目的探究磁共振弹性成像(Magnetic resonance elastography,MRE)在宫颈癌的临床价值。材料与方法本研究前瞻性地招募39名病理诊断为宫颈癌的患者(宫颈癌组),并招募39名年龄、体质指数(body mass index,BMI)相匹配的健康女性志愿者(健康...目的探究磁共振弹性成像(Magnetic resonance elastography,MRE)在宫颈癌的临床价值。材料与方法本研究前瞻性地招募39名病理诊断为宫颈癌的患者(宫颈癌组),并招募39名年龄、体质指数(body mass index,BMI)相匹配的健康女性志愿者(健康对照组)进行宫颈常规磁共振扫描和频率为60 Hz的MRE检查。测量两组受试者宫颈的弹性值以及宫颈癌组肿瘤的体积及浸润深度,收集宫颈癌组患者的肿瘤分期。选择配对样本t检验比较宫颈癌组和健康对照组的弹性值,采用Spearman秩相关系数及受试者工作特征(receiver operating characteristic,ROC)曲线分析弹性值、肿瘤体积和浸润深度与宫颈癌分期间的相关性及诊断宫颈癌分期的效能。结果宫颈癌患者组的平均弹性值[(5.76±0.99)kPa]显著高于健康对照组[(2.94±0.25)kPa;P<0.001]。弹性值、肿瘤体积及浸润深度在早期(≤ⅡA期)、晚期(≥ⅡB期)宫颈癌之间差异存在统计学意义,且与宫颈癌分期呈正相关(r=0.439、0.384、0.322;P均<0.05)。弹性值的诊断效能优于肿瘤体积和浸润深度,ROC曲线下面积(area under the curve,AUC)分别为0.754、0.722、0.687。结论MRE技术可以作为一种非侵入性的辅助检查手段,帮助宫颈癌的诊断和分期评估,在宫颈癌研究和治疗策略的制订中具有潜在的临床应用前景。展开更多
Objective Oral lichen planus(OLP)is one of the most common oral mucosa diseases,and is mainly mediated by T lymphocytes.The metabolic reprogramming of activated T cells has been shown to transform from oxidative phosp...Objective Oral lichen planus(OLP)is one of the most common oral mucosa diseases,and is mainly mediated by T lymphocytes.The metabolic reprogramming of activated T cells has been shown to transform from oxidative phosphorylation to aerobic glycolysis.The present study investigated the serum levels of glycolysis-related molecules(lactate dehydrogenase,LDH;pyruvic acid,PA;lactic acid,LAC)in OLP,and the correlation with OLP activity was assessed using the reticular,atrophic and erosive lesion(RAE)scoring system.Methods Univariate and multivariate linear regression functions based on scikit-learn were designed to predict the RAE scores in OLP patients,and the performance of these two machine learning functions was compared.Results The results revealed that the serum levels of PA and LAC were upregulated in erosive OLP(EOLP)patients,when compared to healthy volunteers.Furthermore,the LDH and LAC levels were significantly higher in the EOLP group than in the nonerosive OLP(NEOLP)group.All glycolysis-related molecules were positively correlated to the RAE scores.Among these,LAC had a strong correlation.The univariate function that involved the LAC level and the multivariate function that involved all glycolysis-related molecules presented comparable prediction accuracy and stability,but the latter was more time-consuming.Conclusion It can be concluded that the serum LAC level can be a user-friendly biomarker to monitor the OLP activity,based on the univariate function developed in the present study.The intervention of the glycolytic pathway may provide a potential therapeutic strategy.展开更多
癫痫性脑病(epileptic encephalopathy,EE)是以顽固性癫痫发作和脑电活动严重异常为主要特征的一组疾病综合征。儿童期间起病的EE通常还伴有精神运动发育迟缓或倒退。2017年国际抗癫痫联盟(International League Against Epilepsy,ILAE...癫痫性脑病(epileptic encephalopathy,EE)是以顽固性癫痫发作和脑电活动严重异常为主要特征的一组疾病综合征。儿童期间起病的EE通常还伴有精神运动发育迟缓或倒退。2017年国际抗癫痫联盟(International League Against Epilepsy,ILAE)对癫痫分类进行更新,强调使用发育性和癫痫性脑病这一术语,EE用于在癫痫发生前没有发育落后,而且基因突变本身也不会导致发育迟缓的情况,发育性和癫痫性是发挥作用的两个因素[1]。展开更多
隐蔽性强及攻击方式灵活的中间人(Man-in-the-Middle Attack,MITM)攻击是当前物联网(Internet of Things,IoT)智能家居安全面临的最大安全隐患之一.从攻击与防御两个角度提出了基于上下文感知融合的物联网设备配对模型和基于熵的异构物...隐蔽性强及攻击方式灵活的中间人(Man-in-the-Middle Attack,MITM)攻击是当前物联网(Internet of Things,IoT)智能家居安全面临的最大安全隐患之一.从攻击与防御两个角度提出了基于上下文感知融合的物联网设备配对模型和基于熵的异构物联设备指纹生成机制,以对抗型思维并行开展监测与防御方案研究,实现了对隐藏安全威胁的感知与过滤,通过相似度阈值分析测试与评估模型的建立完成了设备安全性验证,具有较好的效果与优势.展开更多
