Traffic prediction already plays a significant role in applications like traffic planning and urban management,but it is still difficult to capture the highly non-linear and complicated spatiotemporal correlations of ...Traffic prediction already plays a significant role in applications like traffic planning and urban management,but it is still difficult to capture the highly non-linear and complicated spatiotemporal correlations of traffic data.As well as to fulfil both long-termand short-termprediction objectives,a better representation of the temporal dependency and global spatial correlation of traffic data is needed.In order to do this,the Spatiotemporal Graph Neural Network(S-GNN)is proposed in this research as amethod for traffic prediction.The S-GNN simultaneously accepts various traffic data as inputs and investigates the non-linear correlations between the variables.In terms of modelling,the road network is initially represented as a spatiotemporal directed graph,with the features of the samples at the time step being captured by a convolution module.In order to assign varying attention weights to various adjacent area nodes of the target node,the adjacent areas information of nodes in the road network is then aggregated using a graph network.The data is output using a fully connected layer at the end.The findings show that S-GNN can improve short-and long-term traffic prediction accuracy to a greater extent;in comparison to the control model,the RMSE of S-GNN is reduced by about 0.571 to 9.288 and the MAE(Mean Absolute Error)by about 0.314 to 7.678.The experimental results on two real datasets,Pe MSD7(M)and PEMS-BAY,also support this claim.展开更多
Background: Men who have sex with men (MSM) are highly vulnerable to HIV infection, but this population can be particularly difficult to reach in Thailand. This study aimed to estimate the number of MSM in Chiang Mai ...Background: Men who have sex with men (MSM) are highly vulnerable to HIV infection, but this population can be particularly difficult to reach in Thailand. This study aimed to estimate the number of MSM in Chiang Mai Thailand, in order to plan HIV control and prevention. Methods: The total of 348 potential MSM were identified at eight contact locations, including two public parks, two bars, two massage parlors and two pubs in Chiang Mai. Trained 16 research enumerators and 16 enumerators were trained to extend a recruitment of brooches to MSM. The MSMs were captured one week apart. A record was kept of when, where and by whom the invitation was extended and received, and of refusals. The total estimate of MSM was derived from capture-recapture calculation. Results: The total MSM in Chiang Mai Thailand estimated by capture and recapture method was 733 (95%CI = 480 - 948) or the estimate was 7.3% (95%CI = 7.1% - 14.1%). Conclusions: Capture and recapture method can be used to enumerate and provide accurate and reliable estimates of the MSM population in any area, provided that certain conditions are controlled. MSM who are engaged in personal community represent a sizeable population who urgently need to be targeted by HIV and STDs prevention strategies.展开更多
AIM: To compare the gene expression profile in a pair of HBV-infected twins.METHODS: The gene expression profile was compared in a pair of HBV-infected twins.RESULTS: The twins displayed different disease outcomes. On...AIM: To compare the gene expression profile in a pair of HBV-infected twins.METHODS: The gene expression profile was compared in a pair of HBV-infected twins.RESULTS: The twins displayed different disease outcomes. One acquired natural immunity against HBV,whereas the other became a chronic HBV carrier. Eightyeight and forty-six genes were found to be up- or downregulated in their PBMCs, respectively. Tumor necrosis factor-alpha-induced protein 1 (TNF-αIP1) that expressed at a higher level in the HBV-immune twins was identified and four pairs of siblings with HBV immunity by RTPCR. However, upon HBV core antigen stimulation,TNF-αIP1 was downregulated in PBMCs from subjects with immunity, whereas it was slightly upregulated in HBV carriers. Bioinformatics analysis revealed a K+channel tetramerization domain in TNF-αIP1 that shares a significant homology with some human, mouse, and C elegan proteins.CONCLUSION: TNF-αIP1 may play a role in the innate immunity against HBV.展开更多
We experimentally investigate the effect of the hopper angle on the flow rate of grains discharged from a twodimensional horizontal hopper on a conveyor belt.The flow rate grows with the hopper angle,and finally reach...We experimentally investigate the effect of the hopper angle on the flow rate of grains discharged from a twodimensional horizontal hopper on a conveyor belt.The flow rate grows with the hopper angle,and finally reaches a plateau.The curve feature appears to be similar for different orifice widths and conveyor belt-driven velocities.On the basis of an empirical law of flow rate for a flat-bottom hopper,we propose a modified equation to describe the relation between the flow rate and hopper angle,which is in a good agreement with the experimental results.展开更多
