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白芍通过调控M2巨噬细胞极化有效缓解何首乌引发的特异质肝损伤
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作者 曹波 李蓥滢 +6 位作者 林蒙蒙 徐静 李泰锋 费小非 肖小河 李国辉 李春雨 《Acupuncture and Herbal Medicine》 2024年第2期209-221,I0008,I0009,共15页
特异质药物性肝损伤(IDILI)是一种因药物引起的严重不良反应,通常发生在少数易感人群中。何首乌(PM)虽是一个常用的补益药,但许多临床数据已证明PM会引发IDILI。大多数IDILI的发生与机体免疫应激相关,然而对于PM导致IDILI的内在机制仍... 特异质药物性肝损伤(IDILI)是一种因药物引起的严重不良反应,通常发生在少数易感人群中。何首乌(PM)虽是一个常用的补益药,但许多临床数据已证明PM会引发IDILI。大多数IDILI的发生与机体免疫应激相关,然而对于PM导致IDILI的内在机制仍尚未被阐明。白芍(PRA)在临床上常与其他中药配伍,具有增效减毒缓解炎症等功效。但PRA是否能够缓解PM引发的肝损伤及内在机制仍未可知。在本研究中,通过网络药理学分析预测了PRA配伍PM在天然免疫中的相关靶点可能与巨噬细胞极化相关。同时采用非肝毒性剂量的LPS复制免疫应激模型,通过肝功能指标及病理等结果显示,当PM与PRA联用后,肝损伤的程度有所改善,相关促炎因子TNF-α和IL-6下降,M2巨噬细胞相关因子也有所上升。在体外,PM抑制了小鼠骨髓来源巨噬细胞(BMDMs)中IL-4诱导的Arg1及M2巨噬细胞标记物的表达,PRA则能够促进M2巨噬细胞极化,当二者配伍时,PRA可以改善PM对M2巨噬细胞极化的抑制作用。总之,这些研究结初步表明PRA能够通过促进M2巨噬细胞极化,降低炎症因子的表达,从而缓解PM引发的肝损伤,为解决何首乌引发的IDILI提供了新的思路和方案。 展开更多
关键词 IDILI M2巨噬细胞极化 白芍 何首乌
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存量资产转型与社区再生——昌平区首开LONG街
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作者 盛强 董铭 +2 位作者 乔红玉 韦琳 张喆 《城市设计》 2024年第3期32-35,共4页
昌平区首开LONG街项目是一项城市存量资产转型与社区再生的案例。该项目位于北京市昌平区回天地区,通过创新的政企合作模式,将原本低效的商业楼宇转化为集商业、产业和公共绿地于一体的综合性生活空间。项目实施不仅提升了区域的经济活... 昌平区首开LONG街项目是一项城市存量资产转型与社区再生的案例。该项目位于北京市昌平区回天地区,通过创新的政企合作模式,将原本低效的商业楼宇转化为集商业、产业和公共绿地于一体的综合性生活空间。项目实施不仅提升了区域的经济活力,而且通过满足居民多元化的生活需求,增强了社区的凝聚力。本文分析了项目的实施过程、成效和创新经验,探讨了存量资产转型对于推动城市可持续发展和提升居民生活质量的重要性。 展开更多
关键词 城市更新 老旧低效楼宇 存量资产转型 政企合作模式 经济活力
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肺部结节及肺癌患者新型冠状病毒感染后肺部手术时机的初步建议 被引量:1
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作者 李昕 董明 +11 位作者 徐嵩 赵洪林 韦森 宋作庆 刘明辉 任典 任凡 赵青春 刘仁旺 夏春秋 陈钢 陈军 《中国肺癌杂志》 CAS CSCD 北大核心 2023年第2期148-150,共3页
近年来,新型冠状病毒感染疫情给全球医疗、政治、经济领域带来了巨大的影响。自新型冠状病毒感染疫情流行开始以来,我们对新型冠状病毒感染影响的了解有了几何数级的增长,近期国内新型冠状病毒感染疫情变化迅速,对于肺部发现肿瘤性病变... 近年来,新型冠状病毒感染疫情给全球医疗、政治、经济领域带来了巨大的影响。自新型冠状病毒感染疫情流行开始以来,我们对新型冠状病毒感染影响的了解有了几何数级的增长,近期国内新型冠状病毒感染疫情变化迅速,对于肺部发现肿瘤性病变患者的外科手术如何开展也因近期疫情的变化而出现了争议。一些研究表明,接受肺癌手术的患者感染新型冠状病毒后较普通患者更易发生呼吸衰竭和围术期死亡事件,然而,癌症治疗的推迟也与患者死亡率的上升有关。特别是新型冠状病毒奥密克戎变异株具有更高的传播性,并有可能逃避通过以前的新型冠状病毒感染、疫苗接种获得的免疫力,为了将手术患者发生新型冠状病毒感染的风险降至最低,有必要制定新的治疗指南、专家共识和预防措施,但目前疫情的快速变化导致我们没有充足的时间和证据来制定指南和共识。胸外科医生急需在术前评估发生严重并发症风险较高的特定患者人群的标准,权衡外科治疗的获益与新型冠状病毒感染的风险孰轻孰重。因此,我们尝试结合在新型冠状病毒感染流行情况下不同地区肿瘤学及胸外科学组织对于肺癌手术的指南及共识,给出一些目前国内疫情期间肺部结节及肺癌患者新型冠状病毒感染后肺部手术时机的初步建议,并希望能引发更深入的讨论和建议。 展开更多
关键词 新型冠状病毒感染 肺肿瘤 肺部手术
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Restructuring Tilth Layers Can Change the Microbial Community Structure and Affect the Occurrence of Verticillium Wilt in Cotton Field
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作者 ming dong Yan Wang +6 位作者 Shulin Wang Guoyi Feng Qian Zhang Yongzeng Lin Qinglong Liang Yongqiang Wang Hong Qi 《Phyton-International Journal of Experimental Botany》 SCIE 2023年第10期2841-2860,共20页
