Synthesis and Luminescent Properties of Nano-scale Y2Si2O7：Re^3＋ （Re=Eu, Tb） Phosphors via Sol-Gel Method

By using metal nitrates as starting materials and citric acid as a complexing agent, Y2Si207：Re3＋ （Re=Eu, Tb） phosphors were prepared by a sol-gel method. X-ray diffraction was employed to characterize the resulting samples. The results of XRD indicate that the α-Y2Si2O7 nanocrystal with size of 27 nm is obtained at 1000 ℃ and the doping ion content does not influence the structure. The excitation spectra in the UV and VUV ranges and the emission spectra of Re^3＋ doped samples were measured. The excitation spectra in the VUV range is due to absorption of host, that in the UV range is ascribed to absorption transitions from 4f to 5d state of the Tb^3＋ and the charge transfer in the En^3＋-O^2- bond. The spectral energy distribution of the Tb^3＋ emission depends strongly on the Tb3＋ concentration. The dependence of photolumineseenee intensity on Re^3＋ concentration is also discussed in detail. The fluorescent decay curves at room temperature were measured and analyzed.

中医基础理论三体四维课程思政的教学设计与实施路径

在中医基础理论课程思政教学中,让思政元素与专业课同向同行,形成协同效应,首先要立足课程的性质和特殊视野、理论和方法,尊重专业知识体系,从专业知识中凝练课程思政“契合点”,充分挖掘课程思政元素。在教学实践中,构建“三体四维”课程思政体系,三体即“教师-课程-学生”三个主体,四维即“设计-实践-评价-改进”四个维度。四个维度以教师和学生为实践者体现在课程之中,在具体实践中形成“实践-改进-实践”闭环系统,不断推进并深化课程思政建设。

片仔癀相关研究文献计量学分析

目的:系统探索片仔癀相关研究总体情况,归纳该领域研究热点、趋势。方法:通过文献计量学分析,运用CiteSpace和VOSviewer两款可视化软件,对国内片仔癀相关研究领域的作者、机构、关键词等情况进行系统分析。结果:通过文献研究共纳入文献132篇,其中高产作者有29位,主要机构集中在福建,机构间的合作以中医药大学为主。研究主题主要为应用病种、机制研究等。研究热点与趋势主要为片仔癀质量控制研究、片仔癀调控肿瘤细胞凋亡与增殖的途径研究、片仔癀中药制剂靶向性研究。该研究领域发文量总体呈上升趋势。结论:近10年片仔癀相关研究领域有一定的发展,显示出较大的发展潜力和发展前景,研究者应开展更多研究,推动该领域的进一步发展。

Psychological interventions for depression in children and adolescents:A bibliometric analysis

BACKGROUND Depression has gradually become a common psychological disorder among children and adolescents.Depression in children and adolescents affects their physical and mental development.Psychotherapy is considered to be one of the main treatment options for depressed children and adolescents.However,our understanding of the global performance and progress of psychological interventions for depression in children and adolescents(PIDCA)research is limited.AIM To identify collaborative research networks in this field and explore the current research status and hotspots through bibliometrics.METHODS Articles and reviews related to PIDCA from January 2010 to April 2023 were identified from the Web of Science Core Collection database.The Charticulator website,CiteSpace and VOSviewer software were used to visualize the trends in publications and citations,the collaborative research networks(countries,institutions,and authors),and the current research status and hotspots.RESULTS Until April 16,2023,1482 publications were identified.The number of documents published each year and citations had increased rapidly in this field.The United States had the highest productivity in this field.The most prolific institution was the University of London.Pim Cuijpers was the most prolific author.In the context of research related to PIDCA,both reference co-citation analysis and keywords co-occurrence analysis identified 10 research hotspots,including thirdwave cognitive behavior therapy,short-term psychoanalytic psychotherapy,cognitive behavioral analysis system of psychotherapy,family element in psychotherapy,modular treatment,mobile-health,emotion-regulation-based transdiagnostic intervention program,dementia risk in later life,predictors of the efficacy of psychological intervention,and risks of psychological intervention.CONCLUSION This bibliometric study provides a comprehensive overview of PIDCA from 2010 to present.Psychological intervention characterized as psychological-process-focused,short,family-involved,modular,internet-based,emotionregulation-based,and personalized may benefit more young people.

