Adaptive subsequence adjustment with evolutionary asymmetric path-relinking for TDRSS scheduling

Due to the limited transmission resources for data relay in the tracking and data relay satellite system （TDRSS）, there are many job requirements in busy days which will be discarded in the conventional job scheduling model. Therefore, the improvement of scheduling efficiency in the TDRSS can not only help to increase the resource utilities, but also to reduce the scheduling failure ratio. A model of nonhomogeneous parallel machines scheduling problems with time window （NPM-TW） is firstly built up for the TDRSS, considering the distinct features of the variable preparation time and the nonhomogeneous transmission rates for different types of antennas on each tracking and data relay satellite （TDRS）. Then, an adaptive subsequence adjustment （ASA） framework with evolutionary asymmetric path-relinking （EvAPR） is proposed to solve this problem, in which an asymmetric progressive crossover operation is involved to overcome the local optima by the conventional job inserting methods. The numerical results show that, compared with the classical greedy randomized adaptive search procedure （GRASP） algorithm, the scheduling failure ratio of jobs can be reduced over 11% on average by the proposed ASA with EvAPR.

Adverse Geology Identification Through Mineral Anomaly Analysis During Tunneling:Methodology and Case Study

Accurate and effective identification of adverse geology is crucial for safe and efficient tunnel construction.Current methods of identifying adverse geology depend on the experience of geologists and are prone to misjudgment and omissions.Here,we propose a method for adverse geology identification in tunnels based on mineral anomaly analysis.The method is based on the theory of geoanomaly,and the mineral anomalies are geological markers of the presence of adverse geology.The method uses exploration data analysis(EDA)to calculate mineral anomaly thresholds,then evaluates the mineral anomalies based on the thresholds and identifies adverse geology based on the characteristics of the mineral anomalies.We have established a dynamic expansion process for background samples to achieve the dynamic evaluation of mineral anomalies by adjusting anomaly thresholds.This method has been validated and applied in a tunnel excavated in granite.As shown herein,in the tunnel range of 142+800–142+860,the fault F37 was successfully identified based on an anomalous decrease in the diagenetic minerals plagioclase and hornblende,as well as an anomalous increase in the content of the alteration minerals chlorite,laumonite,and epidote.The proposed method provides a timely warning when a tunnel enters areas affected by adverse geology and identifies whether the tunnel is gradually approaching or moving away from the fault.In addition,the applicability,accuracy,and further improvement of the method are discussed.This method improves our ability to identify adverse geology,from qualitative to quantitative,and can provide reference and guidance for the identification of adverse geology in mining and underground engineering.

医学领域知识融合研究进展

医学领域知识融合旨在将分散在各个知识图谱或不同数据源中的医学知识进行整合,形成一个更全面的知识图谱,在提高知识质量、扩大规模、提高医学知识利用率和共享性等方面具有促进作用。围绕知识融合的问题和解决方案,首先系统地梳理了医学领域知识融合的定义、评价指标及数据集;分类讨论了知识融合过程中存在的问题与挑战;然后从问题、技术两个维度,综述了目前知识融合中实体对齐、实体链接任务各方法的优势与不足;详细讨论和总结了医学领域知识融合每一类问题的相关解决方案;最后,总结并展望了医学领域知识融合的发展方向。

基于深度学习的医学实体和关系联合抽取研究综述

命名实体识别与关系抽取作为医学领域信息抽取的核心任务,能够从非结构化或半结构化的文本中自动识别实体边界、实体类型以及实体之间的关系。不仅能够促进知识的发现与整合,应用于临床决策,加强药物的发现和再利用,还可以助力公共卫生监测和疾病预防。回顾了实体识别和关系抽取的发展历程,介绍了常用评价指标和医学领域实体关系联合抽取数据集,指出目前联合抽取领域存在医学文本结构比较复杂、实体关系重叠句子抽取率低等问题。根据这些问题,进一步探讨了基于深度学习的实体关系联合抽取方法在医学领域上的应用。这些方法根据模型解码的方式主要分为基于共享参数的联合抽取模型和基于联合解码的联合抽取模型,从问题解决角度对不同的模型的优缺点进行探讨分析和总结。讨论了医学领域实体关系抽取面临的挑战和未来的研究方向。

