Application and Effect Evaluation of the Integrated“5A and 3+3”Management Model in the Safe Medication Use for Chemotherapy Patients

Objective:To explore the application and effect evaluation of the integrated“5A and 3+3”management model in ensuring safe medication use for chemotherapy patients.Methods:A total of 100 intravenous chemotherapy patients admitted to the oncology department of Shaanxi Provincial People’s Hospital were randomly divided into two groups using a random number list method.Both groups received conventional nursing management during chemotherapy,while the study group additionally received the integrated“5A and 3+3”safety management model.The nursing intervention effects between the two groups were compared.Results:After the intervention,the study group showed higher levels of self-management ability,compliance,and nursing satisfaction compared to the control group.The overall incidence of adverse events during hospitalization was lower in the study group,with statistically significant differences(P<0.05).The knowledge scores of medical staff in the study group,related to the prevention and treatment of chemotherapy drug side effects,daily symptom management,and daily life management,were higher than those in the control group,with statistically significant differences(P<0.05).Conclusion:Implementing the integrated“5A and 3+3”model in the safe medication management of intravenous chemotherapy patients can effectively enhance patients’self-management abilities and compliance,improve medical staff’s ability to safely administer chemotherapy drugs,reduce adverse events caused by chemotherapy,and increase patient satisfaction.

Boosting Oxygen Evolution Reaction Performance on NiFe‑Based Catalysts Through d‑Orbital Hybridization

Anion-exchange membrane water electrolyzers(AEMWEs)for green hydrogen production have received intensive attention due to their feasibility of using earth-abundant NiFe-based catalysts.By introducing a third metal into NiFe-based catalysts to construct asymmetrical M-NiFe units,the d-orbital and electronic structures can be adjusted,which is an important strategy to achieve sufficient oxygen evolution reaction(OER)performance in AEMWEs.Herein,the ternary NiFeM(M:La,Mo)catalysts featured with distinct M-NiFe units and varying d-orbitals are reported in this work.Experimental and theoretical calculation results reveal that the doping of La leads to optimized hybridization between d orbital in NiFeM and 2p in oxygen,resulting in enhanced adsorption strength of oxygen intermediates,and reduced rate-determining step energy barrier,which is responsible for the enhanced OER performance.More critically,the obtained NiFeLa catalyst only requires 1.58 V to reach 1 A cm^(−2) in an anion exchange membrane electrolyzer and demonstrates excellent long-term stability of up to 600 h.

Outcomes of patients treated with SVILE vs.P-GemOx for extranodal natural killer/T-cell lymphoma,nasal type:a prospective,randomized controlled study

Objective:To compare the efficacy and safety of the novel SVILE regimen with the P-GemOx regimen in patients with newly diagnosed extranodal natural killer/T-cell lymphoma,nasal type(ND-ENKTL).Methods:From April 2015 to July 2018,103 patients with ND-ENKTL were randomly assigned to SVILE(experimental group)or P-GemOx(control group)chemotherapy followed by radiotherapy and consolidation chemotherapy.The primary endpoint was the overall response rate after 3 cycles of chemotherapy,and secondary study endpoints were complete response(CR),progression-free survival(PFS),and overall survival(OS).Safety was also evaluated.Results:There were no significant differences in baseline characteristics in the experimentalvs.control groups.In experimental and control groups,respectively,the overall response rates were 91.7%vs.97.0%for stageI/II and 75.0%vs.72.2%for stage III/IV.The CR rates were 83.4%vs.97.0%for stage I/II and 68.8%vs.61.1%for stage III/IV.None of those differences were significant.There was no significant difference in PFS and OS between groups and between patients in stage I/II and stage III/IV.The 3-year PFS and OS in stage I/II were 88.3%vs.93.3%and 88.8%vs.97.0%,respectively.The 3-year PFS and OS in stage III/IV were 46.2%vs.65.7%and 68.8%vs.72.2%,respectively.The common adverse events were hematological toxicity,hepatotoxicity,and coagulation abnormalities,which were found to be reversible with supportive therapy.Conclusions:The novel SVILE regimen has comparable effects to those of P-GemOx in patients with ND-ENKTL and is well tolerated.SVILE is a therapeutic option for ND-ENKTL.