中医药诊疗原发性肝癌研究进展

原发性肝癌是我国常见恶性肿瘤之一,现代医学针对该病主要采用侵入性手术和化疗等方法治疗,但效果欠佳,患者生存率低。该病属于中医“积”“血臌”等范畴,中医药诊疗该病有较好的效果。文章通过收集并整理近五年关于中医药临床治疗原发性肝癌的相关文献,分别从该病的病因病机、辨证分型和治法治则方面进行归纳总结,希望为临床诊疗原发性肝癌提供借鉴。

《理虚元鉴》“论肺独详”虚劳辨治思想探析

随着人口老龄化不断加剧,中医虚劳病证临床诊疗日益得到重视。《理虚元鉴》作为中医药论治虚劳病证的一部重要经典著作,其对虚劳病证的预防、病因病机的认识、临床诊疗自成体系,其中尤以“论肺”为其特点。书中强调,肺为“五脏之天”、清虚之脏、治虚之枢、“三本二统”之要;辨证分型上提出“伏火刑金”为虚劳的重要病机;遣方用药注重滋阴润肺,确立清伏火、保肺阴、培脾土等治则治法。其立足于肺的学术思想内涵可为拓宽临床虚劳诊疗思路提供借鉴。

聚对苯二甲酸丁二醇酯(PBT)/阻燃剂填充PBT交替层状复合材料阻燃和力学性能

利用微层共挤出技术制备了不同层数的聚对苯二甲酸丁二醇酯(PBT)/阻燃剂(FR)填充的PBT交替层状复合材料,研究层数和层厚对复合材料阻燃性能和力学性能的影响。研究表明,随着层数的增加,体系的阻燃和力学性能均显著提高。当层数由2层增加到64层,材料的极限氧指数从20%提高到了25.5%,拉伸强度提高了4.3%,断裂伸长率保持稳定。这为制备兼具优异阻燃和力学性能的PBT复合材料提供了新的思路和途径。

Effect of various crop rotations on rice yield and nitrogen use efficiency in paddy–upland systems in southeastern China

To evaluate the effects of various rotation systems on rice grain yield and N use efficiency, a paddy–upland cropping experiment(2013–2016) was conducted in southeastern China. The experiment was designed using six different rice––winter crop rotations: rice–fallow(RF),rice–wheat(RW), rice–potato with rice straw mulch(RP), rice–green manure(Chinese milk vetch; RC–G), rice–oilseed rape(RO), and rice–green manure crop(oilseed rape with fresh straw incorporated into soil at flowering; RO–G) and three N rates, N0(0 kg N ha-1), N1(142.5 kg N ha-1), and N2(202.5 kg N ha-1). Average rice yields in the RF(5.93 t ha-1) rotation were significantly lower than those in the rotations with winter crops(7.20–7.48 t ha-1)under the N0 treatment, suggesting that incorporation of straw might be more effective for increasing soil N than winter fallow. The rice yield differences among the rotations varied by year with the N input. In general, the grain yields in the RP and RO–G rotations –were respectively 11.6–28.5% and 14.80–37.19% higher than those in the RF in plots with N applied. Increasing the N rate may have tended to minimize the average yield gap between the RF and the other rotations; the yield gaps were 18.55%, 4.14%, and 0.23% in N0, N1, and N2, respectively. However, the N recovery efficiency in the RF was significantly lower than that in other rotations, except for 2015 under both N1 and N2 rates, a finding that implies a large amount of chemical N loss. No significant differences in nitrogen agronomic efficiency(NAE) and physiological efficiency(NPE) were found between the rotations with legume(RC–G) and non–legume(RO and RW) winter crops, a result that may be due partly to straw incorporation. For this reason, we concluded that the return of straw could reduce differences in N use efficiency between rotations with and without legume crops. The degree of synchrony between the crop N demand and the N supply was evaluated by comparison of nitrogen balance degree(NBD) values. The NBD values in the RP and RW were significantly lower than those in the other rotations under both N1 and N2 rates. Thus,in view of the higher grain yield in the RP compared to the RW under the N1 rate, the RP rotation might be a promising practice with comparable grain yield and greater N use efficiency under reduced N input relative to the other rotations. The primary yield components of the RF and RP were identified as number of panicles m-2 and numbers of kernels panicle-1, respectively. The NAE and NPE were positively correlated with harvest index, possibly providing a useful indicator for evaluating N use efficiency.

