超声人工智能联合剪切波弹性成像用于乳腺结节良恶性鉴别诊断临床研究

目的:探讨超声人工智能(AI)联合剪切波弹性成像(SWE)在乳腺结节良恶性鉴别诊断中的临床效能。方法:回顾性分析200例乳腺良恶性肿瘤患者(共206个结节)的数据,所有病灶均接受SWE及超声AI检查。结果:经病理组织学检查确诊恶性肿瘤98个(47.57%),良性肿瘤108个(52.43%)。乳腺恶性病灶的弹性模量相关指标及AI辅助评分均显著高于良性病灶(P<0.05)。ROC曲线分析显示,SWE与超声AI在乳腺结节良恶性鉴别诊断中均有效,且二者联合使用的效能优于单一指标(P<0.05)。结论:超声AI与SWE联合使用可提高乳腺结节良恶性的鉴别诊断效能。

Lower synaptic density associated with gaming disorder:an^(18)F-SynVesT-1 PET imaging study

Background Internet gaming disorder(IGD)is an ideal model to study the mechanisms underlying synaptic deficits in addiction as it eliminates the confounding effects of substance use.Synaptic loss and deficits are hypothesised to underlie the enduring maladaptive behaviours and impaired cognitive function that contribute to IGD.Aims This study aimed to determine whether subjects with IGD have lower synaptic density than control subjects and the relationship between synaptic density and IGD severity.Methods Eighteen unmedicated subjects diagnosed with current IGD according to the Diagnostic and Statistical Manual of Mental Disorders,Fifth Edition criteria and 16 demographically matched healthy controls(HCs)participated in the study and underwent 18F-labelled difluoro-analogue of UCB-J(18F-SynVesT-1)positron emission tomography scans to assess the density of synaptic vesicle glycoprotein 2A(SV2A).The Internet Gaming Disorder Scale-Short Form(IGDS9-SF),Hamilton Rating Scale for Depression(HAMD),Hamilton Anxiety Rating Scale(HAMA),Barratt Impulsiveness Scale Version 11(BIS-11),Stroop Colour-Word Test(SCWT),stop-signal paradigms and N-back tasks were administered to all subjects.Results Patients with IGD had significantly higher scores on the IGDS9-SF,HAMD,HAMA and BIS-11 than HCs.HCs performed better on the two-back and SCWT tests as well as in terms of stop-signal reaction times(SSRTs)in the stop-signal paradigms than patients with IGD.Lower uptake was found in the bilateral putamen,right pregenual anterior cingulate cortex and Rolandic operculum of patients with IGD compared with HCs.Furthermore,in the IGD group,IGDS9-SF scores and daily gaming hours were negatively correlated with the standardised uptake value ratios of 18F-SynVesT-1 in the bilateral putamen.Longer SSRTs were significantly associated with lower SV2A density in the right pregenual anterior cingulate cortex and right Rolandic operculum.Conclusions The in vivo results in this study suggest that lower synaptic density contributes to the severity and impairments in inhibitory control of IGD.These findings may provide further incentive to evaluate interventions that restore synaptic transmission and plasticity to treat IGD.

Effect of colorectal cancer stem cells on the development and metastasis of colorectal cancer

The relevant mechanism of tumor-associated macrophages(TAMs)in the treatment of colorectal cancer patients with immune checkpoint inhibitors(ICIs)is discussed,and the application prospects of TAMs in reversing the treatment tolerance of ICIs are discussed to provide a reference for related studies.As a class of drugs widely used in clinical tumor immunotherapy,ICIs can act on regulatory molecules on cells that play an inhibitory role-immune checkpoints-and kill tumors in the form of an immune response by activating a variety of immune cells in the immune system.The sensitivity of patients with different types of colorectal cancer to ICI treatment varies greatly.The phenotype and function of TAMs in the colorectal cancer microenvironment are closely related to the efficacy of ICIs.ICIs can regulate the phenotypic function of TAMs,and TAMs can also affect the tolerance of colorectal cancer to ICI therapy.TAMs play an important role in ICI resistance,and making full use of this target as a therapeutic strategy is expected to improve the immunotherapy efficacy and prognosis of patients with colorectal cancer.

