超声乳化术治疗白内障合并高度近视疗效的影响因素

目的:探讨超声乳化手术在白内障合并高度近视患者中的临床效果及疗效影响因素。方法:回顾性分析2016-01/2019-01在我院住院的白内障合并高度近视患者90例109眼,所有患者均拟行白内障超声乳化联合人工晶状体植入术治疗,术后对患者进行6mo随访,根据最佳矫正视力评价手术疗效并进行分组:视力低下组(最佳矫正视力<0.3)和视力正常组(最佳矫正视力≥0.3)。建立Logistic回归分析模型,分析影响术后疗效的因素。结果:视力低下组22例27眼,视力正常组68例82眼。随访期间,发生晶状体后囊膜混浊6眼,均为轻度混浊,激光治疗后改善,未见其他并发症的发生。单因素分析发现,眼轴长度、角膜散光度、Emery分级、眼底病变分级是影响手术疗效的影响因素(P<0.05)。Logistic回归分析结果显示,眼轴长度(OR=2.121)、角膜散光度(OR=1.698)、Emery分级(OR=1.901)和眼底病变分级(OR=1.964)是影响术后疗效的独立因素(P<0.05)。结论:眼轴长度、角膜散光度、Emery分级和眼底病变分级是影响白内障超声乳化手术治疗白内障合并高度近视疗效的独立因素,但是影响患者预后因素较多,应根据影响因素制定有效的措施进行干预,提高患者手术预后。

Epidemiological characteristics of varicella in Chongqing,China,2014-2021

Background:To analyze the epidemiological characteristics of varicella epidemics in Chongqing Municipality from 2014 to 2021,and to provide a scientific basis for the formulation of varicella prevention and control measures.Methods:Data on the incidence of varicella outbreaks and vaccination data in Chongqing from 2014 to 2021 were collected through the China Disease Control and Prevention Information System and statistically analyzed using descriptive epidemiological methods.Results:From 2014 to 2021,213,715 cases of varicella were reported in Chongqing Municipality,with an average annual incidence rate of 86.26/100,000,with a statistically significant difference(χ^(2)=24,972.069,P<0.001);varicella incidence is seasonal,with peaks in May/June and October/December each year,presenting a“double-peak distribution”.The average annual incidence rate of varicella in municipal districts was 90.74/100,000,which was higher than that of counties 69.62/100,000 and autonomous counties 84.04/100,000;the average annual incidence rate of varicella in males was 89.37/100,000,and in females,82.22/100,000,with the difference not being statistically significant;the age of onset of the disease was mainly in the group of people under 15 years of age,with a total of 190,021 cases reported(88.9%),with 5-9 years old(35.7%)as the high incidence age group.The incidence occupation was dominated by students in 133,733 cases(62.6%).Conclusion:The overall varicella epidemic in Chongqing is on the rise,and has obvious seasonal,regional and population distribution characteristics.The prevention and control of varicella epidemic should be strengthened,the publicity of varicella vaccine should be increased,and it is recommended that varicella vaccine should be included in the national immunization program.

急性上消化道出血止血新技术的诊疗进展

急性上消化道出血(acute upper gastrointestinal bleeding,AUGIB)是急诊最常见的急危重症之一,主要指Treitz韧带以上的消化道出血,死亡率约2%-10%.主要临床表现为呕血和(或)便血,诊断主要通过临床表现结合实验室检查、影像学检查.由于该病起病急、病情重,根据不同的病因可有多种治疗方法.本文基于以上情况,对AUGIB的诊断和治疗方法展开综述.

