Glaucoma is a common and complex neurodegenerative disease characterized by progressive loss of retinal ganglion cells(RGCs)and axons.Currently,there is no effective method to address the cause of RGCs degeneration.Ho...Glaucoma is a common and complex neurodegenerative disease characterized by progressive loss of retinal ganglion cells(RGCs)and axons.Currently,there is no effective method to address the cause of RGCs degeneration.However,studies on neuroprotective strategies for optic neuropathy have increased in recent years.Cell replacement and neuroprotection are major strategies for treating glaucoma and optic neuropathy.Regenerative medicine research into the repair of optic nerve damage using stem cells has Received considerable attention.Stem cells possess the potential for multidirectional differentiation abilities and are capable of producing RGCfriendly microenvironments through paracrine effects.This article reviews a thorough researches of recent advances and approaches in stem cell repair of optic nerve injury,raising the controversies and unresolved issues surrounding the future of stem cells.展开更多
Dear Editor,The choice of surgical intervention for nanophthalmos patients with secondary angle-closure glaucoma poses a challenging decision for ophthalmologists.Because nanophthalmos patients who have undergone filt...Dear Editor,The choice of surgical intervention for nanophthalmos patients with secondary angle-closure glaucoma poses a challenging decision for ophthalmologists.Because nanophthalmos patients who have undergone filtration surgery or other intraocular procedures are more susceptible to severe complications,including choroidal effusion,malignant glaucoma,and explosive choroidal hemorrhage,all of which can lead to vision loss[1].This dilemma is particularly pronounced in patients with shorter axial lengths.Micropulse transscleral laser therapy(M-TLT),also known as micropulse transscleral cyclophotocoagulation(MP-TSCPC),is a nonincisional laser therapy surgery for glaucoma[2].In 2015,Golan and Kurtz[3]were the first to report four patients with secondary angle-closure glaucoma in nanophthalmos with axial lengths ranging between 17 and 19 mm(mean 18 mm)who were successfully treated with M-TLT,and choroidal detachment was observed in all patients(recovery spontaneously in two patients and recovery after systemic steroid treatment in the other two),of which two had a slight decrease in visual acuity.展开更多
CJ Health Technology Co.has been an export-oriented supplier of fitness equipment,boasting leading technology innovation and manufacturing capabilities.However,in the process of expanding into the domestic market,the ...CJ Health Technology Co.has been an export-oriented supplier of fitness equipment,boasting leading technology innovation and manufacturing capabilities.However,in the process of expanding into the domestic market,the challenges of unclear market positioning and lack of brand awareness have emerged as major obstacles.To address these issues,a SWOT analysis was conducted to explore a suitable market positioning strategy for the CJ brand.The analysis reveals that the market demand for commercial fitness equipment is relatively saturated,with fierce competition.In contrast,the home fitness market represents a new blue ocean with promising development opportunities for the CJ brand.Leveraging excellent product quality,stringent quality control measures,and innovation-driven cutting-edge technology,it is recommended that CJ brand fitness equipment target young customers aged between 25 and 35 years old.Additionally,vigorously developing the home fitness product line is proposed to capitalize on this burgeoning market segment.展开更多
We report the femtosecond time-resolved studies of room temperature exciton recombination and ultrafast stimulated emission dynamics in ZnO microcrystallite thin films.A free exciton photoluminescence lifetime of a fe...We report the femtosecond time-resolved studies of room temperature exciton recombination and ultrafast stimulated emission dynamics in ZnO microcrystallite thin films.A free exciton photoluminescence lifetime of a few tens of picoseconds and a decay time of a few picoseconds for the stimulated emission were observed.The relatively slow rise time(3ps)for the P band as the result of exciton-exciton scattering compared with the 0.8ps rise time for the N band attributed to electron-hole plasma recombination clearly distinguished the two stimulated emission processes.展开更多
