Objective At present, there is controversy regarding the existence of marine-terrestrial transitional facies that can act as a source of shale gas. This detailed study of Carboniferous-Permian age geological data from...Objective At present, there is controversy regarding the existence of marine-terrestrial transitional facies that can act as a source of shale gas. This detailed study of Carboniferous-Permian age geological data from the northern Shaanxi area （China） provides new insight for this type of shale gas. In addition, a new deposition and accumulation pattern for this type of shale gas is established.展开更多
目的:以非受累侧前运动皮质区(premotor cortex,PMC)为刺激靶点,比较不同治疗时程的重复经颅磁刺激(repeated transcranial magnetic stimulation,rTMS)对脑卒中患者上肢运动功能及脑功能连接的影响。方法:将60例缺血性脑卒中后上肢运...目的:以非受累侧前运动皮质区(premotor cortex,PMC)为刺激靶点,比较不同治疗时程的重复经颅磁刺激(repeated transcranial magnetic stimulation,rTMS)对脑卒中患者上肢运动功能及脑功能连接的影响。方法:将60例缺血性脑卒中后上肢运动功能障碍患者随机分到6周rTMS组、4周rTMS组和2周r TMS组以及对照组,每组15例。在治疗前后采用上肢Brunnstrom分期、Fugl-Meyer运动功能评分上肢部分(Fugl-Meyer assessment of upper extremity,FMA-UE)和Wolf运动功能评分(Wolf motor function test,WMFT)进行行为学评定,另外以非受累侧PMC为种子点采用静息态功能磁共振成像(resting state functional magnetic resonance imaging,rs-fMRI)进行功能连接分析。结果:治疗后,2周rTMS组的FMA-UE和WMFT的评分与4周及6周rTMS组间有显著性差异(P<0.05),但4周rTMS组的FMA-UE和WMFT的评分与6周rTMS组间无显著性差异(P>0.05)。非受累侧PMC区为种子点的功能连接分析显示,rTMS治疗后非受累侧PMC与同侧中央前回、对侧颞中回和楔前叶功能连接增强(P<0.05)。结论:研究结果表明,以非受累侧半球PMC为靶点的低频rTMS治疗可有效促进偏瘫上肢运动功能的恢复,其中与2周rTMS干预和6周rTMS干预相比,4周rTMS干预具有最佳的时间-效益比,这可能与其增强双侧半球间、非受累半球内皮质-皮质间的功能连接有关。展开更多
Objective:CDK4/6 inhibitors(CDK4/6is)in combination with endocrine therapy have secured a central role in the treatment of hormone receptor(HR)-positive advanced breast cancer(ABC)and have transformed the therapeutic ...Objective:CDK4/6 inhibitors(CDK4/6is)in combination with endocrine therapy have secured a central role in the treatment of hormone receptor(HR)-positive advanced breast cancer(ABC)and have transformed the therapeutic landscape.Cross-line CDK4/6i therapy in which another CDK4/6i is continued after progression on a prior CDK4/6i may still offer advantageous therapeutic effects.Cross-line CDK4/6i therapy is an area of active investigation in the ongoing pursuit to improve outcomes for patients with HR+/human epidermal growth factor receptor 2(HER2)–ABC.Methods:This retrospective study enrolled 82 patients with HR+/HER2–ABC who were treated with cross-line CDK4/6is(abemaciclib,palbociclib,ribociclib,and dalpiciclib)after progression with another CDK4/6i.The primary endpoint was progression-free survival(PFS)according to version 1.1 of the Response Evaluation Criteria in Solid Tumors.Secondary endpoints included toxicity,objective response rate,disease control rate,and overall survival.Adverse events(AEs)were graded according to version 5.0 of the Common Terminology Criteria for Adverse Events,as promulgated by the U.S.Department of Health and Human Services.Results:Eighty-two HR+/HER2–ABC patients who received cross-line CDK4/6i therapy from January 2022 to February 2024 were enrolled.The median age of the patients was 60 years.The median PFS of all patients was 7.6 months(95%CI,5.9-9.2).Cox regression analysis identified lung metastasis and a switch to endocrine therapy following prior CDK4/6i therapy as independent predictive factors for PFS.Notably,patients who previously received abemaciclib and switched to palbociclib upon disease progression had a median PFS of 10.7 months.The strategy of transitioning to chemotherapy after progression on a prior CDK4/6i,then to a subsequent CDK4/6i merits further investigation.Hematologic toxicity was the most common grade≥3 AEs.No instances of fatal safety events were observed.Conclusions:Cross-line CDK4/6i therapy is associated with significant clinical benefits and manageable safety profiles in patients with HR+/HER2–ABC,which underscores cross-line CDK4/6i therapy potential as an effective treatment strategy.展开更多
