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Recent progress in the applications of presynaptic dopaminergic positron emission tomography imaging in parkinsonism
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作者 Yujie Yang Xinyi Li +7 位作者 Jiaying Lu Jingjie Ge Mingjia Chen Ruixin Yao mei tian Jian Wang Fengtao Liu Chuantao Zuo 《Neural Regeneration Research》 SCIE CAS 2025年第1期93-106,共14页
Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of parkinsonism.... Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of parkinsonism.This review provides a comprehensive summary of the latest developments in the application of presynaptic dopaminergic positron emission tomography imaging in disorders that manifest parkinsonism.We conducted a thorough literature search using reputable databases such as PubMed and Web of Science.Selection criteria involved identifying peer-reviewed articles published within the last 5 years,with emphasis on their relevance to clinical applications.The findings from these studies highlight that presynaptic dopaminergic positron emission tomography has demonstrated potential not only in diagnosing and differentiating various Parkinsonian conditions but also in assessing disease severity and predicting prognosis.Moreover,when employed in conjunction with other imaging modalities and advanced analytical methods,presynaptic dopaminergic positron emission tomography has been validated as a reliable in vivo biomarker.This validation extends to screening and exploring potential neuropathological mechanisms associated with dopaminergic depletion.In summary,the insights gained from interpreting these studies are crucial for enhancing the effectiveness of preclinical investigations and clinical trials,ultimately advancing toward the goals of neuroregeneration in parkinsonian disorders. 展开更多
关键词 aromatic amino acid decarboxylase brain imaging dopamine transporter Parkinson’s disease PARKINSONISM positron emission tomography presynaptic dopaminergic function vesicle monoamine transporter type 2
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数据库一体机提升医院信息系统性能的探索与实践 被引量:1
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作者 梅甜 林仁回 +1 位作者 李银 伊永菊 《现代医院》 2024年第1期80-83,共4页
目的医院信息系统的数据交互与信息量的快速增长,给系统的运维和服务性能带来了重大挑战。为了解决软件的性能瓶颈、提升医院信息系统的响应性能,某医院探索性引入了Exadata数据库一体机。方法通过硬件参数选型、高可用测试以及数据迁... 目的医院信息系统的数据交互与信息量的快速增长,给系统的运维和服务性能带来了重大挑战。为了解决软件的性能瓶颈、提升医院信息系统的响应性能,某医院探索性引入了Exadata数据库一体机。方法通过硬件参数选型、高可用测试以及数据迁移等实现了数据库一体机的上线,通过对比上线前后数据库的I/O操作时间、SQL语句执行时间和业务系统模块加载时长评估效益。结果上线一体机后I/O操作的整体等待时长下降83.47%、相同语句的执行时间降幅超22%、业务系统加载时间平均下降43.74%。结论数据库一体机能够有效降低查询时间,加快业务模块的运行速度,能够帮助提升医院信息系统的性能。 展开更多
关键词 医院信息系统 数据库一体机 性能提升 数据迁移
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医院智慧医务管理系统建设与应用 被引量:1
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作者 佘广南 赵雨 +1 位作者 梅甜 伊永菊 《中国数字医学》 2024年第8期27-31,共5页
为解决医务管理工作的烦琐和低效问题,基于医院智慧管理分级评估标准建设医务管理系统,实现医师人事档案、资质授权、医疗安全等数字化管理,优化了医务管理流程,提高了医务管理的质量和工作效率,为智慧医院建设提供了有力保障。
关键词 医务管理 智慧医院 系统建设
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基于正交编解码的钢轨探伤数据信噪比提升研究
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作者 梅田 张玉华 +2 位作者 张世红 李忠 熊龙辉 《中国铁道科学》 EI CAS CSCD 北大核心 2024年第5期67-76,共10页
