Organic compounds have the advantages of green sustainability and high designability,but their high solubility leads to poor durability of zinc-organic batteries.Herein,a high-performance quinone-based polymer(H-PNADB...Organic compounds have the advantages of green sustainability and high designability,but their high solubility leads to poor durability of zinc-organic batteries.Herein,a high-performance quinone-based polymer(H-PNADBQ)material is designed by introducing an intramolecular hydrogen bonding(HB)strategy.The intramolecular HB(C=O⋯N-H)is formed in the reaction of 1,4-benzoquinone and 1,5-naphthalene diamine,which efficiently reduces the H-PNADBQ solubility and enhances its charge transfer in theory.In situ ultraviolet-visible analysis further reveals the insolubility of H-PNADBQ during the electrochemical cycles,enabling high durability at different current densities.Specifically,the H-PNADBQ electrode with high loading(10 mg cm^(-2))performs a long cycling life at 125 mA g^(-1)(>290 cycles).The H-PNADBQ also shows high rate capability(137.1 mAh g^(−1)at 25 A g^(−1))due to significantly improved kinetics inducted by intramolecular HB.This work provides an efficient approach toward insoluble organic electrode materials.展开更多
The unstable zinc(Zn)/electrolyte interfaces formed by undesired dendrites and parasitic side reactions greatly hinder the development of aqueous zinc ion batteries.Herein,the hydroxy-rich sorbitol was used as an addi...The unstable zinc(Zn)/electrolyte interfaces formed by undesired dendrites and parasitic side reactions greatly hinder the development of aqueous zinc ion batteries.Herein,the hydroxy-rich sorbitol was used as an additive to reshape the solvation structure and modulate the interface chemistry.The strong interactions among sorbitol and both water molecules and Zn electrode can reduce the free water activity,optimize the solvation shell of water and Zn^(2+)ions,and regulate the formation of local water(H_(2)O)-poor environment on the surface of Zn electrode,which effectively inhibit the decomposition of water molecules,and thus,achieve the thermodynamically stable and highly reversible Zn electrochemistry.As a result,the assembled Zn/Zn symmetric cells with the sorbitol additive realized an excellent cycling life of 2000 h at 1 mA·cm^(-2)and 1 mAh·cm^(-2),and over 250 h at 5 mA.cm^(-2)and 5 mAh.cm^(-2).Moreover,the Zn/Cu asymmetric cells with the sorbitol additive achieved a high Coulombic efficiency of 99.6%,obtaining a better performance than that with a pure 2 mol-L^(-1)ZnSO_(4)electrolyte.And the constructed Zn/poly1,5-naphthalenediamine(PNDA)batteries could be stably discharged for 2300 cycles at 1 A g^(-1)with an excellent capacity retention rate.This result indicates that the addition of 1 mol-L^(-1)non-toxic sorbitol into a conventional ZnSO_(4)electrolyte can successfully protect the Zn anode interface by improving the electrochemical properties of Zn reversible deposition/decomposition,which greatly promotes its cycle performance,providing a new approach in future development of high performance aqueous Zn ion batteries.展开更多
BACKGROUND Cognitive dysfunction is the main manifestation of central neuropathy.Although cognitive impairments tend to be overlooked in patients with diabetes mellitus(DM),there is a growing body of evidence linking ...BACKGROUND Cognitive dysfunction is the main manifestation of central neuropathy.Although cognitive impairments tend to be overlooked in patients with diabetes mellitus(DM),there is a growing body of evidence linking DM to cognitive dysfunction.Hyperglycemia is closely related to neurological abnormalities,while often disregarded in clinical practice.Changes in cerebral neurotransmitter levels are associated with a variety of neurological abnormalities and may be closely related to blood glucose control in patients with type 2 DM(T2DM).AIM To evaluate the concentrations of cerebral neurotransmitters in T2DM patients exhibiting different hemoglobin A1c(HbA1c)levels.METHODS A total of 130 T2DM patients were enrolled at the Department of Endocrinology of Shanghai East Hospital.The participants were divided into four groups according to their HbA1c levels using the interquartile method,namely Q1(<7.875%),Q2(7.875%-9.050%),Q3(9.050%-11.200%)and Q4(≥11.200%).Clinical data were collected and measured,including age,height,weight,neck/waist/hip circumferences,blood pressure,comorbidities,duration of DM,and biochemical indicators.Meanwhile,neurotransmitters in the left hippocampus and left brainstem area were detected by proton magnetic resonance spectroscopy.RESULTS The HbA1c level was significantly associated with urinary microalbumin(mALB),triglyceride,low-density lipoprotein cholesterol(LDL-C),homeostasis model assessment of insulin resistance(HOMA-IR),and beta cell function(HOMA-β),N-acetylaspartate/creatine(NAA/Cr),and NAA/choline(NAA/Cho).Spearman correlation analysis showed that mALB,LDL-C,HOMA-IR and NAA/Cr in the left brainstem area were positively correlated with the level of HbA1c(P<0.05),whereas HOMA-βwas negatively correlated with the HbA1c level(P<0.05).Ordered multiple logistic regression analysis showed that NAA/Cho[Odds ratio(OR):1.608,95%confidence interval(95%CI):1.004-2.578,P<0.05],LDL-C(OR:1.627,95%CI:1.119-2.370,P<0.05),and HOMA-IR(OR:1.107,95%CI:1.031-1.188,P<0.01)were independent predictors of poor glycemic control.CONCLUSION The cerebral neurotransmitter concentrations in the left brainstem area in patients with T2DM are closely related to glycemic control,which may be the basis for the changes in cognitive function in diabetic patients.展开更多
BACKGROUND Pulmonary hypertension is a serious complication in the treatment of maintenance hemodialysis patients,which seriously affects the quality of life of patients and threatens their life safety.Prevention,trea...BACKGROUND Pulmonary hypertension is a serious complication in the treatment of maintenance hemodialysis patients,which seriously affects the quality of life of patients and threatens their life safety.Prevention,treatment and improvement of pulmonary hypertension are of great significance to improve the quality of life of patients.AIM To investigate the intervention and control of pedal-powered bicycle in maintaining quality of life and pulmonary hypertension in hemodialysis patients.METHODS 73 patients with maintenance hemadialysis combined with pulmonary arterial hypertension at a hemodialysis center in a certain hospital from May 2021 to May 2022 are selected.Patients are divided into two groups,37 cases in the control group(group C)and 36 cases in the intervention group(group I).Patients are divided into two groups,group C is treated with oral administration of betaglandin sodium combined with routine nursing care.Based on group C,group I conducts power cycling exercises.RESULTS After treatment,group I patients had higher muscle strength,36-Item Short Form Health Survey scores,and Kidney Disease Targets Areas scores;The 6-minute walk distance test index level was higher and the Borg score was lower;The group I had lower systolic blood pressure,greater vital capacity,higher positive emotion,lower systolic pulmonary artery pressure index level,higher arterial partial oxygen pressure level,lower pulmonary vascular resistance index level,and higher blood oxygen saturation level[158.91±11.89 vs 152.56±12.81,1795.01±603.18 vs 1907.20±574.15,24.00(22.00,29.00)vs 24.00(22.00,28.00),P<0.001].CONCLUSION Aerobic exercise combined with Western medicine treatment can effectively improve patients'pulmonary hypertension,alleviate their negative emotions,and enable them to achieve a higher level of quality of life.