Study on the Impact of Post-Mastectomy Radiotherapy on Immediate Breast Reconstruction and Complications: A Meta-Analysis

Background and objective:Immediate breast reconstruction not only reduces the number of surgeries for patients after mastectomy but also decreases psychological and physical trauma,making it increasingly popular.However,there is currently no consensus on the integration of post-mastectomy radiotherapy(PMRT)with reconstruction techniques.This review evaluates the impact of PMRT on complications following immediate breast reconstruction,providing guidance for clinical treatment decisions.Methods:PubMed,Web of Science,Embase,and other databases were searched for studies published in the past 15 years on outcomes of implant-based breast reconstruction in the context of radiotherapy to identify articles for analysis.RevMan 5.4 software was used to analyze the risks of seroma,infection,wound dehiscence,flap necrosis,implant exposure,capsule contracture,and reconstruction failure.Results:A total of 1l relevant studies were included,comprising 6323 cases of immediate breast reconstruction.It was found that breasts receiving postoperative irradiation had a significantly increased risk of complications,with statistically significant differences in seroma(P=0.004),infection(P<0.00001),wound dehiscence(P=0.04),implant exposure(P<0.00001),capsule contracture(P<0.00001),and reconstruction failure(P<0.00001).There was no statistically significant difference in flap necrosis(P=0.88).Conclusion:The results indicate that postoperative radiotherapy significantly increases the risk of complications for patients undergoing immediate implant-based reconstruction.Preventive measures may be taken in advance with the assistance of healthcare providers if necessary.

Visible-light-induced photoredox-catalyzed synthesis of benzimidazo[2,1-a]iso-quinoline-6(5H)-ones

A simple and efficient visible-light-induced photo redox-catalyzed diarylation of N-methacryloyl-2-arylbenzoimidazoles with aryl diazonium salts was developed.The reaction provides a conve nient access to a variety of benzimidazoisoquinolinones through the construction of two C-C bonds in one step under mild reaction conditions.

Self-consistent effective-one-body theory for spinless binaries based on post-Minkowskian approximation I:Hamiltonian and decoupled equation forψ^(B)_(4)

To build a self-consistent effective-one-body(EOB)theory,in which the Hamiltonian,radiation-reaction force and waveform for the“plus”and“cross”modes of the gravitational wave should be based on the same effective background spacetime,the key step is to look for the decoupled equation forψ^(B)_(4)=h_(+)−ih_(×),which seems a very difficult task because there are non-vanishing tetrad components of the tracefree Ricci tensor for such spacetime.Fortunately,based on an effective spacetime obtained in this paper by using the post-Minkowskian(PM)approximation,we find the decoupled equation forψ^(B)_(4)by dividing the perturbation part of the metric into the odd and even parities.With the effective metric and decoupled equation at hand,we set up a frame of self-consistent EOB model for spinless binaries.