Effects of lysedEnterococcus faecalis FK-23 on experimental allergic rhinitis in a murine model

In the current study, we sought to investigate whether lysed Enterococcus faecalis FK-23 （LFK）, a heat-killed probiotic preparation, attenuated eosinophil influx into the upper airway and had immunomodulatory activity in a murine allergic rhinitis model. Eighteen BALB/c mice were divided into three groups; the ovalbumin （OVA）-sen- sitized/challenged group, which received saline orally for 6 weeks （OVA group）, the OVA-sensitized/challenged group, which received LFK orally for 6 weeks （LFK-fed group）, and the non-sensitized group, which received saline for 6 weeks （saline control group）. Nasal rubbing and sneezing were monitored during the study. After the final challenge, interleukin （IL）-4, interferon （IFN）-y, and OVA-specific IgE levels in the sera and splenocyte culture supernatants were determined, eosinophilic infiltrate into the upper airway was quantified, and splenic CD4~CD25＋ regulatory T cells （Tregs） were examined by flow cytometry. We found that nasal rubbing was sig- nificantly reduced in LFK-fed mice compared to the OVA group on d 27 and 35, and sneezing was significantly inhibited by LFK administration for 35 d. LFK-fed mice had significantly less eosinophil influx into the nasal mucosa than the OVA group. There were no significant differences between the LFK-fed group and OVA group in the serum and splenocyte culture supernatant levels of IL-4, IFN-y, and OVA-specific IgE. Interestingly, the LFK-fed mice had a significantly greater percentage of splenic CD4＋CD25＋ Tregs than OVA group. Our results indicate that oral administration of LFK may alleviate nasal symptoms, reduce nasal eosinophilia, and increase the percentage of CD4＋CD25＋ Tregs in experimental allergic rhinitis.

Visit-to-visit Systolic Blood Pressure Variability and Stroke Risk: A Systematic Review and Meta-analysis

Visit-to-visit variability in systolic blood pressure(SBP)may have an important additional role in increasing the risk of vascular complications,including stroke.We conducted a meta-analysis to assess the relationship between visit-to-visit SBP variability(SBPV)and stroke risk.PubMed,EMBASE,and the Cochrane library databases were searched for cohort studies with data on visit-to-visit SBPV and stroke risk.Studies that reported adjusted relative risks(RRs)with 95%Cis of stroke associated with SBPV were included.Fourteen cohort studies met the inclusion criteria and were included in our meta-analysis.After adjustment for age,sex,and existing vascular risk factors,the analysis showed that the risk of stroke in patients with SBPV was significantly increased compared with patients with a small baseline SBPV[SD(RR=1.20,95%CI=(1.07-1.35),P=0.0005),CV(RR=1.12,95%CI=(1.00-1.26),P=0.008)].In addition,follow-up variations of more than 5 years were associated with a higher risk of stroke than those of less than 5 years[RR=1.08,95%CI=(1.04-1.11)].Visit-to-visit SBPV was associated with an increased risk of stroke,especially in terms of the time of variation.Taken together,SBPV data may be useful as a preventative diagnostic method in the management of stroke.

共建“一带一路”视角下高校中医药服务贸易人才培养研究与对策建议

中医药服务贸易在共建“一带一路”国家和地区中取得显著成效。在构建新发展格局背景下,中医药服务贸易对人才队伍提出了新的要求和考验。本文以共建“一带一路”视角,探讨转变人才培养模式、扩大队伍规模对解决当下中医药服务贸易的现实意义,并提出转变培养理念、扩大人才规模,探索联合培养模式、提升人才质量,发动社会力量、整合人才资源,建设创新高地、激发人才活力等对策建议。

Solar radiation-use characteristics of indica/japonica hybrid rice (Oryza sativa L.) in the late season in southeast China