Extended survival with metastatic pancreatic cancer under fruquintinib treatment after failed chemotherapy:Two case reports

BACKGROUND Pancreatic cancer is a highly malignant disease.After decades of treatment progress,the current five-year survival rate for patients is still less than 10%.For later-line treatment,the treatment options are even more limited.Anti-angiogenic drugs can improve progression-free survival in patients with advanced pancreatic cancer.Preclinical data show that fruquintinib might improve the prognosis of advanced pancreatic cancer by targeting angiogenesis and lymphopoiesis,improving the abnormal vascular structure,and modulating the tumour immune microenvironment.CASE SUMMARY We present two cases of third-line fruquintinib monotherapy that brought an extraprolonged progress-free survival(PFS)of 10 months.Patient 1 took adjuvant gemcitabine-based and first-line nab-paclitaxel-based chemotherapy and then used local radiotherapy combined with programmed cell death 1 receptor(PD-1).Each line lasted approximately 7 months.Moreover,the patient took third-line fruquintinib,which was followed by stable disease for 10 months,during which no additional adverse effect was observed.The patient later refused to take fruquintinib due to difficulty urinating and lower abdominal pain after the coronavirus disease 2019(COVID-19)infection.The patient died in February 2023.Patient 2 also took two prior lines of chemotherapy and then local radiotherapy combined with S-1.After confirmed disease progression,the patient experienced a continuous partial response after using fruquintinib monotherapy in the third line.After the patient had COVID-19 in December 2022,fruquintinib was discontinued.The patient died in January 2023 due to disease progression.CONCLUSION Both cases achieved a PFS benefit from later-line single-agent fruquintinib therapy.With its better safety profile,fruquintinib may be worth exploring and studying in more depth as a later-line treatment for pancreatic cancer patients.

Analysis of alkaline phosphatase and γ-glutamyltransferase after radiofrequency ablation of primary liver cancer: A retrospective study

BACKGROUND Changes in alkaline phosphatase(ALP)andγ-glutamyltransferase(GGT)levels in patients with primary liver cancer(PLC)after radiofrequency ablation(RFA).Hepatocellular carcinoma is a malignant tumor with high incidence worldwide.As a common local treatment,RFA has attracted much attention for its efficacy and influence on liver function.AIM To investigate the effect of serum ALP and GGT levels on the prognosis of patients with PLC treated by RFA.METHODS The preoperative clinical data of 165 patients who were pathologically or clinically diagnosed with PLC and who received RFA in our hospital between October 2018 and June 2023 were collected.The chi-square test was used to compare the data between groups.The Kaplan-Meier method and Cox regression were used to analyze the associ-ations between serum ALP and GGT levels and overall survival,progression-free survival(PFS)and clinical characteristics of patients before treatment.RESULTS The 1-year survival rates of patients with normal(≤135 U/L)and abnormal(>135 U/L)serum ALP before treatment were 91%and 79%,respectively;the 2-year survival rates were 90%and 68%,respectively;and the 5-year survival rates were 35%and 18%,respectively.The difference between the two groups was statistically significant(P=0.01).Before treatment,the 1-year survival rates of patients with normal serum GGT levels(≤45 U/L)and abnormal serum GGT levels(>45 U/L)were 95%and 87%,the 2-year survival rates were 85%and 71%,and the 5-year survival rates were 37%and 21%,respectively.The difference between the two groups was statist-ically significant(P<0.001).Serum ALP[hazard ratio(HR)=1.766,95%confidence interval(95%CI):1.068-2.921,P=0.027]and GGT(HR=2.312,95%CI:1.367-3.912,P=0.002)is closely related to the overall survival of PLC patients after RF ablation and is an independent prognostic factor.The 1-year PFS rates were 72%and 50%,the 2-year PFS rates were 52%and 21%,and the 5-year PFS rates were 14%and 3%,respectively.The difference between the two groups was statistically significant(P<0001).The 1-year PFS rates were 81%and 56%in patients with normal and abnormal serum GGT levels before treatment,respectively;the 2-year PFS rates were 62%and 35%,respectively;and the 5-year PFS rates were 18%and 7%,respectively,with statistical significance between the two groups(P<0.001).The serum ALP concentration(HR=1.653,95%CI:1.001-2.729,P=0.049)and GGT(HR=1.949,95%CI:1.296-2.930,P=0.001)was closely associated with PFS after RFA in patients with PLC.The proportion of male patients with abnormal ALP levels is high,the Child-Pugh grade of liver function is poor,and the incidence of ascites is high.Among GGT-abnormal patients,the Child-Pugh grade of liver function was poor,the tumor stage was late,the proportion of patients with tumors≥5 cm was high,and the incidence of hepatic encephalopathy was high.CONCLUSION Serum ALP and GGT levels before treatment can be used to predict the prognosis of patients with PLC after RFA,and they have certain guiding significance for the long-term survival of patients with PLC after radiofrequency therapy.

