Rational construction of CuFe_(2)O_(4)@C/Cd_(0.9)Zn_(0.1)S S-scheme heterojunction photocatalyst for extraordinary photothermal-assisted photocatalytic H_(2) evolution

Rational design of photocatalyst to maximize the use of sunlight is one of the issues to be solved in photocatalysis technology.In this study,the CuFe_(2)O_(4)@C/Cd_(0.9)Zn_(0.1)S(CFO@C/CZS)S-scheme photocatalyst with photothermal effect was synthesized by ultrasonic self-assembly combined with calcination.The dark CFO@C absorbed visible light and partly converted into heat to promote the hydrogen evolution reaction.The presence of heterojunctions inhibited the photogenerated electron-hole recombination.The graphite-carbon layer provided a stable channel for electron transfer,and the presence of magnetic CFO made recycle easier.Under the action of photothermal assistance and heterojunction,the hydrogen evolution rate of the optimal CFO@C/CZS was 80.79 mmol g^(-1) h^(-1),which was 2.55 times and 260.61 times of that of pure CZS and CFO@C,respectively.Notably,the composite samples also exhibit excellent stability and a wide range of environmental adaptability.Through experimental tests and first-principles simulation calculation methods,the plausible mechanism of photoactivity enhancement was proposed.This work provided a feasible strategy of photothermal assistance for the development of heterojunction photocatalysts with distinctive hydrogen evolution.

Photo-manipulated polyunsaturated fatty acid-doped liposomal hydrogel for flexible photoimmunotherapy

Despite the synergy of immune checkpoint blockade(ICB) therapy and photodynamic therapy(PDT) holds great promise as countermeasures against breast cancer, exploring long-term or flexible short-time therapeutic strategies in “cold” tumors remains a great challenge. Here, we present a polyunsaturated fatty acid-doped liposomal hydrogel Lp(DHA)@CP Gel loaded with photosensitizer chlorin e6(Ce6) and programmed death-ligand 1 antibody(αPD-L1) for flexible local photoimmunotherapy with merely singledosed administration. The presence of polyunsaturated fatty acid(docosahexaenoic acid, DHA) doped in particle membrane endows liposomes with flexibly reactive oxygen species(ROS)-responsive release capability, which was attributed to the presence of abundant unsaturated groups. The αPD-L1 was repeatedly induced to in situ release in response to the PDT under photo-exposure. The immunogenic cell death(ICD) effect of PDT evoked “cold” breast tumor to “hot” one, and then assisted the cascade releasedαPD-L1 to synergistically boost the immunotherapy. After a single dose of peritumoral administration of Lp(DHA)@CP Gel, the on-demand treatment can maximize patient compliance and safety by adjusting therapeutic behaviors via a photo on-off switch. This work presents a flexible medication platform,showing promise in improving the objective response rate of ICB therapy and minimizing its systemic toxicity.

Association between autoimmunity-related disorders and prostate cancer:A Mendelian randomization study

Background:Although many epidemiological studies and meta-analyses have reported an association between autoimmune disorders and prostate cancer,none has reported a clear correlation or the direction of the association.The purpose of our study was to explore the potential relationship between autoimmunity-related disorders and prostate cancer using Mendelian randomization(MR).Methods:We retrieved literature from PubMed using the keywords“autoimmune disorder”AND“prostate cancer”to find more clues on the correlation between prostate cancer and autoimmunity-related disorder.Based on this literature search,we selected 16 autoimmunity-related disorders that had genome-wide association study(GWAS)data and may be associated with prostate cancer.The inverse variance weighting(IVW)method was applied as our primary analysis for two-sample MR and multivariate MR analysis to estimate the odds ratio(OR)and 95%confidence interval(CI).We further verified the robustness of our conclusions using a series of sensitivity analyses.Results:The autoimmunity-related diseases selected include rheumatoid arthritis,ankylosing spondylitis,coxarthrosis,gonarthrosis,Crohn's disease,ulcerative colitis,irritable bowel syndrome,celiac disease,primary sclerosing cholangitis,asthma,type 1 diabetes,systemic lupus erythematosus,multiple sclerosis,autoimmune hyperthyroidism,psoriatic arthropathies,and polymyalgia rheumatica.The results of inverse variance weighting(IVW suggested that six diseases were associated with the development of prostate cancer.The three diseases that may increase the risk of prostate cancer are rheumatoid arthritis(P=0.001),coxarthrosis(P<0.001),and gonarthrosis(P=0.008).The three possible protective factors against prostate cancer are primary sclerosing cholangitis(P=0.001),autoimmune hyperthyroidism(P=0.011),and psoriatic arthropathies(P=0.001).Horizontal pleiotropy was not observed in the MR-Egger test.Conclusions:Our findings provide predictive genetic evidence for an association between autoimmune disorders and prostate cancer.Further research is needed to explore the underlying mechanisms of comorbidities at the molecular level.

Stimulating and harnessing circularly polarized luminescence of helically assembled carbonized polymer dots via interfacial dynamics

Stimulating and harnessing circularly polarized luminescence(CPL)is not only a sine qua non for fundamentally unveiling chirogenesis in physical chemistry,but also a pivotal prerequisite for implementation of such phenomenon in research fields including chiral optoelectronics and theranostics.Herein,red-emissive carbonized polymer dots(CPDs)-based helical structures were synthesized in this work via biomolecule-tailored organic–inorganic co-assembly strategy.The surface statesrelated chirality exhibits enhanced circular dichroism(CD)and CPL activities with anisotropic factors as high as gCD,max=5.4×10^(−3) and glum,max=1.5×10^(−2),respectively.The obtained CPL signals can be further manipulated in an excitationdependent manner,indicating that a synergistic-competition phenomenon exists between configurational chirality and intermolecular energy-transfer dynamics,which is further supported by simulations based on density function theory(DFT).Such tunable CPL behavior triggers revolutionary designs and applications of these chiral CPDs into the realm of chirality-related biological issues and next-generation chiral optoelectronics.