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AB064. Product knowledge predicts greater willingness to buy and gaze-related attention, salience does not
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作者 matthew martin Bianca Grohmann Aaron Johnson 《Annals of Eye Science》 2018年第1期470-470,共1页
Background:Visual salience computed using algorithmic procedures have been shown to predict eye-movements in a number of contexts.However,despite calls to incorporate computationally-defined visual salience metrics as... Background:Visual salience computed using algorithmic procedures have been shown to predict eye-movements in a number of contexts.However,despite calls to incorporate computationally-defined visual salience metrics as a means of assessing the effectiveness of advertisements,few studies have incorporated these techniques in a marketing context.The present study sought to determine the impact of visual salience and knowledge of a brand on eye-movement patterns and buying preferences.Methods:Participants(N=38)were presented with 54 pairs of products presented on the left and right sides of a blank white screen.For each pair,one product was a known North American product,such as Fresca®,and one was an unknown British product of the same category,such as Irn Bru®.Participants were asked to select which product they would prefer to buy while their eye movements were recorded.Salience was computed using Itti&Koch’s[2001]computational model of bottom-up salience.Products were defined as highly salient if the majority of the first five predicted fixations were in the region of the product.Results:Results showed that participants were much more likely to prefer to buy known products,and tentative evidence suggests that participants had longer total dwell times when looking at unknown products.Salience appears to have had little or no effect on preference for a product,nor did it predict total dwell time or time to first fixation.There also appears to be no interaction between knowledge of a product and visual salience on any of the measures analyzed.Conclusions:The results indicate that product salience may not be a useful predictor of attention under the constraints of the present experiment.Future studies could use a different operational definition of visual salience which might be more predictive of visual attention.Furthermore,a more fine-grained analysis of product familiarity based on survey data may reveal patterns obscured by the definitional constraints of the present study. 展开更多
关键词 MARKETING ATTENTION salience EYE-TRACKING
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Analysis of the combined effect of rs699 and rs5051 on angiotensinogen expression and hypertension
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作者 Nicholas R.Powell Tyler Shugg +6 位作者 Jacob Leighty matthew martin Rolf P.Kreutz Michael T.Eadon Dongbing Lai Tao Lu Todd C.Skaar 《Chronic Diseases and Translational Medicine》 CAS CSCD 2024年第2期102-117,共16页
Background Hypertension(HTN)involves genetic variability in the renin-angiotensin system and influences antihypertensive response.We previously reported that angiotensinogen(AGT)messenger RNA(mRNA)is endogenously boun... Background Hypertension(HTN)involves genetic variability in the renin-angiotensin system and influences antihypertensive response.We previously reported that angiotensinogen(AGT)messenger RNA(mRNA)is endogenously bound by miR-122-5p and rs699 A>G decreases reporter mRNA in the microRNA functional-assay PASSPORT-seq.The AGT promoter variant rs5051 C>T is in linkage disequilibrium(LD)with rs699 A>G and increases AGT transcription.The independent effect of these variants is understudied due to their LD therefore we aimed to test the hypothesis that increased AGT by rs5051 C>T counterbalances AGT decreased by rs699 A>G,and when these variants occur independently,it translates to HTN-related phenotypes.Methods We used in silico,in vitro,in vivo,and retrospective models to test this hypothesis.Results In silico,rs699 A>G is predicted to increase miR-122-5p binding affinity by 3%.Mir-eCLIP results show rs699 is 40–45 nucleotides from the strongest microRNA-binding site in the AGT mRNA.Unexpectedly,rs699 A>G increases AGT mRNA in an AGT-plasmid-cDNA HepG2 expression model.Genotype-Tissue Expression(GTEx)and UK Biobank analyses demonstrate liver AGT expression and HTN phenotypes are not different when rs699 A>G occurs independently from rs5051 C>T.However,GTEx and the in vitro experiments suggest rs699 A>G confers cell-type-specific effects on AGT mRNA abundance,and suggest paracrine renal renin-angiotensin-system perturbations could mediate the rs699 A>G associations with HTN.Conclusions We found that rs5051 C>T and rs699 A>G significantly associate with systolic blood pressure in Black participants in the UK Biobank,demonstrating a fourfold larger effect than in White participants.Further studies are warranted to determine if altered antihypertensive response in Black individuals might be due to rs5051 C>T or rs699 A>G.Studies like this will help clinicians move beyond the use of race as a surrogate for genotype. 展开更多
关键词 ANGIOTENSINOGEN genetic and genomic medicine HYPERTENSION rs699
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Role of post-translational modification of the Y box binding protein 1 in human cancers 被引量:3
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作者 Lakshmi Prabhu Antja-Voy Hartley +3 位作者 matthew martin Fadumo Warsame Emily Sun Tao Lu 《Genes & Diseases》 SCIE 2015年第3期240-246,共7页
