Atlantic blocking events in a simplified nonlinear baroclinic model for local finite-amplitude wave activity

为研究北大西洋阻高的形成机制,本文在局部有限振幅波活动(LWA)框架下进行了一系列数值实验.采用的数值模型能显式地描绘出两种重要的大气内部动力过程,即非线性纬向位涡通量和Rossby波包传播.模拟结果显示,这两种动力学过程均是形成大西洋阻高的重要机理.具体地,非线性纬向位涡通量和Rossby波包传播,分别是大西洋阻高南部和北部LWA形成的主导因子.因此,本研究综合了前人关于大西洋阻高的研究成果,为其形成机理提供了新的认识.

Efficacy of hepatic arterial infusion chemotherapy and its combination strategies for advanced hepatocellular carcinoma:A network meta-analysis

BACKGROUND With the rapid progress of systematic therapy for hepatocellular carcinoma(HCC),therapeutic strategies combining hepatic arterial infusion chemotherapy(HAIC)with systematic therapy arised increasing concentrations.However,there have been no systematic review comparing HAIC and its combination strategies in the first-line treatment for advanced HCC.AIM To investigate the efficacy and safety of HAIC and its combination therapies for advanced HCC.METHODS A network meta-analysis was performed by including 9 randomized controlled trails and 35 cohort studies to carry out our study.The outcomes of interest comprised overall survival(OS),progression-free survival(PFS),tumor response and adverse events.Hazard ratios(HR)and odds ratios(OR)with a 95% confidence interval(CI)were calculated and agents were ranked based on their ranking probability.RESULTS HAIC outperformed Sorafenib(HR=0.55,95%CI:0.42-0.72;HR=0.51,95%CI:0.33-0.78;OR=2.86,95%CI:1.37-5.98;OR=5.45,95%CI:3.57-8.30;OR=7.15,95%CI:4.06-12.58;OR=2.89,95%CI:1.99-4.19;OR=0.48,95%CI:0.25-0.92,respectively)and transarterial chemoembolization(TACE)(HR=0.50,95%CI:0.33-0.75;HR=0.62,95%CI:0.39-0.98;OR=3.08,95%CI:1.36-6.98;OR=2.07,95%CI:1.54-2.80;OR=3.16,95%CI:1.71-5.85;OR=2.67,95%CI:1.59-4.50;OR=0.16,95%CI:0.05-0.54,respectively)in terms of efficacy and safety.HAIC+lenvatinib+ablation,HAIC+ablation,HAIC+anti-programmed cell death 1(PD-1),and HAIC+radiotherapy had the higher likelihood of providing better OS and PFS outcomes compared to HAIC alone.HAIC+TACE+S-1,HAIC+lenvatinib,HAIC+PD-1,HAIC+TACE,and HAIC+sorafenib had the higher likelihood of providing better partial response and objective response rate outcomes compared to HAIC.HAIC+PD-1,HAIC+TACE+S-1 and HAIC+TACE had the higher likelihood of providing better complete response and disease control rate outcomes compared to HAIC alone.CONCLUSION HAIC proved more effective and safer than sorafenib and TACE.Furthermore,combined with other interventions,HAIC showed improved efficacy over HAIC monotherapy according to the treatment ranking analysis.

Construction of functional neural network tissue combining CBD-NT3-modified linear-ordered collagen scaffold and TrkC-modified iPSC-derived neural stem cells for spinal cord injury repair

Induced pluripotent stem cells(iPSCs)can be personalized and differentiated into neural stem cells(NSCs),thereby effectively providing a source of transplanted cells for spinal cord injury(SCI).To further improve the repair efficiency of SCI,we designed a functional neural network tissue based on TrkC-modified iPSC-derived NSCs and a CBD-NT3-modified linear-ordered collagen scaffold(LOCS).We confirmed that transplantation of this tissue regenerated neurons and synapses,improved the microenvironment of the injured area,enhanced remodeling of the extracellular matrix,and promoted functional recovery of the hind limbs in a rat SCI model with complete transection.RNA sequencing and metabolomic analyses also confirmed the repair effect of this tissue from multiple perspectives and revealed its potential mechanism for treating SCI.Together,we constructed a functional neural network tissue using human iPSCs-derived NSCs as seed cells based on the interaction of receptors and ligands for the first time.This tissue can effectively improve the therapeutic effect of SCI,thus confirming the feasibility of human iPSCs-derived NSCs and LOCS for SCI repair and providing a valuable direction for SCI research.

