Loss of heterozygosity for loci on chromosome arms 1p and 10q in oligoden-droglial tumors: relationship to outcome and chemosensitivity

Oligodendroglial tumors frequently have deletions ofchromosomal loci on lp and l9q.Loas of heterozygosity(LOH)of chromosome 10 may be a negative prognostic factor.We reviewed 23 patients with oligodendroglial tumors,toevaluate the frequency of lp and 10q LOH and correlate with clinical outcome.Three loci(DlS402,DlSl 172,MCT118)on lp and 2 loci(Dl0S520 and D10S521)on 10q were analyzed for LOH using PCR techniques.

荧光探针在药物分析中的应用

由于一些药物的摄入剂量很小,就需用适当的分析方法研究其药动学。方法之一为荧光分光光度法,它在生物医学分析领域中起着重要的作用。此外,光检测器与流动注射分析或液相色谱技术联用法在分析七更具有优越性。荧光偏振免疫分析。