The scheduling of construction equipment is a means to realize network planning.With the large-scale and low-cost requirements of engineering construction,the cooperation among members of the engineering supply chain ...The scheduling of construction equipment is a means to realize network planning.With the large-scale and low-cost requirements of engineering construction,the cooperation among members of the engineering supply chain has become very important,and effective coordination of project plans at all levels to optimize the resource management and scheduling of a project is helpful to reduce project duration and cost.In this paper,under the milestone constraint conditions,the scheduling problems of multiple construction devices in the same sequence of operation were described and hypothesized mathematically,and the scheduling models of multiple equipment were established.The Palmer algorithm,CDS algorithm and Gupta algorithm were respectively used to solve the optimal scheduling of construction equipment to achieve the optimization of the construction period.The optimization scheduling of a single construction device and multiple construction devices was solved by using sequencing theory under milestone constraint,and these methods can obtain reasonable results,which has important guiding significance for the scheduling of construction equipment.展开更多
A comprehensive study of the phase composition, microstructure evolution, microhardness and wear performance of WC-12 Co composite coatings fabricated by laser cladding using coaxial powder-feed mode was presented. It...A comprehensive study of the phase composition, microstructure evolution, microhardness and wear performance of WC-12 Co composite coatings fabricated by laser cladding using coaxial powder-feed mode was presented. It was shown that a combination of high scan speed and high laser energy density made WC on the edge of WC-12 Co composite powders partially melt in liquid Co and 304 stainless steel matrix, and then new carbides consisting of lamellar WC and herringbone M3 W3 C(M=Fe,Co) were formed. Meanwhile, WC-12 Co composite coatings with no porosity, cracks and drawbacks like decarburization were obtained, showing high densification and good metallurgical bonding with the substrate. Furthermore, a considerably high microhardness of HV0.3 1500-1600, low coefficient of friction of 0.55 and wear rate of(2.15±0.31)×10-7 mm3/(N·m) were achieved owing to the synergistic effect of excellent metallurgical bonding and fine microstructures of composite coating under laser power of 1500 W.展开更多
CDGSH iron sulfur domain 2 can inhibit ferroptosis,which has been associated with cerebral ischemia/reperfusion,in individuals with head and neck cancer.Therefore,CDGSH iron sulfur domain 2 may be implicated in cerebr...CDGSH iron sulfur domain 2 can inhibit ferroptosis,which has been associated with cerebral ischemia/reperfusion,in individuals with head and neck cancer.Therefore,CDGSH iron sulfur domain 2 may be implicated in cerebral ischemia/reperfusion injury.To validate this hypothesis in the present study,we established mouse models of occlusion of the middle cerebral artery and HT22 cell models of oxygen-glucose deprivation and reoxygenation to mimic cerebral ischemia/reperfusion injury in vivo and in vitro,respectively.We found remarkably decreased CDGSH iron sulfur domain 2 expression in the mouse brain tissue and HT22 cells.When we used adeno-associated virus and plasmid to up-regulate CDGSH iron sulfur domain 2 expression in the brain tissue and HT22 cell models separately,mouse neurological dysfunction was greatly improved;the cerebral infarct volume was reduced;the survival rate of HT22 cells was increased;HT22 cell injury was alleviated;the expression of ferroptosis-related glutathione peroxidase 4,cystine-glutamate antiporter,and glutathione was increased;the levels of malondialdehyde,iron ions,and the expression of transferrin receptor 1 were decreased;and the expression of nuclear-factor E2-related factor 2/heme oxygenase 1 was increased.Inhibition of CDGSH iron sulfur domain 2 upregulation via the nuclear-factor E2-related factor 2 inhibitor ML385 in oxygen-glucose deprived and reoxygenated HT22 cells blocked the neuroprotective effects of CDGSH iron sulfur domain 2 up-regulation and the activation of the nuclear-factor E2-related factor 2/heme oxygenase 1 pathway.Our data indicate that the up-regulation of CDGSH iron sulfur domain 2 can attenuate cerebral ischemia/reperfusion injury,thus providing theoretical support from the perspectives of cytology and experimental zoology for the use of this protein as a therapeutic target in patients with cerebral ischemia/reperfusion injury.展开更多
The dynamic control of single-photon scattering in a pair of one-dimensional waveguides mediated by a time-modulated atom-cavity system is investigated.Two cases,where the waveguides are coupled symmetrically or asymm...The dynamic control of single-photon scattering in a pair of one-dimensional waveguides mediated by a time-modulated atom-cavity system is investigated.Two cases,where the waveguides are coupled symmetrically or asymmetrically to the atom-cavity system,are discussed in detail.The results show that such time-modulated atom-cavity configuration can behave as a dynamical tunable directional single-photon router.The photons with different frequencies can dynamically be routed from the incident waveguide into any ports of the other with a 100%probability via adjusting the modulated amplitude or phases of the time-modulated atom-cavity coupling strengths,associate with the help of the asymmetrical waveguide-cavity couplings.Furthermore,the influence of dissipation on the routing capability is investigated.It is shown that the present single-photon router is robust against the dissipative process of the system,especially the atomic dissipation.These results are expected to be applicable in quantum information processing and design quantum devices with dynamical modulation.展开更多