Efficacy and safety of B-ultrasound-guided radiofrequency ablation in the treatment of primary liver cancer: Systematic review and metaanalysis

BACKGROUND Primary liver cancer is one of the most lethal malignancies in the world.Tradi-tional treatment methods have limitations in terms of efficacy and safety.Ra-diofrequency ablation(RFA)guided by B-ultrasound,as a minimally invasive treatment,has attracted increasing attention in the treatment of primary liver cancer in recent years.AIM To study the efficacy and safety of RFA were compared with those of traditional surgery(TS)for treating small liver cancer.METHODS At least 2 people were required to search domestic and foreign public databases,including foreign databases such as EMBASE,PubMed and the Cochrane Library,and Chinese databases such as the China National Knowledge Infrastructure database,China Biomedical Literature database,Wanfang database and VIP database.Controlled trials of RFA vs conventional surgery for small liver cancer were retrieved from January 2008 to January 2023.They were screened and eva-luated according to the quality evaluation criteria in the Cochrane Handbook of Systematic Reviews.The meta-analysis was performed using RevMan 5.3 soft-ware.RESULTS A total of 10 studies were included in this study,including 1503 patients in the RFA group and 1657 patients in the surgery group.The results of the meta-ana-lysis showed that there was no significant difference in 1-year overall survival between the two groups(P>0.05),while the 3-year and 5-year overall survival rates and 1-year,3-year and 5-year tumor-free survival rates in the surgery group were greater than those in the RFA group(P<0.05).In terms of complications,the incidence of complications in the RFA group was lower than that in the surgery group(P<0.05).CONCLUSION In terms of long-term survival,TS is better than RFA for small liver cancer patients.However,RFA has fewer complications and is safer.

聚己内酯/聚丁内酰胺电纺纤维的制备及性能

通过溶液静电纺丝法制备了聚己内酯/聚丁内酰胺(PCL/PBL)电纺纤维膜。采用扫描电子显微镜(SEM)、水相接触角测量仪、原子力显微镜(AFM)、能谱仪(EDS)、透射电子显微镜(TEM)、X射线衍射仪(XRD)、热重分析仪(TGA)、差示扫描量热仪(DSC)、电子万能拉力机对PCL/PBL电纺纤维的形貌、亲疏水性、结晶性能、热性能及力学性能进行了研究。结果表明,随着PBL含量的增加,纤维直径增大、分布变窄,且纤维膜的亲水性明显改善;PCL与PBL有一定相容性,PCL/PBL电纺纤维膜的结晶度高于PCL或PBL均聚物电纺纤维膜,并随PBL含量增加而提高;PCL/PBL电纺纤维膜中PCL熔点随PBL含量增加而略有增加,PBL组分的熔点则基本不变。两组分的结晶温度和纤维膜热稳定性均随PBL含量增加而降低。PBL的加入使电纺纤维膜的力学性能明显提高。

基于弯曲定径带模具挤压的Mg-3Al-1Zn合金力学性能优化

设计了一种采用弯曲定径带模具的新型非对称挤压工艺(TBE),用以改善Mg-3Al-1Zn合金板材的力学性能和成形性能。运用有限元分析揭示了挤压过程中的应变、温度等状态变量的分布。结果表明,在TBE模具的模口处,应变沿板面法向(ND)呈梯度分布,这导致挤压板材显微组织的厚向梯度分布,同时得到TD择优取向的织构,少量基面取向晶粒向挤压方向(ED)偏转。与传统挤压相比,TBE过程中产生更多挤压热,模腔内温度更高,使大量非基面滑移开启,导致板材TD择优取向织构的形成。通过改善织构,TBE板材的塑性和弯曲性能均得到明显提升,沿45°方向的伸长率达到33%,弯曲角度达到83.5°。

Compared discharge characteristics and film modifications of atmospheric pressure plasma jets with two different electrode geometries

Atmospheric pressure plasma jet shows great potential for polymer film processing. The electrode geometry is the key factor to determine discharge characteristics and film modification of jets. In this paper, we compared the discharge characteristics and the film modifications of atmospheric pressure plasma jets with needle-ring electrode(NRE) and doublering electrode(DRE). The results show that jet with NRE has stronger electric field intensity and higher discharge power,making it present more reactive oxygen particles and higher electron temperature, but its discharge stability is insufficient.In contrast, the jet with DRE has uniform electric field distribution of lower field intensity, which allows it to maintain stable discharge over a wide range of applied voltages. Besides, the modification results show that the treatment efficiency of PET film by NRE is higher than that by DRE. These results provide a suitable atmospheric pressure plasma jets device selection scheme for polymer film processing process.

