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Anti-arthritic effects of microneedling with bee venom gel 被引量:2
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作者 mengdi zhao Jie Bai +6 位作者 Yang Lu Shouying Du Kexin Shang Pengyue Li Liu Yang Boyu Dong Ning Tan 《Journal of Traditional Chinese Medical Sciences》 2016年第4期256-262,共7页
Objective:To combine with transdermal drug delivery using microneedle to simulate the bee venom therapy to evaluate the permeation of bee venom gel.Methods:In this study,the sodium urate and LPS were used on rats and ... Objective:To combine with transdermal drug delivery using microneedle to simulate the bee venom therapy to evaluate the permeation of bee venom gel.Methods:In this study,the sodium urate and LPS were used on rats and mice to construct the model.Bee venom gelemicroneedle combination effect on the model is to determine the role of microneedle gel permeation by observing inflammation factors.Results:Compared with the model group,the bee venom gelemicroneedle combination group can reduce the level of serum nitric oxide of the acute gouty inflammation model caused by sodium urate,and on LPS induced mouse model of acute inflammation effect and the micro.Conclusions:Bee venom can significantly suppress the occurrence of gouty arthritis inflammation in rats and mice LPS inflammatory reaction.Choose the 750 mm microneedle with 10N force on skin about 3 minutes,bee venom can play the optimal role,and the anti-inflammatory effect is obvious.Microneedles can promote the percutaneous absorption of the active macromolecules bee venom gel. 展开更多
关键词 ARTHRITIS Bee venom GEL MELITTIN MICRONEEDLE
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Differences in action potential propagation speed and axon initial segment plasticity between neurons from Sprague-Dawley rats and C57BL/6 mice
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作者 Zhi-Ya Chen Luxin Peng +5 位作者 mengdi zhao Yu Li Mochizuki Takahiko Louis Tao Peng Zou Yan Zhang 《Zoological Research》 SCIE CAS CSCD 2022年第4期615-633,共19页
Action potentials(APs)in neurons are generated at the axon initial segment(AIS).AP dynamics,including initiation and propagation,are intimately associated with neuronal excitability and neurotransmitter release kineti... Action potentials(APs)in neurons are generated at the axon initial segment(AIS).AP dynamics,including initiation and propagation,are intimately associated with neuronal excitability and neurotransmitter release kinetics.Most learning and memory studies at the single-neuron level have relied on the use of animal models,most notably rodents.Here,we studied AP initiation and propagation in cultured hippocampal neurons from Sprague-Dawley(SD)rats and C57BL/6(C57)mice with genetically encoded voltage indicator(GEVI)-based voltage imaging.Our data showed that APs traveled bidirectionally in neurons from both species;forward-propagating APs(fpAPs)had a different speed than backpropagating APs(bpAPs).Additionally,we observed distinct AP propagation characteristics in AISs emerging from the somatic envelope compared to those originating from dendrites.Compared with rat neurons,mouse neurons exhibited higher bpAP speed and lower fpAP speed,more distally located ankyrin G(AnkG)in AISs,and longer Nav1.2 lengths in AISs.Moreover,during AIS plasticity,AnkG and Nav1.2 showed distal shifts in location and shorter lengths of labeled AISs in rat neurons;in mouse neurons,however,they showed a longer AnkG-labeled length and more distal Nav1.2 location.Our findings suggest that hippocampal neurons in SD rats and C57 mice may have different AP propagation speeds,different AnkG and Nav1.2 patterns in the AIS,and different AIS plasticity properties,indicating that comparisons between these species must be carefully considered. 展开更多
关键词 Sprague-Dawley rats C57BL/6 mice Action potential Axon initial segment PLASTICITY
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Response of MaHMA2 gene expression and stress tolerance to zinc stress in mulberry(Morus alba L.)
