Non-invasive ventilation improves hemorheology status in hypoxemic patients with acute myocardial infarction after PCI

Background Hypoxemia sometimes occurs in the emergency room in the patients with acute myocardial infarction （AMI） after percutaneous coronary intervention （PCI）, even in those with administration of conventional high-flow oxygen inhalation. The objective of the present study was to evaluate the effectiveness of non-invasive ventilation （NIV） in improving blood oxygen content and hemorheology in patients with AMI and hypoxemia. Methods This prospective study enrolled 50 consecutive eligible patients with AMI （aged 72.3 ± 9.5 years）, who had undergone PCI and been administered high-flow oxygen but still had hypoxemia. Blood was taken before NIV and at 0.5, 1, and 2 h after NIV. Blood gases, hemorheological variables including erythrocyte deformability, erythrocyte aggregation, erythrocyte osmotic fragility, membrane fluidity, and oxidative stress level were measured. Results Blood PaO2 increased to normal by 1 h after NIV. Assessed hemorheological variables had all improved and plasma malondialdehyde concentration decreased significantly after 2 h of NIV. Conclusions Our data suggest that NIV can help to improve blood oxygen content, hemorheological status, and minimize plasma lipid peroxidation injury in hypoxemic patients with AMI who have undergone PCI.

Information service platform for science and technology innovation and entrepreneurship: New information service practice in the NSLC

Purpose: This study explores new content, forms, and fields of science and technology(S&T;) innovation and entrepreneurship information services of the National Science Library of the Chinese Academy of Sciences(NSLC).Design/methodology/approach: We cooperated with incubator enterprises and set up an "S&T; Innovation and Entrepreneurship Information Service Platform." We designed five series of activities, including industrial information release, project financing and roadshows, entrepreneurial sharing, entrepreneurial coaching sessions, and entrepreneurial salons. Based on the implementation of these activities, we designed new NSLC library services for S&T; innovation and entrepreneurship.Findings: Since the construction of the platform, these five series of activities have attracted more than 80 business projects, 90 investors, and 30 researchers. Furthermore, more than 20 media representatives and nearly 300 entrepreneurs have participated in the activities that the NSLC has organized in the past two years. Through these activities, we have defined an S&T; innovation and entrepreneurship knowledge service model for the NSLC.Research limitations: The service practice of the NSLC is still in the demonstration phase. Due to staffing limitations of our service teams, the expansion of our service activities has been greatly restricted.Practical implications: The innovation and entrepreneurship information services of the NSLC provide a lot of material for transformation of library services for domestic and foreign special libraries.Originality/value: It is useful to transform library and business services by embedding them into ways in which we serve innovation and entrepreneurial activities. This opens up a new field of library knowledge services in China.

Modeling and Rectification of Rolling Shutter Effect in CMOS Aerial Cameras

Due to the electronic rolling shutter, high-speed Complementary Metal-Oxide Semiconductor( CMOS) aerial cameras are generally subject to geometric distortions,which cannot be perfectly corrected by conventional vision-based algorithms. In this paper we propose a novel approach to address the problem of rolling shutter distortion in aerial imaging. A mathematical model is established by the coordinate transformation method. It can directly calculate the pixel distortion when an aerial camera is imaging at arbitrary gesture angles.Then all pixel distortions form a distortion map over the whole CMOS array and the map is exploited in the image rectification process incorporating reverse projection. The error analysis indicates that within the margin of measuring errors,the final calculation error of our model is less than 1/2 pixel. The experimental results show that our approach yields good rectification performance in a series of images with different distortions. We demonstrate that our method outperforms other vision-based algorithms in terms of the computational complexity,which makes it more suitable for aerial real-time imaging.

