Although it is well known that the hepatocellular carcinoma (HCC) is an ominous complication in patients with liver cirrhosis, there has been no approved drug to prevent the development of HCC to date. We previously r...Although it is well known that the hepatocellular carcinoma (HCC) is an ominous complication in patients with liver cirrhosis, there has been no approved drug to prevent the development of HCC to date. We previously reported that the combined treatment of vitamin K2 (VK) and angiotensin-converting enzyme inhibitor (ACE-I) significantly suppressed the experimental hepatocarcinogenesis. A 66-year-old Japanese woman with hepatitis C virus (HCV)-related liver cirrhosis developed a dysplastic nodule in the liver detected by enhanced computed tomography along with elevation of the tumor markers, namely, alpha-fetoprotein (AFP) and lectin-reactive demarcation (AFP-L3), suggesting the presence of latent HCC. After oral administration of VK and ACE-I, the serum levels of both AFP and AFP-L3 gradually decreased without any marked alteration of the serum aminotransferase activity. After one-year treatment, not only the serum levels of AFP and AFP-L3 returned to the normal ranges, but also the dysplastic nodule disappeared. Since both VK and ACE-I are widely used without serious side effects, this combined regimen may become a new strategy for chemoprevention against HCC.展开更多
Although the etiology of eosinophilic cholecystitis is still obscure, the postulated causes include allergies, parasites, hypereosinophilic syndrome, and eosinophilic gastroenteritis. It is sometimes accompanied by se...Although the etiology of eosinophilic cholecystitis is still obscure, the postulated causes include allergies, parasites, hypereosinophilic syndrome, and eosinophilic gastroenteritis. It is sometimes accompanied by several complications, but a simultaneous onset with pericarditis is very rares. A 28-year-old woman complained of acute right hypocondrial pain and dyspnea associated with systemic eruption. Several imaging modalities revealed acute cholecystitis and pericarditis with massive pericardial effusion. A marked peripheral blood eosinophilia was observed, and the eruption was diagnosed as urticaria. Her serum had a high titer of antibody against Ascaris lumbricoides . Treatment with albendazole drastically improved all clinical manifestations along with normalization of the imaging features and eosinophilia. We report herein a rare case of simultaneous onset of acute cholecystitis and pericarditis associated with a marked eosinophilia caused by parasitic infection.展开更多
Computed tomography(CT)generates cross-sectional images of the body.Visualizing CT images has been a challenging problem.The emergence of the augmented and virtual reality technology has provided promising solutions.H...Computed tomography(CT)generates cross-sectional images of the body.Visualizing CT images has been a challenging problem.The emergence of the augmented and virtual reality technology has provided promising solutions.However,existing solutions suffer from tethered display or wireless transmission latency.In this paper,we present ARSlice,a proof-of-concept prototype that can visualize CT images in an untethered manner without wireless transmission latency.Our ARSlice prototype consists of two parts,the user end and the projector end.By employing dynamic tracking and projection,the projector end can track the user-end equipment and project CT images onto it in real time.The user-end equipment is responsible for displaying these CT images into the 3D space.Its main feature is that the user-end equipment is a pure optical device with light weight,low cost,and no energy consumption.Our experiments demonstrate that our ARSlice prototype provides part of six degrees of freedom for the user,and a high frame rate.By interactively visualizing CT images into the 3D space,our ARSlice prototype can help untrained users better understand that CT images are slices of a body.展开更多
文摘Although it is well known that the hepatocellular carcinoma (HCC) is an ominous complication in patients with liver cirrhosis, there has been no approved drug to prevent the development of HCC to date. We previously reported that the combined treatment of vitamin K2 (VK) and angiotensin-converting enzyme inhibitor (ACE-I) significantly suppressed the experimental hepatocarcinogenesis. A 66-year-old Japanese woman with hepatitis C virus (HCV)-related liver cirrhosis developed a dysplastic nodule in the liver detected by enhanced computed tomography along with elevation of the tumor markers, namely, alpha-fetoprotein (AFP) and lectin-reactive demarcation (AFP-L3), suggesting the presence of latent HCC. After oral administration of VK and ACE-I, the serum levels of both AFP and AFP-L3 gradually decreased without any marked alteration of the serum aminotransferase activity. After one-year treatment, not only the serum levels of AFP and AFP-L3 returned to the normal ranges, but also the dysplastic nodule disappeared. Since both VK and ACE-I are widely used without serious side effects, this combined regimen may become a new strategy for chemoprevention against HCC.
文摘Although the etiology of eosinophilic cholecystitis is still obscure, the postulated causes include allergies, parasites, hypereosinophilic syndrome, and eosinophilic gastroenteritis. It is sometimes accompanied by several complications, but a simultaneous onset with pericarditis is very rares. A 28-year-old woman complained of acute right hypocondrial pain and dyspnea associated with systemic eruption. Several imaging modalities revealed acute cholecystitis and pericarditis with massive pericardial effusion. A marked peripheral blood eosinophilia was observed, and the eruption was diagnosed as urticaria. Her serum had a high titer of antibody against Ascaris lumbricoides . Treatment with albendazole drastically improved all clinical manifestations along with normalization of the imaging features and eosinophilia. We report herein a rare case of simultaneous onset of acute cholecystitis and pericarditis associated with a marked eosinophilia caused by parasitic infection.
基金the National Natural Science Foundation of China under Grant No.61872210the Guangdong Basic and Applied Basic Research Foundation under Grant Nos.2021A1515012596 and 2021B1515120064the Guangdong Academy of Sciences Special Foundation under Grant No.2021GDASYL-20210102006.
文摘Computed tomography(CT)generates cross-sectional images of the body.Visualizing CT images has been a challenging problem.The emergence of the augmented and virtual reality technology has provided promising solutions.However,existing solutions suffer from tethered display or wireless transmission latency.In this paper,we present ARSlice,a proof-of-concept prototype that can visualize CT images in an untethered manner without wireless transmission latency.Our ARSlice prototype consists of two parts,the user end and the projector end.By employing dynamic tracking and projection,the projector end can track the user-end equipment and project CT images onto it in real time.The user-end equipment is responsible for displaying these CT images into the 3D space.Its main feature is that the user-end equipment is a pure optical device with light weight,low cost,and no energy consumption.Our experiments demonstrate that our ARSlice prototype provides part of six degrees of freedom for the user,and a high frame rate.By interactively visualizing CT images into the 3D space,our ARSlice prototype can help untrained users better understand that CT images are slices of a body.