展开更多
Optomagnetic multifunctional composite based on upconversion luminescence nanomaterial is regarded as a promising strategy for bioimaging,disease diagnosis and targeted delivery of drugs.To explore a mesoporous nanost...Optomagnetic multifunctional composite based on upconversion luminescence nanomaterial is regarded as a promising strategy for bioimaging,disease diagnosis and targeted delivery of drugs.To explore a mesoporous nanostructure with excellent water dispersibility and high drug-loading capacity,a novel nanorattle-structured Fe3O4@SiO2@NaYF4:Yb,Er magnetic upconversion nanorattle(MUCNR)was successfully designed by using Fe3O4 as core and NaYF4:Yb,Er nanocrystals as shell.The microstructures and crystal phase of the as-prepared MUCNRs were evaluated by transmission electron microscopy,Xray powder diffraction and N2 adsorption/desorption isotherms.The Kirkendall effect was adapted to explain the formation mechanism of the MUCNRs.The loading content and encapsulation efficiency of doxorubicin hydrochloride(DOX)could reach as high as 18.2%and 60.7%,respectively.Moreover,the DOX loading MUCNR(DOX-MUCNR)system showed excellent sustained drug release and strong p Hdependent performance,which was conducive to drug release at the slightly acidic microenvironment of tumor.Microcalorimetry was used to quantify the interactions between the carrier structure and drug release rate directly.The heat release rates in the heat-flow diagrams are basically consistent with the DOX release rate,thereby showing that microcalorimetry assay not only provides a unique thermodynamic explanation for the structure–activity relationship of Fe3O4@SiO2@NaYF4:Yb,Er MUCNRs but also provides powerful guidance to avoid the blind selection or design of drug carriers.Therefore,our work firmly provided a comprehensive perspective for using Fe3O4@SiO2@NaYF4:Yb,Er MUCNRs as a remarkable magnetic targeted drug carrier.展开更多
In mobile machinery,hydro-mechanical pumps are increasingly replaced by electronically controlled pumps to improve the automation level,but diversified control functions(e.g.,power limitation and pressure cut-off)are ...In mobile machinery,hydro-mechanical pumps are increasingly replaced by electronically controlled pumps to improve the automation level,but diversified control functions(e.g.,power limitation and pressure cut-off)are integrated into the electronic controller only from the pump level,leading to the potential instability of the overall system.To solve this problem,a multi-mode electrohydraulic load sensing(MELS)control scheme is proposed especially considering the switching stability from the system level,which includes four working modes of flow control,load sensing,power limitation,and pressure control.Depending on the actual working requirements,the switching rules for the different modes and the switching direction(i.e.,the modes can be switched bilaterally or unilaterally)are defined.The priority of different modes is also defined,from high to low:pressure control,power limitation,load sensing,and flow control.When multiple switching rules are satisfied at the same time,the system switches to the control mode with the highest priority.In addition,the switching stability between flow control and pressure control modes is analyzed,and the controller parameters that guarantee the switching stability are obtained.A comparative study is carried out based on a test rig with a 2-ton hydraulic excavator.The results show that the MELS controller can achieve the control functions of proper flow supplement,power limitation,and pressure cut-off,which has good stability performance when switching between different control modes.This research proposes the MELS control method that realizes the stability of multi-mode switching of the hydraulic system of mobile machinery under different working conditions.展开更多
Repetitive transcranial magnetic stimulation （rTMS） is a non-invasive treatment that can enhance the recovery of neurological function after stroke. Whether it can similarly promote the recovery of cognitive functio...Repetitive transcranial magnetic stimulation （rTMS） is a non-invasive treatment that can enhance the recovery of neurological function after stroke. Whether it can similarly promote the recovery of cognitive function after vascular dementia remains unknown, In this study, a rat model for vascular dementia was established by the two-vessel occlusion method. Two days after injury, 30 pulses of rTMS were ad- ministered to each cerebral hemisphere at a frequency of 0.5 Hz and a magnetic field intensity of 1,33 T. The Morris water maze test was used to evaluate learning and memory function. The Karnovsky-Roots method was performed to determine the density of cholinergic neurons in the hippocampal CA1 region. Immunohistochemical staining was used to determine the number of brain-derived neurotroph- ic factor （BDNF）-immunoreactive cells in the hippocampal CA1 region, rTMS treatment for 30 days significantly improved learning and memory function, increased acetylcholinesterase and choline acetyltransferase activity, increased the density of cholinergic neurons, and increased the number of BDNF-immunoreactive cells. These results indicate that rTMS can ameliorate learning and memory deficiencies in rats with vascular dementia, The mechanism through which this occurs might be related to the promotion of BDNF expression and subsequent restoration of cholinergic system activity in hippocampal CA 1 region.展开更多