超声波检测作为钢轨探伤的重要手段已得到广泛应用,但使用传统超声发射接收技术会因幻象波和换能器串扰而造成超声探伤检测数据信噪比较低。为此,基于幻象波和换能器串扰的影响机理,并根据超声换能器压电晶片激发超声波频率与加载换能... 超声波检测作为钢轨探伤的重要手段已得到广泛应用,但使用传统超声发射接收技术会因幻象波和换能器串扰而造成超声探伤检测数据信噪比较低。为此,基于幻象波和换能器串扰的影响机理,并根据超声换能器压电晶片激发超声波频率与加载换能器压电晶片高压脉冲激励频率相同的特点,研究双拍正交编解码技术,即采用正交频率的高压脉冲激励信号作用于超声换能器压电晶片以产生频率正交的超声发射信号,通过对应的解码方式实现幻象波和换能器的串扰抑制,以达到提高探伤检测数据信噪比的目的;通过搭建超声系统试验平台,完成对国标伤损探伤A显、B显试验数据分析。结果表明:对于A显数据,双拍正交编解码技术对幻象波和换能器串扰的抑制作用强于对伤损回波信号抑制作用,平均抑制比为10.39 dB;对于B显数据,采用双拍正交编解码模式时伤损检出率为100%,对幻象波和换能器串扰消除亦为100%;相较于传统超声发射接收模式,采用双拍正交编解码的超声发射接收技术可在不影响伤损检出率的前提下,消除幻象波和换能器串扰影响,提高超声探伤检测数据信噪比,减少伤损误判漏判。 展开更多
关键词 钢轨探伤 双拍正交编解码 幻象波 换能器串扰 伤损报警
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成都市新都区小学生近视流行病学研究 被引量:30
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作者 吴婷 田美 +2 位作者 唐文婷 庹安明 喻谦 《国际眼科杂志》 CAS 北大核心 2019年第7期1239-1244,共6页
目的:调查成都市新都区小学生近视现状,分析本地区小学生近视的流行病学特点及相关影响因素。方法:采用分层整群随机抽样调查的方法,抽取成都市新都区4所小学的一年级到六年级学生,每个年级3个班,分别进行眼科检查和问卷调查,用SPSS21.... 目的:调查成都市新都区小学生近视现状,分析本地区小学生近视的流行病学特点及相关影响因素。方法:采用分层整群随机抽样调查的方法,抽取成都市新都区4所小学的一年级到六年级学生,每个年级3个班,分别进行眼科检查和问卷调查,用SPSS21.0软件进行统计分析。结果:共有3 324名学生参与本次调查,近视的学生1 124人,近视率33.81%。不同性别、不同年龄、不同年级、吃水果蔬菜和喝牛奶频次、父母监督和提醒学生用眼习惯频次、在家看书写字光线情况、每天连续家庭作业及看书时间、睡眠时间、每天课外活动时间、课间休息时去户外活动或做眼保健操频次、躺着看书或在晃动的车内看书频次、看书写字姿势以及父母双方患有近视情况的学生近视患病情况存在不同( P <0.05)。多因素回归分析发现:年级、性别、父母监督和提醒用眼习惯、在家看书写字的光线、每天连续家庭作业及看书时间、每天课外活动时间、躺着看书或在晃动的车内看书、看书写字姿势是否正确、父母近视情况均为近视的独立影响因素,其中父母监督和提醒用眼习惯为影响近视的保护因素,其余各指标均为危险因素。结论:青少年近视与环境、遗传等多种因素有关,应尽早采取相应措施,延缓其发生发展。 展开更多
关键词 小学生 近视 流行病学 影响因素
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角膜塑形镜对青少年近视的视觉质量影响研究 被引量:18
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作者 唐文婷 刘娟 +1 位作者 田美 喻谦 《国际眼科杂志》 CAS 北大核心 2019年第11期1931-1935,共5页
目的:随访观察配戴角膜塑形镜1a的不同程度近视的青少年患者,研究其在近视矫治同时对视觉质量的影响,对角膜塑形镜的安全性进行探讨。方法:选取2016-09/2017-12就诊的-1.00^-8.00D的158例青少年近视患者,患者均配戴同一品牌的夜戴型角... 目的:随访观察配戴角膜塑形镜1a的不同程度近视的青少年患者,研究其在近视矫治同时对视觉质量的影响,对角膜塑形镜的安全性进行探讨。方法:选取2016-09/2017-12就诊的-1.00^-8.00D的158例青少年近视患者,患者均配戴同一品牌的夜戴型角膜塑形镜矫治。随访观察患者配戴1a期间的视觉质量(包括像差、主观不适及视觉质量问卷调查)的改变情况。结果:配戴角膜塑形镜后总像差RMS值均降低,总高阶像差(RMS h)、3阶像差(RMS 3,包括彗差)及4阶像差(RMS 4,包括球差)均增加。基础近视度数越高,主观视觉不适的症状发生率越高,而戴镜前后患者的主观视觉质量总体评分无差异(P>0.05)。结论:角膜塑形镜会造成患者客观视觉质量下降,但长期随访发现整体视觉质量对生活学习无明显影响,是一种安全有效矫治近视的手段。 展开更多
关键词 角膜塑形镜 青少年 近视 视觉质量 安全性
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低浓度阿托品联合角膜塑形镜矫治近视的临床观察 被引量:20
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作者 唐文婷 田美 +1 位作者 李世贝 喻谦 《国际眼科杂志》 CAS 北大核心 2020年第6期1044-1047,共4页
目的:观察低浓度阿托品滴眼液联合角膜塑形镜治疗青少年低中度近视的有效性及安全性。方法:选取2016-05/2018-08于我院就诊的青少年低中度近视患者126例126眼(均取右眼数据),使用夜戴型角膜塑形镜1mo后随机进行分组,试验组患者63眼每晚... 目的:观察低浓度阿托品滴眼液联合角膜塑形镜治疗青少年低中度近视的有效性及安全性。方法:选取2016-05/2018-08于我院就诊的青少年低中度近视患者126例126眼(均取右眼数据),使用夜戴型角膜塑形镜1mo后随机进行分组,试验组患者63眼每晚联合应用低浓度(0.01%)阿托品滴眼液1次,对照组患者63眼每晚联合应用聚乙二醇滴眼液1次。随访观察眼轴、等效球镜度、最佳矫正近视力、瞳孔直径、调节幅度、泪膜破裂时间、眼压的情况。结果:联合治疗1a,试验组和对照组低度近视患者眼轴分别增长0.13±0.03、0.22±0.05mm,中度近视患者眼轴分别增长0.12±0.03、0.20±0.05mm;低度近视患者等效球镜度分别增加0.16±0.07、0.21±0.08D,中度近视患者等效球镜度分别增加0.16±0.05、0.20±0.09D,两组之间眼轴和等效球镜度变化均有差异(均P<0.05)。治疗1a后,两组患者最佳矫正近视力、泪膜破裂时间、眼压均无差异(P>0.05),但试验组患者瞳孔直径较对照组明显增大,调节幅度较对照组降低(P<0.05)。结论:0.01%阿托品滴眼液联合角膜塑形镜能更有效控制青少年近视进展,且安全有效。 展开更多
关键词 低浓度阿托品 角膜塑形镜 青少年 近视 有效性 安全性
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Positron emission tomography for phenotyping inflammation of cardiovascular diseases
