Site testing campaign for the Large Optical/infrared Telescope of China:general introduction of the Daocheng site

The Daocheng site is one of the three candidate sites for the Large Optical/infrared Telescope(LOT)of China.It was discovered by Yunnan Observatories during the survey of potential sites for the next-generation large-aperture solar telescopes of China.This paper describes the overview of the site,the observation platform and the monitor instrument.In addition,simple statistical results are presented(from November,2016 up to December,2017).Detailed data results can refer to the overview of LOT site testing and data analysis articles,which were published during the same period.

On the Relation Between Coronal Green Line Brightness and Magnetic Fields Intensity

Two-dimensional(2 D) solar coronal magnetogram is difficult to be measured directly until now.From the previous knowledge,a general relation has been noticed that the brighter green-line brightness for corona,the higher coronal magnetic field intensity may correspond to.To try to further reveal the relationship between coronal green line brightness and magnetic field intensity,we use the 2 D coronal images observed by Yunnan Observatories Greenline Imaging System(YOGIS) of the 10 cm Lijiang coronagraph and the coronal magnetic field maps calculated from the current-free extrapolations with the photospheric magnetograms taken by Helioseismic and Magnetic Imager(HMI) on board the Solar Dynamics Observatory(SDO) spacecraft.In our analysis,we identified the coronal loop structures and construct two-dimensional maps of the corresponding magnetic field intensity in the plane of the sky(POS) above the limb.We derive the correlation coefficients between the coronal brightness and the magnetic field intensity for different heights of coronal layers.We further use a linear combination of a Gaussian and a quadratic profile to fit the correlation coefficients distribution,finding a largest correlation coefficient of 0.82 near 1.1 R(solar radii) where is almost the top of the closed loop system.For the small closed loop system identified,the correlation coefficient distributions crossing and covering the loop are calculated.We also investigate the correlation with extended heliocentric latitude zones and long period of one whole Carrington Rotation,finding again that the maximum correlation coefficient occurs at the same height.It is the first time for us to find that the correlation coefficients are high(all are larger than 0.8) at the loop-tops and showing poor correlation coefficients with some fluctuations near the feet of the coronal loops.Our findings indicate that,for the heating of the low-latitude closed loops,both DC(dissipation of currents) and AC(dissipation of Alfvén and magnetosonic waves) mechanisms should act simultaneously on the whole closed loop system while the DC mechanisms dominate in the loop-top regions.Therefore,in the distributions of the correlation coefficients with different heights of coronal layers,for both large-and small-scale latitude ranges,the coefficients can reach their maximum values at the same coronal height of 1.1 R,which may indicate the particular importance of the height of closed loops for studying the coupling of the local emission mechanism and the coronal magnetic fields,which maybe helpful for studying the origin of the low-speed solar wind.

参麦注射液联合右旋糖酐、阿司匹林在预防颈动脉内膜剥脱术后并发症中的应用价值

目的探讨围手术期应用参麦注射液联合右旋糖酐、阿司匹林预防颈动脉内膜剥脱(CEA)术后并发症中的应用价值。方法回顾性分析齐齐哈尔医学院附属第三医院接受在CEA手术治疗的颈动脉狭窄患者122例作为观察对象,根据患者围手术期处理措施分为A、B、C 3组,A组39例仅施行建立临时转流的CEA手术,B组35例CEA术后早期应用右旋糖酐与阿司匹林抗凝抗栓治疗方案,C组48例CEA围手术期静滴参麦注射液,术后早期应用右旋糖酐与阿司匹林抗凝抗栓方案,比较3组治疗效果及并发症发生情况。结果 3组患者术后6个月头晕、视力模糊、面部针扎感、上肢沉重感、大脑中动脉收缩期峰值、颈动脉收缩期峰值比较差异无统计学意义(P>0.05)。3组患者围手术期在过度灌注、局部血肿、脑组织损伤和心率、血压降低各项比较差异无统计学意义(P>0.05),在主要并发症发生情况总体比较中差异有统计学意义(P <0.05),组间两两比较,A组与C组比较,B组与C组比较,差异均有统计学意义(P <0.0167)。术后脑卒中、心肌梗死、死亡的比较差异无统计学意义(P>0.05),总体发生情况的比较差异有统计学意义(P <0.05),组间两两比较,A组与C组比较,B组与C组比较,差异均有统计学意义(P <0.0167)。3组患者在1年后随访致残、致死性卒中,以及总体情况比较差异无统计学意义(P>0.05)。结论 CEA围手术期应用参麦注射液联合右旋糖酐、阿司匹林可有效降低CEA围手术期并发症及不良结局发生率,并且对手术治疗效果无影响,具有临床应用及推广价值。

Comparison of the Coronal Green-line Intensities with the EUV Measurements from SDO/AIA

The intensity of the green line(Fe ⅩⅣ 5303 A) is the strongest in the visible spectrum of the solar corona,and this line has been used as long-term powerful diagnostic tools for studying the coronal configurations and hot plasma dynamics.However,it remains unclear and an open question whether there exists close relationship between the green line intensities and the coronal extreme ultraviolet(EUV) line emissions for various coronal structures.In this paper,we use the green-line data by the Lijiang YOGIS Lyot coronagraph and the EUV data from the Solar Dynamics Observatory/Atmospheric Imaging Assembly instruments in order to perform direct comparisons and analyses,based on two algorithms developed to extract particular features in the low corona.It is found that,among the correlation coefficients obtained between the intensities of 5303 A and the EUV lines,the coefficients between the green line and the 211 A wavelength for different coronal structures and different limb locations always keep the highest values(ranging from 0.89 to 0.99),which has not been reported before.This result can be helpful and promising to link together the various physical processes involved at different heights in the corona by precisely tracking the bright loops or other features observed in 5303 A above the limb down to the correct surface locations revealed by the 211 A data.Furthermore,the ground-based observations of the coronal green line and the space-based EUV observations at 211 A can advantageously complement each other when there is a need.