Cu–Mn bimetal catalysts were prepared to remove nitrogen oxides(NOx)from diesel engine exhaust at low temperatures.At a Cu/Mn ratio of 3:2,the NOx conversions at 200°C reached 65%and 90%on Cu–Mn/ZSM‐5 and Cu–...Cu–Mn bimetal catalysts were prepared to remove nitrogen oxides(NOx)from diesel engine exhaust at low temperatures.At a Cu/Mn ratio of 3:2,the NOx conversions at 200°C reached 65%and 90%on Cu–Mn/ZSM‐5 and Cu–Mn/SAPO‐34,respectively.After a hydrothermal treatment and reaction in the presence of C3H6,the activity of Cu–Mn/SAPO‐34 was more stable than that of Cu–Mn/ZSM‐5.No obvious variations in the crystal structure or dealumination were observed,whereas the physical structure was best maintained in Cu–Mn/SAPO‐34.The atomic concentration of Cu on the surface of Cu–Mn/SAPO‐34 was quite stable,and the consumption of octahedrally coordinated Cu2+could be recovered.Conversely,the proportion of octahedrally coordinated Cu2+on the surface of Cu–Mn/ZSM‐5 significantly decreased.Therefore,besides the structure,the redox cycle between Cu+and octahedrally coordinated Cu2+played an important role in the stability of the catalysts.展开更多
BACKGROUND Mesenchymal stem cells(MSCs)have been widely investigated in rheumatic disease due to their immunomodulatory and regenerative properties.Recently,mounting studies have implicated the therapeutic potency of ...BACKGROUND Mesenchymal stem cells(MSCs)have been widely investigated in rheumatic disease due to their immunomodulatory and regenerative properties.Recently,mounting studies have implicated the therapeutic potency of MSCs mostly due to the bioactive factors they produce.Extracellular vesicles(EVs)derived from MSCs have been identified as a promising cell-free therapy due to low immunogenicity.Rheumatic disease,primarily including rheumatoid arthritis and osteoarthritis,is a group of diseases in which immune dysregulation and chronic progressive inflammation lead to irreversible joint damage.Targeting MSCs and MSC-derived EVs may be a more effective and promising therapeutic strategy for rheumatic diseases.AIM To evaluate the potential therapeutic effectiveness of MSCs and EVs generated from MSCs in rheumatic diseases.METHODS PubMed was searched for the relevant literature using corresponding search terms alone or in combination.Papers published in English language from January 1999 to February 2020 were considered.Preliminary screening of papers concerning analysis of"immunomodulatory function"or"regenerative function"by scrutinizing the titles and abstracts of the literature,excluded the papers not related to the subject of the article.Some other related studies were obtained by manually retrieving the reference lists of papers that comply with the selection criteria,and these studies were screened to meet the final selection and exclusion criteria.RESULTS Eighty-six papers were ultimately selected for analysis.After analysis of the literature,it was found that both MSCs and EVs generated from MSCs have great potential in multiple rheumatic diseases,such as rheumatoid arthritis and osteoarthritis,in repair and regeneration of tissues,inhibition of inflammatory response,and regulation of body immunity via promoting chondrogenesis,regulating innate and adaptive immune cells,and regulating the secretion of inflammatory factors.But EVs from MSCs exhibit much more advantages over MSCs,which may represent another promising cell-free restorative strategy.Targeting MSCs and MSC-derived EVs may be a more efficient treatment for patients with rheumatic diseases.CONCLUSION The enormous potential of MSCs and EVs from MSCs in immunomodulation and tissue regeneration offers a new idea for the treatment of rheumatism.However,more in-depth exploration is needed before their clinical application.展开更多
Status epilepticus has been shown to activate the proliferation of neural stem cells in the hippocampus of the brain, while also causing a large amount of neuronal death, especially in the subgranular zone of the dent...Status epilepticus has been shown to activate the proliferation of neural stem cells in the hippocampus of the brain, while also causing a large amount of neuronal death, especially in the subgranular zone of the dentate gyrus and the subventricular zone. Simultaneously, proliferating stem cells tend to migrate to areas with obvious damage. Our previous studies have clearly confirmed the effect of sodium valproate on cognitive function in rats with convulsive status epilepticus. However, whether neurogenesis can play a role in the antiepileptic effect of sodium valproate remains unknown. A model of convulsive status epilepticus was established in Wistar rats by intraperitoneal injection of 3 mEq/kg lithium chloride, and intraperitoneal injection of pilocarpine 40 mg/kg after 18–20 hours. Sodium valproate(100, 200, 300, 400, 500, or 600 mg/kg) was intragastrically administered six times every day(4-hour intervals) for 5 days. To determine the best dosage, sodium valproate concentration was measured from the plasma. The effective concentration of sodium valproate in the plasma of the rats that received the 300-mg/kg intervention was 82.26 ± 11.23 μg/mL. Thus, 300 mg/kg was subsequently used as the intervention concentration of sodium valproate. The following changes were seen: Recording excitatory postsynaptic potentials in the CA1 region revealed high-frequency stimulation-induced long-term potentiation. Immunohistochemical staining for BrdU-positive cells in the brain revealed that sodium valproate intervention markedly increased the success rate and the duration of induced long-term potentiation in rats with convulsive status epilepticus. The intervention also reduced the number of newborn neurons in the subgranular area of the hippocampus and subventricular zone and inhibited the migration of newborn neurons to the dentate gyrus. These results indicate that sodium valproate can effectively inhibit the abnormal proliferation and migration of neural stem cells and newborn neurons after convulsive status epilepticus, and improve learning and memory ability.展开更多