The accessory olfactory bulb(AOB), located at the posterior dorsal aspect of the main olfactory bulb(MOB), is the first brain relay of the accessory olfactory system(AOS), which can parallelly detect and process volat...The accessory olfactory bulb(AOB), located at the posterior dorsal aspect of the main olfactory bulb(MOB), is the first brain relay of the accessory olfactory system(AOS), which can parallelly detect and process volatile and nonvolatile social chemosignals and mediate different sexual and social behaviors with the main olfactory system(MOS). However, due to its anatomical location and absence of specific markers, there is a lack of research on the internal and external neural circuits of the AOB. This issue was addressed by singlecolor labeling and fluorescent double labeling using retrograde rAAVs injected into the bed nucleus of the stria terminalis(BST), anterior cortical amygdalar area(ACo), medial amygdaloid nucleus(MeA), and posteromedial cortical amygdaloid area(PMCo) in mice. We demonstrated the effectiveness of this AOB projection neuron labeling method and showed that the mitral cells of the AOB exhibited efferent projection dispersion characteristics similar to those of the MOB. Moreover, there were significant differences in the number of neurons projected to different brain regions, which indicated that each mitral cell in the AOB could project to a different number of neurons in different cortices. These results provide a circuitry basis to help understand the mechanism by which pheromone information is encoded and decoded in the AOS.展开更多
The study was conducted to explore factors associated with condom use of young Thai men conscripts. Methods: A cross-sectional study was conducted. Participants were 159 conscripts in second year who served in the Roy...The study was conducted to explore factors associated with condom use of young Thai men conscripts. Methods: A cross-sectional study was conducted. Participants were 159 conscripts in second year who served in the Royal Thai Army by lottery method. Demographic data, sexual history including condom use, HIV and STDs and knowledge were collected using a self-administered questionnaire. Logistic regression was used to analyze the data. Results: Condom use at the last sex was 41.18% of the conscripts aged 20 - 27 years and secondary school education completed of 74.2%. 25.78% had experience with drugs used but injection was rare (6.9%). Age at the first sex was reported lowest at 11 years, 9.4% reported first sex with men and 21.38% were married. The participants have sexual history (last six months) with female only of 83.2%, male only of 4.1% and both of 14.6%. Among these only 12.6% reported every time of condom use and 19.5% never used condom. Older age, higher education, drinking alcohol, drugs use and higher knowledge were associated with condom use with statistical significance. Conclusions: Condom use among male Thai conscripts was low. Education and a condom use program are urgently needed to prevent future spread of HIV and STDs.展开更多
Thermosets based on direct curing of multifunctional monomers offer processing flexibility that thermoplastics cannot provide.However,this type of thermoset is typically amorphous since it is difficult to meet the str...Thermosets based on direct curing of multifunctional monomers offer processing flexibility that thermoplastics cannot provide.However,this type of thermoset is typically amorphous since it is difficult to meet the stringent requirement of long-range molecular regularity for crystallization.However,we report here a crystallizable poly(thiourethane)thermoset synthesized directly from the curing of low-viscosity liquid precursors that does not employ any solvent.Its crystalline nature results in superior toughness,comparable to commercial high-density polyethylene,in sharp contrast to the brittleness of the typical,rigid,glassy thermoset materials.Beyond that,the network polymer exhibits shape-memory behavior in which the crystalline transition is utilized for temporary shape fixing/recovery whereas the dynamic thiourethane bonds can be activated for bond exchange as a mechanism for complex shape manipulation.Materials with these combined features represent attractive options for demanding engineering applications due to their high performance and multifunctinality.展开更多
Artificial active matters on a macroscopic scale,including vibrating particles,robots,and camphor boats,have attracted increasing attentions due to their uniform properties,rich and easily controllable parameters,conv...Artificial active matters on a macroscopic scale,including vibrating particles,robots,and camphor boats,have attracted increasing attentions due to their uniform properties,rich and easily controllable parameters,convenient observation,and the independence of biochemical processes from physical processes,especially providing these unique advantages for researching the collective behaviors under strong confinement and crowded surroundings.In this review,we present an overview of motion models,mechanisms,and dynamic characteristics of various active particles,both in free and complex media.Additionally,we delve into the collective behaviors of“dry”active matter,covering structural and dynamic properties observed in experiments and theoretical models.We summarize the impact of hydrodynamic interactions on the dynamics and structures of these active particles within hydrodynamic environments.Lastly,we discuss emerging opportunities and challenges for future advancement of macroscopic artificial active matter.展开更多
基金supported by Science and Technology Plan Project of Zhejiang Provincial Department of Transportation“Research and System Development of Highway Asset Digitalization Technology inUse Based onHigh-PrecisionMap”(Project Number:202203)in part by Science and Technology Plan Project of Zhejiang Provincial Department of Transportation:Research and Demonstration Application of Key Technologies for Precise Sensing of Expressway Thrown Objects(No.202204).
