An Automatic Implementation of Oropharyngeal Swab Sampling for Diagnosing Respiratory Infectious Diseases via Soft Robotic End-Effectors

The most widely adopted method for diagnosing respiratory infectious diseases is to conduct polymerase chain reaction(PCR)assays on patients’respiratory specimens,which are collected through either nasal or oropharyngeal swabs.The manual swab sampling process poses a high risk to the examiner and may cause false-negative results owing to improper sampling.In this paper,we propose a pneumatically actuated soft end-effector specifically designed to achieve all of the tasks involved in swab sampling.The soft end-effector utilizes circumferential instability to ensure grasping stability,and exhibits several key properties,including high load-to-weight ratio,error tolerance,and variable swab-tip stiffness,leading to successful automatic robotic oropharyngeal swab sampling,from loosening and tightening the transport medium tube cap,holding the swab,and conducting sampling,to snapping off the swab tail and sterilizing itself.Using an industrial collaborative robotic arm,we integrated the soft end-effector,force sensor,camera,lights,and remote-control stick,and developed a robotic oropharyngeal swab sampling system.Using this swab sampling system,we conducted oropharyngeal swab-sampling tests on 20 volunteers.Our Digital PCR assay results(RNase P RNA gene absolute copy numbers for the samples)revealed that our system successfully collected sufficient numbers of cells from the pharyngeal wall for respiratory disease diagnosis.In summary,we have developed a pharyngeal swab-sampling system based on an“enveloping”soft actuator,studied the sampling process,and imple-mented whole-process robotic oropharyngeal swab-sampling.

Novel medium entropy perovskite oxide Sr(FeCoNiMo)_(1/4)O_(3−δ)for zinc-air battery cathode

It is widely recognized that the development of ZABs is impeded by the kinetic bottleneck of oxygen evolution reaction(OER)and oxygen reduction reaction(ORR).The application of conformational entropy strategy to oxides often involves introducing multiple elements with different properties,thereby providing outstanding bifunctional catalytic activity for OER/ORR.Nevertheless,the possible underlying catalytic pathways and potential interactions between various components are still poorly understood.This paper presents an excellent medium-entropy perovskite oxide,Sr(FeCoNiMo)_(1/4)O_(3−δ)(lower overpotential of 301 mV at 10 mA cm^(−2)).Zinc-air batteries employing it as a cathode catalyst demonstrate excellent round-trip efficiency(62%).By combining theoretical calculation with experiments,we aim to establish the link between the electronic structure of perovskite oxides with different elemental compositions and their OER mechanism.Research reveals that the conformational entropy strategy can simultaneously shift the O 2p-band center and metal d-band center of perovskite oxide towards the vicinity of the Fermi energy level,thereby triggering a more favorable lattice oxygen-participated mechanism(LOM)during the OER process.The outcomes of this work provide crucial insights into the role of conformational entropy strategies in oxygen catalysis and offer potential avenues for constructing efficient and stable electrocatalysts.

Sound speed profiles in high spatiotemporal resolution using multigrid three-dimensional variational method:a coastal experiment off northern Shandong Peninsula

It is essential to ac quire sound speed profiles(SSPs)in high-precision spatiotemporal resolution for undersea acoustic activities.However,conventional observation methods cannot obtain high-resolution SSPs.Besides,S SPs are complex and changeable in time and space,especially in coastal areas.We proposed a new space-time multigrid three-dimensional variational method with weak constraint term(referred to as STC-MG3DVar)to construct high-precision spatiotemporal resolution SSPs in coastal areas,in which sound velocity is defined as the analytical variable,and the Chen-Millero sound velocity empirical formula is introduced as a weak constraint term into the cost function of the STC-MG3DVar.The spatiotemporal correlation of sound velocity observations is taken into account in the STC-MG3DVar method,and the multi-scale information of sound velocity observations from long waves to short waves can be successively extracted.The weak constraint term can optimize sound velocity by the physical relationship between sound velocity and temperature-salinity to obtain more reasonable and accurate SSPs.To verify the accuracy of the STC-MG3DVar,SSPs observations and CTD observations(temperature observations,salinity observations)are obtained from field experiments in the northern coastal area of the Shandong Peninsula.The average root mean square error(RMSE)of the STC-MG3DVar-constructed SSPs is 0.132 m/s,and the STC-MG3DVar method can improve the SSPs construction accuracy over the space-time multigrid 3DVar without weak constraint term(ST-MG3DVar)by 10.14%and over the spatial multigrid 3DVar with weak constraint term(SC-MG3DVar)by 44.19%.With the advantage of the constraint term and the spatiotemporal correlation information,the proposed STC-MG3DVar method works better than the ST-MG3DVar and the SCMG3DVar in constructing high-precision spatiotemporal re solution SSPs.