Triboelectric–Electromagnetic Hybrid Generator for Harvesting Blue Energy

Progress has been developed in harvesting lowfrequency and irregular blue energy using a triboelectric–electromagnetic hybrid generator in recent years. However,the design of the high-efficiency, mechanically durable hybrid structure is still challenging. In this study, we report a fully packaged triboelectric–electromagnetic hybrid generator(TEHG), in which magnets were utilized as the trigger to drive contact–separation-mode triboelectric nanogenerators(CS-TENGs) and coupled with copper coils to operate rotary freestanding-mode electromagnetic generators(RF-EMGs). The magnet pairs that produce attraction were used to transfer the external mechanical energy to the CS-TENGs, and packaging of the CS-TENGpart was achieved to protect it from the ambient environment. Under a rotatory speed of 100 rpm, the CS-TENGs enabled the TEHG to deliver an output voltage, current,and average power of 315.8 V, 44.6 μA, and ~ 90.7 μW,and the output of the RF-EMGs was 0.59 V, 1.78 m A, and 79.6 μW, respectively. The cylinder-like structure made the TEHG more easily driven by water flow and demonstrated to work as a practical power source to charge commercial capacitors. It can charge a 33μF capacitor from 0 to 2.1 V in 84 s, and the stored energy in the capacitor can drive an electronic thermometer and form a self-powered water-temperature sensing system.

Numerical Analysis of a Floating Offshore Wind Turbine by Coupled Aero-Hydrodynamic Simulation

The exploration for renewable and clean energies has become crucial due to environmental issues such as global warming and the energy crisis. In recent years,floating offshore wind turbines(FOWTs) have attracted a considerable amount of attention as a means to exploit steady and strong wind sources available in deep-sea areas. In this study, the coupled aero-hydrodynamic characteristics of a spar-type 5-MW wind turbine are analyzed. An unsteady actuator line model(UALM) coupled with a twophase computational fluid dynamics solver naoe-FOAM-SJTU is applied to solve three-dimensional Reynolds-averaged NavierStokes equations. Simulations with different complexities are performed. First, the wind turbine is parked. Second, the impact of the wind turbine is simplified into equivalent forces and moments. Third, fully coupled dynamic analysis with wind and wave excitation is conducted by utilizing the UALM. From the simulation, aerodynamic forces, including the unsteady aerodynamic power and thrust, can be obtained, and hydrodynamic responses such as the six-degrees-of-freedom motions of the floating platform and the mooring tensions are also available. The coupled responses of the FOWT for cases of different complexities are analyzed based on the simulation results. Findings indicate that the coupling effects between the aerodynamics of the wind turbine and the hydrodynamics of the floating platform are obvious. The aerodynamic loads have a significant effect on the dynamic responses of the floating platform, and the aerodynamic performance of the wind turbine has highly unsteady characteristics due to the motions of the floating platform. A spar-type FOWT consisting of NREL-5-MW baseline wind turbine and OC3-Hywind platform system is investigated. The aerodynamic forces can be obtained by the UALM. The 6 DoF motions and mooring tensions are predicted by the naoe-FOAM-SJTU. To research the coupling effects between the aerodynamics of the wind turbine and the hydrodynamics of the floating platform, simulations with different complexities are performed. Fully coupled aero-hydrodynamic characteristics of FOWTs, including aerodynamic loads, wake vortex, motion responses, and mooring tensions, are compared and analyzed.

Meta-analysis of the efficacy of probiotics in Helicobacter pylori eradication therapy

AIM: To evaluate the role of probiotics in the standard triple Helicobacter pylori therapy. METHODS: In this meta-analysis, we investigated the efficacy of probiotics in a standard triple H. pylori therapy in adults. Searches were mainly conducted in MEDLINE/PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials. Fourteen studies met our criteria, and the quality of these studies was assessed using the Jadad scale. We used STATA version 12.0 to extract data and to calculate the odds ratios (ORs), which are presented with the corresponding 95% confidence intervals (CIs). The data are presented as forest plots. RESULTS: The pooled ORs for the eradication rates calculated by intention-to-treat analysis and per-protocol analysis in the probiotic group vs the control group were 1.67 (95%CI: 1.38-2.02) and 1.68 (95%CI: 1.35-2.08), respectively, using the fixed-effects model. The sensitivity of the Asian studies was greater than that of the Caucasian studies (Asian: OR = 1.78, 95%CI: 1.40-2.26; Caucasian: OR = 1.48, 95%CI: 1.06-2.05). The pooled OR for the incidence of total adverse effects was signi.cantly lower in the probiotic group (OR = 0.49, 95%CI: 0.26-0.94), using the random effects model, with significant heterogeneity (I-2 = 85.7%). The incidence of diarrhea was significantly reduced in the probiotic group (OR = 0.21, 95%CI: 0.06-0.74), whereas the incidence of taste disorders, metallic taste, vomiting, nausea, and epigastric pain did not differ significantly between the probiotic group and the control group. CONCLUSION: Supplementary probiotic preparations during standard triple H. pylori therapy may improve the eradication rate, particularly in Asian patients, and the incidence of total adverse effects. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.