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作者 Xiaoyun Luo Chentao Jin +5 位作者 Hetian Chen Xiaohui Zhang Yan Zhong Peili Cen Hong Zhang mei tian 《EngMedicine》 2024年第3期69-82,共14页
Inflammatory processes play a central role in the development and complications of cardiovascular diseases(CVDs),profoundly affecting the severity and prognosis of these events.However,the current tools used to measur... Inflammatory processes play a central role in the development and complications of cardiovascular diseases(CVDs),profoundly affecting the severity and prognosis of these events.However,the current tools used to measure inflammation have some limitations.Blood biomarkers cannot pinpoint the location of inflammation and are vulnerable to various factors.Histological assessments ex vivo cannot accurately reflect the full dynamic picture of pathophysiology.The rapid development of positron emission tomography(PET)imaging not only enhances our understanding of biological processes in vivo but also contributes significantly to clinical management as a non-invasive biomarker.This review summarizes the PET imaging of key immune cell responses in CVDs,including immune cell metabolism,ligand/receptor interactions,and enzyme secretion,and discusses emerging opportunities and challenges in PET imaging-based inflammatory phenotyping and future perspectives. 展开更多
关键词 Positron emission tomography Cardiovascular diseases Molecular imaging INFLAMMATION Immune cells
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使用RMAN方式实现医院信息系统数据库升级实践 被引量:3
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作者 伊永菊 梅甜 李银 《现代医院》 2022年第5期754-756,共3页
文章从两个方面介绍了医院信息系统数据库升级工作:第一,调研、论证和测试历史数据迁移方案;第二,制定对应的信息系统突发事件应急预案。升级实践实现了信息系统数服务器硬件升级,服务器操作系统由Red Hat Enterprise Linux 7.8升级为Re... 文章从两个方面介绍了医院信息系统数据库升级工作:第一,调研、论证和测试历史数据迁移方案;第二,制定对应的信息系统突发事件应急预案。升级实践实现了信息系统数服务器硬件升级,服务器操作系统由Red Hat Enterprise Linux 7.8升级为Red Hat Enterprise Linux 7.9,数据库由Oracle Database 11g升级为Oracle Database 19c,并使用RMAN方式实现了历史电子病历数据无损迁移。升级后信息系统数据库性能明显提高,且其升级过程对其他大型医院具有一定参考价值。 展开更多
关键词 医院信息系统 应急预案 数据库 升级 RMAN
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某医院业财融合信息化建设实践 被引量:7
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作者 赵雨 佘广南 +1 位作者 梅甜 王文辉 《现代医院》 2022年第6期908-910,914,共4页
业财融合信息化建设是医院经济业务信息向财务会计信息的自动化转化,推动财务岗位从做账会计向管理会计转变,使得财务核算能够从事后静态处理变成事中动态管理的必经之路。文章以某医院在推行业财融合信息化建设的实践出发,介绍了医院... 业财融合信息化建设是医院经济业务信息向财务会计信息的自动化转化,推动财务岗位从做账会计向管理会计转变,使得财务核算能够从事后静态处理变成事中动态管理的必经之路。文章以某医院在推行业财融合信息化建设的实践出发,介绍了医院信息化建设现状,以此为基础进行了整体方案、信息化建设要点及经验分享。旨在优化业务系统流程,提升医院业财融合程度,推动经济业务信息向财务会计信息的自动化转化,提升医院精细化运营管理水平。 展开更多
关键词 医院 医院综合运营管理系统 业财融合 信息化建设
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基于移动支付的出院线上结算系统的设计与应用 被引量:4
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作者 佘广南 梅甜 +2 位作者 赵雨 李银 伊永菊 《中国数字医学》 2023年第4期63-67,共5页
目的:解决人工窗口办理出院结算单一模式存在的问题,缩短患者出院结算办理时间,改善患者就医体验。方法:基于移动支付、微信小程序等应用技术,优化出院结算业务流程,通过信息流转完成出院线上结算业务交互,实现出院线上结算模式对自费... 目的:解决人工窗口办理出院结算单一模式存在的问题,缩短患者出院结算办理时间,改善患者就医体验。方法:基于移动支付、微信小程序等应用技术,优化出院结算业务流程,通过信息流转完成出院线上结算业务交互,实现出院线上结算模式对自费、医保及公费医疗患者类型的全覆盖。结果:2022年7月出院线上结算系统在我院全院上线,截至2022年9月底,线上结算1 145人次,窗口结算11 807人次。采用Python绘制两种结算模式下结算用时的散点图和概率密度图显示,线上结算的用时相对更集中,平均用时(6.24±9.60)分钟,而窗口结算平均用时为(40.69±21.55)分钟。结论:基于移动支付的出院线上结算模式,大大缩短了患者出院结算的办理时间,丰富了“互联网+医疗健康”便民惠民服务内容。 展开更多
关键词 移动支付 出院线上结算 互联网+ 微信小程序
