Damage from spinal cord injury occurs in two phases-the trauma of the initial mechanical insult and a secondary injury to nervous tissue spared by the primary insult.Apart from damage sustained as a result of direct t...Damage from spinal cord injury occurs in two phases-the trauma of the initial mechanical insult and a secondary injury to nervous tissue spared by the primary insult.Apart from damage sustained as a result of direct trauma to the spinal cord,the post-traumatic inflammatory response contributes significantly to functional motor deficits exacerbated by the secondary injury.Attenuating the detrimental aspects of the inflammatory response is a promising strategy to potentially ameliorate the secondary injury,and promote significant functional recovery.This review details how the inflammatory component of secondary injury to the spinal cord can be treated currently and in the foreseeable future.展开更多
AIMTo prospectively study the outcome of difficult gastroduodenal perforations (GDPs) treated by triple tube drainage (TTD) in order to standardize the procedure.METHODSPatients presenting to a single surgical unit of...AIMTo prospectively study the outcome of difficult gastroduodenal perforations (GDPs) treated by triple tube drainage (TTD) in order to standardize the procedure.METHODSPatients presenting to a single surgical unit of a tertiary hospital with difficult GDPs (large, unfavourable local and systemic factors) were treated with TTD (gastrostomy, duodenostomy and feeding jejunostomy). Postoperative parameters were observed like time to return of bowel sounds, time to start enteral feeds, time to start oral feeds, daily output of all drains, time to clamping/removal of all drains, time for skin to heal, complications, hospital stay, and, mortality. Descriptive statistics were used.RESULTSBetween December 2013 and April 2015, 20 patients undergoing TTD for GDP were included, with mean age of 44.6 ± 19.8 years and male:female ratio of 17:3. Mean pre-operative APACHE II scores were 10.85 ± 3.55; most GDPs were prepyloric (9/20; 45%) or proximal duodenal (8/20; 40%) and mean size was 1.83 ± 0.59 cm (largest 2.5 cm). Median times of resumption of enteral feeding, removal of gastrostomy, removal of duodenostomy, removal of feeding jejunostomy and oral feeding were 4 d (4-5 IQR), 13 (12-16.5 IQR), 16 (16.25-22.25 IQR), 18 (16.5-24 IQR) and 12 d (10.75-18.5 IQR) respectively. Median hospital stay was 22 d (19-26 IQR) while mortality was 4/20 (20%).CONCLUSIONTTD for difficult GDP is feasible, easy in the emergency, and patients recover in two-three weeks. It obviates the need for technically demanding and riskier procedures.展开更多
BACKGROUND:Choledochal cysts are classified into five types based on the location of the cyst.Mixed types of choledochal cysts are extremely rare.Only five cases of mixed typeⅠandⅡcholedochal cysts have been reporte...BACKGROUND:Choledochal cysts are classified into five types based on the location of the cyst.Mixed types of choledochal cysts are extremely rare.Only five cases of mixed typeⅠandⅡcholedochal cysts have been reported, of which one was an adult case.We report a mixed typeⅠ andⅡcholedochal cyst in a 25-year-old man. METHODS:The unusual nature of the choledochal cyst, suspected on magnetic resonance cholangiopancreatography RCP to be typeⅠinitially,was confirmed by laparotomy to be a mixed typeⅠ+Ⅱcyst.Excision of the cyst and hepaticojejunostomy were performed. RESULT:The operation was uneventful,and the patient recovered well. CONCLUSIONS:Mixed type choledochal cysts are rare, and may be missed on imaging,unless careful evaluation is done.The operative method may not need to be modified significantly,as in the management of our case.展开更多
Traditional endoscopic techniques for Barrett’s esophagus(BE)surveillance relied on factor of probability as endoscopists performed cumbersome random biopsies of low yield.Optical coherence tomography(OCT)is a novel ...Traditional endoscopic techniques for Barrett’s esophagus(BE)surveillance relied on factor of probability as endoscopists performed cumbersome random biopsies of low yield.Optical coherence tomography(OCT)is a novel technique based on tissue light interference and is set to break conventional barriers.OCT was initially introduced in ophthalmology but was soon adopted by other areas of medicine.When applied to endoscopy,OCT can render images of the superficial layers of the gastrointestinal tract and is highly sensitive in detecting dysplasia in BE.Volumetric laser endomicroscopy is a second generation OCT endoscope device which is able to identify buried glands after ablation.Addition of artificial intelligence to OCT has rendered it more productive.The newer additions to OCT such as angiogram and laser marking will increase the accuracy of investigation.In spite of the few inevitable drawbacks associated with the technology,it presently outperforms all newer endoscopic techniques for the surveillance of BE.展开更多
文摘Damage from spinal cord injury occurs in two phases-the trauma of the initial mechanical insult and a secondary injury to nervous tissue spared by the primary insult.Apart from damage sustained as a result of direct trauma to the spinal cord,the post-traumatic inflammatory response contributes significantly to functional motor deficits exacerbated by the secondary injury.Attenuating the detrimental aspects of the inflammatory response is a promising strategy to potentially ameliorate the secondary injury,and promote significant functional recovery.This review details how the inflammatory component of secondary injury to the spinal cord can be treated currently and in the foreseeable future.