基于Arduino单片机的双光纤双向干涉条纹计数器

介绍了一种基于Arduino单片机的双光纤双向干涉条纹计数器.该装置可根据干涉条纹的涌出和陷入实现条纹的双向计数.在干涉法测量金属热膨胀系数实验中,使用此计数器对条纹计数,具有成本低廉、操作简易、计数精度高、抗干扰能力强、反应时间短等优点.

3D printed hydrogel for soft thermo-responsive smart window

Smart windows with tunable optical properties that respond to external environments are being developed to reduce energy consumption in buildings.In the present study,we introduce a new type of 3D printed hydrogel with amazing flexibility and stretchability(as large as 1500%),as well as tunable optical performance controlled by surrounding temperatures.The hydrogel on a PDMS substrate shows transparent-opaque transition with high solar modulation(ΔT_(sol))up to 79.332% around its lower critical solution temperature(L_(CST))while maintaining a high luminous transmittance(T_(lum))of 85.847% at 20℃.In addition,selective transparent-opaque transition above LCST can be achieved by patterned hydrogels which are precisely fabricated via a projection micro-stereolithography based 3D printing technique.Our hydrogel promises great potential applications for the next generation of soft smart windows.

RNA interference of pax2 inhibits growth of transplanted human endometrial cancer cells in nude mice

The development of human endometrial carcinoma(HEC) is a complex pathologic process involves several oncogenes and tumor suppressor genes.The full-length paired-box gene 2(pax2),a recently discovered oncogene,promotes cell proliferation and growth and inhibits apoptosis of HEC cells.Here,we examined the effect of pax2 small interfering RNA(siRNA) on the growth of transplanted HEC cells in nude mice.The expression of Pax2 in 21 cases of normal endometrium and 38 cases of HEC was examined by immohistochemistry(IHC).HEC models were developed by subcutaneously transferring HEC cells into nude mice,followed by treatment with empty lentivirus vector,lentivirus vector-based pax2 siRNA,and phosphate buffered saline,respectively.Four weeks later,tumor size was measured,tumor inhibition rate was calculated,and histological analyses were conducted after staining with hematoxylin and eosin.The expression of Pax2 and Bcl-2 was detected by Western blot;proliferating cell nuclear antigen(PCNA) was detected by IHC.Significant differences were observed in the positive rate of Pax2 between normal endometrium and HEC(14.2% vs.60.5%,P<0.01).The expression index of Pax2 in well differentiated tumors was 1.88±1.68,much lower than that in tumors of moderate(3.07±1.96,P<0.05) or poor differentiation(5.45±2.76,P<0.01).Tumor necrosis increased,nuclear basophilia stain decreased,tumor growth was inhibited,and PCNA,Pax2,and Bcl-2 expression was reduced in HEC models treated with pax2 siRNA.These results indicate that Pax2 expression is related to HEC tumor biology with the increased expression of Pax2 correlated to malignancy.pax2 siRNA down-regulates Pax2 expression and inhibits tumorigenesis of HEC in nude mice,possibly due to cell apoptosis and the inhibition of tumor proliferation induced by down-regulation of Bcl-2.