Precursory atmospheric teleconnection patterns for strong Siberian High events

本文利用日本55年逐日再分析资料,发现在SH异常增强前,有三种不同的大气遥相关型前兆信号,即斯堪的纳维亚(SCA)型,西太平洋(WP)型,极地-欧亚(POL)型据此,本文将异常增强的SH分为对应的三类事件.合成结果表明,三类事件在典型环流特征和对东亚气温的影响上存在着明显的不同.具体而言,SCA类事件主要表现为在欧亚中高纬度上自西向东的波列异常,WP类事件表现为环流异常自下游太平洋/俄罗斯远东地区向西发展的特征,POL型事件的显著信号则来源于自极区向南移动的反气旋式环流异常.在对东亚地表气温的影响上,SCA类与POL类事件类似,它们均可造成大范围的低温异常.而WP类仅在我国北方和东部地区造成强度较弱的地表气温异常,但该异常的持续性特征较明显。

Laboratory scoring system to predict hepatic indocyanine green clearance ability during fluorescence imaging-guided laparoscopic hepatectomy

BACKGROUND Indocyanine green(ICG)fluorescence played an important role in tumor localization and margin delineation in hepatobiliary surgery.However,the preoperative regimen of ICG administration was still controversial.Factors associated with tumor fluorescence staining effect were unclear.AIM To investigate the preoperative laboratory indexes corelated with ICG fluorescence staining effect and establish a novel laboratory scoring system to screen specifical patients who need ICG dose adjustment.METHODS To investigate the predictive indicators of ICG fluorescence characteristics in patients undergoing laparoscopic hepatectomy from January 2018 to January 2021 were included.Blood laboratory tests were completed within 1 wk before surgery.All patients received 5 mg ICG injection 24 h before surgery for preliminary tumor imaging.ImageJ software was used to measure the fluorescence intensity values of regions of interest.Correlation analysis was used to identify risk factors.A laboratory risk model was established to identify individuals at high risk for high liver background fluorescence.RESULTS There were 110 patients who were enrolled in this study from January 2019 to January 2021.The mean values of fluorescence intensity of liver background(FI-LB),fluorescence intensity of gallbladder,and fluorescence intensity of target area were 18.87±17.06,54.84±33.29,and 68.56±36.11,respectively.The receiver operating characteristic(ROC)curve showed that FI-LB was a good indicator for liver clearance ability[area under the ROC curve(AUC)=0.984].Correlation analysis found pre-operative aspartate aminotransferase,alanine aminotransferase,gammaglutamyl transpeptidase,adenosine deaminase,and lactate dehydrogenase were positively associated with FI-LB and red blood cell,cholinesterase,and were negatively associated with FI-LB.Total laboratory risk score(TLRS)was calculated according to ROC curve(AUC=0.848,sensitivity=0.773,specificity=0.885).When TLRS was greater than 6.5,the liver clearance ability of ICG was considered as poor.CONCLUSION Preoperative laboratory blood indicators can predict hepatic ICG clearance ability.Surgeons can adjust the dose and timing of ICG preoperatively to achieve better liver fluorescent staining.

OTSC金属夹治疗难治性急性非静脉曲张性上消化道出血的效果评估

目的探讨内镜下OTSC金属夹闭合术在难治性急性非静脉曲张性上消化道出血(ANVUGIB)治疗中的疗效。方法对滨州医学院附属医院消化内科2015年1月1日-2016年6月1日通过OTSC金属夹治疗的16例难治性ANVUGIB的患者进行回顾性分析。其中贲门黏膜撕裂并出血2例,胃溃疡出血7例,胃癌1例,十二指肠球部溃疡出血6例。结果 16例患者均成功的进行了内镜下止血,成功率100.0%,止血夹自安装至释放成功平均所需时间仅为5.0~6.0 min。结论 OTSC在难治性ANVUGIB患者中的治疗安全、有效,值得临床推广。

Mechanisms simultaneously regulate smooth muscle proliferation and differentiation

Vascular smooth muscle cell （VSMC） differentiation and proliferation are two important physiological proc- esses during vascular development. The phenotypic alteration from differentiated to proliferative VSMC contrib- utes to the development of several major cardiovascular diseases including atherosclerosis, hypertension, resteno- sis after angioplasty or bypass, diabetic vascular complications, and transplantation arteriopathy. Since the VSMC phenotype in these pathological conditions resembles that of developing VSMC during embryonic development, understanding of the molecular mechanisms that control VSMC differentiation will provide fundamental insights into the pathological processes of these cardiovascular diseases. Although VSMC differentiation is usually ac- companied by an irreversible cell cycle exit, VSMC proliferation and differentiation occur concurrently during embryonic development. The molecular mechanisms simultaneously regulating these two processes, however, remain largely unknown. Our recent study demonstrates that cell division cycle 7, a key regulator of cell cycle, promotes both VSMC differentiation and proliferation through different mechanisms during the initial phase of VSMC differentiation. Conversely, Kriappel-like factor 4 appears to be a repressor for both VSMC differentia- tion and proliferation. This review attempts to highlight the novel role of cell division cycle 7 in TGF-β-induced VSMC differentiation and proliferation. The role of K141ppel-like factor 4 in suppressing these two processes will also be discussed.