Restructuring tilth layers(RTL)is a tillage method that exchanges the 0–20 and 20–40 cm soil layers that can be applied during cotton cultivation to increase cotton yield,eliminate weeds and alleviate severe disease... Restructuring tilth layers(RTL)is a tillage method that exchanges the 0–20 and 20–40 cm soil layers that can be applied during cotton cultivation to increase cotton yield,eliminate weeds and alleviate severe disease,including Verticillium wilt.However,the mechanism by which RTL inhibits Verticillium wilt is unclear.Therefore,we investigated the distribution of microbial communities after rotary tillage(CK)and RTL treatments to identify the reasons for the reduction of Verticillium wilt in cotton fields subjected to RTL.Illumina high-throughput sequencing was used to sequence the bacterial and fungal genes.The disease incidence and severity of Verticillium wilt decreased by 28.57%and 42.64%,respectively,after RTL.Moreover,RTL significantly enhanced bacterial richness and evenness at 20–40 cm and-reduced the differences in fungal evenness and richness between soil depths of 0–20 and 20–40 cm.The number of Verticillium dahliae decreased,while the relative abundance of biocontrol bacteria such as Bacillus and Pseudoxanthomonas increased significantly following RTL.Overall RTL improved bacterial diversity,decreased the number of Verticillium dahliae and increased the relative abundance of biocontrol bacteria,which may have suppressed the occurrence of Verticillium wilt in cotton fields. 展开更多
关键词 BACTERIA FUNGI restructuring tilth layers diversity disease reduction
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肺癌患者入院时下肢深静脉血栓的发生率及相关危险因素分析 被引量:35
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作者 杜晖 赵洪林 +8 位作者 李梅 纪慧慧 任凡 王攀 李昕 董明 Rehman DAWAR 陈钢 陈军 《中国肺癌杂志》 CAS CSCD 北大核心 2018年第10期761-766,共6页
背景与目的静脉血栓栓塞症(venous thromboembolism, VTE)是一种公认的在肺癌患者中有较高发病率和死亡率的并发症。本研究目的是明确我们中心肺癌患者入院时下肢深静脉血栓(lower extremity venous thrombosis, LEDVT)的发生率,并揭示... 背景与目的静脉血栓栓塞症(venous thromboembolism, VTE)是一种公认的在肺癌患者中有较高发病率和死亡率的并发症。本研究目的是明确我们中心肺癌患者入院时下肢深静脉血栓(lower extremity venous thrombosis, LEDVT)的发生率,并揭示其入院时LEDVT发生的危险因素。方法选择天津医科大学总医院肺部肿瘤外科在2017年7月-2017年12月收治的231例肺癌患者,入院时即行双下肢静脉彩超检查,以分析肺癌患者LEDVT的发生率;同时,对肺良性疾病患者入院时LEDVT的发生率进行比较。在肺癌患者中,进一步分析LEDVT发生与其临床特征的关系,寻找LEDVT发生的可能危险因素;同时,亦分析这些患者的血浆D-二聚体(D-Dimmer)、纤维蛋白原(fibrinogen, FIB)、凝血酶时间(thrombin time, TT)、活化部分凝血酶时间(activated partial thrombin time,APTT)、凝血酶原时间(prothrombin time, PT)及血小板(platelet, PLT)之间的差异。结果在231例肺癌患者中,入院时发生LEDVT者12例,其发生率为5.2%(12/231);而77例肺良性疾病患者入院时均未查见LEDVT的发生,提示肺癌患者入院时LEDVT的发生率明显高于肺良性疾病(P<0.05)。在肺癌患者中进一步分析发现,伴有远处转移(包括N3淋巴结转移)的肺癌患者较不伴有转移者更易发生LEDVT(11.29%, 7/62 vs 2.96%, 5/169)(P<0.05)。肺癌LEDVT组患者入院时的D-Dimer的中位值为1,534mg/L(369 mg/L-10,000 mg/L),明显高于非LEDVT组患者(539 mg/L, 126 mg/L-1,000 mg/L)(P<0.05);而FIB、TT、APTT、PT和PLT在两组患者之间无明显统计学差异(P>0.05)。结论我们中心肺癌患者入院时LEDVT总体发生率约为5%,明显高于肺良性疾病患者。入院时伴有远处转移(包括N3淋巴结转移)的肺癌患者更易发生LEDVT,其中,D-Dimer值较高的患者应考虑到VTE事件发生的可能。 展开更多