A new service model of document and information sharing among consortium members: The collaborative innovation practice of the NSLC and PASs

Purpose： This paper documents an exploration of an innovative approach to the sharing of documents and information among the members of the National Alliance of Academies of Sciences （NAAS） in China, based on the practice initiated by the National Science Library of the Chinese Academy of Sciences （NSLC）.Design/methodology/approach： Through interviews and user surveys, we analyzed the general information demands of users from provincial academies of sciences （PASs） and problems of their document and information service teams. Based on our findings, we designed targeted services to help Alliance members support their document resources, information services for science and technology （S＆T） decisions, and their knowledge transfer achievements. Furthermore, we offered training courses for provincial service teams, researchers, and administrators, to improve their information skills. These activities represent a new collaborative model for professional library consortia.Findings： To date, our service has been extended to all Alliance members, covering 19 provinces in China, and the NSLC service covers all aspects of knowledge services of Alliance members, from basic document delivery services to subject information analyses.Research limitations： Different PASs have different understandings of the role of the document and information services in the process of scientific research. These differences limit information service sharing of the NSLC with the PASs, and affect the service performance. For the sake of convenience, the original survey was conducted in only three provinces, which may not fully reflect the information needs of users in each Alliance institution. In addition, quantitative and qualitative analyses have been limited by the coverage of the sample.Practical implications： Document and information sharing has not only taken advantage of the NSLC knowledge service system and cooperation model, it has also enhanced the range of services of the NAAS in China.Originality/value： Based on knowledge service enhancements, the NAAS in China has formed a new kind of library consortium, which has broken the traditional library alliance model that was based mainly on the sharing of resources and services.

Special library services for regional economic development(SRED)—Practice of the NSLC

Purpose: By case studies of the service for regional economic development(SRED) carried out by the National Science Library of the Chinese Academy of Sciences(NSLC), this article tries to describe basic directions of special libraries in the SRED.Design/methodology/approach: By comparing the aims and service forms of the SRED provided by domestic and foreign libraries and information service institutions, the authors examined the basic services provided by special libraries. Through a summary of the SRED exploration carried out by the NSLC, the authors introduce its main content, service methods, products, and service mechanisms. By analyzing the information needs of SRED users and summarizing users’ practical experiences of services, the authors propose a design for the SRED framework of the NSLC. In addition, the authors mention key points to be noticed during the process of service implementation, illustrating them with a number of selected SRED cases. The authors suggest that the SRED network and joint service mechanism are effective ways to implement SRED services. Findings: Based on information resource and expert networks, special libraries like the NSLC can carry out SRED to meet user requirements. The NSLC has not only constructed its own SRED framework, but has also expanded the patron service to the industrial intelligence service area. By setting up a nationwide S&T;(science and technology) novelty search network and a literature and information service alliance, the NSLC provides a variety of information training services. This enriches the content of the knowledge service of special libraries and enlarges the library service of the NSLC.Research limitations: The SRED of Chinese libraries is still in the exploratory stage. Questions as how to scientifically design service content and service modes, and how to establish a sustainable regional service system based on user needs are still being researchedand discussed. Furthermore, we need to pay more attention to the construction of the service network and respond more quickly to feedback while creating the SRED.Practical implications: The SRED experience of the NSLC has shown that special libraries can implement a knowledge service for economic development, and the SRED is an important direction of knowledge services for special libraries.Originality/value: Through describing a practical SRED, this paper provides a valuable reference for libraries in the transformation process from library service to knowledge service. The experimental SRED of the NSLC has verified the rationality of our service framework in support of regional economic development.

Video-based pedestrian grouping model considering longspan space in a big hall

Pedestrian group detection is a challenging but significant issue in pedestrian flow control and public safety management.To address the issue that most conventional pedestrian grouping models(PGMs)can only identify a pedestrian group at a limited distance of less than 2 m,this study extended the pedestrian distance constraint of conventional PGMs with a reconstruction of the normal group detection criterion and development of a novelgroup detection criterion suitable for long-span space.To measure the movement behaviorsimilarity with normal distance,five necessary constraints:velocity difference,moving direction offset,distance limitation,distance fluctuation,and group-keeping duration were studied quantitatively to form the criterion to detect normal groups.Meanwhile,a long-span group detection criterion was proposed with extended distance and direction con-sistency constraints.Therefore,this study proposed an improved PGM that considers long-span spaces(PGMLS).In the PGMLS workflow,the MMTrack algorithm was used to obtainpedestrian trajectories.A difference measurement method based on sequential pattern analysis(SPA)was adopted to analyze the velocity similarity of pedestrians.To validate the proposed grouping model,experiments based on pedestrian movement videos in the exit hall of the Shanghai Hongqiao International Airport were conducted.The results indicate that the proposed model can detect both normal and widely separated pedestrian groups,with a long span range of 2-12 m.