Fault diagnosis for distillation process based on CNN–DAE

Distillation is the most widely used operation for liquid mixture separation in the chemical industry. It is of great importance to detect and diagnose faults in distillation process. Due to the strong feedback and coupling of processes in a distillation column, it is difficult to use deep auto-encoders(DAEs) alone to achieve good results in detecting and diagnosing faults, in terms of accuracy and efficiency. This paper proposes a hybrid fault-diagnosis model based on convolutional neural networks(CNNs) and DAEs, by integrating the powerful capability of CNN in feature extraction and of DAE in classification. A case study was carried out with the distillation process of depropanization. It is shown that the proposed hybrid model is of good performance compared to other models, in terms of the accuracy of fault detection in such a process. Also, with the increase of structural layers of the CNN–DAE model, the diagnostic accuracy will be improved, with an optimal accuracy of 92.2%.

Functional anatomical hepatectomy guided by indocyanine green fluorescence imaging in patients with localized cholestasis:Report of four cases

BACKGROUND Liver cancer is a malignant tumor with a high incidence.At present,the most effective treatment is laparoscopic hepatectomy(LH).Indocyanine green fluorescence imaging(ICG-FI)has become an important tool in LH,and the most common fluorescent types of tumors are total fluorescence,partial fluorescence,and rim fluorescence.CASE SUMMARY We presented four cases of LH guided by ICG-FI in which we also observed the fourth special fluorescent type.When the tumor or intrahepatic stone compresses the adjacent bile duct to cause local cholestasis,the liver segment or subsegment with obstructed bile drainage will show strong fluorescence.Complete removal of the lesion together with the fluorescent liver parenchyma may help reduce the risk of tumor or stone recurrence.CONCLUSION This type of partial fluorescence can indicate local biliary compression,and the resection method is related to bile drainage,which may be called functional anatomical hepatectomy and ensures radical resection of the lesion.

Responses of the East Asian Jet Stream to the North Pacific Subtropical Front in Spring

This study concerns atmospheric responses to the North Pacific subtropical front （NPSTF） in boreal spring over the period 1982-2014. Statistical results show that a strong NPSTF in spring can significantly enhance the East Asian jet stream （EAJS）. Both transient eddy activity and the atmospheric heat source play important roles in this process. The enhanced atmospheric temperature gradient due to a strong NPSTF increases atmospheric baroclinicity, resulting in an intensification of transient eddy and convection activities. On the one hand, the enhanced transient eddy activities can excite an anomalous cyclonic circulation with a quasi-baraotropical structure in the troposphere to the north of the NPSTF. Accordingly, the related westerly wind anomalies around 30°N can intensify the component of the EAJS over the Northeast Pacific. On the other hand, an enhanced atmospheric heat source over the NPSTF, which is related to increased rainfall, acts to excite an anomalous cyclonic circulation system in the troposphere to the northwest of the NPSTF, which can explain the enhanced component of the EAJS over the Northwest Pacific. The two mechanisms may combine to enhance the EAJS.

Wave-Breaking Features of Blocking over Central Siberia and Its Impacts on the Precipitation Trend over Southeastern Lake Baikal

Precipitation over southeastern Lake Baikal features a significant decreasing trend in July and August over 1979–2018 and is closely related to blocking occurrence over central Siberia(45°–70°N,75°–115°E).This study investigates the formation and maintenance of anticyclonic and cyclonic wave-breaking(AWB and CWB)blocking events and their climate impacts on precipitation in the southeastern Lake Baikal area.Both AWB and CWB blocking events are characterized by a cold trough deepening from the sub-Arctic region and a ridge amplifying toward its north over central Siberia,as well as an evident Rossby wave train over midlatitude Eurasia.For AWB blocking events,the ridge and trough pair tilts clockwise and the wave train exhibits a zonal distribution.In contrast,ridge and trough pair associated with CWB blocking events leans anticlockwise with larger-scale,meridional,and more anisotropic signatures.Moreover,the incoming Rossby wave energy associated with CWB blocking events is more evident than for AWB blocking events.Therefore,CWB blocking events are more persistent.AWB blocking events produce more extensive and persistent precipitation over the southeastern Lake Baikal area than CWB blocking events,in which moderate above-normal rainfall is seen in the decaying periods of blockings.A significant decreasing trend is found in terms of AWB blocking occurrence over central Siberia,which may contribute to the downward trend of precipitation over southeastern Lake Baikal.