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制备用于间充质干细胞成像的荧光成像/磁共振成像/正电子发射断层扫描三模态纳米探针
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作者 徐洋洋 任荣 +8 位作者 岳惠敏 钟燕 王晓燕 和庆钢 谷岩 毛峥伟 孙继红 田梅 张宏 《高分子材料科学与工程》 EI CAS CSCD 北大核心 2021年第6期154-165,共12页
为了在间充质干细胞移植的各个阶段更好地获取移植干细胞的命运信息,制备了一种能同时实现荧光成像(FI)、磁共振成像(MRI)和正电子发射断层扫描(PET)的影像探针。首先制备了一种新型两亲性嵌段共聚物,第1嵌段为叔丁氧羰基保护的2-((叔... 为了在间充质干细胞移植的各个阶段更好地获取移植干细胞的命运信息,制备了一种能同时实现荧光成像(FI)、磁共振成像(MRI)和正电子发射断层扫描(PET)的影像探针。首先制备了一种新型两亲性嵌段共聚物,第1嵌段为叔丁氧羰基保护的2-((叔丁氧羰基)氨基)丙烯酸乙酯的均聚物,第2嵌段为短链聚乙二醇丙烯酸酯和五氟苯酚丙烯酸酯的无规共聚物,再通过氨解和酰胺化反应为聚合物修饰上双功能螯合剂DOTA和近红外染料Cy5.5,通过核磁共振和凝胶渗透色谱对聚合物结构及相对分子质量进行了表征和分析。聚合物在水中自组装并螯合Gd^(3+)得到1 mg/mL的纳米探针Gd-DOTA-Cy5.5-NP,动态光散射和透射电镜观察到探针为平均粒径30 nm的球形颗粒,并用电感耦合等离子体光谱法测得Gd^(3+)浓度为0.084 mmol/L。将纳米探针与间充质干细胞共孵育,通过Cell Counting Kit-8试剂验证1 mg/mL以下的Gd-DOTA-Cy5.5-NP相对细胞毒性较低,同时激光共聚焦显微镜在675 nm激发波长下观测细胞出现红色荧光,利用3.0 T磁共振成像系统测得探针纵向弛豫率为46.969 mmol/(L·s)。最后Gd-DOTA-Cy5.5-NP螯合^(68)Ga^(3+),得到三模态纳米探针^(68)Ga/Gd-DOTA-Cy5.5-NP,伽马计数仪测得间充质干细胞对该探针的摄取在90 min达到饱和。 展开更多
关键词 两亲性嵌段共聚物 纳米探针 磁共振成像 荧光成像 正电子发射断层扫描成像 间充质干细胞
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基于动静态检测数据的轨道精测精调评价技术 被引量:19
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作者 刘学文 杨怀志 +2 位作者 杨飞 梅田 马颖伟 《铁道建筑》 北大核心 2019年第9期111-115,共5页
高速铁路无砟轨道不平顺的整修主要是通过精调作业来完成,轨道精调分为静态精调和动态精调。为优化轨道精调作业组织,提高轨道精调效率,可采用轨道测量仪和轨道检查仪协同工作组织轨道精调,从而提升作业效率和质量。采用多个矩形窗级联... 高速铁路无砟轨道不平顺的整修主要是通过精调作业来完成,轨道精调分为静态精调和动态精调。为优化轨道精调作业组织,提高轨道精调效率,可采用轨道测量仪和轨道检查仪协同工作组织轨道精调,从而提升作业效率和质量。采用多个矩形窗级联的方法优化滤波器和FIR带通滤波器滤波,将静态检测数据与动态检测数据关联起来,实现评价标准的通用、精调效果的静态评估,以及预测精调作业的动态评估结果,促进精调作业快速满足静动态轨道几何不平顺检测标准。通过算例分析可知,轨道精调对轨道几何不平顺的单项高低改善较为明显,轨向只是稍有变化,且目前单项高低标准差最大改善量约为1.0 mm。 展开更多
关键词 高速铁路 无砟轨道 动静态精调 矩形窗级联 FIR带通滤波器
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Prevalence of color vision deficiency among Chinese college students and their quality of life 被引量:1
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作者 Jing-Ge Gao mei tian 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2023年第9期1542-1548,共7页
AIM:To investigate the prevalence of color vision deficiency(CVD)among college students and their quality of life(QoL)in a Chinese college.METHODS:This cross-sectional study was performed in Sichuan University in Chen... AIM:To investigate the prevalence of color vision deficiency(CVD)among college students and their quality of life(QoL)in a Chinese college.METHODS:This cross-sectional study was performed in Sichuan University in Chengdu,China.The questionnaire containing participants’demographic data,as well as CVD related QoL was distributed to students who were screened as CVD[by Color Vision Examination Plates(Version 6)]in 2022 freshman entrance examination.Color blindness QoL(CBQoL)and utility analysis were used to evaluate the QoL of CVD students.RESULTS:There were 381 of 17303(2.20%)students screened as CVD,including 368(4.11%)males and 13(0.16%)females.A total of 317 students completed the questionnaire,the response rate was 83.20%.Only 166 participants(52.3%)knew they have CVD before the physical examination for college entrance examination,while a total of 145 participants(45.74%)hoped to be diagnosed earlier.The medians of CBQoL score and utility were 5.85(range 2.2-6)and 1(range 0-1),respectively.The proportions of students whose