Background: The ovarian reserve, which is an important marker in the management of couple infertility, undergoes depletion over time. This depletion could accelerate in the presence of certain circumstances, such as o...Background: The ovarian reserve, which is an important marker in the management of couple infertility, undergoes depletion over time. This depletion could accelerate in the presence of certain circumstances, such as obesity. The contradictory results of studies on the impact of obesity on the ovarian reserve throughout the world accelerated ovarian ageing in infertile women from Kinshasa, as well as the high rate of obese women in this population, seemed necessary to undertake this study to find out if this obesity impacted the ovarian reserve of Kinshasa women. The objective of this study was to identify the profile of markers of ovarian reserve in obese infertile patients according to certain characteristics. Method: A case-control study with retrospective data collection on 439 obese infertile patients (cases) and 439 normal-weight infertile patients (controls) who had consulted for the desire to conceive at the University Hospital of Kinshasa and the Edith Medical Center between January 2016 and December 2021. Results: The average age of the patients was 33.6 years ± 4.3 years, with 47.8% of patients aged at least 35 years. Menarche and menstrual duration were correlated with AMH in linear regression (p = 0.043 and 0.021, respectively). Late menarche and irregular cycle were risk factors for ovarian ageing [OR: 4.6;95% CI: (1.052 - 20.636);p = 0.043 and OR: 4.8;95% CI: (1.633 - 14.566);p = 0.005] while PCO was a protective factor for ovarian ageing [OR: 0.109;95% CI: (0.182 - 0.652);p = 0.015]. Conclusion: Within the limits of our study, we found that the more obese the patients were, the faster the ovaries aged.展开更多
Background: Infertility is a dramatic situation for a couple, especially in the Sub-Saharan area, known as extremely pro-natalist. Until this day infertility of tubal origin due to infection sexually transmitted, post...Background: Infertility is a dramatic situation for a couple, especially in the Sub-Saharan area, known as extremely pro-natalist. Until this day infertility of tubal origin due to infection sexually transmitted, post abortum or postpartum origin is the most frequent. Worldwide we are witnessing the transition of pathologies: from infectious to non-communicable ones. Objective: To analyze the evolution of infertile couples’ profiles over time to improve management in the future. Setting: University clinic of Kinshasa and a private clinic, the Edith Medical Center. Design: A cross-sectional analytical study. Patients: A total of 4456 patients who sought care for infertility from January 1999 to December 2014 were enrolled. Main Outcome: The evolution of socio-demographic, clinical and paraclinical parameters of infertile couples over time. Results: The average age of female patients was 33.1 ± 5.7 years and it increased by 36 days every year and the male partner by 29 days per year. The average number of cigarette rods consumed decreased by 5% per year. The average intercourse frequency per week decreased by 2% every year. A fifth of patients (21.8%) were obese. And the average BMI increased by 0.04 kg/m2 per year. Tubal occlusion was the main lesion found in hysterosalpingogram and diagnostic laparoscopy. Conclusion: Patients were more and more aged and gaining weight. A part from infection which is the main cause of infertility this day;in the future, infertility care providers will be facing non-communicable diseases, namely obesity.展开更多
文摘Background: The ovarian reserve, which is an important marker in the management of couple infertility, undergoes depletion over time. This depletion could accelerate in the presence of certain circumstances, such as obesity. The contradictory results of studies on the impact of obesity on the ovarian reserve throughout the world accelerated ovarian ageing in infertile women from Kinshasa, as well as the high rate of obese women in this population, seemed necessary to undertake this study to find out if this obesity impacted the ovarian reserve of Kinshasa women. The objective of this study was to identify the profile of markers of ovarian reserve in obese infertile patients according to certain characteristics. Method: A case-control study with retrospective data collection on 439 obese infertile patients (cases) and 439 normal-weight infertile patients (controls) who had consulted for the desire to conceive at the University Hospital of Kinshasa and the Edith Medical Center between January 2016 and December 2021. Results: The average age of the patients was 33.6 years ± 4.3 years, with 47.8% of patients aged at least 35 years. Menarche and menstrual duration were correlated with AMH in linear regression (p = 0.043 and 0.021, respectively). Late menarche and irregular cycle were risk factors for ovarian ageing [OR: 4.6;95% CI: (1.052 - 20.636);p = 0.043 and OR: 4.8;95% CI: (1.633 - 14.566);p = 0.005] while PCO was a protective factor for ovarian ageing [OR: 0.109;95% CI: (0.182 - 0.652);p = 0.015]. Conclusion: Within the limits of our study, we found that the more obese the patients were, the faster the ovaries aged.
文摘Background: Infertility is a dramatic situation for a couple, especially in the Sub-Saharan area, known as extremely pro-natalist. Until this day infertility of tubal origin due to infection sexually transmitted, post abortum or postpartum origin is the most frequent. Worldwide we are witnessing the transition of pathologies: from infectious to non-communicable ones. Objective: To analyze the evolution of infertile couples’ profiles over time to improve management in the future. Setting: University clinic of Kinshasa and a private clinic, the Edith Medical Center. Design: A cross-sectional analytical study. Patients: A total of 4456 patients who sought care for infertility from January 1999 to December 2014 were enrolled. Main Outcome: The evolution of socio-demographic, clinical and paraclinical parameters of infertile couples over time. Results: The average age of female patients was 33.1 ± 5.7 years and it increased by 36 days every year and the male partner by 29 days per year. The average number of cigarette rods consumed decreased by 5% per year. The average intercourse frequency per week decreased by 2% every year. A fifth of patients (21.8%) were obese. And the average BMI increased by 0.04 kg/m2 per year. Tubal occlusion was the main lesion found in hysterosalpingogram and diagnostic laparoscopy. Conclusion: Patients were more and more aged and gaining weight. A part from infection which is the main cause of infertility this day;in the future, infertility care providers will be facing non-communicable diseases, namely obesity.
