目的:系统评价中药虎杖提取物及其复方和中成药对于血脂代谢异常的疗效。方法:检索国家知识基础设施数据库(CNKI)、中国学术期刊数据库(CSPD)、中文科技期刊数据库(CCD)和中国生物医学文献数据库(CBM)和英文数据库PubMed、web of scien...目的:系统评价中药虎杖提取物及其复方和中成药对于血脂代谢异常的疗效。方法:检索国家知识基础设施数据库(CNKI)、中国学术期刊数据库(CSPD)、中文科技期刊数据库(CCD)和中国生物医学文献数据库(CBM)和英文数据库PubMed、web of science,时间限定2000—2020年国内外发表的虎杖治疗高脂血症的临床随机对照试验,利用Note express文献管理软件,根据纳入与排除标准来筛选文献,采用数据提取表提取资料并评价其质量,最后采用Rev Man 5.1分析软件,对纳入文献的研究结果进行Meta分析。结果:共纳入14个RCT,包括1692例患者,结果显示:虎杖提取物及其复方在降低总胆固醇(TC)水平(MD=-0.46,95%CI为-0.67~-0.24,P<0.0001),三酰甘油(TG)水平(MD=-0.44,95%CI为-0.62~-0.26,P<0.00001),高密度脂蛋白胆固醇(HLD-C)水平(MD=0.24,95%CI为0.11~0.37,P=0.0003)和低密度脂蛋白胆固醇(LDL-C)水平(MD=-0.41,95%CI为-0.77~-0.06,P=0.02)均明显优于对照组,并且未发现严重不良反应/不良事件。结论:中药虎杖提取物制剂,以及以虎杖为主要成分的中药复方和上市中成药对于血脂异常有较好疗效,且安全性良好,可为今后临床用药提供依据。展开更多
The association between chronic HCV infection and type 2 diabetes mellitus(T2DM)has been established;however,there is limited research onβ-cell function particularly in the pre-diabetic population.Here,we evaluated i...The association between chronic HCV infection and type 2 diabetes mellitus(T2DM)has been established;however,there is limited research onβ-cell function particularly in the pre-diabetic population.Here,we evaluated indices ofβ-cell function and insulin sensitivity across the spectrum from normal glucose tolerance to T2DMin individuals with and without chronic hepatitis C(CHC),and the effects of antiviral treatments on these variables.A total of 153 noncirrhotic,non-fibrotic CHC patients with a BMI<25 were enrolled in the study.Among them,119 were successfully treated with either direct acting antiviral(DAA)drugs or pegylated interferon/ribavirin(IFN/RBV)anti-HCV therapy.Fasting state-and oral glucose tolerance test(OGTT)-derived indexes were used to evaluateβ-cell function and insulin sensitivity.Among all subjects,19(13%)had T2DM and 21%exhibited pre-diabetes including 8%isolated impaired fasting glucose(IFG)and 13%combined IFG and impaired glucose tolerance(IGT).Early and total insulin secretion adjusted for the degree of insulin resistance were decreased in pre-diabetic CHC patients compared to HCVuninfected individuals.Viral eradication through DAA or IFN/RBV therapy demonstrated positive impacts on insulin sensitivity andβ-cell function in CHC patients who achieved sustained virologic response(SVR),regardless of fasting or OGTT state.These findings emphasize the role of HCV in the development ofβ-cell dysfunction,while also suggesting that viral eradication can improve insulin secretion,reverse insulin resistance,and ameliorate glycemic control.These results have important implications for managing pre-diabetic CHC patients and could prevent diabetes-related clinical manifestations and complications.展开更多
Remote ether groups could be used as directing groups to prepare fully substituted 5-ether-1,2,3-triazoles with exclusive 1,5-regioselectivities and excellent chemoselectivities. Ether group could coordinate with irid...Remote ether groups could be used as directing groups to prepare fully substituted 5-ether-1,2,3-triazoles with exclusive 1,5-regioselectivities and excellent chemoselectivities. Ether group could coordinate with iridium catalyst by lone-pair electron at a distance(up to four σ bonds) away from alkyne to control the regioselectivity by weak coordination effect. The cycloaddition reaction chemoselectively occurred at the propargyl ether moiety of diyne to give unique fully substituted 4-alkynyl-triazole.展开更多