文摘Traffic prediction already plays a significant role in applications like traffic planning and urban management,but it is still difficult to capture the highly non-linear and complicated spatiotemporal correlations of traffic data.As well as to fulfil both long-termand short-termprediction objectives,a better representation of the temporal dependency and global spatial correlation of traffic data is needed.In order to do this,the Spatiotemporal Graph Neural Network(S-GNN)is proposed in this research as amethod for traffic prediction.The S-GNN simultaneously accepts various traffic data as inputs and investigates the non-linear correlations between the variables.In terms of modelling,the road network is initially represented as a spatiotemporal directed graph,with the features of the samples at the time step being captured by a convolution module.In order to assign varying attention weights to various adjacent area nodes of the target node,the adjacent areas information of nodes in the road network is then aggregated using a graph network.The data is output using a fully connected layer at the end.The findings show that S-GNN can improve short-and long-term traffic prediction accuracy to a greater extent;in comparison to the control model,the RMSE of S-GNN is reduced by about 0.571 to 9.288 and the MAE(Mean Absolute Error)by about 0.314 to 7.678.The experimental results on two real datasets,Pe MSD7(M)and PEMS-BAY,also support this claim.
文摘Background: Men who have sex with men (MSM) are highly vulnerable to HIV infection, but this population can be particularly difficult to reach in Thailand. This study aimed to estimate the number of MSM in Chiang Mai Thailand, in order to plan HIV control and prevention. Methods: The total of 348 potential MSM were identified at eight contact locations, including two public parks, two bars, two massage parlors and two pubs in Chiang Mai. Trained 16 research enumerators and 16 enumerators were trained to extend a recruitment of brooches to MSM. The MSMs were captured one week apart. A record was kept of when, where and by whom the invitation was extended and received, and of refusals. The total estimate of MSM was derived from capture-recapture calculation. Results: The total MSM in Chiang Mai Thailand estimated by capture and recapture method was 733 (95%CI = 480 - 948) or the estimate was 7.3% (95%CI = 7.1% - 14.1%). Conclusions: Capture and recapture method can be used to enumerate and provide accurate and reliable estimates of the MSM population in any area, provided that certain conditions are controlled. MSM who are engaged in personal community represent a sizeable population who urgently need to be targeted by HIV and STDs prevention strategies.
文摘AIM: To compare the gene expression profile in a pair of HBV-infected twins.METHODS: The gene expression profile was compared in a pair of HBV-infected twins.RESULTS: The twins displayed different disease outcomes. One acquired natural immunity against HBV,whereas the other became a chronic HBV carrier. Eightyeight and forty-six genes were found to be up- or downregulated in their PBMCs, respectively. Tumor necrosis factor-alpha-induced protein 1 (TNF-αIP1) that expressed at a higher level in the HBV-immune twins was identified and four pairs of siblings with HBV immunity by RTPCR. However, upon HBV core antigen stimulation,TNF-αIP1 was downregulated in PBMCs from subjects with immunity, whereas it was slightly upregulated in HBV carriers. Bioinformatics analysis revealed a K+channel tetramerization domain in TNF-αIP1 that shares a significant homology with some human, mouse, and C elegan proteins.CONCLUSION: TNF-αIP1 may play a role in the innate immunity against HBV.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11475018 and 11974044)the National Key Research and Development Program of China(Grant 2016YFC1401001)。
文摘We experimentally investigate the effect of the hopper angle on the flow rate of grains discharged from a twodimensional horizontal hopper on a conveyor belt.The flow rate grows with the hopper angle,and finally reaches a plateau.The curve feature appears to be similar for different orifice widths and conveyor belt-driven velocities.On the basis of an empirical law of flow rate for a flat-bottom hopper,we propose a modified equation to describe the relation between the flow rate and hopper angle,which is in a good agreement with the experimental results.