不同加热方式对蔗渣三组分热解特性的影响

采用常规热解和微波加热两种方式研究了蔗渣三组分热解的过程,探讨了不同加热方式对蔗渣三组分热解的影响规律。实验结果表明,不管采用何种加热方式,随加热温度的升高,纤维素、半纤维素和木质素三相产物的分布规律基本一致,固体产率和液体产率均随裂解温度的升高逐渐降低,气体产率则逐渐升高。微波独特的体加热方式,加热效率高、裂解更彻底,产物中具有更多的富氢气体(H_(2)+CO)。采用微波加热方式,纤维素与半纤维素裂解气体产率较高,900℃时纤维素与半纤维素热解的气体产物产率分别高达65.88%和63.51%;而木质素热解表现出较好的碳化特性,在600℃热解固体产物产率高达43.61%。

不同有机废弃物载体对Bacillus megaterium有效性的影响

为了给Bacillus megaterium选择理想的吸附载体。测定了草炭、金针菇渣、腐熟鸡粪、牛粪、羊粪的吸菌量及其载体菌剂的有效活菌数、胞外多糖(EPS)含量和发芽指数。草炭的吸菌量最高为1.64 mL/g,但随存放时间延长,草炭载体菌剂的有效活菌数和EPS含量急剧降低,且38 d内的发芽指数均小于80%,表现植物毒性。鸡粪和金针菇渣的吸菌量虽小于草炭,但随存放时间延长,鸡粪载体菌剂的有效活菌数和EPS含量逐渐增大,金针菇渣载体菌剂的EPS含量逐渐增加、有效活菌数降低幅度缓慢,且存放7 d后发芽指数均大于80%,表现植物无毒性。第38天时鸡粪和金针菇渣载体菌剂的有效活菌数分别为1.29×10^(9)CFU/g和6.20×10^(8)CFU/g,EPS含量分别为535.29 mg/kg和559.34 mg/kg,均显著高于其他载体菌剂。鸡粪和金针菇渣是B.megaterium较为理想的吸附载体。

学科竞赛驱动下课程改革与实践——以化学工程与工艺专业为例

本文以化学工程与工艺专业为例,从学科竞赛出发,从课程教学团队、教学内容、教学方法和考核模式等方面对专业课程进行了一系列改革和探索,组建了创新团队,形成了学科竞赛平台,学生实践创新能力和综合素养得到提升,育人成效显著。

卫生专业人员沟通技能量表的汉化及信效度检验

目的:汉化卫生专业人员沟通技能量表(HP-CSS),并检验其信效度。方法:采用Beaton跨文化调试指南翻译量表,形成中文版HP-CSS。选取四川省成都市3所三级甲等医院391名卫生专业人员进行问卷调查,并验证量表的信效度。结果:中文版HP-CSS包括4个维度、18个条目,量表Cronbach′sα系数为0.888,折半信度为0.851,重测信度为0.922。量表水平的内容效度指数为0.98,条目水平的内容效度指数为0.80~1.00。验证性因子分析结果:卡方/自由度(χ^(2)/ν)=1.943,近似误差均方根(RMSEA)=0.064,递增拟合指数(IFI)=0.944,非规准适配度指数(TLI)=0.929,拟合优度指数(GFI)=0.901,比较拟合指数(CFI)=0.943,达到配适标准。结论:中文版HP-CSS具有良好信效度,可作为评估卫生技术人员沟通技能的工具。

Establishment of HIV-1 model cell line GHOST（3） with stable DRiP78 and NHERF1 knockdown

Chemokine receptors CXCR4 and CCR5 are indispensable co-receptors for HIV-1 entry into host cells. In our previous study, we identified that dopamine receptor-interacting protein 78（DRi P78） and Na＋-H＋ exchanger regulatory factor 1（NHERF1） are the CXCR4 and CCR5 homo- or hetero-dimerinteracting proteins. DRi P78 and NHERF1 are able to influence the co-receptor internalization and intracellular trafficking. Over-expression of NHERF1 affects the ligands or HIV-1 gp120-induced CCR5 internalization and HIV-1 production. It is reasonable to speculate that DRi P78 and NHERF1, as well as the signaling pathways involved in viral replication, would probably affect HIV-1 replication through regulating the co-receptors. In this present study, we designed two short hairpin RNAs（sh RNAs） targeting the DRi P78 and NHERF1, respectively, and constructed the p Lenti6/BLOCK-i T-DEST lentiviral plasmids expressing DRi P78 or NHERF1 sh RNA. The packaged lentiviruses were used to transduce the widely-applied HIV-1 model cell line GHOST（3）. Then, cells with stable knockdown were established through selecting transduced cells with Blasticidin. This study, for the first time, reported the establishment of the GHOST（3） with DRi P78 and NHERF1 knockdown, which is the first stable cell line with HIV-1 co-receptor-interacting molecular defects.

