Rock failure phenomena,such as rockburst,slabbing(or spalling) and zonal disintegration,related to deep underground excavation of hard rocks are frequently reported and pose a great threat to deep mining.Currently,the...Rock failure phenomena,such as rockburst,slabbing(or spalling) and zonal disintegration,related to deep underground excavation of hard rocks are frequently reported and pose a great threat to deep mining.Currently,the explanation for these failure phenomena using existing dynamic or static rock mechanics theory is not straightforward.In this study,new theory and testing method for deep underground rock mass under coupled static-dynamic loading are introduced.Two types of coupled loading modes,i.e.'critical static stress + slight disturbance' and 'elastic static stress + impact disturbance',are proposed,and associated test devices are developed.Rockburst phenomena of hard rocks under coupled static-dynamic loading are successfully reproduced in the laboratory,and the rockburst mechanism and related criteria are demonstrated.The results of true triaxial unloading compression tests on granite and red sandstone indicate that the unloading can induce slabbing when the confining pressure exceeds a certain threshold,and the slabbing failure strength is lower than the shear failure strength according to the conventional Mohr-Column criterion.Numerical results indicate that the rock unloading failure response under different in situ stresses and unloading rates can be characterized by an equivalent strain energy density.In addition,we present a new microseismic source location method without premeasuring the sound wave velocity in rock mass,which can efficiently and accurately locate the rock failure in hard rock mines.Also,a new idea for deep hard rock mining using a non-explosive continuous mining method is briefly introduced.展开更多
Using three-phase remote sensing images of China-Brazil Earth Resources Satellite 02B (CBERS02B) and Landsat-5 TM, tobacco field was extracted by the analysis of time series image based on the different phenological c...Using three-phase remote sensing images of China-Brazil Earth Resources Satellite 02B (CBERS02B) and Landsat-5 TM, tobacco field was extracted by the analysis of time series image based on the different phenological characteristics between tobacco and other crops. The spectral characteristics of tobacco and corn in luxuriant growth stage are very similar, which makes them difficult to be distinguished using a single-phase remote sensing image. Field film after tobacco seedlings transplanting can be used as significant sign to identify tobacco. Remote sensing interpre- tation map based on the fusion image of TM and CBERS02B's High-Resolution (HR) camera image was used as stan- dard reference material to evaluate the classification accuracy of Spectral Angle Mapper (SAM) and Maximum Like- lihood Classifier (MLC) for time series image based on full samples test method. SAM has higher classification accu- racy and stability than MLC in dealing with time series image. The accuracy and Kappa of tobacco coverage extracted by SAM are 83.4% and 0.692 respectively, which can achieve the accuracy required by tobacco coverage measurement in a large area.展开更多
Objective： To investigate the frequency of parasympathetic neurogenesis and determine its association with tumor budding and prognosis in pancreatic ductal adenocarcinoma （PDAC）. Methods： Parasympathetic neurogene...Objective： To investigate the frequency of parasympathetic neurogenesis and determine its association with tumor budding and prognosis in pancreatic ductal adenocarcinoma （PDAC）. Methods： Parasympathetic neurogenesis was defined as the distribution of abnormal parasympathetic nerves in the stroma tissue. Staining of vesicular acetylcholine transporter （VAChT）, as a marker for parasympathetic neurogenesis, was performed on a representative specimen of the tumor for 59 PDAC patients with available clinical, pathologic, and follow-up information. Three specimens containing normal pancreatic tissues were stained in parallel. The number of