Nitridation-induced metal-organic framework nanosheet for enhanced water oxidation electrocatalysis

We report the synthesis of nitridation-induced NiFe-MOF through post-synthetic functionalization of terminal ligand in NiFe-MOF nanosheet.We directly identify the key factor of amino ligand in N-NiFe-MOF for boosting the OER performance through combining single X-ray crystallographic characterization and in-situ Raman tracking,as well as ex-situ spectroscopy analysis.Density functional theory(DFT)calculations and experime ntal results indicate irreversible phase rec on structio n from amino ligand oxidation prior to OER could lead to the optimized ΔG_(-O),resulting in the remarkable OER performance with an overpotential of 258 mV to obtain the current density of 100 mA cm^(-2) in 1.0 M KOH solution.Our work will provide new strategy for rational designing advanced MOF-based OER electrocatalysts.

Preparation of new hybrid organic/inorganic polymeric chiral stationary phases for ligand-exchange chromatography

Three new hybrid organic/inorganic polymeric ligand-exchange chiral stationary phases were developed by radical chain transfer reaction and surface grafting on silica gel, and successfully used for the enantioseparations of DL-amino acids and DL-hydroxyl adds. The resolutions were achieved by using water containing 2.0 × 10^-4 mol/L of CuAc2 as a mobile phase, column temperature of 40 ℃, flow rate of 1.0 mL/min and detection at UV 254 nm. The elution order of D-isomer before L-isomer was observed for all DL-amino acids resolved except DL-Pro.

A chiral stationary phase with special hydrophobic framework for ligand-exchange chromatography

A novel chiral stationary phase （CSP1） for ligand-exchange chromatography （CLEC） was prepared by firstly using dimethylchlorosilane as an endcapping reagent for decreasing residual silanol group on the surface of silica gel, and then introducing L-Pro as a chiral selector and hydrophobic octyl group to the silica gel surface simultaneously. The enantioseparations of 14 DL-amino acids on CSP1 were achieved with the enantioselectivity α ranging from 1.09 to 2.44 and the resolution Rs being between 0.8 and 6.3. The chromatographic performances of CSP1 with the bonded phase （CSP2） prepared using reference method were compared. The results showed that the column efficiency and resolution Rs of chiral stationary phase could be improved by using the above modifying method.

Insight into Hydrolytic Stability and Tribological Properties of B-N Coordination Tung Oil-Based Lubricant Additive in Water

A tung oil-based boron-nitrogen coordination polymer(TWE-BN)was specially designed and synthesized as a highly efficient water-based lubricant additive,which has been beneficial to both energy conservation and conducive to environmental protection.Its hydrolysis stability and tribological properties in water were investigated.To better research the lubricating properties,and thus to understand the interaction between the surface and the lubricating additives.Herein,both experimental and theoretical computations based on density functional theory(DFT)were performed.The addition of TWE-BN reduces the water friction coefficient and wear scar diameter,and the maximum non-seizure load increased from 93 to 726 N.Moreover,the anti-corrosion ability on copper was classified as 1b level.The stainless-steel surface was analyzed using scanning electron microscopy(SEM)and X-ray photoelectron spectroscopy(XPS).In hydrolytic stability testing,TWE-BN was better than nitrogen-free tung oil-based lubricant additive(TWE-B)and remained non-hydrolyzed for at least 15 days,implying the feasibility of tung oil-based boron-nitrogen coordination as highly effective and hydrolytic stability lubricant additives.

Multifunctional Lubricant Additive Improves Lubrication and Antioxidation Properties of Tung Oil

It is of considerable significance to develop efficient and environmentally friendly machinery lubricant additives because of the increasing depletion of petrochemical resources and severe environmental problems.Herein,we proposed a facile strategy to synthesize a multifunctional vegetable oil-based lubricant via the lignin derivative vanillin coupled to amine and diethyl phosphite to produce a lubricating additive with both extreme pressure and antioxidant properties.Compared with pure tung oil,the lubricating and antioxidant performance of tung oil is significantly improved after adding additives.Adding the 1.0 wt%additive to the tung oil reduced the friction wear coefficient and the volume,and the oxidation induction time was much longer than pure tung oil.

