Comparison of autofluorescence and optical coherence tomography findings in acute and chronic central serous chorioretinopathy

AIM:To discuss and compare the fundus autofluorescence(FAF)and optical coherence tomography(OCT)in acute or chronic central serous chorioretinopathy(CSCR).METHODS:Medical records of 100 cases of CSCR were reviewed.Acute and chronic cases were evaluated according to the duration of decreased visual acuity,serous retinal detachment(RD)and focal leakage on fluorescein angiography(FA).Chi-square test was used for statistical analysis.RESULTS:Forty cases had acute and 60 cases had chronic CSCR.FAF showed focal hypo-autofluorescence in 34(85%)and iso-autofluorescence in 6(15%)of acute cases and hypo-autofluorescence in 51(85%),hyperautofluorescence in 6(10%)and iso-autofluorescence in3(5%)of chronic cases.OCT showed serous RD with distinct borders correlated with FAF findings(hypoautofluorescence)in all acute CSCR cases.In chronic CSCR group,OCT showed serous RD with indistinct borders correlated with FAF findings.The differences between the OCT and FAF findings of the two groups were significant(P=0.000).CONCLUSION:OCT and FAF findings can support the clinical observations in differential diagnosis of acute and chronic CSCR and help clinicians to evaluate retinal pigment epithelium,outer segments of photoreceptors and the components of serous RD.

Fundus autofluorescence imaging of patients with idiopathic macular hole

AIM:To investigate the role of fundus autofluo rescence(FAF) both in the diagnosis and the preoperative and postoperative evaluation of patients with idiopathic macular hole(MH).METHODS:Forty eyes of 40 patients diagnosed as idiopathic MH between May 2010 and May 2011 were included in this retrospective study.All patients underwent full ophthalmologic examinations and imagings including fluorescein angiography,fundus autofluorescence(FAF) and optical coherence tomography.Thirty of these patients underwent MH surgery.FAF findings were associated with duration of symptoms,visual acuity at presentation,stage of MH,and postoperative anatomical correction.RESULTS:The mean duration of patients’ symptoms was 3.8±2.0(1-9) months.The MH was stage 2 in 4(10%),stage 3 in 24(60%) and stage 4 in 12(30%) eyes.The median preoperative best corrected visual acuity was 20/200(between 20/800 and 20/100).Twenty-eight of cases(70%) showed a stellate appearance with dark radiating striae.Having a visual acuity ≥20/200 was significantly more common in eyes with stellate appearance(P【0.001).The mean duration of symptoms was significantly shorter in eyes with stellate appearance(2.75±0.8 vs 6.33±1.61 months)(P【0.001).The frequency of stage 4 MH was significantly higher in eyes with nonstellate appearance(P【0.001).Anatomical correction of MH was achieved in 91.3%(21/23) of eyes with stellate appearance and 71.4%(5/7) of eyes without this appearance(P=0.225).CONCLUSION:Stellate appearance in FAF is associated with earlier stages of macular hole,better visual acuity at presentation,shorter duration of symptoms,thus more favorable prognosis.