期刊文献+
共找到3篇文章
< 1 >
每页显示 20 50 100
Radix Ilicis Pubescentis total flavonoids combined with mobilization of bone marrow stem cells to protect against cerebral ischemia/reperfusion injury 被引量:3
1
作者 ming-san miao Lin Guo +1 位作者 Rui-qi Li Xiao Ma 《Neural Regeneration Research》 SCIE CAS CSCD 2016年第2期278-284,共7页
Previous studies have shown that Radix Ilicis Pubescentis total flavonoids have a neuroprotective effect, but it remains unclear whether Radix Ilicis Pubescentis total flavonoids have a synergistic effect with the rec... Previous studies have shown that Radix Ilicis Pubescentis total flavonoids have a neuroprotective effect, but it remains unclear whether Radix Ilicis Pubescentis total flavonoids have a synergistic effect with the recombinant human granulocyte colony stimulating factor-mobilized bone marrow stem cell transplantation on cerebral ischemia/reperfusion injury. Rat ischemia models were administered 0.3, 0.15 and 0.075 g/kg Radix Ilicis Pubescentis total flavonoids from 3 days before modeling to 2 days after injury. Results showed that Radix Ilicis Pubescentis total flavonoids could reduce pathological injury in rats with cerebral ischemia/reperfusion injury. The number of Nissl bodies increased, Bax protein expression decreased, Bcl-2 protein expression increased and the number of CD34-positive cells increased. Therefore, Radix Ilicis Pubescentis total flavonoids can improve the bone marrow stem cell mobilization effect, enhance the anti-apoptotic ability of nerve cells, and have a neuroprotective effect on cerebral ischemia/reperfusion injury in rats. 展开更多
关键词 nerve regeneration Radix Ilicis Pubescentis total flavonoids bone marrow stem cells MOBILIZATION cerebral ischemia/reperfusion Nissl bodies Bax Bcl-2 CD34 neurons neural regeneration
下载PDF
Radix Ilicis Pubescentis total flavonoids ameliorates neuronal damage and reduces lesion extent in a mouse model of transient ischemic attack 被引量:2
2
作者 ming-san miao Lin Guo +1 位作者 Rui-qi Li Xiao-lei Zhang 《Neural Regeneration Research》 SCIE CAS CSCD 2016年第3期441-446,共6页
Flavonoids are a major component in the traditional Chinese medicine Radix Ilicis Pubescentis.Previous studies have shown that the administration of Radix Ilicis Pubescentis total flavonoids is protective in cerebral ... Flavonoids are a major component in the traditional Chinese medicine Radix Ilicis Pubescentis.Previous studies have shown that the administration of Radix Ilicis Pubescentis total flavonoids is protective in cerebral ischemia.However,to our knowledge,no studies have examined whether the total flavonoids extracted from Radix Ilicis Pubescentis prevent or ameliorate neuronal damage following transient ischemic attacks.Therefore,Radix Ilicis Pubescentis total flavonoids question and the potential underlying mechanisms.Thus,beginning 3 days before the induction of a mouse model of transient ischemic attack using tert-butyl hydroperoxide injections,mice were intragastrically administered 0.3,0.15,or 0.075 g/kg of Radix Ilicis Pubescentis total flavonoids daily for 10 days.The results of spectrophotometric analyses demonstrated that Radix Ilicis Pubescentis total flavonoids enhanced oxygen free radical scavenging and reduced pathological alterations in the brain.Hematoxylin-eosin staining results showed that Radix Ilicis Pubescentis total flavonoids reduced hippocampal neuronal damage and cerebral vascular injury in this mouse model of transient ischemic attack.These results suggest that the antioxidant effects of Radix Ilicis Pubescentis total flavonoids alleviate the damage to brain tissue caused by transient ischemic attack. 展开更多
关键词 nerve regeneration transient ischemic attack Radix Ilicis Pubescentis total flavonoids tert-butyl hydroperoxide malondialdehyde nitric oxide nitric oxide synthetase superoxide dismutase neural regeneration
下载PDF
Developing new cancer nanomedicines by combination ancient traditional Chinese medicine effective ingredients and advanced nanotechnology 被引量:1
3
作者 Sheng-Nan Huang Xia-Li Zhu +3 位作者 Hong Zhu Jin Zhang Jin-Xin miao ming-san miao 《TMR Cancer》 2021年第2期37-47,共11页
Various effective ingredients extracted from traditional Chinese medicine have achieved more and more attention in the field of cancer therapy due to their high bioactivity and good safety.These traditional Chinese me... Various effective ingredients extracted from traditional Chinese medicine have achieved more and more attention in the field of cancer therapy due to their high bioactivity and good safety.These traditional Chinese medicine effective ingredients include paclitaxel,arsenical trioxide,camptothecin and so on.However,poor water solubility and low bioavailability of these traditional Chinese medicine ingredients severely hindered their clinical application.The rapid development of nanotechnology provided a new platform,new opportunities and new challenges for their effective delivery in vitro and in vivo.This minireview provides a concentrated summary of the most recent progresses made in this emerging field,highlighting the“combination ancient traditional Chinese medicine ingredients and advanced nanotechnology”strategy for favoring the construction of next generation cancer nanomedicines. 展开更多
关键词 TCM effective ingredient NANOTECHNOLOGY Paclitaxel Arsenical trioxide CAMPTOTHECIN
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部