基于异常点检测的大学生异质行为分析

大学生异质行为指的是大学生具有个性特征、不同于他人的行为偏好。针对大学生异质个体的行为挖掘问题,提出一种基于异常点检测的异质行为分析方法。首先以某校大学生成绩数据和校园一卡通数据为基础,建立异质行为分析模型,采用主成分分析、K-Means++和DBSCAN聚类分析寻找异常点,研究关注异常点对应的异质行为人。然后,通过异常点检测辨别学习成绩中的异质个体,并进一步探究其作息规律与学习成绩异常之间是否存在强关联。接下来,运用多种算法相互印证异常点的准确性,借助对相关学生的调研来验证异常点数据的可信度。研究表明,所提方法能对大学生异质行为模式进行深度分析,为提升学校管理水平和管理效率提供了基础依据。

A 220 GHz Frequency-Division Multiplexing Wireless Link with High Data Rate

With the development of wireless communication,the 6G mobile communication technology has received wide attention.As one of the key technologies of 6G,terahertz(THz)communication technology has the characteristics of ultra-high bandwidth,high security and low environmental noise.In this paper,a THz duplexer with a half-wavelength coupling structure and a sub-harmonic mixer operating at 216 GHz and 204 GHz are designed and measured.Based on these key devices,a 220 GHz frequency-division multiplexing communication system is proposed,with a real-time data rate of 10.4 Gbit/s for one channel and a transmission distance of 15 m.The measured constellation diagram of two receivers is clearly visible,the signal-to-noise ratio(SNR)is higher than 22 dB,and the bit error ratio(BER)is less than 10^(−8).Furthermore,the high definition(HD)4K video can also be transmitted in real time without stutter.

Expression of SOX4 in Endometrial Cancer and its Relationship with Clinical-pathological Characteristics in Endometrial Cancer Patients

Objective:To investigate the expression of SOX4 in endometrial carcinoma tissues and its relationship with clinicopathological features.Methods:The clinical and pathological data of 51 patients with pathologically diagnosed endometrial carcinoma who underwent panhysterectomy in the Wenzhou Central Hospitai from March 2017 to March 2019 were retrospectively analyzed.There were 22 cases of typeⅠendometrial carcinoma and 29cases of type Ⅱ endometrial carcinoma.The immunohistochemical expression of SOX4 was detected,and its relationship with clinicopathological parameters was analyzed.Results:Compared with the contro1 group,SOX4 in endometrial cancer group increased significantly(P-0.05);High SOX4 expression were closely related to differentiation,c1inica1 stage and 1ymph node metastasis of endometrial cancer(Pi0.05).Conclusion:Sox4 is related to the occurrence and development of EC.SOX4 may be a clinical evaluation index of EC and a reference index for clinical pathological diagnosis,it is helpful for clinicians to better analyze the high risk factors of EC patients and provide new ideas for early diagnosis,prognosis evaluation and targeted treatment of EC.