Checkpoint inhibitors are designed to rejuvenate depleted or suppressed T cells in the tumor microenvironment,relying on the immune system to control and kill tumors.However,accumulating evidence indicates that tumor-...Checkpoint inhibitors are designed to rejuvenate depleted or suppressed T cells in the tumor microenvironment,relying on the immune system to control and kill tumors.However,accumulating evidence indicates that tumor-infiltrating neutrophils impede the proliferation and activation of T cells and determine the resistance to checkpoint blockade and chemotherapy.In this study,sialic acid ligand-modified colchicine derivative phospholipid complexes specifically targeted tumor-associated neutrophils in the peripheral blood,blocked neutrophil accumulation in tumors,and attenuated the inhibitory effect of infiltrating neutrophils on T cells.Neutrophil blocking therapy enhanced the immunotherapy effect of the PD-L1 antibody in S180 advanced tumors and 4T1 breast cancer.Our study found that PD-L1 antibody monotherapy increased the tumor infiltration of immunosuppressive neutrophils.Combination therapy with neutrophil blocking can greatly reduce tumor-infiltrating neutrophils and increase the proliferation of cytotoxic CD8^(+) T lymphocytes in the tumor.The combination therapy significantly improved the survival rate of mice with advanced S180 tumors and increased the sensitivity of immune checkpoint inhibitors to 4T1 cold tumors.展开更多
Along with the progress of economic globalization and the Belt and Road Initiative,there is a great need for international talents with global vision,knowledge of international rules and regulations,English language p...Along with the progress of economic globalization and the Belt and Road Initiative,there is a great need for international talents with global vision,knowledge of international rules and regulations,English language proficiency,and the ability to participate in international affairs and competitions.Through text analysis and interviews,this study collects typical English language use tasks in the workplace,and uses questionnaires to investigate the importance and difficulty of different tasks for English language users in different industries,positions and ranks,hence providing references for the design of English training and assessment tasks for international talents.展开更多
A waveguide-QED with giant atoms,which is capable of accessing various limits of a small one,provides a new paradigm to study photon scatterings.Thus,how to achieve nonreciprocal photon transmissions via such a giant ...A waveguide-QED with giant atoms,which is capable of accessing various limits of a small one,provides a new paradigm to study photon scatterings.Thus,how to achieve nonreciprocal photon transmissions via such a giant atom setup is highly desirable.In this study,the nonreciprocal single-photon scattering characteristics of a double-drivenΛ-type three-level giant atom,where one of the transition couples to a 1D waveguide at two separate points,and the other is driven by two coherent driving fields,are investigated.It is found that a frequency-tunable single-photon diode with an ideal contrast ratio can be achieved by properly manipulating the local coupling phases between the giant atom and the waveguide,the accumulation phase between the two waveguide coupling points,the Rabi frequencies and phase difference of the two driven fields.Compared to the previous single driving schemes,on the one hand,the presence of the second driving field can provide more tunable parameters to manipulate the nonreciprocal single-photon scattering behavior.On the other hand,here perfect nonreciprocal transmission for photons with arbitrary frequencies is achievable by tuning the driving phases while the two driving fields keep on turning,which provides an alternative way to control the nonreciprocal single-photon scattering.Furthermore,the results reveal that both the location and width of each optimal nonreciprocal transmission window is also sensitive to the driving detuning,and a single-photon diode with wide or narrow bandwidth can be realized based on demand.These results may be beneficial for designing nonreciprocal single-photon devices based on a double-driven giant atom setup.展开更多
文摘The scheduling of construction equipment is a means to realize network planning.With the large-scale and low-cost requirements of engineering construction,the cooperation among members of the engineering supply chain has become very important,and effective coordination of project plans at all levels to optimize the resource management and scheduling of a project is helpful to reduce project duration and cost.In this paper,under the milestone constraint conditions,the scheduling problems of multiple construction devices in the same sequence of operation were described and hypothesized mathematically,and the scheduling models of multiple equipment were established.The Palmer algorithm,CDS algorithm and Gupta algorithm were respectively used to solve the optimal scheduling of construction equipment to achieve the optimization of the construction period.The optimization scheduling of a single construction device and multiple construction devices was solved by using sequencing theory under milestone constraint,and these methods can obtain reasonable results,which has important guiding significance for the scheduling of construction equipment.
