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Frequent loss of heterozygosity at 8p22 chromosomal region in diffuse type of gastric cancer 被引量:9
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作者 Hedayat Allah Hosseini Ali Ahani +4 位作者 Hamid Galehdari Ali mohammad Froughmand Masoud Hosseini Abdolrahim Masjedizadeh mohammad reza zali 《World Journal of Gastroenterology》 SCIE CAS CSCD 2007年第24期3354-3358,共5页
AIM: To study the loss of heterozygosity (LOH) at 8p21-23 locus in diffuse gastric cancer.METHODS: To evaluate the involvement of this region in gastric cancer, we used eight microsatellite markers covering two Mb of ... AIM: To study the loss of heterozygosity (LOH) at 8p21-23 locus in diffuse gastric cancer.METHODS: To evaluate the involvement of this region in gastric cancer, we used eight microsatellite markers covering two Mb of mentioned region, to perform a high-resolution analysis of allele loss in 42 cases of late diffuse gastric adenocarcinoma.RESULTS: Six of these STS makers: D8S1149, D8S1645, D8S1643, D8S1508, D8S1591, and D8S1145 showed 36%, 28%, 37%, 41%, 44% and 53% LOH, respectively.CONCLUSION: A critical region of loss, close to the NAT2 locus and relatively far from FEZ1 gene currently postulated as tumor suppressor gene in this region. 展开更多
关键词 loss of heterozygosity Tumor suppressor genes diffuse type of gastric cancer STS marker N-Acetyltransferase 2 FEZ1
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Predictive value and main determinants of abnormal features of intraoperative cholangiography during cholecystectomy 被引量:11
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作者 Shahram Yousefpour Azary Heshmat Kalbasi +5 位作者 Ali Setayesh Mirhadi Mousavi Asad Hashemi Mahsa Khodadoostan mohammad reza zali Amir Houshang mohammad Alizadeh 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS 2011年第3期308-312,共5页
BACKGROUND:The major issue with intraoperative cholangiography (IOC) is whether its diagnostic accuracy for common bile duct (CBD) stones matches that of other diagnostic procedures,and thus,whether it will become a r... BACKGROUND:The major issue with intraoperative cholangiography (IOC) is whether its diagnostic accuracy for common bile duct (CBD) stones matches that of other diagnostic procedures,and thus,whether it will become a routine diagnostic procedure.The current study aimed to address the main determinants of CBD stone diagnosis in IOC among an Iranian population.METHODS:In a retrospective review database-based study conducted in Taleghani Hospital in Tehran between 2006 and 2008,baseline data and perioperative information of 2060 patients (male to female ratio 542:1518,mean age 53.7 years) who were candidates for cholecystectomy and underwent concomitant IOC for confirming CBD stones were reviewed.The predictive power of this procedure for diagnosis of abnormal biliary ducts with the focus on biliary stones was determined.RESULTS:Overall mortality and morbidity following cholecystectomy in the study population were 0.6% and 2.6%,respectively.Both early mortality and morbidity due to cholecystectomy were higher in male than female.The prevalence of CBD stones in IOC was 3.4% (5.2% in male and 2.8% in female,P=0.008).Among those without gallstones,8.7% had CBD stones and only 3.1% had concomitant gallstones and CBD stones.The main predictors of stone appearance as an abnormal feature of IOC during cholecystectomy were:advanced age (OR=1.022,P=0.001),male gender (OR=1.498,P=0.050),history of abdominal surgery (OR=1.543,P=0.040) and preoperative endoscopic retrograde cholangiopancreatography (OR=5.400,P<0.001).CONCLUSIONS:IOC is a safe and accurate method for the assessment of bile duct anatomy and stones.Therefore,the routine use of IOC within cholecystectomy seems reasonable and is recommended. 展开更多
关键词 intraoperative cholangiography common bile duct stone CHOLECYSTECTOMY predictive value diagnostic accuracy
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Clinical features of hepatopulmonary syndrome in cirrhotic patients 被引量:13