The effect of Wujiadan Recipe on serum sex hormone and expression of Kiss-1, GPR54 and GnRH in arcuate nucleus of hypothalamus in ovariectomized rats

Objective:To explore the effect of wujiadan Recipe on the expression of FSH,E2 in serum and KiSS-1,GPR54,GnRH mRNA in hypothalamic arcuate nucleus tissue homogenate of ovariectomized rats,and to further explore the mechanism of wujiadan Recipe on menopausal syndrome.Methods:Sixty-four adult female rats were randomly divided into three groups:blank group,model group,Chinese medicine control group,western medicine control group,and wujiadan high,medium and low dose groups.Except for the blank group,all the other groups were ovariectomized.The rats in the normal group and the model group were given the same dose of saline once a day.One rat in the blank group died during the experiment.After 4 weeks of continuous administration,blood was collected from abdominal aorta and brain stereotaxic localization was performed to preserve the arcuate nucleus of hypothalamus.The levels of FSH and E2 in serum were detected by enzyme-linked immunosorbent assay(ELISA),and the expression of Kiss-1,GPR54 and GnRH mRNA in arcuate nucleus of hypothalamus were detected by PCR.Results:1.Compared with the blank group,FSH level in the model group was significantly higher(P<0.01),and E2 level was significantly lower(P<0.01).Compared with the model group,the level of serum E2 in the western medicine control group increased significantly(P.The serum FSH content in each group decreased,especially in the high dose group and the western medicine control group(P<0.01),and in the Chinese medicine control group,the middle dose group and the low dose group(P<0.05).Compared with the blank group,the expression of KiSS-1 mRNA,GPR54 mRNA and GnRH mRNA in the model group increased significantly(P<0.01);compared with the model group,the expression of KiSS-1 mRNA and GPR54 mRNA in the high dose group,middle dose group and Western medicine control group of wujiadan prescription decreased significantly(P<0.05).Compared with the model group,the expression of GnRH mRNA in the high dose group and the western medicine control group decreased significantly(P<0.01);the middle dose group of wujiadan decreased significantly(P<0.05).Conclusion:Wujiadan recipe can improve the serum sex hormone level of castrated rats,and reduce the over expression of KiSS-1,GPR54 and GnRH mRNA in hypothalamic arcuate nucleus of castrated rats,which may be the reproductive endocrine mechanism of wujiadan recipe in the treatment of menopausal syndrome.

Study on the effect of Baiban Ointment on the whole gene expression profile of vulvar sclerosing lichen

Objective:To study the effect of Baiban Ointment on gene expression profile of vulvar lichen sclerosus before and after treatment,and to provide theoretical basis for the early diagnosis and clinical treatment of vulvar lichen sclerosus.Methods:Nine patients with vulvar lichen sclerosus diagnosed pathologically were selected as the study object,and the Baiban ointment was applied locally for 3 months.Gene chip technology was used to detect the vulva skin tissue in the same area before and after treatment,and the peripheral normal skin was used as the normal control group to analyze the change of gene expression profile.FC and P values were used as research indicators,and the standard of differential expression was FC value≥1.5,P value<0.05.The differentially expressed genes were screened,and GO analysis and KEGG database gene pathway analysis were carried out.Results:Compared with the normal control group,there were 22 differentially expressed genes in Group A before treatment,of which 21 were up-regulated and 1 was down regulated;compared with Group B before treatment,there were 23 differentially expressed genes,all of which were up regulated.The differentially expressed genes related to Baiban ointment treatment included TBK1、STAT1、ITGAM、VCAN、PRKACB、PROM1、PLAT、SERPINA1.Go analysis showed that the up-regulated differential genes were mainly concentrated in the extracellular exosome,cytosol,extracellular space,Golgi apparatus and other cellular component,using the biological process such as positive regulation of cell metabolism,signal transduction regulation,cell adhesion,etc.,to play a role in protein binding,enzyme activity regulation and other molecular functions.KEGG signaling pathway showed that the differentially expressed genes were significantly enriched in Toll like receptor signaling pathway,Nod like receptor signaling pathway and Fc RI signaling pathway,all of which were up-regulated signaling pathways.Among them,Toll like receptor signaling pathway and Nod like receptor signaling pathway are most closely related to the disease.Conclusion:Baiban ointment may play a role in regulating metabolism,inflammation and immune response by regulating the expression of related genes,affecting the signal transduction such as Toll like receptor signal pathway.The pathway and the genes screened in this study will provide a direction for the future study of this disease.