Molecular simulation of diffusion of rigidity-tuned nanoparticles in biological hydrogels

The penetration capability of the drug nano-carriers (NCs) in biological hydrogels, such as mucus and tumor interstitial matrix, would typically influence the efficiency of drug delivery. Understanding the effect of the physicochemical property of the drug carriers on their diffusion capability in biological hydrogel becomes important for designing and optimizing the nano-carriers. Here, using a coarse-grained molecular dynamics model, we studied how the rigidity of NCs affected their diffusivity in biological hydrogel. The results showed that semi-elastic NCs have higher diffusivity than the hard and the soft NCs. Furthermore, the affinity between the NCs and biological hydrogels and the size ratio between the hydrogel meshes and NCs have also affected the diffusivity of the NCs. Further analysis revealed the mechanism that the deformation of the NCs dominates their diffusivity. These findings demonstrated that the rigidity of NCs is a key parameter in designing efficient NCs for deep penetration into the biological hydrogels.

Geometric Accuracy and Energy Absorption Characteristics of 3D Printed Continuous Ramie Fiber Reinforced Thin-Walled Composite Structures

The application of continuous natural fibers as reinforcement in composite thin-walled structures offers a feasible approach to achieve light weight and high strength while remaining environmentally friendly.In addition,additive manufacturing technology provides a favorable process foundation for its realization.In this study,the printability and energy absorption properties of 3D printed continuous fiber reinforced thin-walled structures with different configurations were investigated.The results suggested that a low printing speed and a proper layer thickness would mitigate the printing defects within the structures.The printing geometry accuracy of the structures could be further improved by rounding the sharp corners with appropriate radii.This study successfully fabricated structures with vari-ous configurations characterized by high geometric accuracy through printing parameters optimization and path smoothing.Moreover,the compressive property and energy absorption characteristics of the structures under quasi-static axial compression were evaluated and compared.It was found that all studied thin-walled structures exhibited progressive folding deformation patterns during compression.In particular,energy absorption process was achieved through the combined damage modes of plastic deformation,fiber pullout and delamination.Furthermore,the com-parison results showed that the hexagonal structure exhibited the best energy absorption performance.The study revealed the structure-mechanical property relationship of 3D printed continuous fiber reinforced composite thin-walled structures through the analysis of multiscale failure characteristics and load response,which is valuable for broadening their applications.

Bionic microchannels for step lifting transpiration

Those various cross-sectional vessels in trees transfer water to as high as 100 meters,but the traditional fabrication methods limit the manufacturing of those vessels,resulting in the non-availability of those bionic microchannels.Herein,we fabricate those bionic microchannels with various cross-sections by employing projection micro-stereolithography(PμSL)based 3D printing technique.The circumradius of bionic microchannels(pentagonal,square,triangle,and five-pointed star)can be as small as 100μm with precisely fabricated sharp corners.What's more,those bionic microchannels demonstrate marvelous microfluidic performance with strong precursor effects enabled by their sharp corners.Most significantly,those special properties of our bionic microchannels enable them outstanding step lifting performance to transport water to tens of millimeters,though the water can only be transported to at most 20 mm for a single bionic microchannel.The mimicked transpiration based on the step lifting of water from bionic microchannels is also achieved.Those precisely fabricated,low-cost,various cross-sectional bionic microchannels promise applications as microfluidic chips,long-distance unpowered water transportation,step lifting,mimicked transpiration,and so on.

PE-EDD:An efficient peer-effect-based financial fraud detection approach in publicly traded China firms

Financial fraud arises from the exaggeration of business interests,and an accurate detection or prediction is a useful tool for both corporate management and capital market systems.A collection of computer technologies has been made on this problem so far,and one of the most important solutions is unsupervised learning algorithms.Among them,most approaches work by analysing the internal relations in financial data and finding a new description of non-fraud firms.However,current studies focus a lot on the geometry attribute of financial data,while overlooking the obvious behaviour patterns and peer effects among firms.This has limited the accuracy of representation and furthermore the detection performance.In this work,a very general class of functions is allowed to represent firms,constraining them by peer effects between firms and presenting an error-distribution-based financial fraud firm detection approach.Experimental results have shown great performance of the proposed approach.