二维超声、弹性成像及超声造影诊断桥本氏甲状腺炎伴发良恶性结节的价值

目的探讨单独二维超声、弹性成像、超声造影及其联合检查在桥本氏甲状腺炎合并良恶性结节中的诊断价值。方法对44例桥本氏甲状腺炎患者的54个结节分别行二维超声、弹性成像及超声造影检查,并与病理结果进行对照分析,计算并比较单独二维超声、弹性成像、超声造影及三者联合应用对桥本氏甲状腺炎合并良恶性结节的诊断效能。结果以TI-RADS 4、5类作为二维超声诊断恶性结节的标准,其诊断敏感性、特异性及准确率分别为50.0%、82.5%、74.0%;以结节杨氏模量值≥46.1 kPa作为剪切波弹性成像预测恶性结节的标准,其诊断敏感性、特异性及准确率分别为57.1%、85.0%、77.7%;以不均匀性低增强作为超声造影诊断恶性结节的标准,其诊断敏感性、特异性及准确率分别为64.3%、80.0%、75.9%;三种方法联合检查的诊断敏感性、特异性及准确率分别为85.7%、95.0%、92.5%。联合检查的准确率高于单一检查,差异均有统计学意义(均P<0.05)。结论不同超声技术联合检查较单一检查对桥本氏甲状腺炎合并良恶性结节有更高诊断价值,值得进一步推广应用。

实时剪切波弹性成像技术在评价盆底肌肉功能中的效能初探

目的:探讨实时剪切波弹性成像技术(SWE)在评价盆底肌肉功能中的效能。方法:选取61例女性患者为研究对象,均接受问卷调查、盆底超声检查、盆底肌力测试及耻骨直肠肌(PR)剪切波弹性成像检查。以肌力是否正常分为肌力正常组(n=22)和肌力异常组(n=39)。利用SWE获取两侧PR静息状态及最大收缩状态耻骨下支附着处和中部的剪切波速度值(SWV)及杨氏模量值(YM),取其平均值,分别计算两种状态所得SWV及YM的差值,分析盆底肌力变化与PR不同状态的SWV、YM及其差值的关系。结果:女性患者PR相同部位最大收缩状态SWV及YM大于静息状态,差异有统计学意义(P<0.05)。静息状态下,肌力正常组PR相同部位SWV及YM与肌力异常组比较,差异无统计学意义(P>0.05)。最大收缩状态下,肌力正常组PR两侧耻骨下支附着处及左侧中部SWV、YM与肌力异常组比较,差异有统计学意义(P<0.05)。两组间PR相同部位比较,肌力正常组PR两侧耻骨下支附着处两种状态SWV及YM的差值较肌力异常组大,差异有统计学意义(P<0.05)。两组PR中部SWV及YM的差值比较,差异无统计学意义(P>0.05)。结论:SWE能够敏感探测到PR力量的改变,PR两侧耻骨下支附着处弹性值的变化对评价盆底肌肌力变化更有价值。

聚乳酸/聚丁内酰胺电纺核-壳结构纤维的制备及性能

通过溶液静电纺丝法制备了基于聚L-乳酸/聚丁内酰胺(PLLA/PBL)共混体系的全生物基可降解纤维。通过扫描电子显微镜(SEM)、接触角测试、差示扫描量热(DSC)、X射线衍射(XRD)、透射电子显微镜(TEM)以及全反射红外光谱(ATR)等方法,表征并分析了PLLA与PBL的共混比例对纤维形貌、直径、亲水性、热性能及结晶性能的影响,并研究了共混纤维的内部结构。结果表明:PLLA与PBL以不同比例共混电纺均可得到形貌均匀的纤维,PLLA/PBL共混纤维的直径低于纯PLLA纤维的直径,且PLLA/PBL共混纤维的平均直径随PBL含量的增加而减小;PBL的加入没有明显改善PLLA/PBL共混纤维的亲水性,但对纤维中PLLA组分的结晶以及晶体的完善有阻碍作用;电纺过程中溶剂挥发导致的相分离使PLLA/PBL共混纤维形成了以PLLA为壳、PBL为核的核-壳结构。