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作者 Amir Houshang mohammadAlizadeh Seyed reza Fatemi +7 位作者 Vahid Mirzaee Manoochehr Khoshbaten Bahman Talebipour Afsaneh Sharifian Ziba Khoram mohammad reza zali Farhad Haj-sheikh-oleslami MasoomehGholamreza-shirazi 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第12期1954-1956,共3页
AIM: To evaluate the frequency, clinical and paraclinical features of hepatopulmonary syndrome (HPS) and to determine their predictive values in diagnosis of this syndrome in patients in Iran. METHODS: Fifty four ... AIM: To evaluate the frequency, clinical and paraclinical features of hepatopulmonary syndrome (HPS) and to determine their predictive values in diagnosis of this syndrome in patients in Iran. METHODS: Fifty four cirrhotic patients underwent contrast enhanced echocardiography to detect intrapulmonary and intracardiac shunts by two cardiologists. Arterial blood oxygen, 02 gradient (A-a) and orthodoxy were measured by arterial blood gas (ABG) test. The patients positive for diagnostic criteria of HPS were defined as clinical HPS cases and those manifesting the intrapulmonary arterial dilation but no other criteria (arterial blood hypoxemia) were defined as IHPS cases. HPS frequency, sensitivity, positive and negative predictive values of clinical and paraclinical features were studied. RESULTS: Ten (18.5%) and seven (13%) cases had clinical and subclinical HPS, respectively. The most common etiology was hepatitis B. Dyspnea (100%) and cyanosis (90%) were the most prevalent clinical features. Dyspnea and clubbing were the/host sensitive and specific clinical features respectively. No significant relationship was found between HPS and splenomegaly, ascites, edema, jaundice, oliguria, and collateral veins. HPS was more prevalent in hepatitis B. PaO2〈 70 and arterial-alveolar gradient had the highest sensitivity in HPS patients. Orthodoxy specificity was 100%. CONCLUSION: Clubbing with positive predictive value (PPV) of 75% and dyspnea with negative predictive value (NPV) of 75% are the best clinical factors in diagnosis of HPS syndrome. PaO2〈70 and P (A-a) 02〉 30 and their sum, are the most valuable negative and positive predictive values in HPS patients. 展开更多
关键词 Hepatopulmonary syndrome CIRRHOSIS Contrast enhanced echocardiography
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Intra-familial prevalence of hepatitis B virologic markers in HBsAg positive family members in Nahavand, Iran 被引量:8
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作者 Amir Houshang mohammad Alizadeh Mitra Ranjbar +4 位作者 Shahin Ansari Seyed Moayed Alavian Hamid Mohaghegh Shalmani Leila Hekmat mohammad reza zali 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第31期4857-4860,共4页
AIM, To determine the prevalence of hepatitis B in Nahavand and evaluate the HBsAg positive prevalence in families with a member who was confirmed to have HBV infection. METHODS: This study was performed in two phase... AIM, To determine the prevalence of hepatitis B in Nahavand and evaluate the HBsAg positive prevalence in families with a member who was confirmed to have HBV infection. METHODS: This study was performed in two phases. In the first phase, 1 824 subjects in Nahavand city were selected. The interviewers visited the houses of chosen families to flU the questionnaire and take the blood samples. All subjects signed an informed consent before interviews and blood sampling. The samples were evaluated for HBV virologic markers. In the second phase, 115 HBsAg-positive cases were enrolled and evaluated for HBV virologic markers. RESULTS: The prevalence of positive HBsAg in Nahavand was 2.3%. The most frequent relatives of index cases were sons and daughters (32.2% and 23.5% respectively). Twelve (11%) of all family members were HBsAg positive. Fifty (56.2%) were isolated HBsAb positive and only one person (2.5%) was isolated HBcAb positive. The higher rates of HBsAg marker were detected in the brothers (1-25%) and fathers (1-12.5%). The infection rate in husbands and wives of index cases was 10%. Only two (16.7%) of all HBsAg-positive participants reported previous HBV vaccination. CONCLUSION: The prevalence of intr-familial HBV infection is lower in Nahavand of Iran compared to other studies. More attention should be paid to HBV vaccination and risk-lowering activities. 展开更多