Extraction of methane hydrate from subseafloor reservoir may potentially trigger seabed slides and induce subsidence.To address the problems,it is crucial to properly characterize the phase equilibrium condition of po...Extraction of methane hydrate from subseafloor reservoir may potentially trigger seabed slides and induce subsidence.To address the problems,it is crucial to properly characterize the phase equilibrium condition of pore hydrate and the shear strength of the soil.As one of the key constitutive components,the phase equilibrium condition enforces a constraint over pore gas pressure,temperature and unhydrated water content.Such a constraint,however,has been traditionally ignored in analyzing the mechanical behavior of hydrate-bearing soil.In this paper,a series of stepwise hydrate dissociation tests was performed,and the phase equilibrium condition of pore hydrate was determined,providing an effective way to evaluate the unhydrated water content during hydrate dissociation.Meanwhile,a series of direct shear tests was also conducted to explore the shear strength characteristics of the soil.It is shown that the shear strength of the hydrate-bearing soil can be significantly influenced by pore gas pressure,unhydrated water content,hydrate saturation and several other factors.In particular,the measured shear strength depends upon the initial water content of the sample,pointing to a potential problem that the shear strength could be wrongly determined if not properly interpreted.A shear strength criterion,which enforces the equilibrium condition of pore hydrate,is developed for hydrate-bearing soil,establishing a link between the equilibrium condition and the shear strength.The proposed equation describes well the shear strength characteristics of hydrate-bearing soils,remarkably unifying the effects of pore pressure,temperature,water content and hydrate saturation.展开更多
Exploring dimensionality effects on cuprates is important for understanding the nature of high-temperature superconductivity.By atomically layer-by-layer growth with oxide molecular beam epitaxy,we demonstrate that La...Exploring dimensionality effects on cuprates is important for understanding the nature of high-temperature superconductivity.By atomically layer-by-layer growth with oxide molecular beam epitaxy,we demonstrate that La_(2−x)Sr_(x)CuO_(4)(x=0.15)thin films remain superconducting down to 2 unit cells of thickness but quickly reach the maximum superconducting transition temperature at and above 4 unit cells.By fitting the critical magnetic field(μ0H_(c2)),we show that the anisotropy of the film’s superconductivity increases with decreasing film thickness,indicating that the superconductivity of the film gradually evolves from weak three-to two-dimensional character.These results are helpful to gain more insight into the nature of high-temperature superconductivity with dimensionality.展开更多
Temporary spinal cord stimulation(tSCS)can effectively reduce the pain and severity of postherpetic neuralgia(PHN).However,there are no effective and objective methods for predicting the effects of tSCS on PHN.Laser s...Temporary spinal cord stimulation(tSCS)can effectively reduce the pain and severity of postherpetic neuralgia(PHN).However,there are no effective and objective methods for predicting the effects of tSCS on PHN.Laser speckle contrast imaging(LSCI)is frequently used in neurology to evaluate the effectiveness of treatment.To assess the accuracy of LSCI in predicting the impact of tSCS on PHN,14 adult patients receiving tSCS treatments for spinal nerve-innervated(C6-T2)PHN participated in this observational study.Visual analog scale(VAS)assessments and LSCI bloodflow images of the-ngers were recorded after the tSCS procedure.The results showed that the VAS scores of all patients decreased signi-cantly.Moreover,the bloodflow index(BFI)values were signi-cantly higher than they were before the procedure.Increased bloodflow and pain alleviation were positively correlated.The-ndings indicated that spinal nerve PHN(C6-T2)was signi-cantly reduced by tSCS.Pain alleviation by tSCS was positively correlated with increased bloodflow in the hand.The effect of tSCS on PHN may thus be predicted using an independent and consistent indicator such as LSCI.展开更多