基于红外热成像的古建筑墙内暗柱材料缺失检测

【目的】墙内暗柱是木结构古建筑的重要承重构件之一,因其处于潮湿和缺乏通风的环境,故多存在腐朽及由严重腐朽导致的材料缺失等缺陷,容易失去原有的承载能力和稳定性。墙内暗柱自身构造导致现有的检测手段受限,易造成不可逆的损坏。故本研究基于红外热成像原理开展墙内暗柱材料缺失缺陷检测理论与试验研究,以期为基于红外热成像的墙内暗柱缺陷状况无损检查方法的建立奠定部分前期基础。【方法】首先,从理论角度探讨古建筑墙内暗柱传热过程,推导稳态下木柱区域与纯墙体区域的温度公式,分析影响木柱材料缺失缺陷区域温度变化的因素;然后,建立试验模型,进行墙内暗柱缺陷红外检查试验,采集红外图像;最后,通过分析所获得的红外热图,探讨墙内暗柱材料缺失缺陷大小与墙体表面温度分布之间的关系。【结果】(1)理论研究表明:由于木材的横向导热系数远小于墙体导热系数,加热面加热温度相同的情况下,木柱墙体外表面所对应的温度偏低;墙内暗柱的检测效果主要受到缺陷尺寸,即缺陷高度、缺陷深度的影响。(2)试验结果表明:在稳态热传导下,木柱处的墙体外表面温度要低于纯墙体,即木柱处红外图像的颜色更浅;木柱缺陷的存在会使缺陷处墙体表面温度变高,红外图像颜色变深;木柱缺陷高度越大,缺陷导致的高温范围越大;木柱缺陷深度越大,缺陷区域温度值越高。(3)在非稳态热传导下,木柱中线温差分别与木柱缺陷高度(R^(2)≥0.964)、深度(R^(2)≥0.951)呈极强的正相关。(4)在木柱缺陷较小的情况下,墙体表面温度不因缺陷的存在而发生明显改变。【结论】木柱的缺陷高度与深度是影响缺陷红外热成像检测效果的主要因素,红外热成像法应用于古建筑墙内暗柱材料缺失缺陷的筛查与评估是可行的。

球形粉体制备技术研究进展

【目的】球形粉体由于具有更好的流动性和均匀性被广泛应用于增强材料、涂料、陶瓷、3D打印等领域。为了满足不同行业对粉体材料的表面特性和物理性能要求,提升产品性能,降低工艺损失,促进绿色制造,对球形粉体制备技术的研究现状进行总结和思考。【研究现状】综述球形粉体常见制备技术,包括传统物理法(机械整形法和喷雾干燥法)、化学法(气相化学反应法、沉淀法、水热合成法、溶胶凝胶法及微乳液法)和高温熔融法(等离子体球化法、雾化法和气体燃烧火焰成球法),总结上述方法的优势及目前的局限性,重点阐述不同球形粉体材料制备技术的基本原理与应用领域的研究进展。【展望】对球形粉体制备技术的发展趋势进行分析与展望,认为高温熔融法是最具实现大规模工业化生产潜力的球形粉体制备技术,提出高纯超细、窄分布、粒径可控、高球化率、高效率工业智能化绿色生产是我国未来球形粉体制备技术的发展趋势。

The Expression and Significance of CyclinD2,MPGES-1,Bcl2 in Diffuse Large B-cell Lymphoma

Objective:To study the expression and significance of cell cycle proteins CyclinD2,mPGES-1,Bcl2 in diffuse large B-cell lymphoma.Methods:Choose lymphoma and sexually hyper-plastic lymphoid tissues as control.Immunohistoc-hemical methods were used to detect the expression of CyclinD2,mPGES-1,and Bcl2,and to compare the positive expression rates of CyclinD2,MPGES-1 and Bcl2 in diffuse large B-cell lymphoma and reactive proliferative lymphoid tissues to compare their diffusion formation.B-cell lymphoma was analyzed for its clinicopathological features.Results:The positive expression rate of CyclinD2,mPGES-1 and Bcl2 in diffuse large B-cell lymphoma is higher than that in reactive proliferative lymphoid tissue,and the difference between the two is statistically significant.There was no statistical difference in CyclinD2,mPGES-1 and Bcl2 in diffuse large B-cell lymphoma between patients according to the age,sex,location,tissue type and degree of differentiation.Conclusion:CyclinD2,mPGES-1 and Bcl2 are highly expressed in patients with diffuse large B-cell lymphoma,and can be used as reference indicators for evaluating the malignant degree and efficacy of dysplasia.

气管切开患者吸痰临床实践的证据转化

目的总结气管切开患者吸痰临床实践的循证证据,将证据进行临床转化,并验证其临床应用效果。方法通过澳大利亚循证护理中心循证框架、结构化检索文献、质量评价和整合,获得气管切开患者吸痰前气道评估、用物评估、氧储备、吸痰负压、吸痰深度、气道湿化、声门下吸引等证据共14条、形成审查指标16条,并将证据转化至临床实践。结果证据应用后,ICU护士对气管切开患者吸痰相关理论知识得分提高[(58.30±12.27)分vs(63.68±11.88)分,P<0.05]、临床实践与最佳证据的16条审查指标规范化执行率亦均有不同程度提高(均P<0.05)。结论经循证实践,气管切开患者吸痰的临床操作现况与最佳证据之间的差距缩小,优化了护理操作,提高了护理质量。

