Magnesium(Mg)alloys are receiving increasing attention as biodegradable implant materials in recent years.However,their low corrosion resistance and fast degradation in the physiological environment remain challenges ...Magnesium(Mg)alloys are receiving increasing attention as biodegradable implant materials in recent years.However,their low corrosion resistance and fast degradation in the physiological environment remain challenges for a widespread application.Hydroxyapatite(HA)coating on Mg alloys can enhance their corrosion resistance,biocompatibility,and bioactivity of the Mg alloy substrates since the compositions of HA are similar to those of the hard tissue of natural bone.This review analyzes the challenges of Mg alloys for biomedical applications,the fundamental requirements for biodegradable metals,and the corrosion mechanisms of Mg alloys in the physiological environment.The benefits of HA coatings on Mg alloys,the most commonly used surface coating techniques and their advantages and limitations,and the in vitro and in vivo performance of Mg alloys with and without surface coatings are comprehensively elucidated.Multistep processes such as alkali treatment and then HA coating by electrochemical deposition on Mg alloys appear to be necessary to achieve a satisfactory surface coating on Mg alloys,which has been demonstrated to have the potential to improve the degrading behavior,bioactivity and biocompatibility.Multifunctional coatings are most effective in achieving safe and bioactive Mg alloy surfaces for promising biodegradable implant applications.展开更多
Intellectual Property(IP)includes ideas,innovations,methodologies,works of authorship(viz.,literary and artistic works),emblems,brands,images,etc.This property is intangible since it is pertinent to the human intellec...Intellectual Property(IP)includes ideas,innovations,methodologies,works of authorship(viz.,literary and artistic works),emblems,brands,images,etc.This property is intangible since it is pertinent to the human intellect.Therefore,IP entities are indisputably vulnerable to infringements and modifications without the owner’s consent.IP protection regulations have been deployed and are still in practice,including patents,copyrights,contracts,trademarks,trade secrets,etc.,to address these challenges.Unfortunately,these protections are insufficient to keep IP entities from being changed or stolen without permission.As for this,some IPs require hardware IP protection mechanisms,and others require software IP protection techniques.To secure these IPs,researchers have explored the domain of Intellectual Property Protection(IPP)using different approaches.In this paper,we discuss the existing IP rights and concurrent breakthroughs in the field of IPP research;provide discussions on hardware IP and software IP attacks and defense techniques;summarize different applications of IP protection;and lastly,identify the challenges and future research prospects in hardware and software IP security.展开更多
基金The authors would like to acknowledge the financial support to this research by the Australian Research Council(ARC)through the Discovery Project DP170102557Future Fellowship Project FT 160100252.
文摘Magnesium(Mg)alloys are receiving increasing attention as biodegradable implant materials in recent years.However,their low corrosion resistance and fast degradation in the physiological environment remain challenges for a widespread application.Hydroxyapatite(HA)coating on Mg alloys can enhance their corrosion resistance,biocompatibility,and bioactivity of the Mg alloy substrates since the compositions of HA are similar to those of the hard tissue of natural bone.This review analyzes the challenges of Mg alloys for biomedical applications,the fundamental requirements for biodegradable metals,and the corrosion mechanisms of Mg alloys in the physiological environment.The benefits of HA coatings on Mg alloys,the most commonly used surface coating techniques and their advantages and limitations,and the in vitro and in vivo performance of Mg alloys with and without surface coatings are comprehensively elucidated.Multistep processes such as alkali treatment and then HA coating by electrochemical deposition on Mg alloys appear to be necessary to achieve a satisfactory surface coating on Mg alloys,which has been demonstrated to have the potential to improve the degrading behavior,bioactivity and biocompatibility.Multifunctional coatings are most effective in achieving safe and bioactive Mg alloy surfaces for promising biodegradable implant applications.
文摘Intellectual Property(IP)includes ideas,innovations,methodologies,works of authorship(viz.,literary and artistic works),emblems,brands,images,etc.This property is intangible since it is pertinent to the human intellect.Therefore,IP entities are indisputably vulnerable to infringements and modifications without the owner’s consent.IP protection regulations have been deployed and are still in practice,including patents,copyrights,contracts,trademarks,trade secrets,etc.,to address these challenges.Unfortunately,these protections are insufficient to keep IP entities from being changed or stolen without permission.As for this,some IPs require hardware IP protection mechanisms,and others require software IP protection techniques.To secure these IPs,researchers have explored the domain of Intellectual Property Protection(IPP)using different approaches.In this paper,we discuss the existing IP rights and concurrent breakthroughs in the field of IPP research;provide discussions on hardware IP and software IP attacks and defense techniques;summarize different applications of IP protection;and lastly,identify the challenges and future research prospects in hardware and software IP security.