基金Project(20171ACE50018)supported by the Key Research and Development Program of Jiangxi Province,ChinaProject(2017-YZD2-16)supported by the Key Research Project of Jiangxi Academy of Sciences,China。
文摘A comprehensive study of the phase composition, microstructure evolution, microhardness and wear performance of WC-12 Co composite coatings fabricated by laser cladding using coaxial powder-feed mode was presented. It was shown that a combination of high scan speed and high laser energy density made WC on the edge of WC-12 Co composite powders partially melt in liquid Co and 304 stainless steel matrix, and then new carbides consisting of lamellar WC and herringbone M3 W3 C(M=Fe,Co) were formed. Meanwhile, WC-12 Co composite coatings with no porosity, cracks and drawbacks like decarburization were obtained, showing high densification and good metallurgical bonding with the substrate. Furthermore, a considerably high microhardness of HV0.3 1500-1600, low coefficient of friction of 0.55 and wear rate of(2.15±0.31)×10-7 mm3/(N·m) were achieved owing to the synergistic effect of excellent metallurgical bonding and fine microstructures of composite coating under laser power of 1500 W.
基金supported by the National Natural Science Foundation of China,No.81402930Natural Science Foundation of Universities in Anhui Province,No.KJ2021A0688+2 种基金National College Students Innovation and Entrepreneurship Program,No.202110367071Key projects of science and technology projects of Bengbu Medical College,No.2020byzd017512 Talents Training Program of Bengbu Medical College,No.BY51201104(all to SYD).
文摘CDGSH iron sulfur domain 2 can inhibit ferroptosis,which has been associated with cerebral ischemia/reperfusion,in individuals with head and neck cancer.Therefore,CDGSH iron sulfur domain 2 may be implicated in cerebral ischemia/reperfusion injury.To validate this hypothesis in the present study,we established mouse models of occlusion of the middle cerebral artery and HT22 cell models of oxygen-glucose deprivation and reoxygenation to mimic cerebral ischemia/reperfusion injury in vivo and in vitro,respectively.We found remarkably decreased CDGSH iron sulfur domain 2 expression in the mouse brain tissue and HT22 cells.When we used adeno-associated virus and plasmid to up-regulate CDGSH iron sulfur domain 2 expression in the brain tissue and HT22 cell models separately,mouse neurological dysfunction was greatly improved;the cerebral infarct volume was reduced;the survival rate of HT22 cells was increased;HT22 cell injury was alleviated;the expression of ferroptosis-related glutathione peroxidase 4,cystine-glutamate antiporter,and glutathione was increased;the levels of malondialdehyde,iron ions,and the expression of transferrin receptor 1 were decreased;and the expression of nuclear-factor E2-related factor 2/heme oxygenase 1 was increased.Inhibition of CDGSH iron sulfur domain 2 upregulation via the nuclear-factor E2-related factor 2 inhibitor ML385 in oxygen-glucose deprived and reoxygenated HT22 cells blocked the neuroprotective effects of CDGSH iron sulfur domain 2 up-regulation and the activation of the nuclear-factor E2-related factor 2/heme oxygenase 1 pathway.Our data indicate that the up-regulation of CDGSH iron sulfur domain 2 can attenuate cerebral ischemia/reperfusion injury,thus providing theoretical support from the perspectives of cytology and experimental zoology for the use of this protein as a therapeutic target in patients with cerebral ischemia/reperfusion injury.