parasympathetic nerve fibers was counted in five high-power microscopic fields （5×0.785 mm2）. Cut-offvalues were calculated by receiver operating characteristic curve analysis. Results： VAChT-positive parasympathetic nerve fibers were not seen in the stroma of 3 cases of normal pancreatic tissues. In 59 PDAC cases, the range of parasympathetic neurogenesis was 4-38 fibers/（5×0.785） mm2, with a median of 18 fibers/（5×0.785） mm2. Patients with parasympathetic neurogenesis 〉 15 fibers/（5×0.785） mm2 were defined as the high-density group （39 patients, 66.1%）, and those with parasympathetic neurogenesis 〈15 fibers/（5×0.785） mm2 as the low-density group （20 patients, 33.9%）. The high-density group had a higher occurrence of tumor budding （P=0.001） and a higher rate of early recurrence （P=0.035）. Parasympathetic neurogenesis appeared to be an independent adverse prognostic factor [hazard ratio （HR）=2.45, 95% confidence interval （95% CI）： 1.25-4.81, P=0.009], in addition to American Joint Committee on Cancer （AJCC） stage （P=0.010） and tumor budding （P=0.009）. Conclusions： Parasympathetic neurogenesis is strongly associated with tumor budding and correlates with an adverse prognosis in PDAC.展开更多
Isolated pillars in underground mines are subjected to uniaxial stress,and the load bearing cross-section of pillars is commonly rectangularly shaped.In addition,the uniaxial compression test(UCT)is widely used for de...Isolated pillars in underground mines are subjected to uniaxial stress,and the load bearing cross-section of pillars is commonly rectangularly shaped.In addition,the uniaxial compression test(UCT)is widely used for determining the basic mechanical properties of rocks and revealing the mechanism of isolated pillar disasters under unidimensional stress.The shape effects of rock mechanical properties under uniaxial compression are mainly quantitatively reflected in the specific shape ratios of rocks.Therefore,it is necessary to study the detailed shape ratio effects on the mechanical properties of rectangular prism rock specimens and isolated pillars under uniaxial compressive stress.In this study,granite,marble and sandstone rectangular prism specimens with various height to width ratios(r)and width to thickness ratios(u)were prepared and tested.The study results show that r and u have a great influence on the bearing ability of rocks,and thin or high rocks have lower uniaxial compressive strength.Reducing the level of r can enhance the u effect on the strength of rocks,and increasing the level of u can enhance the r effect on the strength of rocks.The lateral strain on the thickness side of the rock specimen is larger than that on the width side,which implies that crack growth occurs easily on the thickness side.Considering r and u,a novel strength prediction model of isolated pillars was proposed based on the testing results,and the prediction model was used for the safety assessment of 179 isolated pillars in the Xianglu Mountain Tungsten Mine.展开更多
This study was conducted to explore the feasibility of partial pancreatic head resection and Roux-en-Y pancreatic jejunostomy for the treatment of benign tumors of the pancreatic head(BTPH). From November 2006 to Febr...This study was conducted to explore the feasibility of partial pancreatic head resection and Roux-en-Y pancreatic jejunostomy for the treatment of benign tumors of the pancreatic head(BTPH). From November 2006 to February 2009, four patients(three female and one male) with a mean age of 34.3 years(range: 21-48 years) underwent partial pancreatic head resection and Roux-en-Y pancreatic jejunostomy for the treatment of BTPH(diameters of 3.2-4.5 cm) using small incisions(5.1-7.2 cm). Preoperative symptoms include one case of repeated upper abdominal pain, one case of drowsiness and two cases with no obvious preoperative symptoms. All four surgeries were successfully performed. The mean operative time was 196.8 min(range 165-226 min), and average blood loss was 138.0 m L(range: 82-210 m L). The mean postoperative hospital stay was 7.5 d(range: 7-8 d). In one case, the main pancreatic duct was injured. Pathological examination confirmed that one patient suffered from mucinous cystadenoma, one exhibited insulinoma, and two patients had solid-pseudopapillary neoplasms. There were no deaths or complications observed during the perioperative period. All patients had no signs of recurrence of the BTPH within a follow-up period of 48-76 mo and had good quality of life without diabetes. Partial pancreatic head resection with Roux-en-Y pancreatic jejunostomy is feasible in selected patients with BTPH.展开更多