关键词 Intra-familial prevalence Hepatitis B Nahavand Iran
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Diversity of Helicobacter pylori genotypes in Iranian patients with different gastroduodenal disorders 被引量:5
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作者 Farzam Vaziri Shahin Najar Peerayeh +5 位作者 Masoud Alebouyeh Tabassom Mirzaei Yoshio Yamaoka Mahsa Molaei Nader Maghsoudi mohammad reza zali 《World Journal of Gastroenterology》 SCIE CAS 2013年第34期5685-5692,共8页
AIM:To investigate the diversity of Helicobacter pylori(H.pylori)genotypes and correlations with disease outcomes in an Iranian population with different gastroduodenal disorders.METHODS:Isolates of H.pylori from pati... AIM:To investigate the diversity of Helicobacter pylori(H.pylori)genotypes and correlations with disease outcomes in an Iranian population with different gastroduodenal disorders.METHODS:Isolates of H.pylori from patients with different gastroduodenal disorders were analyzed after culture and identification by phenotypic and genotypic methods.Genomic DNA was extracted with the QIAamp DNA mini kit(Qiagen,Germany).After DNA extraction,genotyping was done for cagA,vacA(s and m regions),iceA(iceA1,iceA2)and babA with specific primers for each allele using polymerase chain reaction(PCR).All patients’pathologic and clinical data and their relation with known genotypes were analyzed by using SPSS version 19.0 software.2test and Fisher’s exact test were used to assess relationships between categorical variables.The level of statistical significance was set at P<0.05.RESULTS:A total of 71 isolates from 177 patients with different gastroduodenal disorders were obtained.Based on analysis of the cagA gene(positive or negative),vacA s-region(s1or s2),vacA m-region(m1or m2),iceA allelic type(iceA1and iceA2)and babA gene(positive or negative),twenty different genotypic combinations were recognized.The prevalence of cagA,vacA s1,vacA s2,vacA m1,vacA m2,iceA1,iceA2,iceA1+iceA2and babA were 62%,78.9%,19.7%,21.1%,78.9%,15.5%,22.5%,40.8%and 95.8%,respectively.Interestingly,evaluation of PCR results for cagA in 6 patients showed simultaneous existence of cagA variants according to their size diversities that proposed mixed infection in these patients.The most prevalent genotype in cagA-positive isolates was cagA+/vacAs1m2/iceA1+A2/babA+and in cagA-negative isolates was cagA-/vacAs1m2/iceA-/babA+.There were no relationships between the studied genes and histo-pathological findings(H.pylori density,neutrophil activity,lymphoid aggregation in lamina propria and glandular atrophy).The strains which carry cagA,vacAs1/m1,iceA2and babA genes showed significant associations with severe active chronic gastritis(P=0.011,0.025,0.020 and 0.031,respectively).The vacAs1genotype had significant correlation with the presence of the cagA gene(P=0.013).Also,babA genotype showed associations with cagA(P=0.024).In the combined genotypes,only cagA+/vacAs1m1/iceA2/babA+genotype showed correlation with severe active chronic gastritis(P=0.025).CONCLUSION:This genotyping panel can be a useful tool for detection of virulent H.pylori isolates and can provide valuable guidance for prediction of the clinical outcomes. 展开更多
关键词 HELICOBACTER PYLORI CAGA VACA ICEA babA
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Polyp detection rate and pathological features in patients undergoing a comprehensive colonoscopy screening 被引量:6
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作者 Hamid Asadzadeh Aghdaei Ehsan Nazemalhosseini Mojarad +5 位作者 Sara Ashtari Mohmad Amin Pourhoseingholi Vahid Chaleshi Fakhrosadat Anaraki Mehrdad Haghazali mohammad reza zali 《World Journal of Gastrointestinal Pathophysiology》 CAS 2017年第1期3-10,共8页