Simultaneous multiplex genome loci editing of Halomonas bluephagenesis using an engineered CRISPR-guided base editor

Halomonas bluephagenesis TD serves as an exceptional chassis for next generation industrial biotechnology to produce various products.However,the simultaneous editing of multiple loci in H.bluephagenesis TD remains a significant challenge.Herein,we report the development of a multiple loci genome editing system,named CRISPR-deaminase-assisted base editor(CRISPR-BE)in H.bluephagenesis TD.This system comprises two components:a cytidine(CRISPR-cBE)and an adenosine(CRISPR-aBE)deaminase-based base editor.CRISPR-cBE can introduce a cytidine to thymidine mutation with an efficiency of up to 100%within a 7-nt editing window in H.bluephagenesis TD.Similarly,CRISPR-aBE demonstrates an efficiency of up to 100%in converting adenosine to guanosine mutation within a 7-nt editing window.CRISPR-cBE has been further validated and successfully employed for simultaneous multiplexed editing in H.bluephagenesis TD.Our findings reveal that CRISPR-cBE efficiently inactivated all six copies of the IS1086 gene simultaneously by introducing stop codon.This system achieved an editing efficiency of 100%and 41.67%in inactivating two genes and three genes,respectively.By substituting the Pcas promoter with the inducible promoter PMmp1,we optimized CRISPR-cBE system and ultimately achieved 100%editing efficiency in inactivating three genes.In conclusion,our research offers a robust and efficient method for concurrently modifying multiple loci in H.bluephagenesis TD,opening up vast possibilities for industrial applications in the future.

基于ChatGPT的企业智能风险管理研究

基于生成式人工智能技术的聊天生成式预先训练变换器(Chat Generative Pre-trained Transformer,ChatGPT),依托于强大数据分析与处理能力以及大型语言处理模型,能够为企业风险管理提供新思路、新路径。本文在阐述ChatGPT与风险管理内涵的基础上,结合ChatGPT的关键特征,从风险识别、风险评估、风险应对、风险监控四个方面分析了其对企业风险管理的作用机理,构建了基于ChatGPT的风险管理框架模型,并从数据安全性、决策科学性、人机智能交互与协同以及组织架构调整四个方面分析了该模型在应用实施中的关注点。希望本文的研究能够为以ChatGPT为代表的生成式人工智能在企业风险管理领域的智能化应用提供参考和借鉴。

Flexible self-charging power units for portable electronics based on folded carbon paper

The urgent demand for portable electronics has promoted the development of high-efficienc）9 sustainable, and even stretchable self-charging power sources. In this work, we propose a flexible self-charging power unit based on folded carbon （FC） paper for harvesting mechanical energy from human motion and power portable electronics. The present unit mainly consists of a triboelectric nanogenerator （FC-TENG） and a supercapacitor （FC-SC）, both based on folded carbon paper, as energy harvester and storage device, respectively. This favorable geometric design provides the high Young＇s modulus carbon paper with excellent stretchability and enables the power unit to work even under severe deformations, such as bending, twisting, and rolling. In addition, the tensile strain can be maximized by tuning the folding angle of the triangle-folded carbon paper. Moreover, the waterproof property of the packaged device make it washable, protect it from human sweat, and enable it to work in harsh environments. Finally, the as-prepared self-charging power unit was tested by placing it on the human body to harvest mechanical energy from hand tapping, foot treading, and arm touching, successfully powering an electronic watch. This work demonstrates the impressive potential of stretchable self-charging power units, which will further promote the development of high Young＇s modulus materials for wearable/portable electronics.