Objectives:To investigate acute toxicity of Bajitian(Morinda officinalis)in zebrafish embryos.Methods:Zebrafish embryos at 48-h post fertilization(hpf)were exposed to Bajitian ethanol extract for72 h.The causative act...Objectives:To investigate acute toxicity of Bajitian(Morinda officinalis)in zebrafish embryos.Methods:Zebrafish embryos at 48-h post fertilization(hpf)were exposed to Bajitian ethanol extract for72 h.The causative action of a delay in yolk sac absorption by Bajitian was investigated by RT-PCR analysis of lipid metabolism-related microsomal triglyceride transfer protein(MTP),apolipoprotein CII(ApoC2)and lipogenesis-related liver x receptor(LXR)genes.The effect of Bajitian eliciting an inflammatory response was studied by exposing 72 hpf myeloperoxidase(MPO):GFP transgenic zebrafish embryos to Bajitian extract for 4 h.Assessment was done by TUNEL,caspase-3/7,and RT-PCR analysis of the apoptosis related pathway B-cell lymphoma 2 associated X protein(Bax),Nuclear factor kappa-lightchain-enhancer of activated B cells(NF-k B)genes,neutrophil development-related stem cell leukaemia(SCL)and transcription factor PU.1 genes,to reveal the causative action of Bajitian reducing neutrophils.Results:RT-PCR analysis found that Bajitian extract had no effect on the expression of MTP or ApoC2 genes,but upregulated LXR gene,which might explain the delay in yolk sac absorption.Analysis of the inflammatory response showed that compared with negative controls,Bajitian extract significantly(P<.05)reduced the number of neutrophils in MPO:GFP embryos.TUNEL,caspase-3/7,and RT-PCR analysis of Bax and NF-k B genes found that Bajitian extract did not trigger the cell apoptosis.Further RT-PCR analysis found that Bajitian extract did not affect SCL expression,but did lead to down-regulation of PU.1.The inhibition of neutrophil development/differentiation may explain the decline in the total number of neutrophils following Bajitian treatment,which could be attributed to the anti-inflammatory effects found clinically for this drug.Conclusions:This study demonstrated that Bajitian caused a delay in yolk sac absorption and a decrease neutrophil in zebrafish embryos,which may be related to the inhibition of neutrophil development.展开更多
This paper presents a new approach for designing the tool paths in the machining of sculptured surfaces for computer nu- merical controlled end milling. In the proposed method, the tool paths are determined so that th...This paper presents a new approach for designing the tool paths in the machining of sculptured surfaces for computer nu- merical controlled end milling. In the proposed method, the tool paths are determined so that the scallop height formed by two adja- cent machining paths is maintained constant across the machined surface. Unlike previous work on iso-scallop height milling, the present work considers the true 3D configuration of the milling procedure and can be used to generate better results, which is shown by examoles.展开更多
The photodissociation dynamics of Br-C bond cleavage for BrCN in the wavelength region from 225 nm to 260 nm has been studied by our homebuilt time-slice velocity-map imaging setup.The images for both of the ground st...The photodissociation dynamics of Br-C bond cleavage for BrCN in the wavelength region from 225 nm to 260 nm has been studied by our homebuilt time-slice velocity-map imaging setup.The images for both of the ground state Br(^(2)P_(3/2))and spin-orbit excited Br^(*)(^(2)P_(1/2))channels are obtained at several photodissociation wavelengths.From the analysis of the translational energy release spectra,the detailed vibrational and rotational distributions of CN products have been measured for both of the Br and Br^(*) channels.It is found that the internal excitation of the CN products for the Br^(*) channel is colder than that for the Br channel.The most populated vibrational levels of the CN products are v=0 and 1 for the Br and Br^(*) channels,respectively.For the Br channel,the photodissociation dynamics at longer wavelengths are found to be different from those at shorter wavelengths,as revealed by their dramatically different vibrational and rotational excitations of the CN products.展开更多
In this study,we report the design and simulation of an electrostatic ion lens system consisting of 22 round metal plates.The opening of the extractor plate is covered withmetal mesh,which is for shielding the interac...In this study,we report the design and simulation of an electrostatic ion lens system consisting of 22 round metal plates.The opening of the extractor plate is covered withmetal mesh,which is for shielding the interaction region of the lens system from the high DC voltages applied to all other plates than the repeller and extractor plates.The Simion simulation shows that both velocity-mapping and time focusing can be achieved simultaneously when appropriate voltages are applied to each of the plates.This makes the ion lens system be able to focus large ionic volumes in all three dimensions,which is an essential requirement for crossed ion-molecule scattering studies.A three-dimensional ion velocity measurement system with multi-hit and potential multi-mass capability is built,which consists of a microchannel plate(MCP),a P47 phosphor screen,a CMOS camera,a fast photomultiplier tube(PMT),and a high-speed digitizer.The two velocity components perpendicular to the flight axis are measured by the CMOS camera,and the time-of-flight,from which the velocity component along the flight axis can be deduced,is measured by the PMT.A Labview program is written to combine the two measurements for building the full three-dimensional ion velocity in real time on a frame-by-frame basis.The multi-hit capability comes from the fact that multiple ions from the camera and PMT in the same frame can be correlated with each other based on their various intensities.We demonstrate this by using the photodissociation of CH31 at 304 nm.展开更多
基金supported by the National Natural Science Foundation of China (22279063 and 52001170)the Fundamental Research Funds for the Central Universities+2 种基金Tianjin Natural Science Foundation (No. 22JCYBJC00590)the financial support by the Ministry of Education, Singapore, under its Academic Research Fund Tier 1 Thematic (RT8/22)the Haihe Laboratory of Sustainable Chemical Transformations, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) for financial support
文摘Organic compounds have the advantages of green sustainability and high designability,but their high solubility leads to poor durability of zinc-organic batteries.Herein,a high-performance quinone-based polymer(H-PNADBQ)material is designed by introducing an intramolecular hydrogen bonding(HB)strategy.The intramolecular HB(C=O⋯N-H)is formed in the reaction of 1,4-benzoquinone and 1,5-naphthalene diamine,which efficiently reduces the H-PNADBQ solubility and enhances its charge transfer in theory.In situ ultraviolet-visible analysis further reveals the insolubility of H-PNADBQ during the electrochemical cycles,enabling high durability at different current densities.Specifically,the H-PNADBQ electrode with high loading(10 mg cm^(-2))performs a long cycling life at 125 mA g^(-1)(>290 cycles).The H-PNADBQ also shows high rate capability(137.1 mAh g^(−1)at 25 A g^(−1))due to significantly improved kinetics inducted by intramolecular HB.This work provides an efficient approach toward insoluble organic electrode materials.