AIMTo identify the prevalence, and clinical and pathologic characteristic of colonic polyps among Iranian patients undergoing a comprehensive colonoscopy, and determine the polyp detection rate (PDR) and adenoma detec... AIMTo identify the prevalence, and clinical and pathologic characteristic of colonic polyps among Iranian patients undergoing a comprehensive colonoscopy, and determine the polyp detection rate (PDR) and adenoma detection rate (ADR). METHODSIn this cross-sectional study, demographics and epidemiologic characteristics of 531 persons who underwent colonoscopies between 2014 and 2015 at Mehrad gastrointestinal clinic were determined. Demographics, indication for colonoscopy, colonoscopy findings, number of polyps, and histopathological characteristics of the polyps were examined for each person. RESULTSOur sample included 295 (55.6%) women and 236 (44.4%) men, with a mean age of 50.25 ± 14.89 years. Overall PDR was 23.5% (125/531). ADR and colorectal cancer detection rate in this study were 12.8% and 1.5%, respectively. Polyps were detected more significantly frequently in men than in women (52.8% vs 47.2%, P vs 56.4 years, P CONCLUSIONThe prevalence of polyps and adenomas in this study is less than that reported in the Western populations. In our patients, distal colon is more susceptible to developing polyps and cancer than proximal colon. 展开更多
关键词 Adenoma detection Polyp detection Iran COLONOSCOPY SCREENING
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Helicobacter pylori infection and expression of DNA mismatch repair proteins 被引量:5
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作者 Vahid Mirzaee Mahsa Molaei +1 位作者 Hamid Mohaghegh Shalmani mohammad reza zali 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第43期6717-6721,共5页
AIM: TO determine the expression of DNA (MMR) proteins, including hMLH1 and hMSH2, in gastric epithelial cells in the patients with or without Helicobacter pylori (H pylori)-infected gastritis. METHODS: Fifty Hp... AIM: TO determine the expression of DNA (MMR) proteins, including hMLH1 and hMSH2, in gastric epithelial cells in the patients with or without Helicobacter pylori (H pylori)-infected gastritis. METHODS: Fifty Hpylori-positive patients and 50 H pylori-negative patients were enrolled in the study. During endoscopy of patients with non-ulcer dyspepsia, two antral and two corpus biopsies were taken for histological examination (Giemsa stain) and for immunohistochemical staining of hMLH1 and hMSH2. RESULTS: The percentage of epithelial cell nuclei that demonstrated positivity for hMLH1 staining was 84.14 ± 7.32% in Hpylori-negative patients, while it was 73.34 ±10.10% in Hpylori-positive patients (P 〈 0.0001). No significant difference was seen between the two groups regarding the percentage of epithelial cell nuclei that demonstrated positivity for hMSH2 staining (81.16±8.32% in H pylori-negative versus 78.24 ± 8.71% in Hpylori-positive patients; P = 0.09). CONCLUSION: This study indicates that Hpylori might promote development of gastric carcinoma at least in part through its ability to affect the DNA MMR system 展开更多
关键词 Helicobacter pylori DNA mismatch repair hMLH1 hMSH2
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Colorectal cancer screening:Time for action in Iran 被引量:2
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作者 Mohamad Amin Pourhoseingholi mohammad reza zali 《World Journal of Gastrointestinal Oncology》 SCIE CAS 2012年第4期82-83,共2页
Colorectal cancer(CRC) is now the third most common cause of cancer-related deaths in the world.According to the Iranian Annual National Cancer Registration Report,CRC is the third most common cancer in Iranian women ... Colorectal cancer(CRC) is now the third most common cause of cancer-related deaths in the world.According to the Iranian Annual National Cancer Registration Report,CRC is the third most common cancer in Iranian women and fifth in men.The incidence of CRC has increased during the last 25 years.CRC screening is an efficient way to reduce the burden of CRC through detection of precursor lesions of cancer or early stage cancer.Iran may benefit even more from screening programs.According to recent studies,the prevalence of colorectal adenoma in first degree relatives of patients diagnosed with CRC is significantly higher than in the average risk population.So,appropriate screening strategies,especially in relatives of patients,should be considered as the first step of CRC screening in Iran. 展开更多