关键词 肺肿瘤 下肢深静脉血栓 发生率 危险因素
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经皮穴位电刺激对大脑神经功能活动影响研究进展 被引量:12
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作者 周鹏 宋雨桐 +4 位作者 张阔 万柏坤 李鑫举 明东 郭义 《航天医学与医学工程》 CAS CSCD 北大核心 2019年第5期463-470,共8页
传统中医经脉穴位针灸调节机体生理功能有着重要作用,通过定量物理刺激穴位手段来探索大脑高级神经活动的机制受到关注。从经皮穴位电刺激、基于脑电和功能磁共振成像构建脑功能网络、脑电功率谱密度、相位同步性、复杂度特征和默认模... 传统中医经脉穴位针灸调节机体生理功能有着重要作用,通过定量物理刺激穴位手段来探索大脑高级神经活动的机制受到关注。从经皮穴位电刺激、基于脑电和功能磁共振成像构建脑功能网络、脑电功率谱密度、相位同步性、复杂度特征和默认模式网络及各种客观变量(如针刺方式)影响等方面回顾了该领域的研究现状、存在问题;归纳小结了有关研究进展及其在脑电θ波段同步性、子频带能量变化、默认模式网络以及针对多穴位协同研究较少且结果模糊等不足之处。 展开更多
关键词 穴位 经皮穴位电刺激 脑电 功能磁共振成像 大脑神经活动
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新型冠状病毒肺炎流行期肺部手术的初步建议 被引量:4
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作者 李昕 刘明辉 +9 位作者 赵青春 刘仁旺 张洪兵 董明 徐嵩 赵洪林 韦森 宋作庆 陈钢 陈军 《中国肺癌杂志》 CAS CSCD 北大核心 2020年第3期133-135,共3页
2019年12月,中国确诊首例新型冠状病毒肺炎患者,疫情发展对中国乃至世界产生了巨大影响。对于肺部发现占位性病变患者的整体诊疗流程也因疫情而不能常规开展。对于胸外科医生而言,外科手术的介入时机需要慎重选择。全国的胸外科同道应... 2019年12月,中国确诊首例新型冠状病毒肺炎患者,疫情发展对中国乃至世界产生了巨大影响。对于肺部发现占位性病变患者的整体诊疗流程也因疫情而不能常规开展。对于胸外科医生而言,外科手术的介入时机需要慎重选择。全国的胸外科同道应根据疫情的改变及对新型冠状病毒肺炎认识的不断更新共同制定诊治流程和路径。在此,我们仅依据自己的认识提出初步建议,以供参考和进一步讨论。 展开更多
关键词 新型冠状病毒肺炎 肺占位性病变 外科手术治疗
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Application Effect of Chinese Medicine Rehabilitation in the Treatment of Adolescent Ankle Sports Injuries
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作者 ming dong 《Journal of Clinical and Nursing Research》 2023年第5期208-213,共6页
Objective:To analyze the clinical effect of traditional Chinese medicine rehabilitation in treating adolescent ankle sports injuries.Methods:From December 2020 to December 2022,adolescent patients with ankle joint spo... Objective:To analyze the clinical effect of traditional Chinese medicine rehabilitation in treating adolescent ankle sports injuries.Methods:From December 2020 to December 2022,adolescent patients with ankle joint sports injuries admitted to our hospital were selected as observation objects,and 67 patients were divided into a control group(n=33,routine rehabilitation treatment)and an experimental group(n=34,traditional Chinese medicine rehabilitation treatment)according to the computer grouping method.Compare the treatment results.Results:(i)The treatment received in the experimental group had an efficacy of 94.11%,which was higher than that of the control group(75.75%),and statistical significance was established(P<0.05).(ii)Before treatment,there was no difference in ankle joint pain,ankle joint activity,and ankle joint function scores between the control group and the experimental group(P>0.05);after treatment,the ankle joint pain,ankle joint activity,and ankle joint function scores in the experimental group were significantly higher than those in the control group(P<0.05).(iii)The experimental group had higher scores on physiological function,physiological function,physical pain,general health status,energy,social function,emotional function,and mental health compared to the control group(P<0.05).Conclusion:Traditional Chinese medicine rehabilitation is effective in treating ankle injuries caused by sports in adolescents and improve their quality of life.Therefore,it should be popularized. 展开更多