QoL is affected by CVD were 67.63%(211/312)and 42.27%(134/317)measured by CBQoL and utility analysis respectively.CONCLUSION:The prevalence of CVD in males is much higher than that in females.The time when CVD students first became aware of their CVD is relatively late.The QoL of the study population is quite high,while a large proportion of students’QoL are affected by CVD.It is suggested that as a congenital defect,CVD screening in China should be earlier,and appropriate guidance and support are needed for CVD patients to help them better adapt to life,study,and work. 展开更多
关键词 color vision deficiency PREVALENCE quality of life utility analysis college student
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Mitochondrial genome of Chthamalus challengeri(Crustacea:Sessilia): gene order comparison within Chthamalidae and phylogenetic consideration within Balanomorpha
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作者 Panpan Chen Jun Song +4 位作者 Xin Shen Yuefeng Cai Ka Hou Chu Yongqi Li mei tian 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2019年第6期25-31,共7页
Acorn barnacles are important model species in researches on intertidal ecology, larval development and biofouling. At present, with the development of mitochondrial genomics, it is helpful to understand the phylogene... Acorn barnacles are important model species in researches on intertidal ecology, larval development and biofouling. At present, with the development of mitochondrial genomics, it is helpful to understand the phylogenetic relationship from the mitogenomic level. The complete mitochondrial genome of Chthamalus challengeri was presented. The genome is a circular molecule of 15 358 bp. Compared with other species in Balanomorpha, the non-coding region is longer, while the length of the genes is similar to the other species. The overall A+T content of the mitochondrial genome of C. challengeri is 70.5%. There are variations of initiation and stop codons in the known Balanomorpha mitochondrial genomes. The C. challengeri and C. antennatus within the same genus share the identical gene arrangement. However, the gene arrangement of different genera in Chthamalidae is different, as there is a translocation between two tRNA genes and an inversion involving a large gene block. In particular, both srRNA and lrRNA of the two species in Chthamalus are encoded in the heavy strand, differing from the former Balanomorpha species. The topology and gene arrangement in Chthamalidae support each other. Phylogenetic analysis indicates that the Chthamalidae is monophyletic, while the Balanidae and Archaeobalanidae are polyphyletic. 展开更多
关键词 Balanomorpha CHTHAMALUS challengeri mitochondrial genome gene REARRANGEMENT PHYLOGENY
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Glucocorticoids combined with tofacitinib in the treatment of Castleman’s disease:A case report
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作者 Xiao-Rui Liu mei tian 《World Journal of Clinical Cases》 SCIE 2022年第29期10794-10802,共9页
