土木工程智能结构健康监测应用综述

在土木工程行业转型的背景下,智能技术为土木工程结构健康监测(SHM)领域的创新和发展带来了新的技术手段和工具,进而拓宽了土木工程SHM系统各个方面的研究领域。系统地梳理了当前土木工程SHM领域智能技术应用的研究现状,涵盖了计算机视觉、机器学习、智能机器人及无人机等方面。在综述现有研究成果的基础上,对未来智能技术在土木工程SHM领域的发展趋势和前景进行了展望,并深入探讨了土木工程SHM与智能学科融合所带来的创新与挑战。

RNA-based NGS检测EML4-ALK融合V1亚型肺腺癌1例

肺癌是全球发病率和死亡率最高的恶性肿瘤。对于肺腺癌而言,识别特定的基因突变并给予相应靶向药物可大大提高患者的生存时间。其中,间变性淋巴瘤激酶(anaplastic lymphoma kinase,ALK)融合发生在3%-7%的非小细胞肺癌(non-small cell lung cancer,NSCLC)中。在临床中,多种检测方法可应用于判断ALK融合状态,但存在检测结果假阴性可能。本文回顾性分析1例肺腺癌患者的诊治经过,经多种检测方式判断ALK融合状态,其中,免疫组化(immunohistochemistry,IHC)(Ventana D5F3)、基于RNA的下一代测序(RNA-based next-generation sequencing,RNA-based NGS)检测证实棘皮类微管关联蛋白样4(echinoderm microtubule associated protein like 4,EML4)-ALK融合阳性,而基于DNA的NGS(DNA-based NGS)检测为阴性。本文比较分析判断ALK融合的检测方法,以明确在不同临床案例中选择何种检测方式最准确、最简便,以便于指导后续治疗。

Fabricating AC/DC nanogenerators based on single ZnO nanowires by using a nanomanipulator in a scanning electron microscope

Single zinc oxide nanowires(ZnO NWs)are promising for nanogenerators because of their excellent semiconducting and piezoelectric properties,but characterizing the latter efficiently is challenging.As reported here,an electrical breakdown strategy was used to construct single ZnO NWs with a specific length.With the high operability of a nanomanipulator in a scanning electron microscope,ZnO-NW-based twoprobe and three-probe structures were constructed for fabricating AC/DC nanogenerators,respectively.For a ZnO NW,an AC output of between−15.31 mV and 5.82 mV was achieved,while for a DC nanogenerator,an output of24.3 mV was realized.Also,the three-probe structure’s output method was changed to verify the distribution of piezoelectric charges when a single ZnO NW is bent by a probe,and DC outputs of different amplitudes were achieved.This study provides a low-cost,highly convenient,and operational method for studying the AC/DC output characteristics of single NWs,which is beneficial for the further development of nanogenerators.

Left inferior phrenic arterial malformation mimicking gastric varices: A case report and review of literature

BACKGROUND Gastric submucosal arterial dilation resulting from splenic artery occlusion represents an exceedingly rare etiology of acute upper gastrointestinal bleeding(UGIB).Although endoscopy is a widely utilized diagnostic and therapeutic modality for gastrointestinal bleeding,it has limitations in detecting arterial abnormalities.CASE SUMMARY This report presents a rare case of massive UGIB in a 57-year-old male with a tortuous left inferior phrenic artery accompanied by splenic artery occlusion.“Gastric varices”was identified during the patient's endoscopy one year before hemorrhage.Despite initial hemostasis by endoscopic clipping,the patient experienced massive rebleeding after one month,requiring intervention with transcatheter arterial embolization(TAE)to achieve hemostasis.CONCLUSION This is the first case to report UGIB due to a tortuous left inferior phrenic artery.This case highlights the limitations of endoscopy in identifying arterial abnormalities and emphasizes the potential of TAE as a viable alternative for the management of arterial bleeding in the gastrointestinal tract.