关键词 COLORECTAL CANCER SCREENING PREVENTION RELATIVES Iran
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Bayesian adjustment for over-estimation and under-estimation of gastric cancer incidence across Iranian provinces 被引量:1
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作者 Nastaran Hajizadeh Mohamad Amin Pourhoseingholi +2 位作者 Ahmad reza Baghestani Alireza Abadi mohammad reza zali 《World Journal of Gastrointestinal Oncology》 SCIE CAS 2017年第2期87-93,共7页
AIM To correct the misclassification in registered gastric cancer incidence across Iranian provinces in cancer registry data. METHODS Gastric cancer data is extracted from Iranian annual of national cancer registratio... AIM To correct the misclassification in registered gastric cancer incidence across Iranian provinces in cancer registry data. METHODS Gastric cancer data is extracted from Iranian annual of national cancer registration report 2008. A Bayesian method with beta prior is implemented to estimate the rate of misclassification in registering patient'spermanent residence in neighboring province. Each time two neighboring provinces with lower and higher than 100% expected coverage of cancer cases are selected to be entered in the model. The expected coverage of cancerous patient is reported by medical university of each province. It is assumed that some cancer cases from a province with a lower than 100% expected coverage are registered in their neighboring province with more than 100% expected coverage. RESULTS The condition was true for 21 provinces from a total of 30 provinces of Iran. It was estimated that 43% of gastric cancer cases of North and South Khorasan provinces in north-east of Iran was registered in Razavi Khorasan as the neighboring facilitate province; also 72% misclassification was estimated between Sistan and balochestan province and Razavi Khorasan. The misclassification rate was estimated to be 36% between West Azerbaijan province and East Azerbaijan province, 21% between Ardebil province and East Azerbaijan, 63% between Hormozgan province and Fars province, 8% between Chaharmahal and bakhtyari province and Isfahan province, 8% between Kogiloye and boyerahmad province and Isfahan, 43% Golestan province and Mazandaran province, 54% between Bushehr province and Khozestan province, 26% between Ilam province and Khuzestan province, 32% between Qazvin province and Tehran province(capital of Iran), 43% between Markazi province and Tehran, and 37% between Qom province and Tehran. CONCLUSION Policy makers should consider the regional misclassification in the time of programming for cancer control, prevention and resource allocation. 展开更多
关键词 Cancer incidence registry MISCLASSIFICATION Bayesian correction Gastric cancer Iran
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Bayesian adjustment of gastric cancer mortality rate in the presence of misclassification 被引量:1
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作者 Nastaran Hajizadeh Mohamad Amin Pourhoseingholi +2 位作者 Ahmad reza Baghestani Alireza Abadi mohammad reza zali 《World Journal of Gastrointestinal Oncology》 SCIE CAS 2017年第4期160-165,共6页
To correct for misclassification error in registering causes of death in Iran death registry using Bayesian method. METHODSNational death statistic from 2006 to 2010 for gastric cancer which reported annually by the M... To correct for misclassification error in registering causes of death in Iran death registry using Bayesian method. METHODSNational death statistic from 2006 to 2010 for gastric cancer which reported annually by the Ministry of Health and Medical Education included in this study. To correct the rate of gastric cancer mortality with reassigning the deaths due to gastric cancer that registered as cancer without detail, a Bayesian method was implemented with Poisson count regression and beta prior for misclassified parameter, assuming 20% misclassification in registering causes of death in Iran. RESULTSRegistered mortality due to gastric cancer from 2006 to 2010 was considered in this study. According