Diabetes,one of the most common chronic diseases in the modern world,has pancreaticβcell deficiency as a major part of its pathophysiological mechanism.Pancreatic regeneration is a potential therapeutic strategy for ...Diabetes,one of the most common chronic diseases in the modern world,has pancreaticβcell deficiency as a major part of its pathophysiological mechanism.Pancreatic regeneration is a potential therapeutic strategy for the recovery ofβcell loss.However,endocrine islets have limited regenerative capacity,especially in adult humans.Almost all hypoglycemic drugs can protectβcells by inhibitingβcell apoptosis and dedifferentiation via correction of hyperglycemia and amelioration of the consequent inflammation and oxidative stress.Several agents,including glucagon-like peptide-1 andγ-aminobutyric acid,have been shown to promoteβcell proliferation,which is considered the main source of the regeneratedβcells in adult rodents,but with less clarity in humans.Pancreatic progenitor cells might exist and be activated under particular circumstances.Artemisinins andγ-aminobutyric acid can induceα-to-βcell conversion,although some disputes exist.Intestinal endocrine progenitors can transdeterminate into insulin-producing cells in the gut after FoxO1 deletion,and pharmacological research into FoxO1 inhibition is ongoing.Other cells,including pancreatic acinar cells,can transdifferentiate intoβcells,and clinical and preclinical strategies are currently underway.In this review,we summarize the clinical and preclinical agents used in different approaches forβcell regeneration and make some suggestions regarding future perspectives for clinical application.展开更多
目的:探讨头针联合推拿法治疗帕金森病(Parkinson’s Disease,PD)的临床效果。方法:以2020年9月-2021年10月医院收治的80例PD患者为试验对象,按照随机信封法分为对照组:40例,常规西医治疗;试验组:40例,常规西医联合头针、推拿治疗。比...目的:探讨头针联合推拿法治疗帕金森病(Parkinson’s Disease,PD)的临床效果。方法:以2020年9月-2021年10月医院收治的80例PD患者为试验对象,按照随机信封法分为对照组:40例,常规西医治疗;试验组:40例,常规西医联合头针、推拿治疗。比较两组临床疗效、帕金森病综合量表(Unified Parkinson's Disease Rating Scale,UPDRS)评分、5-羟色胺(5-hydroxytryptamine,5-HT)水平、运动功能、生活质量。结果:治疗后,试验组临床总有效率95.00%(38/40)高于对照组85.00%(34/40)(P>0.05);UPDRS评分低于对照组(P<0.05);5-HT水平(279.34±25.07)ng/mL高于对照组(230.47±22.39)ng/mL(P<0.05);Berg平衡量表评分(Berg Balance Scale,BBS)(42.07±5.08)分高于对照组(37.24±4.59)分(P<0.05);6分钟步行距离(194.37±30.64)m长于对照组(162.47±20.10)m(P<0.05);健康调查简表(The Mos 36-item Short From Health Survey,SF-36)各维度评分均高于对照组(P<0.05)。结论:在常规西医治疗基础上,给予帕金森病患者中医头针联合推拿疗法,临床效果显著,可有效增强患者运动平衡能力,改善机体5-HT水平,提高生活质量。展开更多
目的分析血清C反应蛋白(CRP)、白细胞介素(IL)-6、IL-10联合检测诊断腹腔镜结直肠癌术后吻合口瘘的临床价值。方法117例行腹腔镜手术治疗的结直肠癌患者,根据术后是否出现吻合口瘘分为吻合口瘘组(15例)和非吻合口瘘组(102例)。两组均采...目的分析血清C反应蛋白(CRP)、白细胞介素(IL)-6、IL-10联合检测诊断腹腔镜结直肠癌术后吻合口瘘的临床价值。方法117例行腹腔镜手术治疗的结直肠癌患者,根据术后是否出现吻合口瘘分为吻合口瘘组(15例)和非吻合口瘘组(102例)。两组均采用免疫比浊法检测血清CRP水平,采用放射免疫法检测血清IL-6水平,采用酶联免疫吸附法检测血清IL-10水平。比较两组患者不同时间点血清CRP、IL-6、IL-10水平,采用受试者工作特征(ROC)曲线分析单一及联合检测诊断吻合口瘘的价值。结果术后3、4、5、6、7 d,吻合口瘘组患者血清CRP水平分别为(74.50±12.17)、(84.07±14.56)、(93.25±17.18)、(90.14±15.44)、(78.32±11.23)mg/L,均明显高于非吻合口瘘组的(50.74±9.34)、(44.18±7.92)、(39.94±6.73)、(31.63±4.97)、(25.03±3.65)mg/L,差异具有统计学意义(P<0.05)。吻合口瘘组患者血清CRP水平在术后5 d达到最高峰值,而非吻合口瘘组患者术后3 d即达到最高峰值。术后3、4、5、6、7 d,吻合口瘘组患者血清IL-6水平分别为(103.77±15.68)、(81.38±12.64)、(75.05±10.21)、(63.21±8.53)、(54.22±7.33)ng/L,均明显高于非吻合口瘘组的(71.43±10.29)、(63.46±9.15)、(51.24±7.87)、(43.36±6.07)、(34.16±5.42)ng/L,差异具有统计学意义(P<0.05)。两组患者血清IL-6水平均在术后3 d均达到最高峰值。术后3、4、5、6、7 d,吻合口瘘组患者血清IL-10水平分别为(24.35±3.12)、(26.89±3.75)、(28.87±4.12)、(30.61±5.02)、(34.14±5.92)ng/ml,均明显低于非吻合口瘘组的(28.57±3.91)、(30.62±4.17)、(33.94±4.56)、(35.27±5.74)、(39.05±6.11)ng/ml,差异具有统计学意义(P<0.05)。两组患者血清IL-10水平在术后3 d均达到最低值。ROC曲线分析显示:术后5 d CRP+术后3 d IL-6+术后3 d IL-10联合检测的曲线下面积(AUC)、灵敏度及特异度均高于术后5 d CRP、术后3 d IL-6、术后3 d IL-10单一检测。结论术后5 d CRP、术后3 d IL-6和IL-10联合检测诊断腹腔镜结直肠癌术后吻合口瘘的价值较高,具有一定的临床应用前景。展开更多