Transcriptomic analysis identifies the neuropeptide cortistatin (CORT) as an inhibitor of temozolomide (TMZ) resistance by suppressing the NF-kB-MGMT signaling axis in human glioma

Glioma is a common tumor originating in the brain that has a high mortality rate.Temozolomide(TMZ)is the first-line treatment for high-grade gliomas.However,a large pro-portion of gliomas are resistant to TMZ,posing a great challenge to their treatment.In the study,the specific functions and mechanism(s)by which cortistatin(CORT)regulates TMZ resis-tance and glioma progression were evaluated.The decreased expression of CoRT was detected in glioma tissues,and highly expressed CORT was associated with a better survival rate in pa-tients with glioma.CORT overexpression notably decreased the capacity of glioma cells to pro-liferate and migrate in vitro and to form tumors in vivo.CORT overexpression also markedly suppressed the viability and enhanced the apoptosis of TMZ-resistant U251 cells by regulating MGMT,p21,and Puma expression.Importantly,CORT overexpression reduced the resistance of gliomas to TMZ in vivo.CORT expression Was negatively correlated with MGMT expression in both glioma tissues and cells,and it was found that CORT inhibited NF-kB pathway activation in glioma cells,thereby inhibiting MGMT expression.In conclusion,CORT regulates glioma cell growth,migration,apoptosis,and TMZ resistance by weakening the activity of NF-kB/p65 and thereby regulating MGMT expression.The CORT/NF-kB/MGMT axis might be regarded as a molecular mechanism contributing to the resistance of glioma to TMZ.Our data also suggest that CORT regulates the viability and metastatic potential of glioma cells,independent of its effects on TMZ resistance,providing evidence of novel therapeutic targets for glioma that should be evaluated infurther studies.

Massive individual orbital angular momentum channels for multiplexing enabled by Dammann gratings

Data transmission rates in optical communication systems are approaching the limits of conventional multiplexing methods.Orbital angular momentum(OAM)in optical vortex beams offers a new degree of freedom and the potential to increase the capacity of free-space optical communication systems,with OAM beams acting as information carriers for OAM division multiplexing(OAM-DM).We demonstrate independent collinear OAM channel generation,transmission and simultaneous detection using Dammann optical vortex gratings(DOVGs).We achieve 80/160 Tbit s^(-1) capacity with uniform power distributions along all channels,with 1600 individually modulated quadrature phase-shift keying(QPSK)/16-QAM data channels multiplexed by 10 OAM states,80 wavelengths and two polarizations.DOVG-enabled OAM multiplexing technology removes the bottleneck of massive OAM state parallel detection and offers an opportunity to raise optical communication systems capacity to Pbit s^(-1) level.

纳米疗法介导铁死亡触发内源性信号特异性激活cGAS-STING通路用于增强肿瘤免疫治疗

激活环状GMP-AMP合成酶-干扰素基因刺激因子(cGAS-STING)通路可以有效启动抗肿瘤免疫,但如何特异性地激活STING通路仍是一个巨大的挑战.本文设计了一种铁死亡触发肿瘤细胞线粒体DNA释放,用于激活STING通路的肿瘤免疫治疗纳米平台(命名为HBMn-FA).一方面,HBMn-FA介导的铁死亡可以诱导肿瘤细胞中活性氧(ROS)水平急剧升高,引起线粒体氧化应激,释放内源性信号分子-线粒体DNA,并在Mn^(2+)的协同作用下特异性启动cGAS-STING通路.另一方面,HBMn-FA也可以造成肿瘤细胞死亡,并释放死亡肿瘤细胞碎片中的胞质双链DNA(dsDNA)进一步激活抗原提呈细胞(如DC细胞)中的cGAS-STING通路.通过建立铁死亡和cGAS-STING通路之间的连接可以快速启动全身抗肿瘤免疫响应,并增强免疫检查点疗法,从而抑制局部和转移性肿瘤的生长.