基金This work is supported by the National Natural Science Foundation of China(No.21973100 and No.22103090)the Program for Young Outstanding Scientists of Institute of Chemistry,Chinese Academy of Science,and Beijing National Laboratory for Molecular Sciences+1 种基金Hong Gao is also supported by the K.C.Wong Education FoundationPan Jiang is supported by the China Postdoctoral Science Foundation(No.2020TQ0324).
基金supported by the National Natural Science Foundation of China(22279063,52001170)Tianjin Natural Science Foundation(22JCYBJC00590)the Fundamental Research Funds for the Central Universities.We thank the Haihe Laboratoryof Sustainable Chemical Transformations for financial support.
文摘The unstable zinc(Zn)/electrolyte interfaces formed by undesired dendrites and parasitic side reactions greatly hinder the development of aqueous zinc ion batteries.Herein,the hydroxy-rich sorbitol was used as an additive to reshape the solvation structure and modulate the interface chemistry.The strong interactions among sorbitol and both water molecules and Zn electrode can reduce the free water activity,optimize the solvation shell of water and Zn^(2+)ions,and regulate the formation of local water(H_(2)O)-poor environment on the surface of Zn electrode,which effectively inhibit the decomposition of water molecules,and thus,achieve the thermodynamically stable and highly reversible Zn electrochemistry.As a result,the assembled Zn/Zn symmetric cells with the sorbitol additive realized an excellent cycling life of 2000 h at 1 mA·cm^(-2)and 1 mAh·cm^(-2),and over 250 h at 5 mA.cm^(-2)and 5 mAh.cm^(-2).Moreover,the Zn/Cu asymmetric cells with the sorbitol additive achieved a high Coulombic efficiency of 99.6%,obtaining a better performance than that with a pure 2 mol-L^(-1)ZnSO_(4)electrolyte.And the constructed Zn/poly1,5-naphthalenediamine(PNDA)batteries could be stably discharged for 2300 cycles at 1 A g^(-1)with an excellent capacity retention rate.This result indicates that the addition of 1 mol-L^(-1)non-toxic sorbitol into a conventional ZnSO_(4)electrolyte can successfully protect the Zn anode interface by improving the electrochemical properties of Zn reversible deposition/decomposition,which greatly promotes its cycle performance,providing a new approach in future development of high performance aqueous Zn ion batteries.
基金Supported by the Academic Leaders Training Program of Pudong Health Bureau of Shanghai,No.PWRd2023-03Clinical Research Fund of Shanghai Municipal Commission of Health,No.202040136+1 种基金National Natural Science Foundation of China,No.82070842Jiangxi Health Commission Science and Technology Plan Project,No.202212838 and No.202212852.
文摘BACKGROUND Cognitive dysfunction is the main manifestation of central neuropathy.Although cognitive impairments tend to be overlooked in patients with diabetes mellitus(DM),there is a growing body of evidence linking DM to cognitive dysfunction.Hyperglycemia is closely related to neurological abnormalities,while often disregarded in clinical practice.Changes in cerebral neurotransmitter levels are associated with a variety of neurological abnormalities and may be closely related to blood glucose control in patients with type 2 DM(T2DM).AIM To evaluate the concentrations of cerebral neurotransmitters in T2DM patients exhibiting different hemoglobin A1c(HbA1c)levels.METHODS A total of 130 T2DM patients were enrolled at the Department of Endocrinology of Shanghai East Hospital.The participants were divided into four groups according to their HbA1c levels using the interquartile method,namely Q1(<7.875%),Q2(7.875%-9.050%),Q3(9.050%-11.200%)and Q4(≥11.200%).Clinical data were collected and measured,including age,height,weight,neck/waist/hip circumferences,blood pressure,comorbidities,duration of DM,and biochemical indicators.Meanwhile,neurotransmitters in the left hippocampus and left brainstem area were detected by proton magnetic resonance spectroscopy.RESULTS The HbA1c level was significantly associated with urinary microalbumin(mALB),triglyceride,low-density lipoprotein cholesterol(LDL-C),homeostasis model assessment of insulin resistance(HOMA-IR),and beta cell function(HOMA-β),N-acetylaspartate/creatine(NAA/Cr),and NAA/choline(NAA/Cho).Spearman correlation analysis showed that mALB,LDL-C,HOMA-IR and NAA/Cr in the left brainstem area were positively correlated with the level of HbA1c(P<0.05),whereas HOMA-βwas negatively correlated with the HbA1c level(P<0.05).Ordered multiple logistic regression analysis showed that NAA/Cho[Odds ratio(OR):1.608,95%confidence interval(95%CI):1.004-2.578,P<0.05],LDL-C(OR:1.627,95%CI:1.119-2.370,P<0.05),and HOMA-IR(OR:1.107,95%CI:1.031-1.188,P<0.01)were independent predictors of poor glycemic control.CONCLUSION The cerebral neurotransmitter concentrations in the left brainstem area in patients with T2DM are closely related to glycemic control,which may be the basis for the changes in cognitive function in diabetic patients.
