyuan Shen Jianhua 《High Technology Letters》 EI CAS 2007年第1期36-41,共6页
This paper presents a resource scheduling approach in grid computing environment. Using P2P technology, this novel approach can schedule dynamic grid computing resources efficiently. Grid computing resources in differ... This paper presents a resource scheduling approach in grid computing environment. Using P2P technology, this novel approach can schedule dynamic grid computing resources efficiently. Grid computing resources in different domains are organized into a structured P2P overlay network. Available resource information is published in type of grid services. Task requests for computational resources are also presented as grid services. Problem of resources scheduling is translated into services discovery. Different from central scheduling approaches that collect available resources information, this Chord-based approach forwards task requests in the overlay network and discovers satisfied resources for these tasks. Using this approach, the computational resources of a grid system can be scheduled dynamically according to the real- time workload on each peer. Furthermore, the application of this approach is introduced into DDG, a grid system for drug discovery and design, to evaluate the performance. Experimental results show that computational resources of a grid system can be managed efficiently, and the system can hold a perfect load balance state and robustness. 展开更多
关键词 grid computing P2P CHORD resource scheduling
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DDGrid: a grid computing system for drug discovery and design
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作者 陈曙东 Zhang Liang +1 位作者 ma fanyuan Shen Jianhua 《High Technology Letters》 EI CAS 2005年第4期337-341,共5页
This paper presents DDGrid, a novel grid computing system for drug discovery and design. By utilizing the idle resources donated by the clusters that scatter over the Intemet, DDGrid can implement efficient data-inten... This paper presents DDGrid, a novel grid computing system for drug discovery and design. By utilizing the idle resources donated by the clusters that scatter over the Intemet, DDGrid can implement efficient data-intensive biologic applications. P2P high-level resource management framework with a GridP2P hybrid architecture is described. With P2P technologies, some problems which are inevitable in the master-slave model can be avoided, such as single point of failure or performance bottleneck. Then an agent-based resource scheduling algorithm is presented. With this scheduling algorithm, the idle computational resources are dynamically scheduled according to the real-time working load on each execution node. Thus DDGrid can hold an excellent load balance state. Furthermore, the framework is introduced into the practical protein molecules docking applications. Solid experimental results show the load balance and robustness of the proposed system, which can greatly speed up the process of protein molecules docking. 展开更多
关键词 DDGrid resource scheduling load balance P2P
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大理地区2102例孕妇常见遗传性聋基因筛查结果分析
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作者 王博文 马藩源 田春杰 《临床耳鼻咽喉头颈外科杂志》 CAS 2024年第11期1061-1065,共5页
目的:通过对大理地区孕17周以内的孕妇开展遗传性聋基因检测,强调孕期基因检测和遗传咨询的重要性。方法:通过PCR扩增技术,对GJB2、GJB3、SLC26A4和mtDNA等4个耳聋基因的21个突变位点进行检测,并对阳性样本的阳性率、突变率和民族分布... 目的:通过对大理地区孕17周以内的孕妇开展遗传性聋基因检测,强调孕期基因检测和遗传咨询的重要性。方法:通过PCR扩增技术,对GJB2、GJB3、SLC26A4和mtDNA等4个耳聋基因的21个突变位点进行检测,并对阳性样本的阳性率、突变率和民族分布进行统计描述性分析。结果:GJB2和SLC26A4基因的阳性率为1.24%和1.43%,在阳性样本中突变率分别占40.62%和46.88%,GJB3基因的阳性率为0.19%,mtDNA突变基因占0.14%,且全部为mtDNA(Heterozygous),双阳多基因突变型GJB2/SLC26A4仅为1例,阳性率为0.05%,GJB2 c.235delC位点携带频率最高,占GJB2突变基因的65.38%,占突变基因样本26.56%。结论:GJB2和SLC26A4为最常见的耳聋基因,且GJB2 c.235delC位点最常见,确认耳聋突变位点有助于防止遗传性耳聋儿童出生,基因诊断、遗传咨询和适当的干预对于缓解先天性问题是至关重要的。 展开更多
关键词 遗传性聋 听力损失 基因突变 孕妇 基因筛查
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