An R2R3-type transcription factor gene AtMYB59 regulates root growth and cell cycle progression in Arabidopsis

MYB proteins play important roles in eukaryotic organisms. In plants, the R1R2R3-type MYB proteins function in cell cycle control. However, whether the R2R3-type MYB protein is also involved in the cell division process remains unknown. Here, we report that an R2R3-type transcription factor gene, AtMYB59, is involved in the regulation of cell cycle progression and root growth. The AtMYB59 protein is localized in the nuclei of onion epidermal cells and has transactivation activity. Expression of AtMYB59 in yeast cells suppresses cell proliferation, and the transfor- mants have more nuclei and higher anenpioid DNA content with longer cells. Mutation in the conserved domain of AtMYB59 abolishes its effects on yeast cell growth. In synchronized Arabidopsis cell suspensions, the AtMYB59 gene is specifically expressed in the S phase during cell cycle progression. Expression and promoter-GUS analysis reveals that the AtMYB59 gene is abundantly expressed in roots. Transgenic plants overexpressing AtMYB59 have shorter roots compared with wild-type plants （Arabidopsis accession Col-0）, and around half of the mitotic cells in root tips are at metaphase. Conversely, the null mutant myb59-1 has longer roots and fewer mitotic cells at metaphase than Col, suggesting that AtMYB59 may inhibit root growth by extending the metaphase of mitotic cells. AtMYB59 regulates many downstream genes, including the CYCB1;1 gene, probably through binding to MYB-responsive elements. These results support a role forAtMYB59 in cell cycle regulation and plant root growth.

Energy Efficient Power Allocation for Relay-Aided D2D Communications in 5G Networks

As one of the key technologies for the fifth generation(5G) wireless networks,device-to-device(D2D) communications allow user equipment(UE) in close proximity to communicate with each other directly.Forwarded by a relay,the relay-aided D2D(RA-D2D) communications can not only be applied to communications in much longer distance but also achieve a high quality of service(Qo S) .In this paper,we first propose a two-layer system model allowing RA-D2 D links to underlay traditional cellular uplinks.Then we maximize the energy efficiency of the RA-D2 D link while satisfying the minimum data-rate of the cellular link.The optimal transmit power at both D2 D transmitter and D2 D relay sides is obtained by transforming the nonlinear fractional programming into a nonlinear parameter programming.Simulation results show that our proposed power allocation method is more energy efficient than the existing works,and the proposed RA-D2 D scheme outperformed direct D2 D scheme when the distance between two D2 D users is longer.

Immune checkpoint inhibitors in cancer therapy

In recent years immune checkpoint inhibitors have garnered attention as being one of the most promising types of immunotherapy on the horizon. There has been particular focus on the immune checkpoint molecules, cytotoxic Tlymphocyte antigen-4（CTLA-4） and programmed cell death protein 1（PD-1） which have been shown to have potent immunomodulatory effects through their function as negative regulators of T cell activation. CTLA-4, through engagement with its ligands B7-1（CD80） and B7-2（CD86）, plays a pivotal role in attenuating the activation of naive and memory T cells. In contrast, PD-1 is primarily involved in modulating T cell activity in peripheral tissues via its interaction with PD-L1 and PD-L2. The discovery of these negative regulators of the immune response was crucial in the development of checkpoint inhibitors. This shifted the focus from developing therapies that targeted activation of the host immune system against cancer to checkpoint inhibitors, which aimed to mediate tumor cell destruction through the removal of coinhibitory signals blocking anti-tumor T cell responses.

