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Loss of chromosome 9p21 is associated with a poor prognosis in adenosquamous carcinoma of the pancreas
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作者 Yina Jiang Yinying Wu +9 位作者 Liwen Zhang Yan Wang Guiping xu Yuan Deng Liang Han Enxiao Li Qingyong Ma mian xu Zheng Wu Zheng Wang 《Precision Clinical Medicine》 2023年第4期226-238,共13页
Adenosquamous carcinoma of the pancreas(ASCP)is a rare histological subtype of pancreatic cancer with a poor prognosis and a high metastasis rate.However,little is known about its genomic landscape and prognostic biom... Adenosquamous carcinoma of the pancreas(ASCP)is a rare histological subtype of pancreatic cancer with a poor prognosis and a high metastasis rate.However,little is known about its genomic landscape and prognostic biomarkers.A total of 48 ASCP specimens and 98 pancreatic ductal adenocarcinoma(PDAC)tumour specimens were sequenced to explore the genomic landscape and prognostic biomarkers.The homozygous deletion of the 9p21.3 region(including CDKN2A,CDKN2B,and MTAP)(9p21 loss)occurred in both ASCP and PDAC,and a higher frequency of 9p21 loss was observed in ASCP(12.5%vs 2.0%,P=0.022).Notably,9p21 loss was significantly associated with poor disease-free survival(DFS)in ASCP patients(mDFS(Median DFS)=4.17 vs 7.33 months,HR(Hazard Ratio)=3.70,P=0.009).The most common gene alterations in patients with ASCP were KRAS(96%),TP53(81%),CDKN2A(42%),SMAD4(21%),CDKN2B(13%),and FAT3(13%).The mutation rates of ACVR2A(6.25%vs 0%),FANCA(6.25%vs 0%),RBM10(6.25%vs 0%),and SPTA1(8.33%vs 1.02%)were significantly higher in ASCP than in PDAC.In conclusion,we have comprehensively described the genomic landscape of the largest cohort of ASCP patients to date and highlight that 9p21 loss may be a promising prognostic biomarker for ASCP,which provides a molecular basis for prognosis prediction and new therapeutic strategies for ASCP. 展开更多
关键词 adenosquamous carcinoma of the pancreas genomic pattern 9p21 loss BIOMARKER PROGNOSTIC
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Responses of Arctic sea ice to stratospheric ozone depletion 被引量:3
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作者 Jiankai Zhang Wenshou Tian +9 位作者 John A.Pyle James Keeble Nathan Luke Abraham Martyn P.Chipperfield Fei Xie Qinghua Yang Longjiang Mu Hong-Li Ren Lin Wang mian xu 《Science Bulletin》 SCIE EI CSCD 2022年第11期1182-1190,共9页
The Arctic has experienced several extreme springtime stratospheric ozone depletion events over the past four decades,particularly in 1997,2011 and 2020.However,the impact of this stratospheric ozone depletion on the ... The Arctic has experienced several extreme springtime stratospheric ozone depletion events over the past four decades,particularly in 1997,2011 and 2020.However,the impact of this stratospheric ozone depletion on the climate system remains poorly understood.Here we show that the stratospheric ozone depletion causes significant reductions in the sea ice concentration(SIC)and the sea ice thickness(SIT)over the Kara Sea,Laptev Sea and East Siberian Sea from spring to summer.This is partially caused by enhanced ice transport from Barents-Kara Sea and East Siberian Sea to the Fram Strait,which is induced by a strengthened and longer lived polar vortex associated with stratospheric ozone depletion.Additionally,cloud longwave radiation and surface albedo feedbacks enhance the melting of Arctic sea ice,particularly along the coast of the Eurasian continent.This study highlights the need for realistic representation of stratosphere-troposphere interactions in order to accurately predict Arctic sea ice loss. 展开更多
关键词 平流层臭氧 东西伯利亚海 北极海冰 地表反照率 喀拉海 长波辐射 拉普捷夫海 海冰密集度
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