BACKGROUND Castleman’s disease(CD),also known as vascular follicular lymphadenopathy is a rare proliferative disease of lymphoid tissue of unknown etiology that is clinically classified as unicentric CD(UCD) or multi... BACKGROUND Castleman’s disease(CD),also known as vascular follicular lymphadenopathy is a rare proliferative disease of lymphoid tissue of unknown etiology that is clinically classified as unicentric CD(UCD) or multicentric CD(MCD) depending on lymph node involvement.At present,idiopathic MCD(iMCD) is treated with interleukin-6 inhibitors,but some patients have poor clinical outcomes.This paper reports on a case of iMCD that achieved a good therapeutic effect after treatment with glucocorticoids combined with tofacitinib.The relevant data are summarized and reported below.CASE SUMMARY This paper reports on a case of MCD in a 49-year-old female with persistent peritoneal effusion as the first manifestation and combined with multiple lymphadenopathies.Lymph node biopsy showed Castleman’s disease-like changes.The ascites subsided after treatment with glucocorticoids and tofacitinib,indicating that the treatment was effective.CONCLUSION The combination of glucocorticoids with tofacitinib is an effective regimen for the treatment of CD. 展开更多
关键词 Castleman’s disease Multicentric Castleman’s disease Idiopathic multicentric Castleman’s disease Abdominal dropsy Tofacitinib GLUCOCORTICOIDS Case report
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Serum-negative Sjogren's syndrome with minimal lesion nephropathy as the initial presentation:A case report
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作者 Chun-Yan Li Yi-Man Li mei tian 《World Journal of Clinical Cases》 SCIE 2022年第14期4625-4631,共7页
BACKGROUND Primary Sjogren's syndrome(pSS)is an autoimmune disease,and renal involvement has been considered to be one of the systemic complications of pSS.Patients who have sjogren's syndrome with renal disea... BACKGROUND Primary Sjogren's syndrome(pSS)is an autoimmune disease,and renal involvement has been considered to be one of the systemic complications of pSS.Patients who have sjogren's syndrome with renal disease as the first manifestation and no exocrine gland involvement or autoantibodies can be missed clinically.CASE SUMMARY We here in report an unusual case of a primary Sjogren's syndrome in a 43-yearold female who had minimal lesion nephropathy as the initial presentation,and the patient was negative for serum anti-SSA and anti-SSB antibodies and did not have signs of exocrine gland involvement.The patient’s Sjogren's syndrome was confirmed by a minor salivary gland biopsy(MSGB)and a filter paper test.the patient’s oedema subsided,and the patient’s urinary protein resolved,showing that the treatment was effective.CONCLUSION MSGB should be considered if pSS is suspected in patients who do not have the typical pSS symptoms or who are positive for the specific autoantibodies. 展开更多
关键词 Sjogren's syndrome Anti-SSA Anti-SSB antibodies Minimal lesion nephropathy Minor salivary gland biopsy Case report
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Systemic lupus erythematosus with visceral varicella:A case report
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作者 Jing Zhao mei tian 《World Journal of Clinical Cases》 SCIE 2022年第25期9168-9175,共8页
