Patients with osteomyelitis require lengthy antibiotic treatment, often only to see the inflammation flare up once antibiotics are suspended. Unfortunately, patients often discontinue the antibiotic treatment due to c...Patients with osteomyelitis require lengthy antibiotic treatment, often only to see the inflammation flare up once antibiotics are suspended. Unfortunately, patients often discontinue the antibiotic treatment due to collateral effects. Patients with osteitis are often polymorbid patients with other severe diseases such as diabetes mellitus and polyneuropathy, arteriopathy or polyarthfitis with immunosuppression. The eight patients included in the study presented nine bones with osteomyelitis （macroscopically, bacteriologically, histologically or radiologically）. The diseased part of the bone was resected, a locally radical debridement was done and a biopsy for bacteriology and histology were taken. The residual bone was then drilled out and filled with antibiotic-loaded （gentamicin） resorbable bone-graft substitute under radiologic imaging control. In total, seven patients are currently without recurrent osteomyelitis with a mean follow-up of 5.77 months （2-11 months）. The Kaplan Meier curve shows 80% survival rate without recurrent osteomyelitis at 11 months. Only one patient suffering from Morbus Buerger had a relapse osteomyelitis after cutting off severing his foot while swimming in the sea. Antibiotic-loaded resorbable bone-graft substitute is easy to use, has in our hands few complications and low recurrence rate.展开更多
Skin necrosis of the foot, oedema and lymphangitis from stonefish （Synanceia verrucosa） sting are complications well known for a tong time and with potential long-term sequelae. Literature reports of stonefish enven...Skin necrosis of the foot, oedema and lymphangitis from stonefish （Synanceia verrucosa） sting are complications well known for a tong time and with potential long-term sequelae. Literature reports of stonefish envenomation give no specific reference on soft tissue management and surgical reconstruction. This is the first report describing a case of foot stonefish envenomation treated by vacuum-assisted closure therapy as an easy to use, accessible and simple adjuvant tool for management of large soft tissue necrosis.展开更多
Pyoderma gangrenosum （PG） is a cutaneous ulcer developing so rapidly that may mimic a fulminating infection. The correct treatment is nonsurgical, and surgery may get the condition worse.^1 FK-506 ointment （0.1% P...Pyoderma gangrenosum （PG） is a cutaneous ulcer developing so rapidly that may mimic a fulminating infection. The correct treatment is nonsurgical, and surgery may get the condition worse.^1 FK-506 ointment （0.1% Protopic, Astellas Pharma AG, Fribourg） is usually indicated for inflammatory skin diseases, such as atopic dermatitis and psoriasis^2 or for acute rejection reversal of human hand transplantation^3. Afew reports of PG affecting the functions of hands can be found in the scientific literature and this report describes the first case treated by FK-506 ointment as an adjuvant therapy.展开更多
文摘Patients with osteomyelitis require lengthy antibiotic treatment, often only to see the inflammation flare up once antibiotics are suspended. Unfortunately, patients often discontinue the antibiotic treatment due to collateral effects. Patients with osteitis are often polymorbid patients with other severe diseases such as diabetes mellitus and polyneuropathy, arteriopathy or polyarthfitis with immunosuppression. The eight patients included in the study presented nine bones with osteomyelitis （macroscopically, bacteriologically, histologically or radiologically）. The diseased part of the bone was resected, a locally radical debridement was done and a biopsy for bacteriology and histology were taken. The residual bone was then drilled out and filled with antibiotic-loaded （gentamicin） resorbable bone-graft substitute under radiologic imaging control. In total, seven patients are currently without recurrent osteomyelitis with a mean follow-up of 5.77 months （2-11 months）. The Kaplan Meier curve shows 80% survival rate without recurrent osteomyelitis at 11 months. Only one patient suffering from Morbus Buerger had a relapse osteomyelitis after cutting off severing his foot while swimming in the sea. Antibiotic-loaded resorbable bone-graft substitute is easy to use, has in our hands few complications and low recurrence rate.
文摘Skin necrosis of the foot, oedema and lymphangitis from stonefish （Synanceia verrucosa） sting are complications well known for a tong time and with potential long-term sequelae. Literature reports of stonefish envenomation give no specific reference on soft tissue management and surgical reconstruction. This is the first report describing a case of foot stonefish envenomation treated by vacuum-assisted closure therapy as an easy to use, accessible and simple adjuvant tool for management of large soft tissue necrosis.
文摘Pyoderma gangrenosum （PG） is a cutaneous ulcer developing so rapidly that may mimic a fulminating infection. The correct treatment is nonsurgical, and surgery may get the condition worse.^1 FK-506 ointment （0.1% Protopic, Astellas Pharma AG, Fribourg） is usually indicated for inflammatory skin diseases, such as atopic dermatitis and psoriasis^2 or for acute rejection reversal of human hand transplantation^3. Afew reports of PG affecting the functions of hands can be found in the scientific literature and this report describes the first case treated by FK-506 ointment as an adjuvant therapy.