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作者 LEI WANG QIUXIA DU +11 位作者 YISU SHI MICHAEL ACKAH PENG GUO DANYAN ZHENG MENGMENG WU XIN JIN PEILAN LI QIAONAN ZHANG RUIXUE LI ZHI YIN mengdi zhao WEIGUO zhao 《BIOCELL》 SCIE 2022年第10期2327-2342,共16页
HMA2(heavy metal ATPase 2)plays a crucial role in extracellular and intracellular Zn^(2+)transport across biomembranes,maintaining ion homeostasis,and playing an important role in the normal physiological metabolism,g... HMA2(heavy metal ATPase 2)plays a crucial role in extracellular and intracellular Zn^(2+)transport across biomembranes,maintaining ion homeostasis,and playing an important role in the normal physiological metabolism,growth,and development of plants.In our study,a novel HMA2 gene,named MaHMA2,was isolated and cloned from white mulberry(Morus alba L.).The gene sequence obtained was 1,342 bp long,with an open reading frame of 1,194 bp,encoding a protein of 397 amino acids,with a predicted molecular mass of 42.852 kD and an isoelectric point of 7.53.This protein belonged to the PIB-type ATPase transport protein family.We analyzed the expression of the MaHMA2 gene by quantitative real-time PCR.The results showed that the level of MaHMA2 gene expression decreased to a Zn concentration of 800 mg/kg.Malondialdehyde and proline levels increased and responded to increasing Zn when the MaHMA2 gene was silenced,whereas the activities of peroxidase and superoxide dismutase tended to increase in response to increasing Zn^(2+)ion stress concentrations but were lower in the gene-silenced plants.These findings suggested that the MaHMA2 gene played an active role in the tolerance response of mulberry to Zn stress. 展开更多
关键词 MULBERRY Zn stress MaHMA2 gene VGIS PHYSIOLOGICAL BIOCHEMICAL
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The pharmacokinetics of aspirin in combination with total ginsenoside of ginseng stems and leaves in rats
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作者 Gangyan Yu Li Tan +2 位作者 Yutao Xue mengdi zhao Yang Lu 《Journal of Traditional Chinese Medical Sciences》 2017年第4期366-371,共6页
Objective:To investigate the effect of total ginsenoside of ginseng stems and leaves (TGSL) on the pharmacokinetics of aspirin in rats.Methods:Sprague-Dawley rats were randomly divided into two groups (n =6),a combine... Objective:To investigate the effect of total ginsenoside of ginseng stems and leaves (TGSL) on the pharmacokinetics of aspirin in rats.Methods:Sprague-Dawley rats were randomly divided into two groups (n =6),a combined group that received TGSL (625 mg/kg body weight) and aspirin (10 mg/kg body weight) by gavage,and an aspirin group that received aspirin (10 mg/kg body weight) by gavage.The concentration of salicylic acid,an important metabolite of aspirin,was determined by highperformance liquid chromatography in supernatant from blood obtained from the orbital sinus at various time points to examine the effect of TGSL on aspirin.Results:The results showed that the Tmax of salicylic acid was [0.92 (0.58)] hours in the aspirin group and [2.50 (1.22)] hours in the combined group,and was statistically significantly different between the groups (p <.05).Conclusions:TGSL can affect the pharmacokinetics of aspirin at Tmax in rats. 展开更多
关键词 ASPIRIN TOTAL GINSENOSIDE of GINSENG STEMS and leaves (TGSL) PHARMACOKINETICS
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Diffusion-Free All-Solid-State Batteries Enabled by an Ionic/Electronic Dual-Conductive Anode
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作者 Yue Ji Zaifa Wang +14 位作者 Changtai zhao Zhiqiang Fang Yue Gong Qihang Jing Yu Xia Tengjiao Luan Yingying Jiang Jianwen Liang Xiaona Li mengdi zhao Ximin Zhai Xiaofei Bie Tao Jiang Dongsheng Geng Xueliang Sun 《Renewables》 2024年第3期194-203,共10页
Silicon(Si)is one of the most promising anodes for enabling all-solid-state batteries(ASSBs)with high energy density and safety.However,the tremendous volume change and sluggish kinetics result in poor electrochemical... Silicon(Si)is one of the most promising anodes for enabling all-solid-state batteries(ASSBs)with high energy density and safety.However,the tremendous volume change and sluggish kinetics result in poor electrochemical performance.Herein,we proposed an ionic/electronic dual-conductive material of Li_(x)Si as a diffusion-rapid and all-active anode for ASSBs.Compared with pure Si anode,the as-fabricated Li_(x)Si showed dramatic promotions of 35 times electronic and 400 times ionic conductivities.The three-dimensional(3D)ionic-electronic transport system of Li_(x)Si enabled rapid kinetics and uniform volume change of electrode materials in the whole electrode,corresponding to a lower volumechange rate.As a result,the ASSBs with LiCoO_(2)cathode exhibited a reversible discharge capacity of 154.4 mAh g−1,corresponding to an initial Coulombic efficiency of 97.3%.Besides,the batteries delivered a high rate capacity of 99.3 mAh g^(−1)at 2 C and long-term cycle stability of 94.0%after 800 cycles at 1 C,which was much better than the pure Si anode.This study sheds light on a new understanding of the importance of ionic conductivity for Si-based anode and might help inspire the design of advanced anode materials for ASSBs. 展开更多