Fatigue limit assessment of a 6061 aluminum alloy based on infrared thermography and steady ratcheting effect

To quickly predict the fatigue limit of 6061 aluminum alloy,two assessment methods based on the temperature evolution and the steady ratcheting strain difference under cyclic loading,respectively,were proposed.The temperature evolutions during static and cyclic loadings were both measured by infrared thermography.Fatigue tests show that the temperature evolution was closely related to the cyclic loading,and the cyclic loading range can be divided into three sections according to the regular of temperature evolution in different section.The mechanism of temperature evolution under different cyclic loadings was also analyzed due to the thermoelastic,viscous,and thermoplastic effects.Additionally,ratcheting strain under cyclic loading was also measured,and the results show that the evolution of the ratcheting strain under cyclic loading above the fatigue limit undergone three stages:the first increasing stage,the second steady state,and the final abrupt increase stage.The fatigue limit of the 6061 aluminum alloy was quickly estimated based on transition point of linear fitting of temperature increase and the steady value of ratcheting strain difference.Besides,it is feasible and quick of the two methods by the proof of the traditional S-N curve.

From nerve to blood vessel:a new role of Olfm2 in smooth muscle differentiation from human embryonic stem cell-derived mesenchymal cells

Vascular smooth muscle cell （SMC） differentiation is an important process in vasculogenesis and angio- genesis during embryonic development. The altera- tions in the differentiated state in SMCs contribute to a variety of major cardiovascular diseases such as atherosclerosis, hypertension, restenosis and vascular aneurysm . A better understanding of the cellular and molecular mechanisms that control SMC differen-tiation is essential to help develop new approaches to both prevent and treat these diseases. Therefore, development of reliable and reproducible in vitro cellular models in order to study the differentiation mechanisms is important although it has been challenging because of intrinsic peculiarities of SMC.

Inherently safer reactors and procedures to prevent reaction runaway

Reaction runaway has longtime been an issue in chemical industry as it often leads to severe accidents if not controlled and inhibited properly.Herein we have reviewed several key considerations and procedures to prevent such phenomena,including inherently safer reactor design,thermal risk assessment and early warning detection of runaway,and pointed out that the basic principle underlying is necessary heat management and construction of resilient processes.For inherently safer reactor design,important factors such as heat removal,heat capacitance,flow behaviors and explosive behaviors have been investigated.The survey shows that heat exchanger(HEX) reactor and microreactor outperform traditional reactors.Meanwhile,we have looked into the effect of thermal risk ranking and safety operation region determining for thermal risk assessment,and the influence of runaway criteria and construction methods for early detection of reaction runaway as well.It shows that thermal risk assessment plays a key role on process design,and early warning detection system(EWDS) is preferable on prevention of reaction runaway.In the end,perspectives regarding inherently safer designs with the measures discussed above have been provided.

Inhibition of different types of inert dust on aluminum powder explosion

Aluminum powder explosion accidents occurred frequently,but the mechanism of aluminum powder explosion is unclear.Therefore,the inhibitive effect of aluminum powder explosion plays a key role.To evaluate the inhibition capacity of different kinds of carbonates and phosphates:Na H2PO4,(NH4)2HPO4,NH4H2PO4,KHCO3 and Na HCO3 on aluminum deflagrations,a standard 20-L spherical chamber was used to determine the explosion severity,characterized by the maximum explosion pressure(Pmax).New parameters have been proposed:the minimum significant inert concentration(MSIC)and the minimum complete inert concentration(MCIC),which characterized the effect of inert.Experimental results showed that from the minimum significant inert concentration(MSIC)and the minimum complete inert concentration(MCIC),phosphate can have a significant inhibiting effect.40%Na H2PO4 can totally inert the aluminum explosion,and 50%(NH4)2HPO4or 50%NH4H2PO4 can also suppress the explosion.Through simulation,phosphate mainly acts via a chemical inhibition pathway,which inhibits the reaction of aluminum powder and oxygen by catalyzing the recombination of H atoms and O atoms.Carbonate performs inhibition in chemically,producing CO2,diluting the oxygen around the aluminum powder.Studies indicated that the explosion pressure of the mixture decreases as the concentration of inert dust increases.However,when the concentration of carbonates was low,SEEP(suppressant enhanced explosion parameter)phenomenon was found.This research work has a potential industrial application in high hazard aluminum working condition,which can help decrease the explosion pressure and reduce the accident loss.