Study on Adsorption Removal of Polycyclic Aromatic Hydrocarbons by Modified Mussel Shells

Polycyclic aromatic hydrocarbons(PAHs)are typical persistent organic pollutants(POPs)that are commonly found in the environment.They are carcinogenic,teratogenic,mutagenic and biodegradable obviously.In this paper,the modified mussel shells were used to adsorb and remove anthracene.The results show that the adsorption removal rate of the mussel shells was higher after calcination at 600℃.5%H_(3)PO_(4) solution was more suitable for shell treatment than 3 mol/L ZnCl_(2) solution.As the dosage of the modified shells was 0.5 g/L,the adsorption reached a stable state,and the removal rate of PAHs was about 69.44%;the adsorption efficiency rose with the increase of time.It can be seen that as a new and cheap biological adsorbent,the modified shells can be used to remove PAHs from wastewater.

Application of PDCA Cycle in Hand Hygiene Management of Psychiatric Medical Staff

Objective:To study the application effect of the plan-do-check-act(PDCA)cycle management in the hand hygiene management of psychiatric medical staff.Methods:One hundred and twenty medical staff from a psychiatric hospital from May 2023 to December 2023 were selected and divided into two groups.The control group(May 2023 to August 2023)applied the conventional management model,and the observation group(September 2023 to December 2023)applied the PDCA cycle management.The hand hygiene compliance,hand hygiene knowledge,and hygiene qualifications were compared,including the amount of hand sanitizer used.Results:The proportion of medical staff’s hand hygiene compliance and hand hygiene knowledge mastery scores in the observation group were higher than those in the control group(P<0.05);the hand hygiene passing rate in the observation group was higher than that of the control group(P<0.05);the daily amount of hand sanitizer per patient bed and the amount of hand sanitizer used was higher than that of the control group(P<0.05).Conclusion:The PDCA cycle management model for psychiatric medical staff promoted the improvement of hand hygiene compliance and increased their hand hygiene qualifications.It is suitable for further popularization and application in future clinical practice.

“Three-Wide Education”Reform,Innovation,and Practice in Guangdong University of Petrochemical Technology

The comprehensive reform of“three-wide education”is important to achieve inheritance and innovation in ideological education in colleges and universities.The Guangdong University of Petrochemical Technology aims to address the practical problems of a weak ideological education team,incomplete system and mechanism,and insufficient resource mobilization in“three-wide education.”It actively explores the“three-wide education”based on the university’s existing foundation and advantages.Comprehensive,innovative ideas for reform,practice,and promotion of unique practices and paths are necessary,to continuously deepen education reforms and strive to build a new“three-wide education”work pattern to help the country’s modern talent cultivation work.

云南省青少年儿童斜视手术回顾性分析

目的:分析云南省青少年儿童斜视手术情况。方法:回顾性分析2017-01/2021-12于云南大学附属医院行斜视手术的青少年儿童患者3 068例的病历资料,分析纳入患者的性别和年龄构成、斜视类型分布、合并其它眼部疾病等情况。结果:纳入患者中男性占52.12%,女性占47.88%;学龄前(1~6岁)患者占32.89%,小学生(7~12岁)占45.89%,中学生(13~18岁)占21.22%;外斜视占63.17%,其中以间歇性外斜视最常见,内斜视占19.69%,其中以共同性内斜视最常见,特殊类型斜视占17.14%,其中以A-V综合征和分离性垂直斜视(DVD)最常见;合并屈光不正者占61.02%,合并弱视者占10.89%,少数患者还合并其他眼部疾病。结论:云南省青少年儿童斜视类型以间歇性外斜视最普遍,部分患者合并其他眼部疾病。