New indica and japonica hybrid rice cultivars,such as the Yongyou series,provide farmers with very high yield potential.However,information on their canopy light capture and solar radiation use efficiency in the late season is limited.Field experiments were performed to compare the radiation-use parameters of four rice types:indica rice(IR),inbred japonica rice(IJR),hybrid japonica rice(HJR),and hybrid indica/japonica rice(HIJR),from 2016 to 2018 during the late season in Hangzhou,China.The grain yield,aboveground biomass,intercepted solar radiation(SI),and radiation-use efficiency(RUE)of the HIJR were on average respectively 13.4%–53.4%,14.3%–30.6%,7.6%–21.4%,and 8.2%–14.9%higher than those of the HJR,IJR,and IR.The leaf area index(LAI)of the HIJR was 18.2%–57.0%greater than that of the IJR and HJR at four growth stages,resulting in respectively 17.8%–38.5%and 10.7%–42.8%greater canopy light interception rates(LIR)and amount of intercepted solar radiation during the vegetative stage.The prolonged grain-filling stage also led to respectively 33.9%–52.6%and 30.5%–51.4%increases in amounts of incident and intercepted radiation for the HIJR relative to the IR during grain filling.These results indicate that the SI superiority of the HIJR was caused by canopy closure as rapid as that of the IR during the vegetative stage(greater LAI and canopy LIR during the growing season)and a grain-filling stage as long as that of the HJR.For grain-filling stage,differences in leaf Pn between HIJR,IR,and IJR were not significant,suggesting that the greater RUE of the HIJR(12.7%–52.8%higher)than that of the other rice types resulted from improved canopy architecture after flowering(FL).Principal components analysis(PCA)revealed that the superiority of the HIJR in terms of solar radiation use resulted from the greater canopy light capture capability of IR and the prolonged growth period(especially during grain filling)of japonica rice in the late growing season.

The anti-inflammatory regulation of calcitonin gene-related peptide in mouse Aspergillus fumigatus keratitis

AIM:To analyze the impact of calcitonin gene-related peptide(CGRP)in mouse keratitis after Aspergillus fumigatus(A.fumigatus)infection.METHODS:C57 BL/6 mice were treated subconjunctivally with different concentrations of exogenous CGRP,and BALB/c mice were treated with CGRP8-37(a CGRP antagonist)before corneas were infected with A.fumigatus.The cornea was assessed under the slit-lamp and the clinical score was recorded.The mRNA levels of IL-1β,TNF-α,IL-6,and MIP-2 were detected by quantitative real-time polymerase chain reaction(PCR),while the protein level of IL-1βwas determined by Western blotting.In vitro,RAW264.7 cells were used to investigate NLRP3 and IL-1βexpression induced by A.fumigatus after the pretreatment of exogenous CGRP or CGRP8-37.Cytokines expression in RAW264.7 cells was evaluated by real-time PCR and Western blotting.RESULTS:Using exogenous CGRP resulted in downregulated synthesis of IL-1βand MIP-2 stimulated by A.fumigatus in C57 BL/6 mice keratitis,and the synthesis of IL-1β,MIP-2 and IL-6 was up-regulated in BALB/c mice corneas after the pretreatment with CGRP8-37.Pretreatment with exogenous CGRP and CGRP8-37 did not influence TNF-αmRNA levels either in BALB/c or C57 BL/6 mice keratitis.The levels of NLRP3 and IL-1βwere both reduced in A.fumigatus stimulated-macrophages after treatment with exogenous CGRP.And CGRP8-37 pretreatment would increase NLRP3 and IL-1βlevels.CONCLUSION:CGRP may alleviate the inflammatory reaction in mice keratitis after infection with A.fumigatus.The anti-inflammatory effect may be related to the inhibition of NLRP3 expression by CGRP.

