Objective:To estimate the risk of chronic kidney disease in patients with leptospirosis.Methods:All reported(41890)and later confirmed leptospirosis(1990)cases from 2010-2020 were traced by universal sampling.386 Labo...Objective:To estimate the risk of chronic kidney disease in patients with leptospirosis.Methods:All reported(41890)and later confirmed leptospirosis(1990)cases from 2010-2020 were traced by universal sampling.386 Laboratory-confirmed leptospirosis cases were enrolled and 413 age,gender,area,and occupation matched healthy persons were included as controls.Variables including socio-demographic characteristics,medical history,and health-related behaviours were compared between the two groups and association between these variables and reduced estimated glomerular filtration rate(eGFR)was analyzed with multiple linear regression.Results:The median of eGFR was 49.0(27.0,75.0)mL/min/1.73 m^(2) in the cases and 96.0(72.0,121.0)mL/min/1.73 m^(2) in the controls,showing significant differences(P<0.001).Bivariate analysis showed that leptospirosis seropositivitiy,repeat leptospirosis infection,diabetes,male gender,working in field(sun exposure),COVID-19 infection and smoking had statistically significant association with reduced eGFR.Leptospirosis seropositivity had negative effects on eGFR.Multiple linear regression confirmed that leptospirosis seropositivity had negative effects on eGFR(unstandardised β coefficients=−30.86,95%CI−49.7 to−11.9,P<0.001).Conclusions:Chronic kidney disease is a complex disease with multiple risk factors involved.Exposure to leptospirosis is one of the essential factors in accelerating its progression.展开更多
The aim of the study was to investigate the vibriocidal activity of crude extracts of 18 ethnomedicinal plants used by Nicobarese tribe. Plants were collected from the villages of Car Nicobar Island with the help of T...The aim of the study was to investigate the vibriocidal activity of crude extracts of 18 ethnomedicinal plants used by Nicobarese tribe. Plants were collected from the villages of Car Nicobar Island with the help of TKPs （traditional knowledge practitioners）. The methanol extracts were obtained by cold percolation method and the antimicrobial activity of the extracts was observed by agar well diffusion method. Results indicated that out of 18 plants, seven plants exhibited vibriocidal activity. Morinda citrifolia, Ganophyllumfalcatum and Leea aequata were most active among the plants tested. This study thus can be further utilized to formulate the new antimicrobial agents to fight against Vibrio cholerae.展开更多
文摘Objective:To estimate the risk of chronic kidney disease in patients with leptospirosis.Methods:All reported(41890)and later confirmed leptospirosis(1990)cases from 2010-2020 were traced by universal sampling.386 Laboratory-confirmed leptospirosis cases were enrolled and 413 age,gender,area,and occupation matched healthy persons were included as controls.Variables including socio-demographic characteristics,medical history,and health-related behaviours were compared between the two groups and association between these variables and reduced estimated glomerular filtration rate(eGFR)was analyzed with multiple linear regression.Results:The median of eGFR was 49.0(27.0,75.0)mL/min/1.73 m^(2) in the cases and 96.0(72.0,121.0)mL/min/1.73 m^(2) in the controls,showing significant differences(P<0.001).Bivariate analysis showed that leptospirosis seropositivitiy,repeat leptospirosis infection,diabetes,male gender,working in field(sun exposure),COVID-19 infection and smoking had statistically significant association with reduced eGFR.Leptospirosis seropositivity had negative effects on eGFR.Multiple linear regression confirmed that leptospirosis seropositivity had negative effects on eGFR(unstandardised β coefficients=−30.86,95%CI−49.7 to−11.9,P<0.001).Conclusions:Chronic kidney disease is a complex disease with multiple risk factors involved.Exposure to leptospirosis is one of the essential factors in accelerating its progression.
文摘The aim of the study was to investigate the vibriocidal activity of crude extracts of 18 ethnomedicinal plants used by Nicobarese tribe. Plants were collected from the villages of Car Nicobar Island with the help of TKPs （traditional knowledge practitioners）. The methanol extracts were obtained by cold percolation method and the antimicrobial activity of the extracts was observed by agar well diffusion method. Results indicated that out of 18 plants, seven plants exhibited vibriocidal activity. Morinda citrifolia, Ganophyllumfalcatum and Leea aequata were most active among the plants tested. This study thus can be further utilized to formulate the new antimicrobial agents to fight against Vibrio cholerae.