基金Zhejiang Province Medicine and Health Science and Technology Programme,No.2019RC092 and No.2020KY394the Public Welfare Project of Zhejiang Provincial Department of Science and Technology,No.LGF19H170003.
文摘BACKGROUND Pulmonary hypertension is a serious complication in the treatment of maintenance hemodialysis patients,which seriously affects the quality of life of patients and threatens their life safety.Prevention,treatment and improvement of pulmonary hypertension are of great significance to improve the quality of life of patients.AIM To investigate the intervention and control of pedal-powered bicycle in maintaining quality of life and pulmonary hypertension in hemodialysis patients.METHODS 73 patients with maintenance hemadialysis combined with pulmonary arterial hypertension at a hemodialysis center in a certain hospital from May 2021 to May 2022 are selected.Patients are divided into two groups,37 cases in the control group(group C)and 36 cases in the intervention group(group I).Patients are divided into two groups,group C is treated with oral administration of betaglandin sodium combined with routine nursing care.Based on group C,group I conducts power cycling exercises.RESULTS After treatment,group I patients had higher muscle strength,36-Item Short Form Health Survey scores,and Kidney Disease Targets Areas scores;The 6-minute walk distance test index level was higher and the Borg score was lower;The group I had lower systolic blood pressure,greater vital capacity,higher positive emotion,lower systolic pulmonary artery pressure index level,higher arterial partial oxygen pressure level,lower pulmonary vascular resistance index level,and higher blood oxygen saturation level[158.91±11.89 vs 152.56±12.81,1795.01±603.18 vs 1907.20±574.15,24.00(22.00,29.00)vs 24.00(22.00,28.00),P<0.001].CONCLUSION Aerobic exercise combined with Western medicine treatment can effectively improve patients'pulmonary hypertension,alleviate their negative emotions,and enable them to achieve a higher level of quality of life.
基金supported by the Key Research and Development Plan of Shaanxi Province(2020GY-313)the Specialized Research Fund of Education Department of Shaanxi Province(19JK0255)+1 种基金the Specialized Scientific Research Fund Projects of Academician Shengyong Zhang(18YSZX001)the Science and Technology Innovation Team of Shangluo University(20SCX02)。
文摘Optomagnetic multifunctional composite based on upconversion luminescence nanomaterial is regarded as a promising strategy for bioimaging,disease diagnosis and targeted delivery of drugs.To explore a mesoporous nanostructure with excellent water dispersibility and high drug-loading capacity,a novel nanorattle-structured Fe3O4@SiO2@NaYF4:Yb,Er magnetic upconversion nanorattle(MUCNR)was successfully designed by using Fe3O4 as core and NaYF4:Yb,Er nanocrystals as shell.The microstructures and crystal phase of the as-prepared MUCNRs were evaluated by transmission electron microscopy,Xray powder diffraction and N2 adsorption/desorption isotherms.The Kirkendall effect was adapted to explain the formation mechanism of the MUCNRs.The loading content and encapsulation efficiency of doxorubicin hydrochloride(DOX)could reach as high as 18.2%and 60.7%,respectively.Moreover,the DOX loading MUCNR(DOX-MUCNR)system showed excellent sustained drug release and strong p Hdependent performance,which was conducive to drug release at the slightly acidic microenvironment of tumor.Microcalorimetry was used to quantify the interactions between the carrier structure and drug release rate directly.The heat release rates in the heat-flow diagrams are basically consistent with the DOX release rate,thereby showing that microcalorimetry assay not only provides a unique thermodynamic explanation for the structure–activity relationship of Fe3O4@SiO2@NaYF4:Yb,Er MUCNRs but also provides powerful guidance to avoid the blind selection or design of drug carriers.Therefore,our work firmly provided a comprehensive perspective for using Fe3O4@SiO2@NaYF4:Yb,Er MUCNRs as a remarkable magnetic targeted drug carrier.
基金National Key Research and Development Program of China(Grant No.2020YFB2009702)National Natural Science Foundation of China(Grant Nos.52075055,U21A20124 and 52111530069)Chongqing Natural Science Foundation of China(Grant No.cstc2020jcyj-msxmX0780)。
文摘In mobile machinery,hydro-mechanical pumps are increasingly replaced by electronically controlled pumps to improve the automation level,but diversified control functions(e.g.,power limitation and pressure cut-off)are integrated into the electronic controller only from the pump level,leading to the potential instability of the overall system.To solve this problem,a multi-mode electrohydraulic load sensing(MELS)control scheme is proposed especially considering the switching stability from the system level,which includes four working modes of flow control,load sensing,power limitation,and pressure control.Depending on the actual working requirements,the switching rules for the different modes and the switching direction(i.e.,the modes can be switched bilaterally or unilaterally)are defined.The priority of different modes is also defined,from high to low:pressure control,power limitation,load sensing,and flow control.When multiple switching rules are satisfied at the same time,the system switches to the control mode with the highest priority.In addition,the switching stability between flow control and pressure control modes is analyzed,and the controller parameters that guarantee the switching stability are obtained.A comparative study is carried out based on a test rig with a 2-ton hydraulic excavator.The results show that the MELS controller can achieve the control functions of proper flow supplement,power limitation,and pressure cut-off,which has good stability performance when switching between different control modes.This research proposes the MELS control method that realizes the stability of multi-mode switching of the hydraulic system of mobile machinery under different working conditions.