Anti-infection effects of heparin on SARS-CoV-2 in a diabetic mouse model

Severe acute respiratory syndrome coronavirus 2(SARSCo V-2)infection can result in more severe syndromes and poorer outcomes in patients with diabetes and obesity.However,the precise mechanisms responsible for the combined impact of coronavirus disease 2019(COVID-19)and diabetes have not yet been elucidated,and effective treatment options for SARS-Co V-2-infected diabetic patients remain limited.To investigate the disease pathogenesis,K18-h ACE2 transgenic(h ACE2^(Tg))mice with a leptin receptor deficiency(h ACE2-Lepr^(-/-))and high-fat diet(h ACE2-HFD)background were generated.The two mouse models were intranasally infected with a 5×10^(5) median tissue culture infectious dose(TCID_(50))of SARSCo V-2,with serum and lung tissue samples collected at 3days post-infection.The h ACE2-Lepr^(-/-)mice were then administered a combination of low-molecular-weight heparin(LMWH)(1 mg/kg or 5 mg/kg)and insulin via subcutaneous injection prior to intranasal infection with1×10^(4) TCID_(50)of SARS-Co V-2.Daily drug administration continued until the euthanasia of the mice.Analyses of viral RNA loads,histopathological changes in lung tissue,and inflammation factors were conducted.Results demonstrated similar SARS-Co V-2 susceptibility in h ACE2^(Tg)mice under both lean(chow diet)and obese(HFD)conditions.However,compared to the h ACE2-Lepr^(+/+)mice,h ACE2-Lepr^(-/-)mice exhibited more severe lung injury,enhanced expression of inflammatory cytokines and hypoxia-inducible factor-1α(HIF-1α),and increased apoptosis.Moreover,combined LMWH and insulin treatment effectively reduced disease progression and severity,attenuated lung pathological changes,and mitigated inflammatory responses.In conclusion,preexisting diabetes can lead to more severe lung damage upon SARS-Co V-2 infection,and LMWH may be a valuable therapeutic approach for managing COVID-19patients with diabetes.

Fidgetin interacting with microtubule end binding protein EB3 affects axonal regrowth in spinal cord injury

Fidgetin,a microtubule-severing enzyme,regulates neurite outgrowth,axonal regeneration,and cell migration by trimming off the labile domain of microtubule polymers.Because maintenance of the microtubule labile domain is essential for axon initiation,elongation,and navigation,it is of interest to determine whether augmenting the microtubule labile domain via depletion of fidgetin serves as a therapeutic approach to promote axonal regrowth in spinal cord injury.In this study,we constructed rat models of spinal cord injury and sciatic nerve injury.Compared with spinal cord injury,we found that expression level of tyrosinated microtubules in the labile portion of microtubules continuously increased,whereas fidgetin decreased after peripheral nerve injury.Depletion of fidgetin enhanced axon regeneration after spinal cord injury,whereas expression level of end binding protein 3(EB3)markedly increased.Next,we performed RNA interference to knockdown EB3 or fidgetin.We found that deletion of EB3 did not change fidgetin expression.Conversely,deletion of fidgetin markedly increased expression of tyrosinated microtubules and EB3.Deletion of fidgetin increased the amount of EB3 at the end of neurites and thereby increased the level of tyrosinated microtubules.Finally,we deleted EB3 and overexpressed fidgetin.We found that fidgetin trimmed tyrosinated tubulins by interacting with EB3.When fidgetin was deleted,the labile portion of microtubules was elongated,and as a result the length of axons and number of axon branches were increased.These findings suggest that fidgetin can be used as a novel therapeutic target to promote axonal regeneration after spinal cord injury.Furthermore,they reveal an innovative mechanism by which fidgetin preferentially severs labile microtubules.

Pick-up strategies for and electrical characterization of ZnO nanowires with a SEM-based nanomanipulator

Because of their unique mechanical and electrical properties,zinc oxide(ZnO)nanowires are used widely in microscopic and nanoscopic devices and structures,but characterizing them remains challenging.In this paper,two pick-up strategies are proposed for characterizing the electrical properties of ZnO nanowires using SEM equipped with a nanomanipulator.To pick up nanowires efficiently,direct sampling is compared with electrification fusing,and experiments show that direct sampling is more stable while electrification fusing is more efficient.ZnO nanowires have cut-off properties,and good Schottky contact with the tungsten probes was established.In piezoelectric experiments,the maximum piezoelectric voltage generated by an individual ZnO nanowire was 0.07 V,and its impedance decreased with increasing input signal frequency until it became stable.This work offers a technical reference for the pick-up and construction of nanomaterials and nanogeneration technology.