Multi-Bit Sliding Stack Decoding Algorithm for OVXDM

Overlapped x domain multiplexing(OVXDM) is a promising encoding technique to obtain high spectral efficiency by utilizing inter-symbol interference(ISI) intelligently. However, the computational complexity of maximum likelihood sequence detection(MLSD) increases exponentially with the growth of spectral efficiency in OVXDM, which is unbearable for practical implementations. In this paper, based on a novel path metric associating adjacent symbols, we propose a multi-bit sliding stack decoding(Multi-Bit SSD) algorithm to achieve multiple-bit decoding simultaneously in OVXDM. Theoretical analysis is provided for the algorithm, which indicates the relationship between the performance and parameters including multiplexing waveform, overlapping fold and sliding window size. Simulation results show that the proposed algorithm can achieve better decoding performance and higher spectral efficiency than conventional fast decoding algorithms.

TA2/Q235B复合板不同作用面成形极限及界面损伤行为

采用Nakazima实验法对不同尺寸的退火态TA2/Q235B复合板样品进行胀形实验,研究不同作用面对TA2/Q235B复合板的成形极限和界面损伤行为的影响。结果表明,当凹模与碳钢侧接触时,由于接触材料、界面变形协调能力和应变状态的不同,复合板的胀形高度和成形极限增加,其中R140试样的极限拱高达到最大值(46.17 mm),R60和R180试样在3个方向上的厚度减薄量和界面裂纹更大。此外,由于硬度和拉应力不同,两组样品中所有的水平和斜向孔都向纯钛侧延伸。

局部晚期食管鳞状细胞癌患者新辅助化疗联合免疫和新辅助放化疗的病理反应和生存结果的比较:倾向评分匹配分析

目的:比较新辅助化疗联合免疫(nICT)与新辅助放化疗(nCRT)治疗局部晚期、可切除的食管鳞状细胞癌(ESCC)的病理反应和远期生存。方法:纳入接受新辅助治疗后手术切除的313例局部晚期食管鳞癌(ESCC)患者为研究对象。根据新辅助治疗方式将患者分为nICT组和nCRT组。按照1∶2匹配,采用倾向评分匹配(PSM)来平衡两组间因素。结果:PSM后共纳入146例患者,两组间的基线特征无统计学差异。nICT组病理完全缓解率(pCR)较低(11.54%vs.35.11%,P=0.004),神经侵犯(32.69%vs.12.77%,P=0.008)和脉管癌栓的比例相对nCRT组较高(40.38%vs.10.64%,P<0.001)。然而,nICT组和nCRT组的3年无病生存率(DFS)和总生存率(OS)相当[DFS(54.6%vs.53.8%,P=0.370);OS(62.8%vs.67.2%,P=0.400)]。结论:虽然nCRT在病理反应上更好,但这种成功并没有转化为生存的获益。在病理结果和新辅助治疗方式中存在更多影响生存的因素应该加以研究以阐明其关联。

石墨相氮化碳/壳聚糖复合材料对水中U(Ⅵ)的吸附性能与机理

针对核能发展与应用过程中产生的含铀废水所导致的环境铀污染难题,通过共混交联法将石墨相氮化碳(g-C_(3)N_(4))负载在壳聚糖(CS)上,制备了复合材料-石墨相氮化碳/壳聚糖(g-C_(3)N_(4)/CS),用来吸附水溶液中的U(Ⅵ)。对g-C_(3)N_(4)/CS的表面性质和作用机制进行了分析。结果表明:g-C_(3)N_(4)/CS投加量为0.2 g/L,g-C_(3)N_(4)质量分数为20%,吸附时间为120 min,温度为308 K,pH=6条件下,g-C_(3)N_(4)/CS对U(Ⅵ)的最大吸附量达到324.45 mg/g。Langmuir等温模型和准二级动力学模型符合该吸附过程,是一个自发吸热过程。g-C_(3)N_(4)/CS对U(Ⅵ)的吸附机理主要为—NH,—OH,C—O,C=O,C—N等官能团与U(Ⅵ)发生的配位络合。g-C_(3)N_(4)/CS在循环再生实验中显示出良好的重复利用性。