基金supported by a grant from the Major Project of Educational Commission of Hubei Province of China,No.D20152101
文摘Repetitive transcranial magnetic stimulation （rTMS） is a non-invasive treatment that can enhance the recovery of neurological function after stroke. Whether it can similarly promote the recovery of cognitive function after vascular dementia remains unknown, In this study, a rat model for vascular dementia was established by the two-vessel occlusion method. Two days after injury, 30 pulses of rTMS were ad- ministered to each cerebral hemisphere at a frequency of 0.5 Hz and a magnetic field intensity of 1,33 T. The Morris water maze test was used to evaluate learning and memory function. The Karnovsky-Roots method was performed to determine the density of cholinergic neurons in the hippocampal CA1 region. Immunohistochemical staining was used to determine the number of brain-derived neurotroph- ic factor （BDNF）-immunoreactive cells in the hippocampal CA1 region, rTMS treatment for 30 days significantly improved learning and memory function, increased acetylcholinesterase and choline acetyltransferase activity, increased the density of cholinergic neurons, and increased the number of BDNF-immunoreactive cells. These results indicate that rTMS can ameliorate learning and memory deficiencies in rats with vascular dementia, The mechanism through which this occurs might be related to the promotion of BDNF expression and subsequent restoration of cholinergic system activity in hippocampal CA 1 region.
基金supported by the National Natural Science Foundation of China(51008277)the Natural Science Foundation of Zhejiang Province(LY14E080001)the Key Project of Zhejiang Provincial Science and Technology Program(2012C03003-4)~~
文摘Cu–Mn bimetal catalysts were prepared to remove nitrogen oxides(NOx)from diesel engine exhaust at low temperatures.At a Cu/Mn ratio of 3:2,the NOx conversions at 200°C reached 65%and 90%on Cu–Mn/ZSM‐5 and Cu–Mn/SAPO‐34,respectively.After a hydrothermal treatment and reaction in the presence of C3H6,the activity of Cu–Mn/SAPO‐34 was more stable than that of Cu–Mn/ZSM‐5.No obvious variations in the crystal structure or dealumination were observed,whereas the physical structure was best maintained in Cu–Mn/SAPO‐34.The atomic concentration of Cu on the surface of Cu–Mn/SAPO‐34 was quite stable,and the consumption of octahedrally coordinated Cu2+could be recovered.Conversely,the proportion of octahedrally coordinated Cu2+on the surface of Cu–Mn/ZSM‐5 significantly decreased.Therefore,besides the structure,the redox cycle between Cu+and octahedrally coordinated Cu2+played an important role in the stability of the catalysts.
基金Supported by National Natural Science Foundation of China,No.81601408.
文摘BACKGROUND Mesenchymal stem cells(MSCs)have been widely investigated in rheumatic disease due to their immunomodulatory and regenerative properties.Recently,mounting studies have implicated the therapeutic potency of MSCs mostly due to the bioactive factors they produce.Extracellular vesicles(EVs)derived from MSCs have been identified as a promising cell-free therapy due to low immunogenicity.Rheumatic disease,primarily including rheumatoid arthritis and osteoarthritis,is a group of diseases in which immune dysregulation and chronic progressive inflammation lead to irreversible joint damage.Targeting MSCs and MSC-derived EVs may be a more effective and promising therapeutic strategy for rheumatic diseases.AIM To evaluate the potential therapeutic effectiveness of MSCs and EVs generated from MSCs in rheumatic diseases.METHODS PubMed was searched for the relevant literature using corresponding search terms alone or in combination.Papers published in English language from January 1999 to February 2020 were considered.Preliminary screening of papers concerning analysis of"immunomodulatory function"or"regenerative function"by scrutinizing the titles and abstracts of the literature,excluded the papers not related to the subject of the article.Some other related studies were obtained by manually retrieving the reference lists of papers that comply with the selection criteria,and these studies were screened to meet the final selection and exclusion criteria.RESULTS Eighty-six papers were ultimately selected for analysis.After analysis of the literature,it was found that both MSCs and EVs generated from MSCs have great potential in multiple rheumatic diseases,such as rheumatoid arthritis and osteoarthritis,in repair and regeneration of tissues,inhibition of inflammatory response,and regulation of body immunity via promoting chondrogenesis,regulating innate and adaptive immune cells,and regulating the secretion of inflammatory factors.But EVs from MSCs exhibit much more advantages over MSCs,which may represent another promising cell-free restorative strategy.Targeting MSCs and MSC-derived EVs may be a more efficient treatment for patients with rheumatic diseases.CONCLUSION The enormous potential of MSCs and EVs from MSCs in immunomodulation and tissue regeneration offers a new idea for the treatment of rheumatism.However,more in-depth exploration is needed before their clinical application.
基金supported by the National Natural Science Foundation of China for Youth Science Project,No.81201507(to PW)
文摘Status epilepticus has been shown to activate the proliferation of neural stem cells in the hippocampus of the brain, while also causing a large amount of neuronal death, especially in the subgranular zone of the dentate gyrus and the subventricular zone. Simultaneously, proliferating stem cells tend to migrate to areas with obvious damage. Our previous studies have clearly confirmed the effect of sodium valproate on cognitive function in rats with convulsive status epilepticus. However, whether neurogenesis can play a role in the antiepileptic effect of sodium valproate remains unknown. A model of convulsive status epilepticus was established in Wistar rats by intraperitoneal injection of 3 mEq/kg lithium chloride, and intraperitoneal injection of pilocarpine 40 mg/kg after 18–20 hours. Sodium valproate(100, 200, 300, 400, 500, or 600 mg/kg) was intragastrically administered six times every day(4-hour intervals) for 5 days. To determine the best dosage, sodium valproate concentration was measured from the plasma. The effective concentration of sodium valproate in the plasma of the rats that received the 300-mg/kg intervention was 82.26 ± 11.23 μg/mL. Thus, 300 mg/kg was subsequently used as the intervention concentration of sodium valproate. The following changes were seen: Recording excitatory postsynaptic potentials in the CA1 region revealed high-frequency stimulation-induced long-term potentiation. Immunohistochemical staining for BrdU-positive cells in the brain revealed that sodium valproate intervention markedly increased the success rate and the duration of induced long-term potentiation in rats with convulsive status epilepticus. The intervention also reduced the number of newborn neurons in the subgranular area of the hippocampus and subventricular zone and inhibited the migration of newborn neurons to the dentate gyrus. These results indicate that sodium valproate can effectively inhibit the abnormal proliferation and migration of neural stem cells and newborn neurons after convulsive status epilepticus, and improve learning and memory ability.