Numerical‐discrete‐scheme‐incorporated recurrent neural network for tasks in natural language processing

A variety of neural networks have been presented to deal with issues in deep learning in the last decades.Despite the prominent success achieved by the neural network,it still lacks theoretical guidance to design an efficient neural network model,and verifying the performance of a model needs excessive resources.Previous research studies have demonstrated that many existing models can be regarded as different numerical discretizations of differential equations.This connection sheds light on designing an effective recurrent neural network(RNN)by resorting to numerical analysis.Simple RNN is regarded as a discretisation of the forward Euler scheme.Considering the limited solution accuracy of the forward Euler methods,a Taylor‐type discrete scheme is presented with lower truncation error and a Taylor‐type RNN(T‐RNN)is designed with its guidance.Extensive experiments are conducted to evaluate its performance on statistical language models and emotion analysis tasks.The noticeable gains obtained by T‐RNN present its superiority and the feasibility of designing the neural network model using numerical methods.

Determination of an Appropriate Endoscopic Monitoring Interval for Patients with Gastric Precancerous Conditions in China

Objective Gastric precancerous conditions such as atrophic gastritis(AG)and intestinal metaplasia(IM)are considered independent risk factors for gastric cancer(GC).The suitable endoscopic monitoring interval is unclear when we attempt to prevent GC development.This study investigated the appropriate monitoring interval for AG/IM patients.Methods Totally,957 AG/IM patients who satisfied the criteria for evaluation between 2010 and 2020 were included in the study.Univariate and multivariate analyses were used to determine the risk factors for progression to high-grade intraepithelial neoplasia(HGIN)/GC in AG/IM patients,and to determine an appropriate endoscopic monitoring scheme.Results During follow-up,28 AG/IM patients developed gastric neoplasia lesions including gastric low-grade intraepithelial neoplasia(LGIN)(0.7%),HGIN(0.9%),and GC(1.3%).Multivariate analysis identified H.pylori infection(P=0.022)and extensive AG/IM lesions(P=0.002)as risk factors for HGIN/GC progression(P=0.025).Conclusion In our study,HGIN/GC was present in 2.2%of AG/IM patients.In AG/IM patients with extensive lesions,a 1–2-year surveillance interval is recommended for early detection of HIGN/GC in AG/IM patients with extensive lesions.

Echo State Network With Probabilistic Regularization for Time Series Prediction

Recent decades have witnessed a trend that the echo state network(ESN)is widely utilized in field of time series prediction due to its powerful computational abilities.However,most of the existing research on ESN is conducted under the assumption that data is free of noise or polluted by the Gaussian noise,which lacks robustness or even fails to solve real-world tasks.This work handles this issue by proposing a probabilistic regularized ESN(PRESN)with robustness guaranteed.Specifically,we design a novel objective function for minimizing both the mean and variance of modeling error,and then a scheme is derived for getting output weights of the PRESN.Furthermore,generalization performance,robustness,and unbiased estimation abilities of the PRESN are revealed by theoretical analyses.Finally,experiments on a benchmark dataset and two real-world datasets are conducted to verify the performance of the proposed PRESN.The source code is publicly available at https://github.com/LongJinlab/probabilistic-regularized-echo-state-network.