关键词 Chinese medicine rehabilitation TEENAGERS Ankle joints Sports injuries
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FGFR作为肺鳞癌潜在治疗靶点的研究进展 被引量:2
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作者 董明 李彤 陈军 《中国肺癌杂志》 CAS CSCD 北大核心 2018年第2期116-120,共5页
肺鳞状细胞癌(squamous-cell lung cancer,SqCLC)是非小细胞肺癌中一类独特的病理类型,患者多为高龄、发病隐匿、发现时常属晚期、常伴有心肺合并症、缺乏有效的靶向治疗药物等因素,相对于非鳞非小细胞肺癌,SqCLC的治疗面临着更大的挑... 肺鳞状细胞癌(squamous-cell lung cancer,SqCLC)是非小细胞肺癌中一类独特的病理类型,患者多为高龄、发病隐匿、发现时常属晚期、常伴有心肺合并症、缺乏有效的靶向治疗药物等因素,相对于非鳞非小细胞肺癌,SqCLC的治疗面临着更大的挑战。近年针对肺癌的分子靶向药物迅速发展,我们发现,FGFR家族(FGFR1-4)基因改变存在于约12%的SqCLC中,是SqCLC中突变频率最高的酪氨酸激酶家族基因,同时许多靶向FGFR的小分子药物都在各类肿瘤中发挥了较好的治疗效果。目前,许多FGFR抑制治疗SqCLC的临床试验也都正在进行当中,可能为SqCLC治疗提供新的策略和方向。 展开更多
关键词 FGFR 肺鳞癌 治疗靶点
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节律性经颅交流电刺激对运动序列学习能力的影响 被引量:2
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作者 魏泽 许敏鹏 +1 位作者 明东 穆思雨 《中国康复理论与实践》 CSCD 北大核心 2019年第11期1327-1331,共5页
目的探究经颅交流电刺激对脑电节律和认知功能的影响。方法 2017年12月,年轻健康志愿者60例均分为4组,分别采用20 Hz经颅交流电刺激行左侧运动皮层(C3)真/伪刺激或右侧初级运动皮层(C4)真/伪刺激,刺激前后受试者完成左/右手随机/规律按... 目的探究经颅交流电刺激对脑电节律和认知功能的影响。方法 2017年12月,年轻健康志愿者60例均分为4组,分别采用20 Hz经颅交流电刺激行左侧运动皮层(C3)真/伪刺激或右侧初级运动皮层(C4)真/伪刺激,刺激前后受试者完成左/右手随机/规律按键4种手指序列按键任务,任务过程中采集脑电信号。观察反应时、正确率;脑电信号进行事件相关谱扰动多重差值分析。结果 C4真刺激后,受试者左手任务反应时缩短。结论右侧初级运动皮层20 Hz经颅交流电刺激能提高左侧肢体运动序列学习能力。 展开更多
关键词 经颅交流电刺激 序列反应时任务 脑电图 运动学习 事件相关谱扰动
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我国智能医学高等教育发展的思考 被引量:4
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作者 李伟锋 杜育任 +7 位作者 姚旺 李桐 汪酉晨 徐卉子 兰巧玲 舒识宇 明东 顾晓松 《医学信息学杂志》 CAS 2021年第12期85-87,84,共4页
介绍我国智能医学发展的时代背景,阐述智能医学学科建设情况,分析智能医学高端人才培养路径,包括资源整合、规范重点学科建设,稳固学科支撑体系持续输送高端人才等。
关键词 智能医学 智慧医疗 医学高等教育 人才培养
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人工智能与智能医学发展 被引量:3
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作者 徐来 欧阳昭连 +4 位作者 房梦雅 杜育任 李伟锋 明东 顾晓松 《交通医学》 2021年第1期29-31,36,共4页
人工智能融合了众多学科及相关新兴产业,是引领未来的战略性技术,人工智能与医学融合,催生了智能医学的发展,智能医学是现代医学发展的新模式、新方向。通过文献分析、调研与咨询对智能医学发展内涵与价值追求提出了战略性的思考,并对... 人工智能融合了众多学科及相关新兴产业,是引领未来的战略性技术,人工智能与医学融合,催生了智能医学的发展,智能医学是现代医学发展的新模式、新方向。通过文献分析、调研与咨询对智能医学发展内涵与价值追求提出了战略性的思考,并对智能医学抗击新冠肺炎,智能医学与中医药传承创新进行了论述。 展开更多
关键词 人工智能 智能医学 智慧医疗 新冠肺炎 中医中药
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智能医学发展战略思考 被引量:6
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作者 徐来 杜育任 +3 位作者 李伟锋 房梦雅 明东 顾晓松 《交通医学》 2019年第6期543-544,547,共3页
随着我国科技创新与人工智能的快速发展,人工智能在医学中的应用越来越广,时代提出了智能医学的概念.本文通过文献分析,调研与咨询,从大数据、互联网、人工智能与智能医学、智慧医疗,以及学科建设、人才培养、相关法规制度、伦理建设等... 随着我国科技创新与人工智能的快速发展,人工智能在医学中的应用越来越广,时代提出了智能医学的概念.本文通过文献分析,调研与咨询,从大数据、互联网、人工智能与智能医学、智慧医疗,以及学科建设、人才培养、相关法规制度、伦理建设等方面提出智能医学发展战略相关建议. 展开更多