基金supported by the National Natural Science Foundation of China(31400946,31771156,91632303/H09,91732304 and 31830035)Strategic Priority Research Program of the Chinese Academy of Sciences(XDB32030200)。
文摘The accessory olfactory bulb(AOB), located at the posterior dorsal aspect of the main olfactory bulb(MOB), is the first brain relay of the accessory olfactory system(AOS), which can parallelly detect and process volatile and nonvolatile social chemosignals and mediate different sexual and social behaviors with the main olfactory system(MOS). However, due to its anatomical location and absence of specific markers, there is a lack of research on the internal and external neural circuits of the AOB. This issue was addressed by singlecolor labeling and fluorescent double labeling using retrograde rAAVs injected into the bed nucleus of the stria terminalis(BST), anterior cortical amygdalar area(ACo), medial amygdaloid nucleus(MeA), and posteromedial cortical amygdaloid area(PMCo) in mice. We demonstrated the effectiveness of this AOB projection neuron labeling method and showed that the mitral cells of the AOB exhibited efferent projection dispersion characteristics similar to those of the MOB. Moreover, there were significant differences in the number of neurons projected to different brain regions, which indicated that each mitral cell in the AOB could project to a different number of neurons in different cortices. These results provide a circuitry basis to help understand the mechanism by which pheromone information is encoded and decoded in the AOS.
文摘The study was conducted to explore factors associated with condom use of young Thai men conscripts. Methods: A cross-sectional study was conducted. Participants were 159 conscripts in second year who served in the Royal Thai Army by lottery method. Demographic data, sexual history including condom use, HIV and STDs and knowledge were collected using a self-administered questionnaire. Logistic regression was used to analyze the data. Results: Condom use at the last sex was 41.18% of the conscripts aged 20 - 27 years and secondary school education completed of 74.2%. 25.78% had experience with drugs used but injection was rare (6.9%). Age at the first sex was reported lowest at 11 years, 9.4% reported first sex with men and 21.38% were married. The participants have sexual history (last six months) with female only of 83.2%, male only of 4.1% and both of 14.6%. Among these only 12.6% reported every time of condom use and 19.5% never used condom. Older age, higher education, drinking alcohol, drugs use and higher knowledge were associated with condom use with statistical significance. Conclusions: Condom use among male Thai conscripts was low. Education and a condom use program are urgently needed to prevent future spread of HIV and STDs.
基金supported by the National Natural Science Foundation of China(grant nos.52322307,52033009,22275162,and 52003232).
文摘Thermosets based on direct curing of multifunctional monomers offer processing flexibility that thermoplastics cannot provide.However,this type of thermoset is typically amorphous since it is difficult to meet the stringent requirement of long-range molecular regularity for crystallization.However,we report here a crystallizable poly(thiourethane)thermoset synthesized directly from the curing of low-viscosity liquid precursors that does not employ any solvent.Its crystalline nature results in superior toughness,comparable to commercial high-density polyethylene,in sharp contrast to the brittleness of the typical,rigid,glassy thermoset materials.Beyond that,the network polymer exhibits shape-memory behavior in which the crystalline transition is utilized for temporary shape fixing/recovery whereas the dynamic thiourethane bonds can be activated for bond exchange as a mechanism for complex shape manipulation.Materials with these combined features represent attractive options for demanding engineering applications due to their high performance and multifunctinality.
基金supported by the National Natural Science Foundation of China(12374205,12304245 and 12364029)the Science Foundation of China University of Petroleum,Beijing(2462023YJRC031 and 2462024BJRC010)+4 种基金the Beijing Institute of Technology Research Fund Program for Young Scholars,the Young Elite Scientist Sponsorship Program by BAST(BYESS2023300)the Natural Science Foundation of Inner Mongolia Autonomous Region(2023QN01015)the Beijing National Laboratory for Condensed Matter Physics(2023BNLCMPKF014)the Academic Research Fund from the Singapore Ministry of Education Tier 1 Gant(RG59/21)the National Research Foundation,Singapore,under its 29th Competitive Research Programme(CRP)Call(Award ID NRF-CRP29-2022-0002)
文摘Artificial active matters on a macroscopic scale,including vibrating particles,robots,and camphor boats,have attracted increasing attentions due to their uniform properties,rich and easily controllable parameters,convenient observation,and the independence of biochemical processes from physical processes,especially providing these unique advantages for researching the collective behaviors under strong confinement and crowded surroundings.In this review,we present an overview of motion models,mechanisms,and dynamic characteristics of various active particles,both in free and complex media.Additionally,we delve into the collective behaviors of“dry”active matter,covering structural and dynamic properties observed in experiments and theoretical models.We summarize the impact of hydrodynamic interactions on the dynamics and structures of these active particles within hydrodynamic environments.Lastly,we discuss emerging opportunities and challenges for future advancement of macroscopic artificial active matter.