AIM： To evaluate the utility of local tumor therapy combined with percutaneous transhepatic bilian/drainage （PTBD） for malignant obstructive bilian/disease. METHODS： A total of 233 patients with malignant billan/o...AIM： To evaluate the utility of local tumor therapy combined with percutaneous transhepatic bilian/drainage （PTBD） for malignant obstructive bilian/disease. METHODS： A total of 233 patients with malignant billan/obstruction were treated in our hospital with PTBD by placement of metallic stents and/or plastic tubes. After PTBD, 49 patients accepted brachytherapy or extraradiation therapy or arterial infusion chemotherapy. The patients were followed up with clinical and radiographic evaluation. The survival and stent patency rate were calculated by Kaplan-Meier survival analysis. RESULTS： Twenty-two patients underwent chemotherapy （11 cases of hepatic carcinoma, 7 cases of pancreatic carcinoma, 4 cases of metastatic lymphadenopathy）, and 14 patients received radiotherapy （10 cases of cholangiocardnoma, 4 cases of pancreatic carcinoma）, and 13 patients accepted brachytherapy （7 cases of cholangiocarcinoma, 3 cases of pancreatic carcinoma, 4 cases of metastatic lymphadenopathy）. The survival rate of the local tumor treatment group at 1, 3, 6, and 12 months was 97.96%, 95.92%, 89.80%, and 32.59% respectively, longer than that of the non treatment group. The patency rate at 1, 3, 6, and 12 months was 97.96%, 93.86%, 80.93%, and 56.52% respectively. The difference of patency rate was not significant between treatment group and non treatment group. CONCLUSION： Our results suggest that local tumor therapy could prolong the survival time of patients with malignant biliary obstruction, and may improve stent patency.展开更多
A better understanding of previous accidents is an effective way to reduce the occurrence of similar accidents in the future. In this paper, a complex network approach is adopted to construct a directed weighted hazar...A better understanding of previous accidents is an effective way to reduce the occurrence of similar accidents in the future. In this paper, a complex network approach is adopted to construct a directed weighted hazard network(DWHN) to analyze topological features and evolution of accidents in the subway construction. The nodes are hazards and accidents, the edges are multiple relationships of these nodes and the weight of edges are occurrence times of repetitive relationships. The results indicate that the DWHN possesses the property of small-world with small average path length and large clustering coefficient, indicating that hazards have better connectivity and will spread widely and quickly in the network. Moreover,the DWHN has the property of scale-free network for the cumulative degree distribution follows a power-law distribution.It makes DWHN more vulnerable to target attacks. Controlling key nodes with higher degree, strength and betweenness centrality will destroy the connectivity of DWHN and mitigate the spreading of accidents in the network. This study is helpful for discovering inner relationships and evolutionary features of hazards and accidents in the subway construction.展开更多
High-flow hydraulic one-way valves in water pipes are typically used to mitigate conditions,which would otherwise cause vibration and cavitation erosion after long-term operation.To prevent cavitation and enhance the ...High-flow hydraulic one-way valves in water pipes are typically used to mitigate conditions,which would otherwise cause vibration and cavitation erosion after long-term operation.To prevent cavitation and enhance the performance of hydraulic one-way valves,in the present work a dedicated experimental study has been conducted.The structural parameters relating to the pilot valve core,the main valve core,and the through-flow section of the considered flow channel have been changed to analyse reverse impact,and cavitation,characteristics.The results show that the control pressure has a weak effect on the cavitation characteristics,while changes in the structural parameters can significantly affect them.In particular,the cavitation index,representing the extent of cavitation,has been found to display a linear correlation with the inlet pressure,but,not with the inlet flow rate.Most importantly,a stepped throttling structure can reduce the pressure oscillation,improve the response speed,enhance the impact characteristics,and decrease the likelihood and severity of cavitation.The larger the flow passage area,the shorter the unloading time.Cavitation mainly occurs when the pilot valve core is fully opened.The stepped main valve core throttling structure has been found to be an optimal option.展开更多