Expression and role of calcitonin gene-related peptide in mouse Aspergillus fumigatus keratitis

AIM: To investigate the expression and role of calcitonin gene-related peptide(CGRP) in the mouse models induced by Aspergillus fumigatus(A. fumigatus). METHODS: C57 BL/6 mice were randomized into a control group and A. fumigatus keratitis group. The cornea photography was assessed under the slit lamp and the clinical score was recorded after infection. Western blot, real-time polymerase chain reaction(PCR) and immunohistofluorescence analysis were applied to detect CGRP expression in cornea of both groups. In vitro, tests were conducted with C57 BL/6 mice macrophages to investigate CGRP expression after interaction with A. fumigatus. Cytokines expression induced by exogenous CGRP and the antagonist CGRP8-37 in A. fumigatus-exposed macrophages was evaluated by real-time PCR and ELISA.RESULTS: The cornea expression of CGRP was significantly elevated in C57 BL/6 mice corneas and macrophages after A. fumigatus infection. After treatment with exogenous CGRP, the levels of interleukin-1β(IL-1β), tumor necrosis factor-α(TNF-α) and IL-6 were reduced, and IL-10 level was increased in the A. fumigatus stimulatedmacrophages. However, IL-1β, TNF-α and IL-6 levels were upregulated after pretreatment of CGRP8-37. But the m RNA levels of MIP-2, TGF-β and IL-10 were not changed. CONCLUSION: This study provides evidence that A. fumigatus increased CGRP expression. CGRP may play a protective role against inflammation in A. fumigatus keratitis.

Acceptability and feasibility of public square dancing for community senior citizens with mild cognitive impairment and depressive symptoms:A pilot study

Objectives:To explore the acceptability and feasibility of public square dancing among community residents with mild cognitive impairment(MCI)and depressive symptoms.Methods:This mixed-method study consisted of a quantitative and a qualitative phase.From January to July 2018,a total of 241 community-dwelling senior citizens who complained of memory loss in one community in the Haidian District in Beijing were approached and screened,and 41 qualified for the study.Among them,35 senior citizens participated in the public square dancing intervention.By the end of the three-month follow-up,31 senior citizens completed the whole study.The Subjective Exercise Experience Scale(SEES)was used to survey senior citizens at the end of the three-month public square dancing intervention and follow-up to measure the participants’subjective exercise experience.Then 15 senior citizens were interviewed to collect attitudes,opinions,and suggestions related to the intervention.Results:During the intervention,90.6%of senior citizens met the requirement for defined hours.All senior citizens continued to dance at the three-month follow-up,and 32.3%met the requirement for defined hours.The scores of psychological well-being(11.03±2.82 vs.14.87±3.93,P<0.001)and fatigue(11.00[8.00,12.00]vs.14.00[9.00,18.00],P<0.001)increased at the end of the three-month follow-up.Qualitative research results extracted four major themes:increased confidence and a sense of accomplishment;easy to learn,close to real life,and sense of belonging;promotes physical and mental health;future expectations include music selection,reduced weather disruption,and self-organizing workouts.Conclusion:Public square dancing proved to be an acceptable,viable,and valuable intervention for MCI residents with depressive symptoms,which could be carried out by nursing staff in the community.Future studies should consider the appropriate population,intensity,and frequency of public square dancing and its effect on specific cognitive functions.

Diversity and Bioactivity of Cultivable Animal Fecal Actinobacteria

Microbial symbionts play important roles in food digestion and absorption, immunity, pathogens resistance, and health maintaining of their hosts by coevolution. To provide new sources for discovering new leader compounds of drugs, the diversity and bioactivities of cultivable actinobacteria from animal feces have been studied. 31 species of animal fecal samples were collected fromYunnanWildAnimalPark. The purified cultures of actinobacteria were isolated from these samples by using 5 media. The 16S rRNA gene sequences of 528 selected strains were determined, the phylogenetic analysis was carried out, and anti-microbial and anti-tumor activities were determined. 35 genera (including a new genus, Enteractinococcus) of actinobacteria from the 31 species of animal feces were identified. Some strains had high anti-tumor and antimicrobial activities. More than 50 secondary metabolites were isolated and identified, a novel bioactive macrolactam polyketide glycoside, Sannastatin, was found. Nine fecal streptomycete strains were fermented respectively, blended to the microbial manure, and used to prophylaxis and treatment of soil-borne disease of notoginseng in field. The incidence rate of the disease was lower 81% than agricultural chemicals. Fecal actinobacteria, a possibility as a new source for discovering drug leader, agricultural chemicals and other industry products, will be discussed.