Research on the Impact of Low Carbon Economy on China’s Foreign Trade

Considering the growing prominence of global environmental issues,a low-carbon economy has emerged as a crucial direction for economic development across various countries.As the world’s second-largest economy,China has also witnessed the influence of a low-carbon economy on its international trade development.This article aims to commence with an exploration of the development background,meaning,and significance of a low-carbon economy.Subsequently,it delves into an in-depth analysis of the impact that a low-carbon economy has on China’s international trade.The article concludes by proposing pertinent countermeasures and suggestions.

Strategies for China’s Response to and Improvement of Third-Party Funding in International Investment Arbitration

China should prioritize the establishment and enhancement of a third-party funding system.It should actively refine the existing arbitration rules,addressing any loopholes in the current regulatory framework.Comprehensive measures should be implemented to regulate third-party funding,aligning with international trends.This is crucial not only to safeguard the foreign investment of the Chinese government and enterprises but also to position China as a globally influential arbitration center.

Manipulating the electronic structure of Ni electrocatalyst through d‐p orbital hybridization induced by B‐doping for efficient alkaline hydrogen oxidation reaction

Developing highly efficient platinum‐group‐metal‐free electrocatalysts towards hydrogen oxidation reaction(HOR)under alkaline electrolyte is critical for the development of alkaline exchange member fuel cells.Herein,we reported the synthesis of boron doped Ni electrocatalyst(B‐Ni/C)and its remarkable alkaline HOR performance,with a 10‐fold mass activity enhancement compared with that of undoped Ni catalyst.Experimental results and density functional theory calculations indicate the d‐p hybridization between the p orbital of B and the d orbital of Ni via B‐doping could lead to promoted OH adsorption and optimized hydrogen binding energy on Ni surface,which together with the reduced formation energy of water species,contributes to the enhanced HOR performance under alkaline electrolyte.

Comparison Test on Adaptability of Six Medicago sativa (Alfalfa) Varieties in Guangxi

In order to screen the Medicago sativa(alfalfa)varieties suitable for planting in Guangxi,six domestic and foreign heat-resistant alfalfa varieties,namely WL903,WL712,WL525HQ,59N59,Elite 9 and Longwei 6010,were selected and tested for growth performance,nutritional value and over-summer rate by the random block method.The results showed that the alfalfa varieties with better plant height and fresh grass yield were 59N59 and WL903,which showed the plant heights reaching 62.01 and 62.53 cm,respectively,and the fresh grass yields up to 40.93 and 38.38 t/hm 2,respectively,exhibiting extremely significant differences from the poorly performing Longwei 6010(P<0.01).The nutritional value of each tested variety was good,and the crude protein content was more than 20%.Among them,Elite 9 had a crude protein content as high as 28.43%.The over-summer rates of the six alfalfa varieties were all higher than 75%.It showed that the alfalfa varieties with fast growth,high yield,high nutritional value and high over-summer rate in this experimental area were 59N59 and WL903,which are suitable as the first varieties for planting in Guangxi.

Application of the Just-in-Time Teaching(JiTT)Model in Bilingual Courses of Chinese-Foreign Cooperative Education

The teaching abilities of bilingual teachers have emerged as one of the major bottlenecks hindering the further development of Chinese-foreign cooperative education projects.Implementing the JiTT(Just-in-Time Teaching)model in bilingual courses of Chinese-foreign cooperative education can effectively integrate information technology with traditional classroom teaching.This integration enhances teaching quality and effectiveness,encourages university instructors to improve their diverse and collective capabilities,promotes digital development,and contributes to the enhancement of students’learning abilities and overall improvement.