3D Printed Ultrastretchable,Hyper-Antifreezing Conductive Hydrogel for Sensitive Motion and Electrophysiological Signal Monitoring

Conductive hydrogels with high stretchability can extend their applications as a flexible electrode in electronics,biomedicine,human-machine interfaces,and sensors.However,their time-consuming fabrication and narrow ranges of working temperature and working voltage severely limit their further potential applications.Herein,a conductive nanocomposite network hydrogel fabricated by projection microstereolithography(PμSL)based 3D printing is proposed,enabling fast fabrication ability with high precision.The 3D printed hydrogels exhibit ultra-stretchability(2500%),hyper-antifreezing(-125℃),extremely low working voltage(<100μV),and super cyclic tensile stability(1 million cycles).The hydrogel-based strain sensor can probe both large-scale and tiny human motions,even with ultralow voltage of 100μV at extremely low temperature around-115℃.It is demonstrated that the present hydrogels can be used as a flexible electrode for capturing human electrophysiological signals(EOG and EEG),where the alpha and beta waves from the brain can be recorded precisely.Therefore,the present hydrogels will pave the way for the development of next-generation intelligent electronics,especially for those working under extremely lowtemperature environments.

Sustainable routes for quantitative green selenocyanation of activated alkynes

Most organic reactions require the usage of volatile organic compounds in the synthesis, work-up and purification processes, thus resulting in major environmental pollution and high manufacturing cost. By using cheap biomass lactic acid as the reaction media and catalyst, a sustainable protocol for the synthesis of Z-3-selenocyanatoacrylates and analogues through green selenocyanation of activated alkynes has been achieved. A principal advantage of this protocol is that the usage of organic volatile compounds can be avoided entirely, as the conversion of substrate is almost quantitative or quantitative with a minimal amount of lactic acid employed as reaction media, and the pure products can be conveniently collected through water precipitation.

Tubulointerstitial nephritis antigen-like 1 is a novel matricellular protein that promotes gastric bacterial colonization and gastritis in the setting of Helicobacter pylori infection

The interaction between the gastric epithelium and immune cells plays key roles in H. pylori-associated pathology. Here, we demonstrate a procolonization and proinflammatory role of tubulointerstitial nephritis antigen-like 1 (TINAGL1), a newly discovered matricellular protein, in H. pylori infection. Increased TINAGL1 production by gastric epithelial cells (GECs) in the infected gastric mucosa was synergistically induced by H. pylori and IL-1β via the ERK-SP1 pathway in a cagA-dependent manner. Elevated human gastric TINAGL1 correlated with H. pylori colonization and the severity of gastritis, and mouse TINAGL1 derived from non-bone marrow-derived cells promoted bacterial colonization and inflammation. Importantly, H. pylori colonization and inflammation were attenuated in Tinagl1−/− and Tinagl1ΔGEC mice and were increased in mice injected with mouse TINAGL1. Mechanistically, TINAGL1 suppressed CCL21 expression and promoted CCL2 production in GECs by directly binding to integrin α5β1 to inhibit ERK and activate the NF-κB pathway, respectively, which not only led to decreased gastric influx of moDCs via CCL21-CCR7-dependent migration and, as a direct consequence, reduced the bacterial clearance capacity of the H. pylori-specific Th1 response, thereby promoting H. pylori colonization, but also resulted in increased gastric influx of Ly6Chigh monocytes via CCL2-CCR2-dependent migration. In turn, TINAGL1 induced the production of the proinflammatory protein S100A11 by Ly6Chigh monocytes, promoting H. pylori-associated gastritis. In summary, we identified a model in which TINAGL1 collectively ensures H. pylori persistence and promotes gastritis.

数字化管理会计人才培养的理论与实践

潘飞:当前数字经济加速发展,数字化转型不仅推动企业在业务、流程等方面全面变革,也对企业会计人才的培养提出了新要求。今天我们很荣幸地邀请到科大讯飞的段大为总、上海国家会计学院刘勤副院长、重庆理工大学云会计大数据智能研究所所长程平教授,来到我们的圆桌论坛,与大家一起交流、分享数字化管理会计人才培养的理论与实践。首先欢迎三位专家简单做一下自我介绍。