关键词 人工智能 智能医学 智慧医疗
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Numerical study on non-uniform heat transfer deterioration of supercritical RP-3 aviation kerosene in a horizontal tube 被引量:14
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作者 Yanhong Wang Yingnan Lu +1 位作者 Sufen Li ming dong 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2020年第6期1542-1557,共16页
The convective heat transfer of supercritical-pressure RP-3(Rocket Propellant 3)aviation kerosene in a horizontal circular tube has been numerically studied,focusing mainly on the non-uniform heat transfer deteriorati... The convective heat transfer of supercritical-pressure RP-3(Rocket Propellant 3)aviation kerosene in a horizontal circular tube has been numerically studied,focusing mainly on the non-uniform heat transfer deterioration along the circumferential direction.The governing equations of mass,momentum and energy have been solved using the pressure-based segregated solver based on the finite volume method.The re-normalization group(RNG)k-εturbulence model with an enhanced wall treatment was selected.Considering the heat conduction in the solid wall,the mechanism of heat transfer deterioration and the buoyancy effect on deteriorated heat transfer were discussed.The evolution of secondary flow was analyzed.Effects of the outer-wall heat flux,mass flux,pressure and tube thermal conductivity on heat transfer were investigated.Moreover,the buoyancy criterion and the heat transfer correlation were obtained.Results indicate that the poor flow performance of near-wall fluid causes the pseudo-film boiling,further leads to the heat transfer deterioration.The strong buoyancy has an effect of enhancing the heat transfer at the bottom of tube,and weakening the heat transfer at the top of tube,which results in the non-uniform inner-wall temperature and heat flux distributions.Decreasing the ratio of outer-wall heat flux and mass flux,increasing the pressure could weaken the heat transfer difference along the circumferential direction,while the effect of thermal conductivity of tube on the circumferential parameters distributions is more complicated.When the buoyancy criterion of(Grq/Grth)max≤0.8 is satisfied,the effect of buoyancy could be ignored.The new correlations work well for non-uniform heat transfer predictions. 展开更多
关键词 Supercritical pressure Aviation kerosene Non-uniform heat transfer Heat transfer deterioration BUOYANCY Prediction correlation
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Electroacupuncture diminishes P2X_2 and P2X_3 purinergic receptor expression in dorsal root ganglia of rats with visceral hypersensitivity 被引量:7
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作者 Zhijun Weng Luyi Wu +4 位作者 Yuan Lu Lidong Wang Linying Tan ming dong Yuhu Xin 《Neural Regeneration Research》 SCIE CAS CSCD 2013年第9期802-808,共7页
