In the present study, two new compounds from Ipomoea cairica were identified and demonstrated to have a-glucosidase inhibitory activity. They were isolated by column chromatography on silica gel and sephadex LH-20 and...In the present study, two new compounds from Ipomoea cairica were identified and demonstrated to have a-glucosidase inhibitory activity. They were isolated by column chromatography on silica gel and sephadex LH-20 and finally purified by prep-HPLC, with their structures being elucidated by spectroscopic methods, such as 1D- and 2D-NMR and HR-TOF-MS, and chemical methods. Compounds 1 and 2, named cairicoside A and cairicoside B, were evaluated for a-glucosidase inhibitory activity by the MTT method, with the ICs0 values being 25.3 ± 1.6 and 28.5± 3.3 μmol·L-1, respectively.展开更多
In the present study, three compounds were isolated from Argyreia acuta, among them, compounds 1 and 2 were new and Compounds 1 and 3 were isomers. They were separated by several types of columns, such as normal phase...In the present study, three compounds were isolated from Argyreia acuta, among them, compounds 1 and 2 were new and Compounds 1 and 3 were isomers. They were separated by several types of columns, such as normal phase, RP, size exclusion and preparative HPLC, and their structures were elucidated by several spectroscopic methods, such as 1D-and 2D-NMR and HR-TOF-MS.展开更多
基金supported by Chinese National Natural Science Fund(No.81202885)the Natural Science Foundation of Guangdong province of China(No.2015A030313585)
文摘In the present study, two new compounds from Ipomoea cairica were identified and demonstrated to have a-glucosidase inhibitory activity. They were isolated by column chromatography on silica gel and sephadex LH-20 and finally purified by prep-HPLC, with their structures being elucidated by spectroscopic methods, such as 1D- and 2D-NMR and HR-TOF-MS, and chemical methods. Compounds 1 and 2, named cairicoside A and cairicoside B, were evaluated for a-glucosidase inhibitory activity by the MTT method, with the ICs0 values being 25.3 ± 1.6 and 28.5± 3.3 μmol·L-1, respectively.
基金supported by National Natural Science Fundation of China(Nos.81202885,81373931,81573877,and 81403074)the Natural Science Foundation of Guangdong Province of China(No.2015A030313585)
文摘In the present study, three compounds were isolated from Argyreia acuta, among them, compounds 1 and 2 were new and Compounds 1 and 3 were isomers. They were separated by several types of columns, such as normal phase, RP, size exclusion and preparative HPLC, and their structures were elucidated by several spectroscopic methods, such as 1D-and 2D-NMR and HR-TOF-MS.