To study the heat and mass transfer characteristics of alkali metals in a combined porous wick in high-temperature heat pipes,a three-dimensional(3-D)numerical model is constructed by using the finite volume method,Da...To study the heat and mass transfer characteristics of alkali metals in a combined porous wick in high-temperature heat pipes,a three-dimensional(3-D)numerical model is constructed by using the finite volume method,Darcy’s theory,and the theory of local thermal equilibrium.The research finds that the pressure drop of fluids flowing through a combined porous wick exhibits an increasing trend with increasing flow velocity at the inlet and with decreasing permeability of the porous media;a combined porous wick of lower porosity and permeability and larger fluid velocity at the inlet is found to have a less uniformly distributed fluid velocity;the different temperatures of the fluid at the inlet mainly influence the inlet section of the computational model,while having negligible effect thereon in the axial direction(this embodies the thermal homogeneity of such heat pipes).The result reveals that the temperature change in fluids at the inlet does not significantly affect the overall temperature distribution in a combined wick.展开更多
Objective:To measure the expression pattern of STAT2 in cenical cancer initiation and progression in tissue sections from patients with cervicitis,dysplasia,and cenical cancer. Methods:Antibody against human STAT2 was...Objective:To measure the expression pattern of STAT2 in cenical cancer initiation and progression in tissue sections from patients with cervicitis,dysplasia,and cenical cancer. Methods:Antibody against human STAT2 was confirmed by plasmids transient transfection and Western blot Immunohistochemistry was used to delect STAT2 expression in the cervical biopsies by using the confirmed antibody against STAT2 as the primary antibody.Results:It was found that the overall rate of positive STAT2 expression in the cervicitis,dysplasia and cenical cancer groups were 38.5%,69.49%and 76.991,respectively.The STAT2 levels are significantly increased in premalignant dysplasia and cervical cancer,as compared lo cervicitis(P【 0.05). Noticeably,STAT2 signals were mainly found in the cytoplasm,implying that STAT2 was not biologically active.Conclusions:These findings reveal an association between cenical cancer progression and augmented STAT2 expression.In conclusion.STAT2 increase appears to be an early detectable cellular event in cenical cancer development.展开更多
基金Supported by Science&Technology Department of Sichuan Province(No.2021YFS0214).
文摘Glaucoma is a common and complex neurodegenerative disease characterized by progressive loss of retinal ganglion cells(RGCs)and axons.Currently,there is no effective method to address the cause of RGCs degeneration.However,studies on neuroprotective strategies for optic neuropathy have increased in recent years.Cell replacement and neuroprotection are major strategies for treating glaucoma and optic neuropathy.Regenerative medicine research into the repair of optic nerve damage using stem cells has Received considerable attention.Stem cells possess the potential for multidirectional differentiation abilities and are capable of producing RGCfriendly microenvironments through paracrine effects.This article reviews a thorough researches of recent advances and approaches in stem cell repair of optic nerve injury,raising the controversies and unresolved issues surrounding the future of stem cells.
文摘Dear Editor,The choice of surgical intervention for nanophthalmos patients with secondary angle-closure glaucoma poses a challenging decision for ophthalmologists.Because nanophthalmos patients who have undergone filtration surgery or other intraocular procedures are more susceptible to severe complications,including choroidal effusion,malignant glaucoma,and explosive choroidal hemorrhage,all of which can lead to vision loss[1].This dilemma is particularly pronounced in patients with shorter axial lengths.Micropulse transscleral laser therapy(M-TLT),also known as micropulse transscleral cyclophotocoagulation(MP-TSCPC),is a nonincisional laser therapy surgery for glaucoma[2].In 2015,Golan and Kurtz[3]were the first to report four patients with secondary angle-closure glaucoma in nanophthalmos with axial lengths ranging between 17 and 19 mm(mean 18 mm)who were successfully treated with M-TLT,and choroidal detachment was observed in all patients(recovery spontaneously in two patients and recovery after systemic steroid treatment in the other two),of which two had a slight decrease in visual acuity.