Electroacupuncture at Shangjuxu (ST37) and Tianshu (ST25) can improve visceral hypersensitivity in rats. Colorectal distension was used to establish a rat model of chronic visceral hypersensitivity. Immunohistoche... Electroacupuncture at Shangjuxu (ST37) and Tianshu (ST25) can improve visceral hypersensitivity in rats. Colorectal distension was used to establish a rat model of chronic visceral hypersensitivity. Immunohistochemistry was used to detect P2X2 and P2X3 receptor expression in dorsal root ganglia from rats with chronic visceral hypersensitivity. Results demonstrated that abdominal withdrawal reflex scores obviously increased following establishment of the model, indicating visceral hypersensitivity. Simultaneously, P2X2 and P2X3 receptor expression increased in dorsal root ganglia. After bilateral electroacupuncture at Shangjuxu and Tianshu, abdominal withdrawal reflex scores and P2X2 and P2X3 receptor expression decreased in rats with visceral hypersensitivity. These results indicated that electroacupuncture treatment improved visceral hypersensitivity in rats with irritable bowel syndrome by reducing P2X2 and P2X3 receptor expression in dorsal root ganglia. 展开更多
关键词 neural regeneration acupuncture and moxibustion P2X2 P2X3 visceral hypersensitivity irritablebowel syndrome ELECTROACUPUNCTURE P2 purinergic receptors abdominal withdrawal reflex scoresacupuncture and moxibustion peripheral nerve injury grants-supported paper photographscontaining paper neuroregeneration
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基于神经认知科学的音乐对情绪诱发的机制研究综述
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作者 甘霖 田佳宜 +2 位作者 许敏鹏 明东 周鹏 《复旦学报(自然科学版)》 CAS CSCD 北大核心 2021年第3期340-346,共7页
为更好地了解音乐对人脑情绪诱发机制的规律,解决认知机制不清的问题,本文基于神经认知科学的基础理论,总结了目前国际上使用脑电图检查、功能性磁共振成像等技术方法的研究结果,得到音乐对情绪诱发在不同脑区、不同频段的差异化及规律... 为更好地了解音乐对人脑情绪诱发机制的规律,解决认知机制不清的问题,本文基于神经认知科学的基础理论,总结了目前国际上使用脑电图检查、功能性磁共振成像等技术方法的研究结果,得到音乐对情绪诱发在不同脑区、不同频段的差异化及规律性影响等结论.该项工作将更加清晰地梳理与总结音乐对大脑情绪诱发的机制,对于音乐在脑认知与发育、音乐教育、神经疾病治疗等应用中均具有重要意义. 展开更多
关键词 音乐 情绪 脑电图 功能性磁共振成像 事件相关电位
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新型碳系头皮脑电干式电极的制备及性能分析
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作者 张利剑 明东 贾正伟 《中国生物医学工程学报》 CAS CSCD 北大核心 2022年第3期380-384,共5页
为研究碳系材料干电极性能,采用化学气相沉积技术,制备掺硼金刚石(BDD)及垂直生长多孔石墨烯薄膜,以SEM、TEM、XPS及Raman等手段进行形貌与结构的表征,并对比这两种碳系干电极在采集脑电信号时的响应特征。在眨眼、咬牙、睁闭眼范式下... 为研究碳系材料干电极性能,采用化学气相沉积技术,制备掺硼金刚石(BDD)及垂直生长多孔石墨烯薄膜,以SEM、TEM、XPS及Raman等手段进行形貌与结构的表征,并对比这两种碳系干电极在采集脑电信号时的响应特征。在眨眼、咬牙、睁闭眼范式下采集脑电信号,石墨烯和BDD电极与商用Ag/AgCl湿电极的相关度均不低于95%。研究表明,该BDD电极是由大量金刚石晶体紧密堆垛而成,其(100)和(111)晶面硼掺杂水平的差异造成(111)晶面具有更高的导电效果,构成不同取向“5~10μm微电极”集合,即使不依赖液体导电层,也能与头皮紧密接触而传递电子;直立石墨烯阵列起到电极与头皮之间固态导电介质的作用,其三维多级孔隙结构构筑长程导电网,而开放的多级孔表面则构筑短程离子传输通道,可有效降低电极与头皮之间的界面阻抗。实验验证了二者作为干式脑电传感电极使用的可行性。 展开更多
关键词 脑电 掺硼金刚石 垂直石墨烯 干电极