Discharge properties of Mg-Sn-Y alloys as anodes for Mg-air batteries

Mg-Sn-Y alloys with different Sn contents(wt%)were assessed as anode candidates for Mg-air batteries.The relationship between microstructure(including the second phase,grain size,and texture)and discharge properties of the Mg-Sn-Y alloys was examined using microstructure observation,electrochemical measurements,and galvanostatic discharge tests.The Mg-0.7Sn-1.4Y alloy had a high steady discharge voltage of 1.5225 V and a high anodic efficiency of 46.6% at 2.5 mA·cm^(-2).These good properties were related to its microstructure:small grain size of 3.8μm,uniform distribution of small second phase particles of 0.6μm,and a high content(vol%)of(1120)/(1010)orientated grains.The scanning Kelvin probe force microscopy(SKPFM)indicated that the Sn_(3)Y_(5) and MgSnY phases were effective cathodes causing micro-galvanic corrosion which promoted the dissolution of Mg matrix during the discharge process.

Prediction of coal structure using particle size characteristics of coalbed methane well cuttings

Severely deformed coal seams barely deliver satisfactory gas production. This research was undertaken to develop a new method to predict the positions of deformed coals for a horizontal CBM well. Firstly, the drilling cuttings of different structure coals were collected from a coal mine and compared. In light of the varying cuttings characteristics for different structure coals, the coal structure of the horizontally drilled coal seam was predicted. And the feasibility of this prediction method was discussed. The result shows that exogenetic fractures have an important influence on the deformation of coal seams. The hardness coefficient of coal decreases with the deformation degree in the order of primary structural, cataclastic and fragmented coal. And the expanding-ratio of gas drainage holes and the average particle size of cuttings increase with the increase of the deformation degree. The particle size distribution of coal cuttings for the three types of coals is distinctive from each other. Based on the particle size distribution of cuttings from X-2 well in a coal seam, six sections of fragmented coal which are unsuitable for perforating are predicted. This method may benefit the optimization of perforation and fracturing of a horizontal CBM well in the study area.

Enhanced mechanical properties of Mg-3Al-1Zn alloy sheets through slope extrusion

A novel extrusion approach,entitled slope extrusion(SE),was employed to manufacture AZ31(Mg-3Al-1 Zn,wt%)alloy sheets.The microstructures,textures,and mechanical properties were investigated,compared with those of the AZ31 sheet fabricated by conventional extrusion(CE).Through the combination of finite element simulation and actual experiment,the ultimate results indicated that significant grain refinement(from 9.1 to 7.7 and 5.6μm)and strong basal texture(from 12.6 to 17.6 and 19.5 mrd)were achieved by the SE process.The essence was associated with the additional introduced inclined interface in the process of SE,which could bring about more asymmetric deformation and stronger accumulated strain along the ND when compared with the process of CE.As a consequence,the SE sheets exhibited a higher yield strength(YS)and ultimate tensile strength(UTS)than the counterparts of the CE sheet,which was mainly assigned to the synergistic effects from grain refining and texture strengthening.

Improving the room-temperature bendability of Mg-3Al-1Zn alloy sheet by introducing a bimodal microstructure and the texture re-orientation

A significant enhancement of bendability was achieved by the introduction of bimodal microstructure for AZ31B alloy sheets via pre-compression and subsequent annealing(PCA)process.This combined treatment led to the c-axis of the extracted samples that were inclined by 30°to the rolling direction(30°sample)further shifting toward the rolling direction(RD)and resulting in a higher Schmid factor(SF)value of basal slip under the RD tensile stress.Furthermore,the bimodal microstructure that was introduced by the PCA process broke the damage bands(DBs)in the initial hot rolled AZ31B alloy sheets and gave rise to a more uniform strain distribution in the outer tension region of the bending samples,in which the tensile deformation was accommodated by the equally distributed{101^(-)2}tension twinning and basal slip.Consequently,the bimodal microstructure,shifted basal texture and the modification of DBs were responsible for the significant enhancement in the bendability of the AZ31 alloys.

粉末直接压片法制备盐酸曲美他嗪分散片

采用粉末直接压片法制备了盐酸曲美他嗪分散片,为流动性差的原料药提供粉末直接压片技术,为盐酸曲美他嗪提供新型片剂。采用药物与多孔性载体预混的方法提高原料药的流动性,使用新型辅料改善药物整体流动性及可压性,制备质量符合要求的盐酸曲美他嗪分散片。将原料药与胶态二氧化硅预混后,再与其他优良的直压辅料混匀,制得的分散片崩解及溶出均比市售片加快。结果表明:采用粉末直接压片法制备盐酸曲美他嗪分散片,工艺简单,节约成本,提高了经济效益;制得的分散片口感良好,崩解迅速,携带方便,提高了老人、儿童及吞咽困难患者的顺应性。