文摘目的:系统评价中药虎杖提取物及其复方和中成药对于血脂代谢异常的疗效。方法:检索国家知识基础设施数据库(CNKI)、中国学术期刊数据库(CSPD)、中文科技期刊数据库(CCD)和中国生物医学文献数据库(CBM)和英文数据库PubMed、web of science,时间限定2000—2020年国内外发表的虎杖治疗高脂血症的临床随机对照试验,利用Note express文献管理软件,根据纳入与排除标准来筛选文献,采用数据提取表提取资料并评价其质量,最后采用Rev Man 5.1分析软件,对纳入文献的研究结果进行Meta分析。结果:共纳入14个RCT,包括1692例患者,结果显示:虎杖提取物及其复方在降低总胆固醇(TC)水平(MD=-0.46,95%CI为-0.67~-0.24,P<0.0001),三酰甘油(TG)水平(MD=-0.44,95%CI为-0.62~-0.26,P<0.00001),高密度脂蛋白胆固醇(HLD-C)水平(MD=0.24,95%CI为0.11~0.37,P=0.0003)和低密度脂蛋白胆固醇(LDL-C)水平(MD=-0.41,95%CI为-0.77~-0.06,P=0.02)均明显优于对照组,并且未发现严重不良反应/不良事件。结论:中药虎杖提取物制剂,以及以虎杖为主要成分的中药复方和上市中成药对于血脂异常有较好疗效,且安全性良好,可为今后临床用药提供依据。
基金supported by grants from the National Natural Science Foundation of China(grant number 82170838,82370873)Open Research Fund Program of the State Key Laboratory of Virology of China(grant number 2018IOV003).
文摘The association between chronic HCV infection and type 2 diabetes mellitus(T2DM)has been established;however,there is limited research onβ-cell function particularly in the pre-diabetic population.Here,we evaluated indices ofβ-cell function and insulin sensitivity across the spectrum from normal glucose tolerance to T2DMin individuals with and without chronic hepatitis C(CHC),and the effects of antiviral treatments on these variables.A total of 153 noncirrhotic,non-fibrotic CHC patients with a BMI<25 were enrolled in the study.Among them,119 were successfully treated with either direct acting antiviral(DAA)drugs or pegylated interferon/ribavirin(IFN/RBV)anti-HCV therapy.Fasting state-and oral glucose tolerance test(OGTT)-derived indexes were used to evaluateβ-cell function and insulin sensitivity.Among all subjects,19(13%)had T2DM and 21%exhibited pre-diabetes including 8%isolated impaired fasting glucose(IFG)and 13%combined IFG and impaired glucose tolerance(IGT).Early and total insulin secretion adjusted for the degree of insulin resistance were decreased in pre-diabetic CHC patients compared to HCVuninfected individuals.Viral eradication through DAA or IFN/RBV therapy demonstrated positive impacts on insulin sensitivity andβ-cell function in CHC patients who achieved sustained virologic response(SVR),regardless of fasting or OGTT state.These findings emphasize the role of HCV in the development ofβ-cell dysfunction,while also suggesting that viral eradication can improve insulin secretion,reverse insulin resistance,and ameliorate glycemic control.These results have important implications for managing pre-diabetic CHC patients and could prevent diabetes-related clinical manifestations and complications.
基金supported by grants from the National Natural Science Foundation of China (No. 21978039)Special Funds of the Central Government Leading Local Government for the Technology Development (Nos. 2021JH6/10500146, 2021JH6/10500148)the Fundamental Research Funds for the Central Universities (Nos. DUT20YG120, DUT19LK60)。
文摘Remote ether groups could be used as directing groups to prepare fully substituted 5-ether-1,2,3-triazoles with exclusive 1,5-regioselectivities and excellent chemoselectivities. Ether group could coordinate with iridium catalyst by lone-pair electron at a distance(up to four σ bonds) away from alkyne to control the regioselectivity by weak coordination effect. The cycloaddition reaction chemoselectively occurred at the propargyl ether moiety of diyne to give unique fully substituted 4-alkynyl-triazole.