Failure of irregular rock samples may provide implications in the rapid estimation of rock strength,which is imperative in rock engineering practice.In this work,analytical,experimental and numerical investigations we...Failure of irregular rock samples may provide implications in the rapid estimation of rock strength,which is imperative in rock engineering practice.In this work,analytical,experimental and numerical investigations were carried out to study the mechanical properties and failure characteristics of rock spheres under paired point loads.Analytical solutions indicted that with the increase in sample size(contact angle)and decrease in Poisson’s ratio,the uneven tensile stress in theta direction decreased.Then laboratory experiments were carried out to investigate the load characteristics and failure mode of spherical marble samples with different sizes subjected to a pair of diametral point loads.The discrete element method(DEM)was adopted to study the failure process of rock spheres.The effect of the sphere diameter on the point load contact angle was examined in terms of peak load,crushed zone distribution and energy dissipation.Experimental and numerical results showed that the samples primarily fail in tension,with crushed zones formed at both loading points.With increase in the sample size,the contact angle,crushed area and total work increase.As the specimen diameter increases from 30 mm to 50 mm,the peak load on the specimen increases from 3.6 kN to 8.8 kN,and the percentage of crushed zone(ratio of crushing zone to sample radius,d/r)increased from 0.191 to 0.262.The results of the study have implications for understanding the failure of irregular rock specimens under point loading conditions and their size effects.展开更多
基金supported by the National Natural Science Foundation of China(No.12072376)the Fundamental Research Funds for the Central Universities of Central South University,China(No.2020zzts708).
基金supported by the National Natural Science Foundation of China(Nos.12072376,52174140)the Fundamental Research Funds for Central Universities of the Central South University,China(No.2020zzts195)。
基金jointly supported by the State Key Research Development Program of China (Grant No.2016YFC0600706)the National Natural Science Foundation of China (Grant Nos.41630642 and 11472311)
文摘Rock failure phenomena,such as rockburst,slabbing(or spalling) and zonal disintegration,related to deep underground excavation of hard rocks are frequently reported and pose a great threat to deep mining.Currently,the explanation for these failure phenomena using existing dynamic or static rock mechanics theory is not straightforward.In this study,new theory and testing method for deep underground rock mass under coupled static-dynamic loading are introduced.Two types of coupled loading modes,i.e.'critical static stress + slight disturbance' and 'elastic static stress + impact disturbance',are proposed,and associated test devices are developed.Rockburst phenomena of hard rocks under coupled static-dynamic loading are successfully reproduced in the laboratory,and the rockburst mechanism and related criteria are demonstrated.The results of true triaxial unloading compression tests on granite and red sandstone indicate that the unloading can induce slabbing when the confining pressure exceeds a certain threshold,and the slabbing failure strength is lower than the shear failure strength according to the conventional Mohr-Column criterion.Numerical results indicate that the rock unloading failure response under different in situ stresses and unloading rates can be characterized by an equivalent strain energy density.In addition,we present a new microseismic source location method without premeasuring the sound wave velocity in rock mass,which can efficiently and accurately locate the rock failure in hard rock mines.Also,a new idea for deep hard rock mining using a non-explosive continuous mining method is briefly introduced.