基金Infinitus(China)Company Ltd.internal research funding。
文摘Objectives:To investigate acute toxicity of Bajitian(Morinda officinalis)in zebrafish embryos.Methods:Zebrafish embryos at 48-h post fertilization(hpf)were exposed to Bajitian ethanol extract for72 h.The causative action of a delay in yolk sac absorption by Bajitian was investigated by RT-PCR analysis of lipid metabolism-related microsomal triglyceride transfer protein(MTP),apolipoprotein CII(ApoC2)and lipogenesis-related liver x receptor(LXR)genes.The effect of Bajitian eliciting an inflammatory response was studied by exposing 72 hpf myeloperoxidase(MPO):GFP transgenic zebrafish embryos to Bajitian extract for 4 h.Assessment was done by TUNEL,caspase-3/7,and RT-PCR analysis of the apoptosis related pathway B-cell lymphoma 2 associated X protein(Bax),Nuclear factor kappa-lightchain-enhancer of activated B cells(NF-k B)genes,neutrophil development-related stem cell leukaemia(SCL)and transcription factor PU.1 genes,to reveal the causative action of Bajitian reducing neutrophils.Results:RT-PCR analysis found that Bajitian extract had no effect on the expression of MTP or ApoC2 genes,but upregulated LXR gene,which might explain the delay in yolk sac absorption.Analysis of the inflammatory response showed that compared with negative controls,Bajitian extract significantly(P<.05)reduced the number of neutrophils in MPO:GFP embryos.TUNEL,caspase-3/7,and RT-PCR analysis of Bax and NF-k B genes found that Bajitian extract did not trigger the cell apoptosis.Further RT-PCR analysis found that Bajitian extract did not affect SCL expression,but did lead to down-regulation of PU.1.The inhibition of neutrophil development/differentiation may explain the decline in the total number of neutrophils following Bajitian treatment,which could be attributed to the anti-inflammatory effects found clinically for this drug.Conclusions:This study demonstrated that Bajitian caused a delay in yolk sac absorption and a decrease neutrophil in zebrafish embryos,which may be related to the inhibition of neutrophil development.
基金Partially supported by a grant from NSFC (60821002)
文摘This paper presents a new approach for designing the tool paths in the machining of sculptured surfaces for computer nu- merical controlled end milling. In the proposed method, the tool paths are determined so that the scallop height formed by two adja- cent machining paths is maintained constant across the machined surface. Unlike previous work on iso-scallop height milling, the present work considers the true 3D configuration of the milling procedure and can be used to generate better results, which is shown by examoles.
基金supported by the Beijing Municipal Natural Science Foundation(No.8212043)the support from Program for Young Outstanding Scientists of Institute of Chemistry,Chinese Academy of ScienceBeijing National Laboratory for Molecular Sciences。
文摘The photodissociation dynamics of Br-C bond cleavage for BrCN in the wavelength region from 225 nm to 260 nm has been studied by our homebuilt time-slice velocity-map imaging setup.The images for both of the ground state Br(^(2)P_(3/2))and spin-orbit excited Br^(*)(^(2)P_(1/2))channels are obtained at several photodissociation wavelengths.From the analysis of the translational energy release spectra,the detailed vibrational and rotational distributions of CN products have been measured for both of the Br and Br^(*) channels.It is found that the internal excitation of the CN products for the Br^(*) channel is colder than that for the Br channel.The most populated vibrational levels of the CN products are v=0 and 1 for the Br and Br^(*) channels,respectively.For the Br channel,the photodissociation dynamics at longer wavelengths are found to be different from those at shorter wavelengths,as revealed by their dramatically different vibrational and rotational excitations of the CN products.
基金This work is supported by the Program for Young Outstanding Scientists of Institute of Chemistry,Chinese Academy of Science,and Beijing National Laboratory for Molecular SciencesHong Gao and Li-chang Guan are also supported by the K.C.Wong Education Foundation.
文摘In this study,we report the design and simulation of an electrostatic ion lens system consisting of 22 round metal plates.The opening of the extractor plate is covered withmetal mesh,which is for shielding the interaction region of the lens system from the high DC voltages applied to all other plates than the repeller and extractor plates.The Simion simulation shows that both velocity-mapping and time focusing can be achieved simultaneously when appropriate voltages are applied to each of the plates.This makes the ion lens system be able to focus large ionic volumes in all three dimensions,which is an essential requirement for crossed ion-molecule scattering studies.A three-dimensional ion velocity measurement system with multi-hit and potential multi-mass capability is built,which consists of a microchannel plate(MCP),a P47 phosphor screen,a CMOS camera,a fast photomultiplier tube(PMT),and a high-speed digitizer.The two velocity components perpendicular to the flight axis are measured by the CMOS camera,and the time-of-flight,from which the velocity component along the flight axis can be deduced,is measured by the PMT.A Labview program is written to combine the two measurements for building the full three-dimensional ion velocity in real time on a frame-by-frame basis.The multi-hit capability comes from the fact that multiple ions from the camera and PMT in the same frame can be correlated with each other based on their various intensities.We demonstrate this by using the photodissociation of CH31 at 304 nm.