Effect of Oxygen on Surface Properties and Drug Release Behavior of Plasma Polymer of n-Butyl Methacrylate

The effects of oxygen on the chemical structure, morphology, hydrophilicity and drug release behavior of radio-frequency plasma poly n- butyl methacrylate （PPBMA） thin film were carded out for the first time. ATR-FTIR and XPS showed that oxygen had little influence on the chemical structure and composition of PPBMAs, which did not agree with the thought that the presence of oxygen gas would increase the oxidized carbon functionalities in the plasma polymer. SEM and static contact angle measurement indicated that in case of deposition with oxygen, the smoothness and hydrophilicity of PPBMA were dramatically improved. The drug release behavior showed that drug release from the PPBMA coating without oxygen was biphasic patterns, while from PPBMA coating with oxygen was Higuchi release. These results were helpful for the design and tailoring of the PPBMA polymer film and other of plasma polymers film, but could provide a new idea for the drug release controlled form.

First-principles study on persistent luminescence mechanism of LiYGeO_(4):Eu^(3+)

LiYGeO_(4):Eu^(3+)is a red persistent luminescent material with a duration of more than 21 h.Although its persistent luminescence phenomenon has been fully studied,its detailed mechanism is still the subject of debates.Herein,we performed first-principles study on the intrinsic point defects and the charge transfer processes in LiYGeO_(4):Eu^(3+)to reveal the mechanism of persistent luminescence.The results show that,under charge transfer excitation,the electron is promoted from the valence band(oxygen ion ligand)to the central Eu^(3+)ion to form Eu^(2+)ion in LiYGeO_(4):Eu^(3+),leaving a hole behind.The charge transfer excitation can relax quickly to the excited state of the Eu^(3+)ion,which produces the characteristic^(5)D_(0)→^(7)F_(J)(J=0-6)emission.The Li vacancies(V_(Li))and the antisite defects of Li replacing Y site(Li_(Y))and Y replacing Li site(YLi)are main defects,while O vacancies(V_(O))are less important in concentration due to high formation energy.VLi and Liy can serve as hole-type traps,with the trap depths suitable for trapping the holes produced by illumination.The delayed release holes can combine with the Eu^(2+)left behind by the illumination,leading to persistent luminescence.The VLi trap is shallower than Li_(Y),and the latter is responsible for the long duration of persistent luminescence.A schematic based on the calculation results is constructed to illustrate the mechanism of persistent luminescence.

Improved growth rate of anodized TiO2 nanotube arrays under reduced pressure field and light illumination

The one-dimensional titanium oxide(TiO_2) nanotubes(TONT) can be rationally fabricated in the fluoridecontaining electrolyte by electrochemical anodization. The high-speed growth of TONT for elongated nanotubes is highly desirable because the undesirable chemical etching will induce ‘‘nanograss" on the top of nanotubes and restrain the continued elongation of nanotubes. Herein, the external fields were employed to accelerate the growth of TONTs and obtain the elongated TONT arrays. A growth rate up to 18 lm/h was achieved under the presence of reduced pressure(0.07 MPa) and UV light(365 nm) stimulation. The generation of longer nanotube arrays could be attributed to the applied fields, which facilitate timely gas pumping out and induce chemical equilibrium shift forward. The TONT films obtained under different parameters were subsequently employed as anodes for photoelectrochemical(PEC) water splitting. The photocurrent(at 0 V vs Ag/Ag Cl) of TONT electrode obtained under external fields represented a 50% enhancement compared with the photoanode produced by the conventional method.

从《黄帝内经》的思维方法探讨“气”和能量的相关性

文章以整体观念认识人体和细胞在整体层面的统一性,采用取象比类法认识中医脾藏象的部分功能和线粒体生理功能的统一性,并运用普遍联系思维,对脾所产生的气以及线粒体合成的能量之间的内在联系进行微观层面的讨论。得到如下结论:人体和细胞都是统一的整体;脾运化食饮转化为水谷精微的过程和线粒体进行三羧酸循环产生能量的过程具有内在规律上的统一性;脾运化产生的水谷精微之气是维持人体后天最基本的物质之一,线粒体产生的能量是生命活动的基础,二者功能统一。