Y box binding protein-1(YBX1)belongs to a DNA-and RNA-binding family of transcription factors,containing the highly conserved cold shock domain(CSD).YBX1 is involved in a number of cellular functions including transcr... Y box binding protein-1(YBX1)belongs to a DNA-and RNA-binding family of transcription factors,containing the highly conserved cold shock domain(CSD).YBX1 is involved in a number of cellular functions including transcription,translation,DNA damage repair etc.,and it is upregulated during times of environmental stress.YBX1 is localized in both the cytoplasm and the nucleus.There,its nuclear translocation is observed in a number of cancers and is associated with poor prognosis and disease progression.Additionally,YBX1 expression is upregulated in a variety of cancers,pointing towards its role as a potential oncogene.Under certain circumstances,YBX1 also promotes the expression of multidrug resistance 1(MDR1)gene,which is involved in the development of drug resistance.Thus,it is critical to understand the mechanism of YBX1 regulation and its downstream effects on promoting cancer development.A number of recent studies have highlighted the mechanisms of YBX1 regulation.Mass spectrometric analyses have reported several post-translational modifications that possibly play an important role in modulating YBX1 function.Phosphorylation is the most widely occurring post-translational modification in YBX1.In vivo analyses of sites like S102 and more recently,S165 illustrate the relationship of post-translational regulation of YBX1 in promoting cell proliferation and tumor growth.This review provides a comprehensive and up-to-date account of post-translational modifications identified in YBX1.This knowledge is a key in allowing us to better understand the mechanism of YBX1 regulation,which will aid in development of novel therapeutic strategies to target YBX1 in many types of cancer in the future. 展开更多
关键词 CANCER Cold shock domain PHOSPHORYLATION Post-translational modification Y box binding protein 1
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Inhibition of PRMT5 by market drugs as a novel cancer therapeutic avenue
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作者 Lakshmi Prabhu matthew martin +15 位作者 Lan Chen Ozlem Demir Jiamin Jin Xiumei Huang Aishat Motolani Mengyao Sun Guanglong Jiang Harikrishna Nakshatri Melissa L.Fishel Steven Sun Ahmad Safa Rommie E.Amaro Mark R.Kelley Yunlong Liu Zhong-Yin Zhang Tao Lu 《Genes & Diseases》 SCIE CSCD 2023年第1期267-283,共17页
Market drugs,suchas Foodand Drug Administration(FDA)or European Medicines Agency(EMA)-approved drugs for specific indications provide opportunities for repurposing for newer therapeutics.This potentially saves resourc... Market drugs,suchas Foodand Drug Administration(FDA)or European Medicines Agency(EMA)-approved drugs for specific indications provide opportunities for repurposing for newer therapeutics.This potentially saves resources invested in clinical trials that verify drug safety and tolerance in humans prior to alternative indication approval.Protein arginine methyltransferase 5(PRMT5)overexpression has been linked to promoting the tumor phenotype in several cancers,including pancreatic ductal adenocarcinoma(PDAC),colorectal cancer(CRC),and breast cancer(BC),making PRMT5 an important target for cancer therapy.Previously,we showed that PRMT5-mediated methylation of the nuclear factor(NF)-kB,partially contributes to its constitutive activation observed in cancers.In this study,we utilized an AlphaLiSA-based high-throughput screening method adapted in our lab,and identified one FDA-approved drug,Candesartan cilexetil(Can,used in hypertension treatment)and one EMA-approved drug,Cloperastine hydrochloride(Clo,used in cough treatment)that had significant PRMT5-inhibitory activity,and their anti-tumor properties were validated using cancer phenotypic assays in vitro.Furthermore,PRMT5 selective inhibition of methyltransferase activity was confirmed by reduction of both NF-kB methylation and its subsequent activation upon drug treatment.Using in silico prediction,we identified critical residues on PRMT5 targeted by these drugs that may interfere with its enzymatic activity.Finally,Clo and Can treatment have exhibited marked reduction in tumor growth in vivo.Overall,we provide basis for pursuing repurposing Clo and Can as anti-PRMT5 cancer therapies.Our study offers potential safe and fast repurposing of previously unknown PRMT5 inhibitors into clinical practice. 展开更多
关键词 Cancer Research NF-KB PHARMACOLOGY PRMT5 PRMT5 inhibitors
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迪拜明星投资家麻烦大了
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作者 Tracy Alloway Dinesh Nair +1 位作者 matthew martin 许诺(译) 《商业周刊(中文版)》 2018年第13期28-29,共2页
2018年1月的瑞士达沃斯世界经济论坛期间,在一个有关全球健康话题的专题讨论会上,巴基斯坦金融家阿里夫·纳基维(Arif Naqvi)与比尔·盖茨(Bill Gates)一同出现在讲坛上。即便是与这位亿万富翁慈善家以及另外两名医疗专... 2018年1月的瑞士达沃斯世界经济论坛期间,在一个有关全球健康话题的专题讨论会上,巴基斯坦金融家阿里夫·纳基维(Arif Naqvi)与比尔·盖茨(Bill Gates)一同出现在讲坛上。即便是与这位亿万富翁慈善家以及另外两名医疗专家在一起,纳基维因为他的高度热情仍显得很突出。 展开更多
关键词 投资家 明星 迪拜 世界经济论坛 专题讨论会 巴基斯坦 亿万富翁 达沃斯
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新王储整顿商业环境沙特建筑业面临挑战
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作者 Vivian Nereim Sarah Algethami +1 位作者 matthew martin 融汐 《商业周刊(中文版)》 2017年第20期36-36,38,共2页
在建筑巨头沙特敖件公司(Saudi Oger Ltd.)位于利雅得(Riyadh)的一间办公室里,灰尘覆满桌面,烟头和空水瓶四散在地,信箱里塞满了皱巴巴的信封。
关键词 建筑业 商业环境 沙特 办公室 公司 水瓶
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