Preparation and Properties of Vegetable-Oil-Based Thioether Polyol and Ethyl Cellulose Supramolecular Composite Films

Ethyl cellulose(EC),an important biomass-based material,has excellent film-forming properties.Nevertheless,the high interchain hydrogen bond interaction leads to a high glass transition temperature of EC,which makes it too brittle to be used widely.The hydroxyl group on EC can form a supramolecular system in the form of a non-covalent bond with an effective plasticizer.In this study,an important vegetable-oil-based derivative named dimer fatty acid was used to prepare a novel special plasticizer for EC.Dimer-fatty-acid-based thioether polyol(DATP)was synthesized and used to modify ethyl cellulose films.The supramolecular composite films of DATP and ethyl cellulose were designed using the newly-formed van der Waals force.The thermal stability,morphology,hydrophilicity,and mechanical properties of the composite films were all tested.Pure EC is fragile,and the addition of DATP makes the ethyl cellulose films more flexible.The elongation at the break of EC supramolecular films increased and the tensile strength decreased with the increasing DATP content.The elongation at the break of EC/DATP(60/40)and EC/DATP(50/50)was up to 40.3%and 43.4%,respectively.Noticeably,the thermal initial degradation temperature of the film with 10%DATP is higher than that of pure EC,which may be attributed to the formation of a better supramolecular system in this composite film.The application of bio-based material(EC)is environmentally friendly,and the novel DATP can be used as a special and effective plasticizer to prepare flexible EC films,making it more widely used in energy,chemical industry,materials,agriculture,medicine,and other fields.

The Reform Process of English Medium Instruction in Korean Higher Education

In the context of the internationalization of higher education,many non-English speaking countries,from Europe to Asia,are promoting English as a medium of instruction(EMI).The EMI in South Korea started earlier and developed rapidly under the promotion.From the initial“Study Abroad in Korea Plan”to the World Class University(WCU)and Brain Korea 21st century(BK21)PLUS programs,with the support and guidance of the government,South Korea’s higher education has made significant progress,with the global top 100 universities in QS increasing from 1 to 6 in South Korea.

An emerging role of arecoline on growth performance,intestinal digestion and absorption capacities and intestinal structural integrity of adult grass carp(Ctenopharyngodon idella)

Arecoline is an alkaloid with important pharmacological effects in the plant areca nut,which has been demonstrated to be an agonist of muscarinic receptors(M receptor).This study explored the influences of dietary arecoline on growth performance,intestinal digestion and absorption abilities,antioxidant capacity,and the apical junction complex(AJC)of adult grass carp(Ctenopharyngodon idella).Adult grass carp(608to 1512 g)were fed at 6 graded levels of dietary arecoline(0,0.5,1.0,1.5,2.0,and 2.5 mg/kg diet)for 9weeks.The results suggested that appropriate dietary supplementation of arecoline(1.0 mg/kg)increased growth parameters and intestinal growth in adult grass carp(P<0.05),enhanced digestion and absorption capacities(P<0.05),up-regulated muscarinic receptor 3(M3)mRNA level(P<0.05),increased the content of neuropeptide fish substance P(P<0.05),improved antioxidant capacity by activating the Keap1a/Nrf2signaling pathway(P<0.05),reduced intestinal mucosal permeability(P<0.05),and increased m RNA levels of tight junction(TJ)and adherent junction AJ-related proteins in fish by inhibiting the RhoA/ROCK signaling pathway(RhoA/ROCK/MLCK/NMII)(P<0.05).In addition,the appropriate arecoline supplementation for adult grass carp was determined to be 1.20,1.21,1.07,and 1.19 mg/kg based on percentage weight gain,lipase activity,serum diamine oxidase,and protein carbonyl,respectively.Overall,to the best of our knowledge,we investigated for the first time the effects and possible mechanisms of dietary arecoline on intestinal digestive and absorptive capacities and structural integrity in fish and evaluated the appropriate level of supplementation.

Identification of in situ Generated Iron-Vacancy Induced Oxygen Evolution Reaction Kinetics on Cobalt Iron Oxyhydroxide

Developing highly efficient and low-cost electrocatalysts towards oxygen evolution reaction(OER)is essential for practical application in water electrolyzers and rechargeable metal-air batteries.Although Fe-based oxyhydroxides are regarded as state-of-the-art non-noble OER electrocatalysts,the origin of performance enhancement derived from Fe doping remains a hot topic of considerable discussion.Herein,we demonstrate that in situ generated Fe vacancies in the pristine CoFeOOH catalyst through a pre-conversion process during alkaline OER result from dynamic Fe dissolution,identifying the origin of Fe-vacancy-induced enhanced OER kinetics.Density functional theory(DFT)calculations and experimental results including X-ray absorption fine-structure spectroscopy,in situ UV-Vis spectroscopy,and in situ Raman spectroscopy reveal that the Fe vacancies could significantly promote the d-band center and valence states of adjacent Co sites,alter the active site from Fe atom to Co atom,accelerate the formation of high-valent active Co^(4+)species,and reduce the energy barrier of the potential-determining step,thereby contribute to the significantly enhanced OER performance.