BACKGROUND As an autoimmune disease,systemic lupus erythaematosus(SLE)can affect multiple systems of the body and is mainly treated by steroids and immunosuppressive agents.SLE results in a long-term immunocompromised... BACKGROUND As an autoimmune disease,systemic lupus erythaematosus(SLE)can affect multiple systems of the body and is mainly treated by steroids and immunosuppressive agents.SLE results in a long-term immunocompromised state with the potential of infection complications(e.g.,bacterial,fungal and viral infections).Abdominal pain or acute abdomen are frequently the only manifestations of SLE at disease onset or during the early stage of the disease course.Thus,multidisciplinary collaboration is required to identify these patients because timely diagnosis and treatment are crucial for improving their prognosis.CASE SUMMARY Herein,we reported a case of an SLE patient with visceral varicella that was identified after the onset of abdominal pain.The 16-year-old female patient with SLE was admitted to our hospital due to initial attacks of abdominal pain and intermittent fever.The patient’s condition rapidly became aggravated within a short time after admission,with large areas of vesicular rash,severe pneumonia,respiratory failure,shock,and haematologic system and hepatic function impairment.Based on multidisciplinary collaboration,the patient was diagnosed with visceral disseminated varicella and was administered life support,antiviral(acyclovir),immunomodulatory(intravenous injection of human immunoglobulin),anti-infection(vancomycin)and anti-inflammatory(steroid)therapies.After treatment,her clinical symptoms and laboratory indicators gradually improved,and the patient was discharged.CONCLUSION SLE patients long treated with steroids and immunosuppressive agents are susceptible to various infections.Considering that visceral varicella with abdominal pain as the initial presentation is characterized by rapid progression and often coexists with serious complications,prompt diagnosis and early antiviral therapy are critical to prevent severe life-threatening complications. 展开更多
关键词 Systemic lupus erythematosus Visceral varicella Severe pneumonia TACROLIMUS Mycophenolate mofetil Case report
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The Role of CHMP4C on Proliferation in the Human Lung Cancer A549 Cells
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作者 Kang Li Jianxiang Liu +6 位作者 mei tian Chunnan Piao Jianlei Ruan Ling Gao Xuesong Qi Gang Gao Xu Su 《Journal of Cancer Therapy》 2015年第15期1223-1228,共6页
The human lung cancer has high incidence rate and mortality among the carcinoma. The research on enhancing the efficacy of therapy for lung cancer is significant. A resent research found that as a subunit of ESCRT-III... The human lung cancer has high incidence rate and mortality among the carcinoma. The research on enhancing the efficacy of therapy for lung cancer is significant. A resent research found that as a subunit of ESCRT-III, CHMP4C functioned to retard abscission timing to coordinate midbody resolution and prevent accumulation of DNA damage in the abscission checkpoint through phosphorylated by AuroraB. In the current study, we evaluated the possible mechanism of the effects of CHMP4C inhibition on cell cycle and cell