Preparation of ferronickel from nickel laterite via coal-based reduction followed by magnetic separation

The sticking phenomenon between molten slag and refractory is one of the crucial problems when preparing ferronickel from laterite ore using rotary hearth fulnace or rotary kiln processes. This study aims to ameliorate sticking problems by using silicon dioxide （SiO2） to adjust the melting degree of file briquette during reduction roasting. Thermodynamic analysis indicates that the melting temperature of the slag gradually increases with an increase in the SiO2 proportion （SiO2/（SiO2 ＋ A1203 ＋ MgO） mass ratio）. Experimental validations also prove that the briquette retains its original shape when the SiO2 proportion is greater than 75wt%, and sticking problems axe avoided during reduction. A ferronickel product with 8.33wt% Ni and 84.71wt% Fe was prepared via reductive roasting at 1500~C for 90 min with a SiO2 proportion of 75wt% and a C/O molar ratio of 1.0 followed by dry magnetic separation; the corresponding recoveries of Ni and Fe reached 75.70% and 77.97%, respectively. The micro stxucture and phase txmlsformation of reduced briquette reveals that the aggregation and growth of ferroinckel particles were not significantly affected after adding SiO2 to the reduction process.

Endoscopic and surgical treatment of jejunal gallstone ileus caused by cholecystoduodenal fistula:A case report

BACKGROUND Gallstone ileus is a rare complication of gallstone disease in which a stone enters the enteric lumen and causes mechanical obstruction usually by bilioenteric fistula.Gallstone ileus accounts for 25%of all bowel obstructions among the population>65 years of age.Despite medical advances over the last decades,gallstone ileus is still associated with high rates of morbidity and mortality.CASE SUMMARY An 89-year-old man with a history of gallstones was admitted to the Gastroenterology Department of our hospital,complaining of vomiting and cessation of bowel movements and flatus.Abdominal computed tomography showed cholecystoduodenal fistula and upper jejunum obstruction due to gallstones,pneumatosis in the gallbladder,and pneumobilia indicating Rigler’s triad.Considering the high risk of surgical management,we performed propulsive enteroscopy and laser lithotripsy twice to relieve the bowel occlusion.However,the intestinal obstruction was not relieved by the less invasive procedure.Then,the patient was transferred to the Department of Biliary-pancreatic Surgery.The patient underwent the one-stage procedure including laparoscopic duodenoplasty(fistula closure),cholecystectomy,enterolithotomy,and repair.After surgery,the patient presented with complications of acute renal failure,postoperative leak,acute diffuse peritonitis,septicopyemia,septic shock,and multiple organ failure,and finally died.CONCLUSION Early surgical intervention is the mainstay of treatment for gallstone ileus.For elderly patients with significant comorbidities,enterolithotomy alone is advised.

Expression and Purification of Human Coagulation Factor X in Mammalian CHO-DG44 Cells

[Objectives]This study was conducted to obtain a Chinese hamster ovary cell line that stably expresses recombinant human coagulation factor X(rhFX),and to induce efficient expression of the target gene with different concentrations of methotrexate(MTX).[Methods]PCR was performed to obtain the rhFX gene,and a recombinant expression plasmid pOptiVEC-rhFX was constructed and subjected to double restriction endonuclease digestion and sequencing identification.CHO-DG44(DHFR-)cells were transfected by the liposome method,and the target protein was purified by affinity chromatography and detected by SDS-PAGE electrophoresis and Western blot.A cell line with efficient and stable expression of the target gene was obtained by increasing the concentration of MTX to select positive clones.[Results]PCR yielded a 1509 bp rhFX sequence,and the results of double digestion and sequencing showed that the constructed pOptiVEC-rhFX plasmid was correct.After transfection of cells,MTX significantly increased protein expression.When MTX reached 1.0μmol/L,the expression efficiency of the target protein was(9±0.27)μg/ml.The purity of the target protein purified by affinity chromatography was 93%,which could be used for subsequent experiments.The expression efficiency of rhFX in eukaryotic mammalian cells was improved by increasing MTX concentration,and an affinity chromatography purification process for the target protein was preliminarily established.[Conclusions]The results of this study provide data support for the expression and purification of rhFX,and will lay a solid foundation for the development of drugs related to rhFX.