to the Bayesian re-estimate, about 3%-7% of deaths due to gastric cancer have registered as cancer without mentioning details. It makes an undercount of gastric cancer mortality in Iranian population. The number and age standardized rate of gastric cancer death is estimated to be 5805 (10.17 per 100000 populations), 5862 (10.51 per 100000 populations), 5731 (10.23 per 100000 populations), 5946 (10.44 per 100000 populations), and 6002 (10.35 per 100000 populations), respectively for years 2006 to 2010. CONCLUSIONThere is an undercount in gastric cancer mortality in Iranian registered data that researchers and authorities should notice that in sequential estimations and policy making. 展开更多
关键词 MISCLASSIFICATION Bayesian method Cause of death Gastric cancer Iran
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Trend of hepatocellular carcinoma incidence after Bayesian correction for misclassified data in Iranian provinces
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作者 Nastaran Hajizadeh Ahmad reza Baghestani +4 位作者 Mohamad Amin Pourhoseingholi Sara Ashtari Zeinab Fazeli Mohsen Vahedi mohammad reza zali 《World Journal of Hepatology》 CAS 2017年第15期704-710,共7页
To study the trend of hepatocellular carcinoma incidence after correcting the misclassification in registering cancer incidence across Iranian provinces in cancer registry data. METHODSIncidence data of hepatocellular... To study the trend of hepatocellular carcinoma incidence after correcting the misclassification in registering cancer incidence across Iranian provinces in cancer registry data. METHODSIncidence data of hepatocellular carcinoma were extracted from Iranian annual of national cancer registration reports 2004 to 2008. A Bayesian method was implemented to estimate the rate of misclassification in registering cancer incidence in neighboring province. A beta prior is considered for misclassification parameter. Each time two neighboring provinces were selected to be entered in the Bayesian model based on their expected coverage of cancer cases which is reported by medical university of the province. It is assumed that some cancer cases from a province that has an expected coverage of cancer cases lower than 100% are registered in their neighboring facilitate province with more than 100% expected coverage. RESULTSThere is an increase in the rate of hepatocellular carcinoma in Iran. Among total of 30 provinces of Iran, 21 provinces were selected to be entered to the Bayesian model for correcting the existed misclassification. Provinces with more medical facilities of Iran are Tehran (capital of the country), Razavi Khorasan in north-east of Iran, East Azerbaijan in north-west of the country, Isfahan in central part and near to Tehran, Khozestan and Fars in south and Mazandaran in north of the Iran, had an expected coverage more than their expectation. Those provinces had significantly higher rates of hepatocellular carcinoma than their neighboring provinces. In years 2004 to 2008, it was estimated to be on average 34% misclassification between North Khorasan province and Razavi Khorasan, 43% between South Khorasan province and Razavi Khorasan, 47% between Sistan and balochestan province and Razavi Khorasan, 23% between West Azerbaijan province and East Azerbaijan province, 25% between Ardebil province and East Azerbaijan province, 41% between Hormozgan province and Fars province, 22% betweenChaharmahal and bakhtyari province and Isfahan province, 22% between Kogiloye and boyerahmad province and Isfahan, 22% between Golestan province and Mazandaran province, 43% between Bushehr province and Khozestan province, 41% between Ilam province and Khuzestan province, 42% between Qazvin province and Tehran province, 44% between Markazi province and Tehran, and 30% between Qom province and Tehran. CONCLUSIONAccounting and correcting the regional misclassification is necessary for identifying high risk areas and planning for reducing the cancer incidence. 展开更多
关键词 Trend of hepatocellular carcinoma Cancer incidence registry MISCLASSIFICATION Bayesian correction
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