关键词 all-solid-state batteries lithium silicon anodes interface stability ionic-electronic conductors long-term cycling performance
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Cellbow:a robust customizable cell segmentation program
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作者 Huixia Ren mengdi zhao +7 位作者 Bo Liu Ruixiao Yao Qi liu Zhipeng Ren Zirui Wu Zongmao Gao Xiaojing Yang Chao Tang 《Quantitative Biology》 CAS CSCD 2020年第3期245-255,共11页
Backgrounds Time-lapse live cell imaging of a growing cell population is routine in many biological investigations.A major challenge in imaging analysis is accurate segmentation,a process to define the boundaries of c... Backgrounds Time-lapse live cell imaging of a growing cell population is routine in many biological investigations.A major challenge in imaging analysis is accurate segmentation,a process to define the boundaries of cells based on raw image data.Current segmentation methods relying on single boundary features have problems in robustness when dealing with inhomogeneous foci which invariably happens in cell population imaging.Methods:Combined with a multi-layer training set strategy,we developed a neural-network-based algorithm—Cellbow.Results'Cellbow can achieve accurate and robust segmentation of cells in broad and general settings.It can also facilitate long-term tracking of cell growth and division.To facilitate the application of Cellbow,we provide a website on which one can online test the software,as well as an I mage J plugin for the user to visualize the performance before software installation.Conclusions Cellbow is customizable and generalizable.It is broadly applicable to segmenting fluorescent images of diverse cell types with no further training needed.For bright-field images,only a small set of sample images of the specific cell type from the user may be needed for training. 展开更多
关键词 deep neural network cell segmentation fluorescent cell imaging bright-field cell imaging lineage tracking
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Dendritic Morphology Affects the Velocity and Amplitude of Back-propagating Action Potentials
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作者 Wu Tian Luxin Peng +3 位作者 mengdi zhao Louis Tao Peng Zou Yan Zhang 《Neuroscience Bulletin》 SCIE CAS CSCD 2022年第11期1330-1346,共17页
The back-propagating action potential(bpAP)is crucial for neuronal signal integration and synaptic plasticity in dendritic trees.Its properties(velocity and amplitude)can be affected by dendritic morphology.Due to lim... The back-propagating action potential(bpAP)is crucial for neuronal signal integration and synaptic plasticity in dendritic trees.Its properties(velocity and amplitude)can be affected by dendritic morphology.Due to limited spatial resolution,it has been difficult to explore the specific propagation process of bpAPs along dendrites and examine the influence of dendritic morphology,such as the dendrite diameter and branching pattern,using patch-clamp recording.By taking advantage of Optopatch,an all-optical electrophysiological method,we made detailed recordings of the real-time propagation of bpAPs in dendritic trees.We found that the velocity of bpAPs was not uniform in a single dendrite,and the bpAP velocity differed among distinct dendrites of the same neuron.The velocity of a bpAP was positively correlated with the diameter of the dendrite on which it propagated.In addition,when bpAPs passed through a dendritic branch point,their velocity decreased significantly.Similar to velocity,the amplitude of bpAPs was also positively correlated with dendritic diameter,and the attenuation patterns of bpAPs differed among different dendrites.Simulation results from neuron models with different dendritic morphology corresponded well with the experimental results.These findings indicate that the dendritic diameter and branching pattern significantly influence the properties of bpAPs.The diversity among the bpAPs recorded in different neurons was mainly due to differences in dendritic morphology.These results may inspire the construction of neuronal models to predict the propagation of bpAPs in dendrites with enormous variation in morphology,to further illuminate the role of bpAPs in neuronal communication. 展开更多
关键词 DENDRITE Action potential Backpropagation Synaptic integration
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