基于改进遗传算法与Morphin算法的机器人路径规划方法（英文）

为了实现动态复杂环境下机器人路径的优化,在建立栅格地图模型的基础上,针对传统遗传算法的不足,一是通过改进适应度函数使得到的路径更加平滑,二是将改进后的遗传算法与Morphin算法结合起来,使得机器人能够实时有效的躲避障碍物。仿真实验结果表明:通过结合改进遗传算法和Morphin算法的特点,能够使机器人沿着一条短而平滑的最优路径快速、安全地到达目标点。

微创肺表面活性物质治疗早产儿呼吸窘迫综合征对发育结局的影响

目的探讨微创肺表面活性物质(LISA)治疗早产儿呼吸窘迫综合征(NRDS)对发育结局的影响。方法回顾性分析2019年12月—2021年5月阜阳市人民医院收治的67例NRDS患儿的临床资料。将采用LISA治疗的30例患儿作为研究组,采用气管插管-肺表面活性物质-拔管治疗的37例患儿作为对照组,随访至纠正胎龄12个月。统计两组患儿肺表面活性物质(PS)给药过程中不良反应,分析两组通气、吸氧及再次使用PS情况,比较两组治疗前后血气指标的变化,对比两组并发症发生情况,比较两组随访期间体格发育及听力、视觉、神经系统发育情况。结果对照组与研究组PS给药操作过程中心动过缓、呼吸暂停、经皮血氧饱和度下降、药物反流发生率,72 h内有创机械通气率、总吸氧时间、无创通气时间、再次使用PS率,视网膜病、坏死性小肠结肠炎、脑室内出血、听力损伤、视觉损伤发生率比较,差异均无统计学意义(P>0.05)。研究组支气管肺发育不良发生率低于对照组(P<0.05)。两组治疗前后动脉血氧分压、动脉血二氧化碳分压、动脉血氧分压/吸入气氧浓度的差值比较,差异均无统计学意义(P>0.05)。两组出院时、纠正6个月、纠正12个月体重、头围、身长、宫外生长迟缓(EUGR)发生率比较,差异均无统计学意义(P>0.05)。两组纠正6个月、12个月的EUGR发生率均低于出院时(P<0.05),两组12个月的EUGR发生率均低于纠正6个月(P<0.05)。研究组智力发展指数、精神运动发展指数、发育商优于对照组(P<0.05)。结论LISA治疗NRDS早产儿是一种安全有效的PS给药方法,可降低支气管肺发育不良发生风险,改善神经系统发育情况。

单根锉WaveOne镍钛器械高效治疗弯曲根管的实验研究

目的研究单根锉Wave One镍钛器械治疗弯曲根管的疗效,并与不锈钢K锉、Pro Taper镍钛器械进行比较。方法选取根管弯曲度在20~40°的单根管离体前磨牙60颗,随机分为A、B、C 3组,每组20颗离体牙,3组分别采用Wave One/Crown-down法、K锉逐步后退法及Pro Taper/Crown-down法行根管预备,并采用口腔颌面锥形束计算机体层摄影分别于根管预备前后对离体牙行横向扫描。预备完成后,对3组中的60颗离体牙行冷牙胶侧方加压充填。测量3组中每颗离体牙的根管预备时间、根管充填时间;分析每颗离体牙根管预备前后,根管距根尖孔2、4和6 mm处的根管偏移量和轴中心率,并对以上结果进行统计学分析。结果 A组根管预备时间低于B、C组;在根管充填时间上,A组与C组比较差异无统计学意义(P>0.05),但A组短于B组(P<0.05)。在距根尖孔2、4和6 mm处,A组与B组间的根管偏移量及轴中心率比较,差异有统计学意义(P<0.05);A组与C组比较,差异无统计学意义(P>0.05)。结论与不锈钢K锉及Pro Taper相比,Wave One治疗弯曲根管具有效率高、根管成形效果好的优点,可广泛应用于临床弯曲根管的治疗。