文摘目的探究磁共振弹性成像(Magnetic resonance elastography,MRE)在宫颈癌的临床价值。材料与方法本研究前瞻性地招募39名病理诊断为宫颈癌的患者(宫颈癌组),并招募39名年龄、体质指数(body mass index,BMI)相匹配的健康女性志愿者(健康对照组)进行宫颈常规磁共振扫描和频率为60 Hz的MRE检查。测量两组受试者宫颈的弹性值以及宫颈癌组肿瘤的体积及浸润深度,收集宫颈癌组患者的肿瘤分期。选择配对样本t检验比较宫颈癌组和健康对照组的弹性值,采用Spearman秩相关系数及受试者工作特征(receiver operating characteristic,ROC)曲线分析弹性值、肿瘤体积和浸润深度与宫颈癌分期间的相关性及诊断宫颈癌分期的效能。结果宫颈癌患者组的平均弹性值[(5.76±0.99)kPa]显著高于健康对照组[(2.94±0.25)kPa;P<0.001]。弹性值、肿瘤体积及浸润深度在早期(≤ⅡA期)、晚期(≥ⅡB期)宫颈癌之间差异存在统计学意义,且与宫颈癌分期呈正相关(r=0.439、0.384、0.322;P均<0.05)。弹性值的诊断效能优于肿瘤体积和浸润深度,ROC曲线下面积(area under the curve,AUC)分别为0.754、0.722、0.687。结论MRE技术可以作为一种非侵入性的辅助检查手段,帮助宫颈癌的诊断和分期评估,在宫颈癌研究和治疗策略的制订中具有潜在的临床应用前景。
基金support of the National Natural Science Foundation of China (No. 52074357)National Key Research and Development Program of China (No. 2019YFC1803500)。
基金This work was supported by grants from the National Natural Science Foundation of China(No.62171193)the Natural Science Foundation of Hubei Province(No.2021CFB399)+1 种基金the Foundation of Health Commission of Hubei Province(No.WJ2021M125)the Key Research and Development Project of Hubei Province of China(No.2022BCA033).
文摘Objective Oral lichen planus(OLP)is one of the most common oral mucosa diseases,and is mainly mediated by T lymphocytes.The metabolic reprogramming of activated T cells has been shown to transform from oxidative phosphorylation to aerobic glycolysis.The present study investigated the serum levels of glycolysis-related molecules(lactate dehydrogenase,LDH;pyruvic acid,PA;lactic acid,LAC)in OLP,and the correlation with OLP activity was assessed using the reticular,atrophic and erosive lesion(RAE)scoring system.Methods Univariate and multivariate linear regression functions based on scikit-learn were designed to predict the RAE scores in OLP patients,and the performance of these two machine learning functions was compared.Results The results revealed that the serum levels of PA and LAC were upregulated in erosive OLP(EOLP)patients,when compared to healthy volunteers.Furthermore,the LDH and LAC levels were significantly higher in the EOLP group than in the nonerosive OLP(NEOLP)group.All glycolysis-related molecules were positively correlated to the RAE scores.Among these,LAC had a strong correlation.The univariate function that involved the LAC level and the multivariate function that involved all glycolysis-related molecules presented comparable prediction accuracy and stability,but the latter was more time-consuming.Conclusion It can be concluded that the serum LAC level can be a user-friendly biomarker to monitor the OLP activity,based on the univariate function developed in the present study.The intervention of the glycolytic pathway may provide a potential therapeutic strategy.
文摘癫痫性脑病(epileptic encephalopathy,EE)是以顽固性癫痫发作和脑电活动严重异常为主要特征的一组疾病综合征。儿童期间起病的EE通常还伴有精神运动发育迟缓或倒退。2017年国际抗癫痫联盟(International League Against Epilepsy,ILAE)对癫痫分类进行更新,强调使用发育性和癫痫性脑病这一术语,EE用于在癫痫发生前没有发育落后,而且基因突变本身也不会导致发育迟缓的情况,发育性和癫痫性是发挥作用的两个因素[1]。
文摘隐蔽性强及攻击方式灵活的中间人(Man-in-the-Middle Attack,MITM)攻击是当前物联网(Internet of Things,IoT)智能家居安全面临的最大安全隐患之一.从攻击与防御两个角度提出了基于上下文感知融合的物联网设备配对模型和基于熵的异构物联设备指纹生成机制,以对抗型思维并行开展监测与防御方案研究,实现了对隐藏安全威胁的感知与过滤,通过相似度阈值分析测试与评估模型的建立完成了设备安全性验证,具有较好的效果与优势.