基金Under the auspices of China Postdoctoral Science Foundation (No. 20080430586, 20070420018)National Natural Science Foundation of China (No. 40801161, 40801172)Sino US International Cooperation in Science and Technology (No. 2007DFA20640)
文摘Using three-phase remote sensing images of China-Brazil Earth Resources Satellite 02B (CBERS02B) and Landsat-5 TM, tobacco field was extracted by the analysis of time series image based on the different phenological characteristics between tobacco and other crops. The spectral characteristics of tobacco and corn in luxuriant growth stage are very similar, which makes them difficult to be distinguished using a single-phase remote sensing image. Field film after tobacco seedlings transplanting can be used as significant sign to identify tobacco. Remote sensing interpre- tation map based on the fusion image of TM and CBERS02B's High-Resolution (HR) camera image was used as stan- dard reference material to evaluate the classification accuracy of Spectral Angle Mapper (SAM) and Maximum Like- lihood Classifier (MLC) for time series image based on full samples test method. SAM has higher classification accu- racy and stability than MLC in dealing with time series image. The accuracy and Kappa of tobacco coverage extracted by SAM are 83.4% and 0.692 respectively, which can achieve the accuracy required by tobacco coverage measurement in a large area.
基金supported by grants from China Cancer Research Foundation Y-N2013-008the Doctoral Program of the Ministry of Education 20130001110089 to DR Xiu+1 种基金the National Natural Science Foundation of China 81272709 to W FuPeking University Third Hospital Grant Y81524-01 to LF Zhang
文摘Objective： To investigate the frequency of parasympathetic neurogenesis and determine its association with tumor budding and prognosis in pancreatic ductal adenocarcinoma （PDAC）. Methods： Parasympathetic neurogenesis was defined as the distribution of abnormal parasympathetic nerves in the stroma tissue. Staining of vesicular acetylcholine transporter （VAChT）, as a marker for parasympathetic neurogenesis, was performed on a representative specimen of the tumor for 59 PDAC patients with available clinical, pathologic, and follow-up information. Three specimens containing normal pancreatic tissues were stained in parallel. The number of parasympathetic nerve fibers was counted in five high-power microscopic fields （5×0.785 mm2）. Cut-offvalues were calculated by receiver operating characteristic curve analysis. Results： VAChT-positive parasympathetic nerve fibers were not seen in the stroma of 3 cases of normal pancreatic tissues. In 59 PDAC cases, the range of parasympathetic neurogenesis was 4-38 fibers/（5×0.785） mm2, with a median of 18 fibers/（5×0.785） mm2. Patients with parasympathetic neurogenesis 〉 15 fibers/（5×0.785） mm2 were defined as the high-density group （39 patients, 66.1%）, and those with parasympathetic neurogenesis 〈15 fibers/（5×0.785） mm2 as the low-density group （20 patients, 33.9%）. The high-density group had a higher occurrence of tumor budding （P=0.001） and a higher rate of early recurrence （P=0.035）. Parasympathetic neurogenesis appeared to be an independent adverse prognostic factor [hazard ratio （HR）=2.45, 95% confidence interval （95% CI）： 1.25-4.81, P=0.009], in addition to American Joint Committee on Cancer （AJCC） stage （P=0.010） and tumor budding （P=0.009）. Conclusions： Parasympathetic neurogenesis is strongly associated with tumor budding and correlates with an adverse prognosis in PDAC.
基金funded by the National Natural Science Foundation of China(Nos.51774326,42177164,41807259,and41702350)Hunan Young Talent(No.2021RC3007)+2 种基金the open fund of Mining Disaster Prevention and Control Ministry Key Laboratory at Shandong University of Science and Technology(No.MDPC201917)the Fundamental Research Funds for the Central Universities of Central South University(No.2019zzts668)the Innovation-Driven Project of Central South University(No.2020CX040)。
文摘Isolated pillars in underground mines are subjected to uniaxial stress,and the load bearing cross-section of pillars is commonly rectangularly shaped.In addition,the uniaxial compression test(UCT)is widely used for determining the basic mechanical properties of rocks and revealing the mechanism of isolated pillar disasters under unidimensional stress.The shape effects of rock mechanical properties under uniaxial compression are mainly quantitatively reflected in the specific shape ratios of rocks.Therefore,it is necessary to study the detailed shape ratio effects on the mechanical properties of rectangular prism rock specimens and isolated pillars under uniaxial compressive stress.In this study,granite,marble and sandstone rectangular prism specimens with various height to width ratios(r)and width to thickness ratios(u)were prepared and tested.The study results show that r and u have a great influence on the bearing ability of rocks,and thin or high rocks have lower uniaxial compressive strength.Reducing the level of r can enhance the u effect on the strength of rocks,and increasing the level of u can enhance the r effect on the strength of rocks.The lateral strain on the thickness side of the rock specimen is larger than that on the width side,which implies that crack growth occurs easily on the thickness side.Considering r and u,a novel strength prediction model of isolated pillars was proposed based on the testing results,and the prediction model was used for the safety assessment of 179 isolated pillars in the Xianglu Mountain Tungsten Mine.