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Potential applications of artificial intelligence in colorectal polyps and cancer: Recent advances and prospects 被引量:7
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作者 Ke-Wei Wang ming dong 《World Journal of Gastroenterology》 SCIE CAS 2020年第34期5090-5100,共11页
Since the advent of artificial intelligence(AI)technology,it has been constantly studied and has achieved rapid development.The AI assistant system is expected to improve the quality of automatic polyp detection and c... Since the advent of artificial intelligence(AI)technology,it has been constantly studied and has achieved rapid development.The AI assistant system is expected to improve the quality of automatic polyp detection and classification.It could also help prevent endoscopists from missing polyps and make an accurate optical diagnosis.These functions provided by AI could result in a higher adenoma detection rate and decrease the cost of polypectomy for hyperplastic polyps.In addition,AI has good performance in the staging,diagnosis,and segmentation of colorectal cancer.This article provides an overview of recent research focusing on the application of AI in colorectal polyps and cancer and highlights the advances achieved. 展开更多
关键词 Artificial intelligence Deep learning Computer-assisted diagnosis Colorectal polyps Colorectal cancer
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Boundary-layer disturbances subjected to free-stream turbulence and simulation on bypass transition 被引量:3
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作者 Hong QIN ming dong 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2016年第8期967-986,共20页
The phenomena associated with the entrainment of free-stream turbulence (FST) into boundary-layer flows are relevant for a number of subjects. It has been be- lieved that the continuous spectra of the Orr-Sommerfeld... The phenomena associated with the entrainment of free-stream turbulence (FST) into boundary-layer flows are relevant for a number of subjects. It has been be- lieved that the continuous spectra of the Orr-Sommerfeld (O-S)/Squire equations describe the entrainment process, and thus they are used to specify the inlet condition in simulation of bypass transition. However, Dong and Wu (Dong, M. and Wu, X. On continuous spectra of the Orr-Sommerfeld/Squire equations and entrainment of free-stream vortical disturbances. Journal of Fluid Mechanics, 732, 616-659 (2013)) pointed out that continuous spectra exhibit several non-physical features due to neglecting the non-parallelism. They further proposed a large-Reynolds-number asymptotic approach, and showed that the non-parallelism is a leading-order effect even for the short-wavelength disturbance, for which the response concentrates in the edge layer. In this paper, the asymptotic solution is verified numerically by studying