文摘AIMTo prospectively study the outcome of difficult gastroduodenal perforations (GDPs) treated by triple tube drainage (TTD) in order to standardize the procedure.METHODSPatients presenting to a single surgical unit of a tertiary hospital with difficult GDPs (large, unfavourable local and systemic factors) were treated with TTD (gastrostomy, duodenostomy and feeding jejunostomy). Postoperative parameters were observed like time to return of bowel sounds, time to start enteral feeds, time to start oral feeds, daily output of all drains, time to clamping/removal of all drains, time for skin to heal, complications, hospital stay, and, mortality. Descriptive statistics were used.RESULTSBetween December 2013 and April 2015, 20 patients undergoing TTD for GDP were included, with mean age of 44.6 ± 19.8 years and male:female ratio of 17:3. Mean pre-operative APACHE II scores were 10.85 ± 3.55; most GDPs were prepyloric (9/20; 45%) or proximal duodenal (8/20; 40%) and mean size was 1.83 ± 0.59 cm (largest 2.5 cm). Median times of resumption of enteral feeding, removal of gastrostomy, removal of duodenostomy, removal of feeding jejunostomy and oral feeding were 4 d (4-5 IQR), 13 (12-16.5 IQR), 16 (16.25-22.25 IQR), 18 (16.5-24 IQR) and 12 d (10.75-18.5 IQR) respectively. Median hospital stay was 22 d (19-26 IQR) while mortality was 4/20 (20%).CONCLUSIONTTD for difficult GDP is feasible, easy in the emergency, and patients recover in two-three weeks. It obviates the need for technically demanding and riskier procedures.
文摘BACKGROUND:Choledochal cysts are classified into five types based on the location of the cyst.Mixed types of choledochal cysts are extremely rare.Only five cases of mixed typeⅠandⅡcholedochal cysts have been reported, of which one was an adult case.We report a mixed typeⅠ andⅡcholedochal cyst in a 25-year-old man. METHODS:The unusual nature of the choledochal cyst, suspected on magnetic resonance cholangiopancreatography RCP to be typeⅠinitially,was confirmed by laparotomy to be a mixed typeⅠ+Ⅱcyst.Excision of the cyst and hepaticojejunostomy were performed. RESULT:The operation was uneventful,and the patient recovered well. CONCLUSIONS:Mixed type choledochal cysts are rare, and may be missed on imaging,unless careful evaluation is done.The operative method may not need to be modified significantly,as in the management of our case.
文摘Traditional endoscopic techniques for Barrett’s esophagus(BE)surveillance relied on factor of probability as endoscopists performed cumbersome random biopsies of low yield.Optical coherence tomography(OCT)is a novel technique based on tissue light interference and is set to break conventional barriers.OCT was initially introduced in ophthalmology but was soon adopted by other areas of medicine.When applied to endoscopy,OCT can render images of the superficial layers of the gastrointestinal tract and is highly sensitive in detecting dysplasia in BE.Volumetric laser endomicroscopy is a second generation OCT endoscope device which is able to identify buried glands after ablation.Addition of artificial intelligence to OCT has rendered it more productive.The newer additions to OCT such as angiogram and laser marking will increase the accuracy of investigation.In spite of the few inevitable drawbacks associated with the technology,it presently outperforms all newer endoscopic techniques for the surveillance of BE.