survival in A549 cells. We found that CHMP4C knockdown caused lagging S phase in cell cycle through enhancing the phosphorylation of Rb, raising the expression of cyclin B1-cdc2 and suppressing the activation of cyclin A. Meanwhile, CHMP4Cdeletion depressed cell survival via decreasing cell viability and increasing caspase 3/7 activity. This study may promote new significant reference and advance for the mechanism underlying specific function of CHMP4C as well as further research on enhancing therapy effect on non-small lung cancer. 展开更多
关键词 The Human LUNG CANCER A549 CHMP4C SIRNA
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Friend or foe? Using eye-tracking technology to investigate the visual discrimination ability of giant pandas
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作者 Xinrui Huang Guo Li +9 位作者 Guiquan Zhang Zixiang Li Lin Zhao Mengdie Zhu Qinghua Xiang Xuefeng Liu mei tian Hemin Zhang Christina D.Buesching Dingzhen Liu 《Current Zoology》 SCIE CAS CSCD 2024年第4期430-439,共10页
The role that visual discriminative ability plays among giant pandas in social communication and individual discrimination has received less attention than olfactory and auditory modalities.Here,we used an eye-tracker... The role that visual discriminative ability plays among giant pandas in social communication and individual discrimination has received less attention than olfactory and auditory modalities.Here,we used an eye-tracker technology to investigate pupil fixation patterns for 8 captive male giant pandas Ailuropoda melanoleuca.We paired images(N=26)of conspecifics against:1)sympatric predators(gray wolves and tigers),and non-threatening sympatric species(golden pheasant,golden snub-nosed monkey,takin,and red panda),2)conspecifics with atypical fur colora-tion(albino and brown),and 3)zookeepers/non-zookeepers wearing either work uniform or plain clothing.For each session,we tracked the pan-da's pupil movements and measured pupil first fixation point(FFP),fixation latency,total fixation count(TFC),and duration(TFD)of attention to each image.Overall,pandas exhibited similar attention(FFPs and TFCs)to images of predators and non-threatening sympatric species.Images of golden pheasant,snub-nosed monkey,and tiger received less attention(TFD)than images of conspecifics,whereas images of takin and red panda received more attention,suggesting a greater alertness to habitat or food competitors than to potential predators.Pandas'TFCs were greater for images of black-white conspecifics than for albino or brown phenotypes,implying that familiar color elicited more interest.Pandas reacted differently to images of men versus women.For images of women only,pandas gave more attention(TFC)to familiar combinations(uniformed zookeepers and plain-clothed non-zookeepers),consistent with the familiarity hypothesis.That pandas can use visual perception to discriminate intra-specifically and inter-specifically,including details of human appearance,has applications for panda conservation and captive husbandry. 展开更多
关键词 eye movement tracker giant panda images total fixation duration total pupil fixation count visual discrimination.
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