its evolution in incompressible boundary layers. It is found that the numerical results can be accurately predicted by the asymptotic solution, implying that the latter is adequate for moderate Reynolds numbers. By introducing a series of such solutions as the inflow perturbations, the bypass transition is investigated via the direct numerical simulation (DNS). The transition processes, including the evolution of streaks, the amplification of secondary-instability modes, and the emergence of turbulent spots, agree with the experimental observations. 展开更多
关键词 free-stream turbulence (FST) bypass transition boundary layer ASYMPTOTIC direct numerical simulation (DNS)
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Scattering of Tollmien-Schlichting waves as they pass over forward-/backward-facing steps 被引量:3
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作者 ming dong Anyong ZHANG 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2018年第10期1411-1424,共14页
Forward-/backward-facing steps in boundary-layer flows are often seen in engineering applications, and they have potential impacts on laminar-turbulent transition through scattering of the oncoming instability modes(e... Forward-/backward-facing steps in boundary-layer flows are often seen in engineering applications, and they have potential impacts on laminar-turbulent transition through scattering of the oncoming instability modes(e.g., Tollmien-Schlichting(T-S) waves). This issue is studied in the present paper by applying a local scattering framework, which is a rather generic mathematical framework on describing the mode scattering process. In this framework, a high-Reynolds-number triple-deck formalism is employed, and a transmission coefficient, defined as the ratio of the asymptotic amplitude of the instability mode downstream of the step to that upstream, is introduced. Through the systematical study, it has been found that both the forward-and backward-facing steps have a destabilizing effect on the oncoming T-S waves in subsonic boundary layers, this effect increases with the height of the step and/or the frequency of the T-S wave, and a backward-facing step(BFS) always has a greater impact than a forward-facing step(FFS). These facts agree with most of the previous investigations.However, one numerical study(WORNER, A., RIST, U., and WAGNER, S. Humps/steps influence on stability characteristics of two-dimensional laminar boundary layer. AIAA Journal, 41, 192–197(2003)), which was based on an ad-hoc configuration, showed an opposite impact of an FFS. Through the investigation on the specific configuration, it is revealed that the wrong conclusion was drawn by misinterpreting the numerical results. 展开更多
关键词 boundary layer SCATTERING instability Tollmien-Schlichting(T-S) wave triple deck
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