文摘CJ Health Technology Co.has been an export-oriented supplier of fitness equipment,boasting leading technology innovation and manufacturing capabilities.However,in the process of expanding into the domestic market,the challenges of unclear market positioning and lack of brand awareness have emerged as major obstacles.To address these issues,a SWOT analysis was conducted to explore a suitable market positioning strategy for the CJ brand.The analysis reveals that the market demand for commercial fitness equipment is relatively saturated,with fierce competition.In contrast,the home fitness market represents a new blue ocean with promising development opportunities for the CJ brand.Leveraging excellent product quality,stringent quality control measures,and innovation-driven cutting-edge technology,it is recommended that CJ brand fitness equipment target young customers aged between 25 and 35 years old.Additionally,vigorously developing the home fitness product line is proposed to capitalize on this burgeoning market segment.
基金Supported by the National Natural Science Foundation of China under Grant No.69608002the Excellent Young Teacher's Foundation of the Minis try of Education.
文摘We report the femtosecond time-resolved studies of room temperature exciton recombination and ultrafast stimulated emission dynamics in ZnO microcrystallite thin films.A free exciton photoluminescence lifetime of a few tens of picoseconds and a decay time of a few picoseconds for the stimulated emission were observed.The relatively slow rise time(3ps)for the P band as the result of exciton-exciton scattering compared with the 0.8ps rise time for the N band attributed to electron-hole plasma recombination clearly distinguished the two stimulated emission processes.
基金Supported by the Natural Science Foundation of Beijing, No.7982035
文摘AIM： To evaluate the utility of local tumor therapy combined with percutaneous transhepatic bilian/drainage （PTBD） for malignant obstructive bilian/disease. METHODS： A total of 233 patients with malignant billan/obstruction were treated in our hospital with PTBD by placement of metallic stents and/or plastic tubes. After PTBD, 49 patients accepted brachytherapy or extraradiation therapy or arterial infusion chemotherapy. The patients were followed up with clinical and radiographic evaluation. The survival and stent patency rate were calculated by Kaplan-Meier survival analysis. RESULTS： Twenty-two patients underwent chemotherapy （11 cases of hepatic carcinoma, 7 cases of pancreatic carcinoma, 4 cases of metastatic lymphadenopathy）, and 14 patients received radiotherapy （10 cases of cholangiocardnoma, 4 cases of pancreatic carcinoma）, and 13 patients accepted brachytherapy （7 cases of cholangiocarcinoma, 3 cases of pancreatic carcinoma, 4 cases of metastatic lymphadenopathy）. The survival rate of the local tumor treatment group at 1, 3, 6, and 12 months was 97.96%, 95.92%, 89.80%, and 32.59% respectively, longer than that of the non treatment group. The patency rate at 1, 3, 6, and 12 months was 97.96%, 93.86%, 80.93%, and 56.52% respectively. The difference of patency rate was not significant between treatment group and non treatment group. CONCLUSION： Our results suggest that local tumor therapy could prolong the survival time of patients with malignant biliary obstruction, and may improve stent patency.
基金supported by the Co-Funding of National Natural Science Foundation of China and Shenhua Group Corporation Ltd(Grant No.U1261212)the Program of Major Achievements Transformation and Industrialization of Beijing Education Commission,China(Grant No.ZDZH20141141301)
文摘A better understanding of previous accidents is an effective way to reduce the occurrence of similar accidents in the future. In this paper, a complex network approach is adopted to construct a directed weighted hazard network(DWHN) to analyze topological features and evolution of accidents in the subway construction. The nodes are hazards and accidents, the edges are multiple relationships of these nodes and the weight of edges are occurrence times of repetitive relationships. The results indicate that the DWHN possesses the property of small-world with small average path length and large clustering coefficient, indicating that hazards have better connectivity and will spread widely and quickly in the network. Moreover,the DWHN has the property of scale-free network for the cumulative degree distribution follows a power-law distribution.It makes DWHN more vulnerable to target attacks. Controlling key nodes with higher degree, strength and betweenness centrality will destroy the connectivity of DWHN and mitigate the spreading of accidents in the network. This study is helpful for discovering inner relationships and evolutionary features of hazards and accidents in the subway construction.