The detrimental effect of imprint,which can cause misreading problem,has hindered the application of ferroelectric HfO_(2).In this work,we present results of a comprehensive reliability evaluation of Hf_(0.5)Zr_(0.5)O...The detrimental effect of imprint,which can cause misreading problem,has hindered the application of ferroelectric HfO_(2).In this work,we present results of a comprehensive reliability evaluation of Hf_(0.5)Zr_(0.5)O_(2)-based ferroelectric random access memory.The influence of imprint on the retention and endurance is demonstrated.Furthermore,a solution in circuity is pro-posed to effectively solve the misreading problem caused by imprint.展开更多
In-Ga-Zn-O(IGZO) channel based thin-film transistors(TFT), which exhibit high on-off current ratio and relatively high mobility, has been widely researched due to its back end of line(BEOL)-compatible potential for th...In-Ga-Zn-O(IGZO) channel based thin-film transistors(TFT), which exhibit high on-off current ratio and relatively high mobility, has been widely researched due to its back end of line(BEOL)-compatible potential for the next generation dynamic random access memory(DRAM) application. In this work, thermal atomic layer deposition(TALD) indium gallium zinc oxide(IGZO) technology was explored. It was found that the atomic composition and the physical properties of the IGZO films can be modulated by changing the sub-cycles number during atomic layer deposition(ALD) process. In addition, thin-film transistors(TFTs) with vertical channel-all-around(CAA) structure were realized to explore the influence of different IGZO films as channel layers on the performance of transistors. Our research demonstrates that TALD is crucial for high density integration technology, and the proposed vertical IGZO CAA-TFT provides a feasible path to break through the technical problems for the continuous scale of electronic equipment.展开更多
基金funded by the Geological Survey Project of China Geological Survey(No.1212011085516)Geological Survey Level 2 Project(No.121201103000150011)Basic Research Professional Expenses of CAGS(No. YYWF201609)
文摘Objective At present, there is controversy regarding the existence of marine-terrestrial transitional facies that can act as a source of shale gas. This detailed study of Carboniferous-Permian age geological data from the northern Shaanxi area （China） provides new insight for this type of shale gas. In addition, a new deposition and accumulation pattern for this type of shale gas is established.
文摘目的:以非受累侧前运动皮质区(premotor cortex,PMC)为刺激靶点,比较不同治疗时程的重复经颅磁刺激(repeated transcranial magnetic stimulation,rTMS)对脑卒中患者上肢运动功能及脑功能连接的影响。方法:将60例缺血性脑卒中后上肢运动功能障碍患者随机分到6周rTMS组、4周rTMS组和2周r TMS组以及对照组,每组15例。在治疗前后采用上肢Brunnstrom分期、Fugl-Meyer运动功能评分上肢部分(Fugl-Meyer assessment of upper extremity,FMA-UE)和Wolf运动功能评分(Wolf motor function test,WMFT)进行行为学评定,另外以非受累侧PMC为种子点采用静息态功能磁共振成像(resting state functional magnetic resonance imaging,rs-fMRI)进行功能连接分析。结果:治疗后,2周rTMS组的FMA-UE和WMFT的评分与4周及6周rTMS组间有显著性差异(P<0.05),但4周rTMS组的FMA-UE和WMFT的评分与6周rTMS组间无显著性差异(P>0.05)。非受累侧PMC区为种子点的功能连接分析显示,rTMS治疗后非受累侧PMC与同侧中央前回、对侧颞中回和楔前叶功能连接增强(P<0.05)。结论:研究结果表明,以非受累侧半球PMC为靶点的低频rTMS治疗可有效促进偏瘫上肢运动功能的恢复,其中与2周rTMS干预和6周rTMS干预相比,4周rTMS干预具有最佳的时间-效益比,这可能与其增强双侧半球间、非受累半球内皮质-皮质间的功能连接有关。
基金supported by grants from the CAMS Innovation Fund for Medical Sciences[CIFMS](Grant Nos.2021-I2M-1-014 and 2022-I2M-2-002).