基金Supported by Capital Medical Science Development Funds of China,No.2009-3027
文摘This study was conducted to explore the feasibility of partial pancreatic head resection and Roux-en-Y pancreatic jejunostomy for the treatment of benign tumors of the pancreatic head(BTPH). From November 2006 to February 2009, four patients(three female and one male) with a mean age of 34.3 years(range: 21-48 years) underwent partial pancreatic head resection and Roux-en-Y pancreatic jejunostomy for the treatment of BTPH(diameters of 3.2-4.5 cm) using small incisions(5.1-7.2 cm). Preoperative symptoms include one case of repeated upper abdominal pain, one case of drowsiness and two cases with no obvious preoperative symptoms. All four surgeries were successfully performed. The mean operative time was 196.8 min(range 165-226 min), and average blood loss was 138.0 m L(range: 82-210 m L). The mean postoperative hospital stay was 7.5 d(range: 7-8 d). In one case, the main pancreatic duct was injured. Pathological examination confirmed that one patient suffered from mucinous cystadenoma, one exhibited insulinoma, and two patients had solid-pseudopapillary neoplasms. There were no deaths or complications observed during the perioperative period. All patients had no signs of recurrence of the BTPH within a follow-up period of 48-76 mo and had good quality of life without diabetes. Partial pancreatic head resection with Roux-en-Y pancreatic jejunostomy is feasible in selected patients with BTPH.
基金Supported by the National Key Research and Development Program of China,No.2016YFA0100501the National Natural Science Foundation of China,No.81770768 and No.81970671and the Natural Science Foundation of Beijing,No.7192225.
文摘Diabetes,one of the most common chronic diseases in the modern world,has pancreaticβcell deficiency as a major part of its pathophysiological mechanism.Pancreatic regeneration is a potential therapeutic strategy for the recovery ofβcell loss.However,endocrine islets have limited regenerative capacity,especially in adult humans.Almost all hypoglycemic drugs can protectβcells by inhibitingβcell apoptosis and dedifferentiation via correction of hyperglycemia and amelioration of the consequent inflammation and oxidative stress.Several agents,including glucagon-like peptide-1 andγ-aminobutyric acid,have been shown to promoteβcell proliferation,which is considered the main source of the regeneratedβcells in adult rodents,but with less clarity in humans.Pancreatic progenitor cells might exist and be activated under particular circumstances.Artemisinins andγ-aminobutyric acid can induceα-to-βcell conversion,although some disputes exist.Intestinal endocrine progenitors can transdeterminate into insulin-producing cells in the gut after FoxO1 deletion,and pharmacological research into FoxO1 inhibition is ongoing.Other cells,including pancreatic acinar cells,can transdifferentiate intoβcells,and clinical and preclinical strategies are currently underway.In this review,we summarize the clinical and preclinical agents used in different approaches forβcell regeneration and make some suggestions regarding future perspectives for clinical application.