基金This research was funded by the National Science Foundation of China(NSFC)(Grant Nos.51939011 and 42171135)Youth Innovation Promotion Association,Chinese Academy of Sciences(CAS)(Grant No.2020326),which are gratefully acknowledged.
文摘Extraction of methane hydrate from subseafloor reservoir may potentially trigger seabed slides and induce subsidence.To address the problems,it is crucial to properly characterize the phase equilibrium condition of pore hydrate and the shear strength of the soil.As one of the key constitutive components,the phase equilibrium condition enforces a constraint over pore gas pressure,temperature and unhydrated water content.Such a constraint,however,has been traditionally ignored in analyzing the mechanical behavior of hydrate-bearing soil.In this paper,a series of stepwise hydrate dissociation tests was performed,and the phase equilibrium condition of pore hydrate was determined,providing an effective way to evaluate the unhydrated water content during hydrate dissociation.Meanwhile,a series of direct shear tests was also conducted to explore the shear strength characteristics of the soil.It is shown that the shear strength of the hydrate-bearing soil can be significantly influenced by pore gas pressure,unhydrated water content,hydrate saturation and several other factors.In particular,the measured shear strength depends upon the initial water content of the sample,pointing to a potential problem that the shear strength could be wrongly determined if not properly interpreted.A shear strength criterion,which enforces the equilibrium condition of pore hydrate,is developed for hydrate-bearing soil,establishing a link between the equilibrium condition and the shear strength.The proposed equation describes well the shear strength characteristics of hydrate-bearing soils,remarkably unifying the effects of pore pressure,temperature,water content and hydrate saturation.
基金supported by the National Key Research and Development Program of China(Grant No.2022YFA1403000)the Na-tional Natural Science Foundation of China(Grant No.12250710675).
文摘Exploring dimensionality effects on cuprates is important for understanding the nature of high-temperature superconductivity.By atomically layer-by-layer growth with oxide molecular beam epitaxy,we demonstrate that La_(2−x)Sr_(x)CuO_(4)(x=0.15)thin films remain superconducting down to 2 unit cells of thickness but quickly reach the maximum superconducting transition temperature at and above 4 unit cells.By fitting the critical magnetic field(μ0H_(c2)),we show that the anisotropy of the film’s superconductivity increases with decreasing film thickness,indicating that the superconductivity of the film gradually evolves from weak three-to two-dimensional character.These results are helpful to gain more insight into the nature of high-temperature superconductivity with dimensionality.
基金supported by the Clinical Frontier Technology Program of the First A±liated Hospital of Jinan University,China(No.JNU1AFCFTP-2022-a01212)the Clinical Research Funds for the First Clinical Medicine College of Jinan University(Grant No.2018006).
文摘Temporary spinal cord stimulation(tSCS)can effectively reduce the pain and severity of postherpetic neuralgia(PHN).However,there are no effective and objective methods for predicting the effects of tSCS on PHN.Laser speckle contrast imaging(LSCI)is frequently used in neurology to evaluate the effectiveness of treatment.To assess the accuracy of LSCI in predicting the impact of tSCS on PHN,14 adult patients receiving tSCS treatments for spinal nerve-innervated(C6-T2)PHN participated in this observational study.Visual analog scale(VAS)assessments and LSCI bloodflow images of the-ngers were recorded after the tSCS procedure.The results showed that the VAS scores of all patients decreased signi-cantly.Moreover,the bloodflow index(BFI)values were signi-cantly higher than they were before the procedure.Increased bloodflow and pain alleviation were positively correlated.The-ndings indicated that spinal nerve PHN(C6-T2)was signi-cantly reduced by tSCS.Pain alleviation by tSCS was positively correlated with increased bloodflow in the hand.The effect of tSCS on PHN may thus be predicted using an independent and consistent indicator such as LSCI.
