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Efficacy of Photogem(Hematoporphyrin Derivative) as a Photoactivatable Larvicide against Aedes aegypti (Diptera: Culicidae) Larvae
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作者 Larissa Marila de Souza natalia mayumi inada +3 位作者 Sebastiao Pratavieira Juliano Jose Corbi Cristina Kurachi Vanderlei Salvador Bagnato 《Journal of Life Sciences》 2017年第2期74-81,共8页
Dengue vector is responsible for millions of deaths every year and has caused disastrous impacts on health systems. The continuous use of chemical insecticides, such as carbamates, pyrethroids and organophosphates gen... Dengue vector is responsible for millions of deaths every year and has caused disastrous impacts on health systems. The continuous use of chemical insecticides, such as carbamates, pyrethroids and organophosphates generates resistant populations of the mosquito, therefore, new control methods must be investigated. The joint action of the population and guidelines for preventing the reproduction of the mosquito associated with the use of photoactivatable insecticides can be the alternative for the control of epidemiological outbreaks in affected regions. In this study, the photo-larvicidal activity of Photogem^(PG), a derivative of hematoporphyrin, was investigated against 2nd-early 3rd instar of Aedes aegypti larvae (Diptera: Culicidae) under different lighting conditions (artificial lighting system and sunlight). The dynamics of PG accumulation was characterized by CLSM (confocal laser scanning microscopy) and total time PG eliminationin solution was investigated by ultraviolet-visible spectrophotometry. The maximum photo-activity of PG was observed in 0.5 h under sunlight exposure which achieved 100% larval mortality. Fluorescence images showed a uniform distribution of PG along the digestive tract. PG remained stable in the sunlight for 48 h and in an artificial lighting system for longer periods, therefore, it can be used for the control ofAedes aegypti larvae as a new alternative to chemical insecticides. The method is considered environmentally friendly due to its rapid degradation in the presence of light. Further studies are required, so that the potential of the technique can be explored in real breeding places. 展开更多
关键词 Photoactivatable larvicide PG hematoporphyrin derivative Aedes aegypti natural lighting artificial lighting.
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In Vitro Study of Photodynamic Therapy for Treatment of Bacteremia in Whole Blood
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作者 Jennifer Machado Soaxes Thaila Quatrini Correa +2 位作者 natalia mayumi inada Vanderlei Salvador Bagnato Kate Cristina Blanco 《Journal of Pharmacy and Pharmacology》 2018年第9期863-869,共7页
Antibiotic resistance has been compromised hospitalized patients with serious infections. The main cases of bacteremia can be caused by antibiotic resistant pathogens. Photodynamic therapy (PDT) has been shown as an... Antibiotic resistance has been compromised hospitalized patients with serious infections. The main cases of bacteremia can be caused by antibiotic resistant pathogens. Photodynamic therapy (PDT) has been shown as an alternative for inactivation of microorganisms in blood. In this therapy photochemical mechanisms occur that may prevent the development of bacteria. This study aims optimization of PDT parameters for blood decontamination. Concentration ofphotosensitizer (PS), light dose (LD) and incubation time (IT) were studied for hemolysis and cell toxic effects. It was observed that PDT can be used for microbial inactivation in total blood reducing 0.85 log10 CFU/mL ofS. aureus at 15 J/cm^2 and 50μg/mL of Photogem . 展开更多
关键词 Staphylococcus aureus photodynamic therapy BACTEREMIA BLOOD
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