基金Project supported by China Postdoctoral Science Foundation (Grant No.2023M732028)the Fund from Zhejiang Province Key Laboratory of Quantum Technology and Device (Grant No.20230201)+3 种基金the Fundamental Research Funds for the Provincial Universities of Zhejiang Province,China (Grant No.GK199900299012-015)the Natural Science Foundation of Zhejiang Province,China (Grant No.LY21A040003)the National Natural Science Foundation of China (Grant Nos.12164022,12174288,and 12274326)the Natural Science Foundation of Jiangxi Province,China (Grant No.20232BAB201044)。
文摘The dynamic control of single-photon scattering in a pair of one-dimensional waveguides mediated by a time-modulated atom-cavity system is investigated.Two cases,where the waveguides are coupled symmetrically or asymmetrically to the atom-cavity system,are discussed in detail.The results show that such time-modulated atom-cavity configuration can behave as a dynamical tunable directional single-photon router.The photons with different frequencies can dynamically be routed from the incident waveguide into any ports of the other with a 100%probability via adjusting the modulated amplitude or phases of the time-modulated atom-cavity coupling strengths,associate with the help of the asymmetrical waveguide-cavity couplings.Furthermore,the influence of dissipation on the routing capability is investigated.It is shown that the present single-photon router is robust against the dissipative process of the system,especially the atomic dissipation.These results are expected to be applicable in quantum information processing and design quantum devices with dynamical modulation.
基金This work was supported by the National Natural Science Foundation of China[grant number:81973271].
文摘Checkpoint inhibitors are designed to rejuvenate depleted or suppressed T cells in the tumor microenvironment,relying on the immune system to control and kill tumors.However,accumulating evidence indicates that tumor-infiltrating neutrophils impede the proliferation and activation of T cells and determine the resistance to checkpoint blockade and chemotherapy.In this study,sialic acid ligand-modified colchicine derivative phospholipid complexes specifically targeted tumor-associated neutrophils in the peripheral blood,blocked neutrophil accumulation in tumors,and attenuated the inhibitory effect of infiltrating neutrophils on T cells.Neutrophil blocking therapy enhanced the immunotherapy effect of the PD-L1 antibody in S180 advanced tumors and 4T1 breast cancer.Our study found that PD-L1 antibody monotherapy increased the tumor infiltration of immunosuppressive neutrophils.Combination therapy with neutrophil blocking can greatly reduce tumor-infiltrating neutrophils and increase the proliferation of cytotoxic CD8^(+) T lymphocytes in the tumor.The combination therapy significantly improved the survival rate of mice with advanced S180 tumors and increased the sensitivity of immune checkpoint inhibitors to 4T1 cold tumors.
基金funded by China Language Assessment project“Survey of Typical Tasks across Jobs for International Talents”(Project No.:ZGWYCPJJ2018002A).Email:zhengcl@fltrp.com。
文摘Along with the progress of economic globalization and the Belt and Road Initiative,there is a great need for international talents with global vision,knowledge of international rules and regulations,English language proficiency,and the ability to participate in international affairs and competitions.Through text analysis and interviews,this study collects typical English language use tasks in the workplace,and uses questionnaires to investigate the importance and difficulty of different tasks for English language users in different industries,positions and ranks,hence providing references for the design of English training and assessment tasks for international talents.
基金supported by the China Postdoctoral Science Foundation (Grant No.2023M732028)the Zhejiang Province Key Laboratory of Quantum Technology and Device (Grant No.20230201)+2 种基金the Zhejiang Provincial Natural Science Foundation of China (Grant No.LY21A040003)the National Key Research and Development Program of China (Grant No.2021YFA1400602)the National Natural Science Foundation of China (Grant Nos.11864018,12164022,12174288 and 12274326)。
文摘A waveguide-QED with giant atoms,which is capable of accessing various limits of a small one,provides a new paradigm to study photon scatterings.Thus,how to achieve nonreciprocal photon transmissions via such a giant atom setup is highly desirable.In this study,the nonreciprocal single-photon scattering characteristics of a double-drivenΛ-type three-level giant atom,where one of the transition couples to a 1D waveguide at two separate points,and the other is driven by two coherent driving fields,are investigated.It is found that a frequency-tunable single-photon diode with an ideal contrast ratio can be achieved by properly manipulating the local coupling phases between the giant atom and the waveguide,the accumulation phase between the two waveguide coupling points,the Rabi frequencies and phase difference of the two driven fields.Compared to the previous single driving schemes,on the one hand,the presence of the second driving field can provide more tunable parameters to manipulate the nonreciprocal single-photon scattering behavior.On the other hand,here perfect nonreciprocal transmission for photons with arbitrary frequencies is achievable by tuning the driving phases while the two driving fields keep on turning,which provides an alternative way to control the nonreciprocal single-photon scattering.Furthermore,the results reveal that both the location and width of each optimal nonreciprocal transmission window is also sensitive to the driving detuning,and a single-photon diode with wide or narrow bandwidth can be realized based on demand.These results may be beneficial for designing nonreciprocal single-photon devices based on a double-driven giant atom setup.