文摘Objective:CDK4/6 inhibitors(CDK4/6is)in combination with endocrine therapy have secured a central role in the treatment of hormone receptor(HR)-positive advanced breast cancer(ABC)and have transformed the therapeutic landscape.Cross-line CDK4/6i therapy in which another CDK4/6i is continued after progression on a prior CDK4/6i may still offer advantageous therapeutic effects.Cross-line CDK4/6i therapy is an area of active investigation in the ongoing pursuit to improve outcomes for patients with HR+/human epidermal growth factor receptor 2(HER2)–ABC.Methods:This retrospective study enrolled 82 patients with HR+/HER2–ABC who were treated with cross-line CDK4/6is(abemaciclib,palbociclib,ribociclib,and dalpiciclib)after progression with another CDK4/6i.The primary endpoint was progression-free survival(PFS)according to version 1.1 of the Response Evaluation Criteria in Solid Tumors.Secondary endpoints included toxicity,objective response rate,disease control rate,and overall survival.Adverse events(AEs)were graded according to version 5.0 of the Common Terminology Criteria for Adverse Events,as promulgated by the U.S.Department of Health and Human Services.Results:Eighty-two HR+/HER2–ABC patients who received cross-line CDK4/6i therapy from January 2022 to February 2024 were enrolled.The median age of the patients was 60 years.The median PFS of all patients was 7.6 months(95%CI,5.9-9.2).Cox regression analysis identified lung metastasis and a switch to endocrine therapy following prior CDK4/6i therapy as independent predictive factors for PFS.Notably,patients who previously received abemaciclib and switched to palbociclib upon disease progression had a median PFS of 10.7 months.The strategy of transitioning to chemotherapy after progression on a prior CDK4/6i,then to a subsequent CDK4/6i merits further investigation.Hematologic toxicity was the most common grade≥3 AEs.No instances of fatal safety events were observed.Conclusions:Cross-line CDK4/6i therapy is associated with significant clinical benefits and manageable safety profiles in patients with HR+/HER2–ABC,which underscores cross-line CDK4/6i therapy potential as an effective treatment strategy.
基金This research was supported by the National Key R&D Program of China(Grant No.2022YFB3606900)in part by the National Natural Science of China(Grant No.62004217).
文摘The detrimental effect of imprint,which can cause misreading problem,has hindered the application of ferroelectric HfO_(2).In this work,we present results of a comprehensive reliability evaluation of Hf_(0.5)Zr_(0.5)O_(2)-based ferroelectric random access memory.The influence of imprint on the retention and endurance is demonstrated.Furthermore,a solution in circuity is pro-posed to effectively solve the misreading problem caused by imprint.
基金funded in part by the National Key R&D Program of China(Grant No.2022YFB3606900)in part by the National Natural Science of China(Grant No.62004217)。
文摘In-Ga-Zn-O(IGZO) channel based thin-film transistors(TFT), which exhibit high on-off current ratio and relatively high mobility, has been widely researched due to its back end of line(BEOL)-compatible potential for the next generation dynamic random access memory(DRAM) application. In this work, thermal atomic layer deposition(TALD) indium gallium zinc oxide(IGZO) technology was explored. It was found that the atomic composition and the physical properties of the IGZO films can be modulated by changing the sub-cycles number during atomic layer deposition(ALD) process. In addition, thin-film transistors(TFTs) with vertical channel-all-around(CAA) structure were realized to explore the influence of different IGZO films as channel layers on the performance of transistors. Our research demonstrates that TALD is crucial for high density integration technology, and the proposed vertical IGZO CAA-TFT provides a feasible path to break through the technical problems for the continuous scale of electronic equipment.