A new proof-of-work mechanism for bitcoin

Background:Bitcoin system,when more than 51%computing power is controlled by a single node,the block chain can be distorted maliciously.This is called 51%attack which is a well-known potential risk that could destroy the Bitcoin system.Method:The paper proves that under the current proof-of-work mechanism,computing power eventually will be centralized at a single node if miners are rational enough.Result:The paper propose a new proof-of-work mechanism that improves decentralization and reduces the risk of 51%attack without increasing the risk of Sybil attack.Concusions:This new mechanism introduces a series of principles such as Career open to all talents,without distinction of birth,Distribution according to labor and All Men are created equal.

Study on Physical Simulation Test for Pipeline Vulnerability in Case of Landslide

Landslide is one of the most harmful geological disasters for long-distance oil and gas pipelines, and evaluating pipeline vulnerability in case of landslide consequently plays an important role in improving the landslide risk assessment level. To ensure creditability, applicability and operability of pipeline vulnerability evaluation results, a physical simulation test based on the similarity principle was carried out between landslide and pipeline to verify the deformation behavior, stress and strain distribution status of pipeline in case of landslide and to acquire the empirical formula of pipeline vulnerability and distribution of thrust applied on the pipeline by landslide.

Protective effect of liquiritin on oxidative stress injury of SH-EP1 cell lines caused by hydrogen peroxide

Objective:To study the protective effect of liquiritin on the oxidative stress injury of SH-EP1 cell lines caused by hydrogen peroxide.Methods: SH-EP1 cell lines were cultured and randomly divided into control group, H2O2 group and liquiritin group that were treated with the culture medium without serum, 200 μmol/L H2O2 as well as 100 μmol/L, 200 μmol/L and 400 μmol/L liquiritin combined with 200 μmol/L H2O2 respectively. After treatment, cell viability values as well as the content of mitochondrial apoptosis molecules and antioxidant molecules in cells were determined.Results:After 12 h, 24 h, 36 h and 48 h of treatment, the cell viability values of H2O2 group were significantly lower than those of control group, the cell viability values of 100 μmol/L, 200 μmol/L and 400 μmol/L liquiritin group were significantly higher than those of H2O2 group and the larger the liquiritin dosage, the higher the cell viability value;after 24 h of treatment, Bax, Caspase-3, Nrf2 and ARE content of H2O2 group were significantly higher than those of control group while Bcl-2, XIAP, SOD, GHS-Px and HO-1 content were significantly lower than those of control group;Bax and Caspase-3 content of 100 μmol/L, 200 μmol/L and 400 μmol/L liquiritin group were significantly lower than those of H2O2 group while Bcl-2, XIAP, Nrf2, ARE, SOD, GHS-Px and HO-1 content were significantly higher than those of H2O2group, and the larger the liquiritin dosage, the lower the Bax and Caspase-3 content while the higher the Bcl-2, XIAP, Nrf2, ARE, SOD, GHS-Px and HO-1 content.Conclusions:Liquiritin can inhibit the mitochondrial apoptosis and enhance the antioxidant system function to relieve the oxidative stress injury of SH-EP1 cell lines caused by hydrogen peroxide.

Cordycepin regulates the malignant biological behaviors of lung cancer cell lines A549

Objective:To study the effect of cordycepin on proliferation, apoptosis and invasion-related molecule expression in lung cancer cell lines A549. Methods:Lung cancer cell lines A549 were cultured and treated with different doses of cordycepin (0, 0.25, 0.5, 1.0, 2.0 and 4.0 ng/mL) for 24 h, and then the proliferation, apoptosis and invasion-related molecule mRNA expression in cells were detected. Results:After 0.25, 0.5, 1.0, 2.0 and 4.0 ng/mL cordycepin treatment, Caspase-3, Caspase-8, NOX1 and LATS1 mRNA expression were significantly higher than those after 0 ng/mL cordycepin treatment (P<0.05) while CyclinD1, Bcl-2, c-Myc, c-FLIP, TRAF6, N-cadherin and Vimentin mRNA expression were significantly lower than those after 0 ng/mL cordycepin treatment (P<0.05). The greater the cordycepin dosage, the higher the Caspase-3, Caspase-8, NOX1 and LATS1 mRNA expression, and the lower the CyclinD1, Bcl-2, c-Myc, c-FLIP, TRAF6, N-cadherin and Vimentin mRNA expression. Conclusions: Cordycepin can promote pro-apoptosis gene expression and inhibit pro-proliferation and pro-invasion gene expression in lung cancer cell lines A549.