文摘目的:探讨头针联合推拿法治疗帕金森病(Parkinson’s Disease,PD)的临床效果。方法:以2020年9月-2021年10月医院收治的80例PD患者为试验对象,按照随机信封法分为对照组:40例,常规西医治疗;试验组:40例,常规西医联合头针、推拿治疗。比较两组临床疗效、帕金森病综合量表(Unified Parkinson's Disease Rating Scale,UPDRS)评分、5-羟色胺(5-hydroxytryptamine,5-HT)水平、运动功能、生活质量。结果:治疗后,试验组临床总有效率95.00%(38/40)高于对照组85.00%(34/40)(P>0.05);UPDRS评分低于对照组(P<0.05);5-HT水平(279.34±25.07)ng/mL高于对照组(230.47±22.39)ng/mL(P<0.05);Berg平衡量表评分(Berg Balance Scale,BBS)(42.07±5.08)分高于对照组(37.24±4.59)分(P<0.05);6分钟步行距离(194.37±30.64)m长于对照组(162.47±20.10)m(P<0.05);健康调查简表(The Mos 36-item Short From Health Survey,SF-36)各维度评分均高于对照组(P<0.05)。结论:在常规西医治疗基础上,给予帕金森病患者中医头针联合推拿疗法,临床效果显著,可有效增强患者运动平衡能力,改善机体5-HT水平,提高生活质量。
文摘目的分析血清C反应蛋白(CRP)、白细胞介素(IL)-6、IL-10联合检测诊断腹腔镜结直肠癌术后吻合口瘘的临床价值。方法117例行腹腔镜手术治疗的结直肠癌患者,根据术后是否出现吻合口瘘分为吻合口瘘组(15例)和非吻合口瘘组(102例)。两组均采用免疫比浊法检测血清CRP水平,采用放射免疫法检测血清IL-6水平,采用酶联免疫吸附法检测血清IL-10水平。比较两组患者不同时间点血清CRP、IL-6、IL-10水平,采用受试者工作特征(ROC)曲线分析单一及联合检测诊断吻合口瘘的价值。结果术后3、4、5、6、7 d,吻合口瘘组患者血清CRP水平分别为(74.50±12.17)、(84.07±14.56)、(93.25±17.18)、(90.14±15.44)、(78.32±11.23)mg/L,均明显高于非吻合口瘘组的(50.74±9.34)、(44.18±7.92)、(39.94±6.73)、(31.63±4.97)、(25.03±3.65)mg/L,差异具有统计学意义(P<0.05)。吻合口瘘组患者血清CRP水平在术后5 d达到最高峰值,而非吻合口瘘组患者术后3 d即达到最高峰值。术后3、4、5、6、7 d,吻合口瘘组患者血清IL-6水平分别为(103.77±15.68)、(81.38±12.64)、(75.05±10.21)、(63.21±8.53)、(54.22±7.33)ng/L,均明显高于非吻合口瘘组的(71.43±10.29)、(63.46±9.15)、(51.24±7.87)、(43.36±6.07)、(34.16±5.42)ng/L,差异具有统计学意义(P<0.05)。两组患者血清IL-6水平均在术后3 d均达到最高峰值。术后3、4、5、6、7 d,吻合口瘘组患者血清IL-10水平分别为(24.35±3.12)、(26.89±3.75)、(28.87±4.12)、(30.61±5.02)、(34.14±5.92)ng/ml,均明显低于非吻合口瘘组的(28.57±3.91)、(30.62±4.17)、(33.94±4.56)、(35.27±5.74)、(39.05±6.11)ng/ml,差异具有统计学意义(P<0.05)。两组患者血清IL-10水平在术后3 d均达到最低值。ROC曲线分析显示:术后5 d CRP+术后3 d IL-6+术后3 d IL-10联合检测的曲线下面积(AUC)、灵敏度及特异度均高于术后5 d CRP、术后3 d IL-6、术后3 d IL-10单一检测。结论术后5 d CRP、术后3 d IL-6和IL-10联合检测诊断腹腔镜结直肠癌术后吻合口瘘的价值较高,具有一定的临床应用前景。
文摘Failure of irregular rock samples may provide implications in the rapid estimation of rock strength,which is imperative in rock engineering practice.In this work,analytical,experimental and numerical investigations were carried out to study the mechanical properties and failure characteristics of rock spheres under paired point loads.Analytical solutions indicted that with the increase in sample size(contact angle)and decrease in Poisson’s ratio,the uneven tensile stress in theta direction decreased.Then laboratory experiments were carried out to investigate the load characteristics and failure mode of spherical marble samples with different sizes subjected to a pair of diametral point loads.The discrete element method(DEM)was adopted to study the failure process of rock spheres.The effect of the sphere diameter on the point load contact angle was examined in terms of peak load,crushed zone distribution and energy dissipation.Experimental and numerical results showed that the samples primarily fail in tension,with crushed zones formed at both loading points.With increase in the sample size,the contact angle,crushed area and total work increase.As the specimen diameter increases from 30 mm to 50 mm,the peak load on the specimen increases from 3.6 kN to 8.8 kN,and the percentage of crushed zone(ratio of crushing zone to sample radius,d/r)increased from 0.191 to 0.262.The results of the study have implications for understanding the failure of irregular rock specimens under point loading conditions and their size effects.