基金supported by the University Natural Science Research Programme of Jiangsu Province(grant numbers 18KJB460028)the Natural Science Foundation of Jiangsu Province(grant numbers BK20180177)+1 种基金the Major Programme from the Natural Science Foundation for Colleges and Universities of Jiangsu Province(grant numbers 18KJA460008)the Project of Xuzhou Applied and Basic Research(grant numbers KH17012).
文摘High-flow hydraulic one-way valves in water pipes are typically used to mitigate conditions,which would otherwise cause vibration and cavitation erosion after long-term operation.To prevent cavitation and enhance the performance of hydraulic one-way valves,in the present work a dedicated experimental study has been conducted.The structural parameters relating to the pilot valve core,the main valve core,and the through-flow section of the considered flow channel have been changed to analyse reverse impact,and cavitation,characteristics.The results show that the control pressure has a weak effect on the cavitation characteristics,while changes in the structural parameters can significantly affect them.In particular,the cavitation index,representing the extent of cavitation,has been found to display a linear correlation with the inlet pressure,but,not with the inlet flow rate.Most importantly,a stepped throttling structure can reduce the pressure oscillation,improve the response speed,enhance the impact characteristics,and decrease the likelihood and severity of cavitation.The larger the flow passage area,the shorter the unloading time.Cavitation mainly occurs when the pilot valve core is fully opened.The stepped main valve core throttling structure has been found to be an optimal option.
基金supported by the Natural Science Foundation of Jiangsu Province,China(Grant No.BK20180177)the Science and Technology Foundation of Xuzhou,China(Grant No.KH17007)the Natural Science Foundation for Colleges and Universities of Jiangsu Province,China(Grant No.17KJB460015,No.18KJB460028).
文摘To study the heat and mass transfer characteristics of alkali metals in a combined porous wick in high-temperature heat pipes,a three-dimensional(3-D)numerical model is constructed by using the finite volume method,Darcy’s theory,and the theory of local thermal equilibrium.The research finds that the pressure drop of fluids flowing through a combined porous wick exhibits an increasing trend with increasing flow velocity at the inlet and with decreasing permeability of the porous media;a combined porous wick of lower porosity and permeability and larger fluid velocity at the inlet is found to have a less uniformly distributed fluid velocity;the different temperatures of the fluid at the inlet mainly influence the inlet section of the computational model,while having negligible effect thereon in the axial direction(this embodies the thermal homogeneity of such heat pipes).The result reveals that the temperature change in fluids at the inlet does not significantly affect the overall temperature distribution in a combined wick.
基金funded by 'Chinese National Nature Science Foundation(30771122)''Chinese Ministry of Education,Research Start-up Funding for Home Smdents' to Ming Li
文摘Objective:To measure the expression pattern of STAT2 in cenical cancer initiation and progression in tissue sections from patients with cervicitis,dysplasia,and cenical cancer. Methods:Antibody against human STAT2 was confirmed by plasmids transient transfection and Western blot Immunohistochemistry was used to delect STAT2 expression in the cervical biopsies by using the confirmed antibody against STAT2 as the primary antibody.Results:It was found that the overall rate of positive STAT2 expression in the cervicitis,dysplasia and cenical cancer groups were 38.5%,69.49%and 76.991,respectively.The STAT2 levels are significantly increased in premalignant dysplasia and cervical cancer,as compared lo cervicitis(P【 0.05). Noticeably,STAT2 signals were mainly found in the cytoplasm,implying that STAT2 was not biologically active.Conclusions:These findings reveal an association between cenical cancer progression and augmented STAT2 expression.In conclusion.STAT2 increase appears to be an early detectable cellular event in cenical cancer development.