西藏墨脱县城中小学生的弱视患病率调查

目的:调查我国西藏自治区林芝市墨脱县城区中小学生的弱视患病率及其影响因素。方法:横断面调查研究。在2017年5月对墨脱县城区小学初中的全体学生共833名开展视力普查及基本的眼科检查,包括视力及屈光、眼前段、眼底、眼位等检查,对确诊为弱视的学生进行问卷调查并分析发病原因。应用Fisher's精确检验、卡方检验比较不同性别的弱视患病率差异;用Logistic回归分析年龄、性别对弱视患病率的影响。结果:墨脱县城区小学和初中共833名学生参与调查,其中弱视患者为22例(31眼),患病率为2.6%。弱视的发病原因包括屈光参差10例,占45%;屈光不正6例,占27%;斜视3例,占14%;形觉剥夺2例,占9%;其他1例,占5%。性别、年龄不是弱视患病率的影响因素。结论:墨脱城区中小学生弱视患病率较全国水平偏高。屈光参差及屈光不正是引起弱视的主要原因。

Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial

Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection.Blocking CD147 via anti-CD147 antibody could suppress the in vitro SARS-CoV-2 replication.Meplazumab is a humanized anti-CD147 IgG_(2) monoclonal antibody,which may effectively prevent SARS-CoV-2 infection in coronavirus disease 2019(COVID-19)patients.Here,we conducted a randomized,double-blinded,placebo-controlled phase 1 trial to evaluate the safety,tolerability,and pharmacokinetics of meplazumab in healthy subjects,and an open-labeled,concurrent controlled add-on exploratory phase 2 study to determine the efficacy in COVID-19 patients.In phase 1 study,59 subjects were enrolled and assigned to eight cohorts,and no serious treatment-emergent adverse event(TEAE)or TEAE grade≥3 was observed.The serum and peripheral blood Cmax and area under the curve showed non-linear pharmacokinetic characteristics.No obvious relation between the incidence or titer of positive anti-drug antibody and dosage was observed in each cohort.The biodistribution study indicated that meplazumab reached lung tissue and maintained>14 days stable with the lung tissue/cardiac blood-pool ratio ranging from 0.41 to 0.32.In the exploratory phase 2 study,17 COVID-19 patients were enrolled,and 11 hospitalized patients were involved as concurrent control.The meplazumab treatment significantly improved the discharged(P=0.005)and case severity(P=0.021),and reduced the time to virus negative(P=0.045)in comparison to the control group.These results show a sound safety and tolerance of meplazumab in healthy volunteers and suggest that meplazumab could accelerate the recovery of patients from COVID-19 pneumonia with a favorable safety profile.

Ni_(3)N Modified MOF Heterostructure with Tailored Electronic Structure for Efficient Overall Water Splitting

Exploring bifunctional electrocatalysts with high-efficiency and stability toward overall water splitting is desirable for sustainable energy technologies,yet challenging.Herein,we report the construction of Ni_(3)N on the surface of Ni-MOF-74 through an in-situ nitriding process.The obtained Ni-MOF-74/Ni_(3)N exhibits remarkable HER activity with an overpotential of 73 mV to deliver 10 mA cm^(-2).Theoretical calculations and experimental study demonstrate the electron transport between Ni_(3)N and Ni-MOF-74,leading to the improved H_(2)O adsorption,optimized hydrogen adsorption,and increased H_(ad)diffusion,which contributes to the enhanced HER performance.Besides,the obtained Ni-MOF-74/Ni_(3)N also possesses outstanding activity toward OER and overall water splitting.