In Situ Coupling Strategy for Anchoring Monodisperse Co_9S_8 Nanoparticles on S and N Dual?Doped Graphene as a Bifunctional Electrocatalyst for Rechargeable Zn–Air Battery

An in situ coupling strategy to prepare Co_9S_8/S and N dual?doped graphene composite(Co_9S_8/NSG) has been proposed. The key point of this strategy is the function?oriented design of organic compounds. Herein, cobalt porphyrin derivatives with sulfo groups are employed as not only the coupling agents to form and anchor Co_9S_8 on the graphene in situ, but also the heteroatom?doped agent to generate S and N dual?doped graphene. The tight coupling of multiple active sites endows the composite materials with fast electrochemical kinetics and excellent stability for both oxygen reduction reaction(ORR) and oxygen evolution reaction(OER). The obtained electrocatalyst exhibits better activity parameter(ΔE = 0.82 V) and smaller Tafel slope(47.7 mV dec^(-1) for ORR and 69.2 mV dec^(-1) for OER) than commercially available Pt/C and RuO_2. Most importantly, as electrocatalyst for rechargeable Zn–air battery, Co_9S_8/NSG displays low charge–discharge voltage gap and outstanding long?term cycle stability over 138 h compared to Pt/C–RuO_2. To further broaden its application scope, a homemade all?solid?state Zn–air battery is also prepared, which displays good charge–discharge performance and cycle performance. The function?oriented design of N_4?metallomacrocycle derivatives might open new avenues to strategic construction of high?performance and long?life multifunctional electrocatalysts for wider electro?chemical energy applications.

Supply-based optimal scheduling of oil product pipelines

Oil product pipelines have features such as transporting multiple materials, ever-changing operating conditions, and synchronism between the oil input plan and the oil offloading plan. In this paper, an optimal model was established for a single-source multi-distribution oil pro- duct pipeline, and scheduling plans were made based on supply. In the model, time node constraints, oil offloading plan constraints, and migration of batch constraints were taken into consideration. The minimum deviation between the demanded oil volumes and the actual offloading volumes was chosen as the objective function, and a linear programming model was established on the basis of known time nodes＇ sequence. The ant colony optimization algo- rithm and simplex method were used to solve the model. The model was applied to a real pipeline and it performed well.

镍基金属有机框架及其衍生物在电催化析氧反应中的研究进展

作为未来最有潜力的制氢技术之一,电解水为解决环境污染和能源危机等问题提供了一种有效的解决途径。然而,阳极析氧反应缓慢的动力学和较高的过电位使其成为电解水装置效率提升的主要瓶颈。因此,开发高活性和高稳定性的析氧反应催化剂对于电解水技术的发展具有重要意义。近年来,镍基金属有机框架材料因其具有丰富可调的拓扑结构、较大的比表面积以及多孔特性,在催化领域受到了越来越多的关注。本文综述了镍基金属有机框架及其衍生材料在析氧催化研究中的最新进展。首先简要介绍了镍基材料在析氧反应中的原理及评价析氧催化剂活性的一些重要参数,并列举了几种镍基金属有机框架材料的结构及其在催化中的优势。随后,结合近年来发表的文献,对单金属、双金属和三金属镍基金属有机框架材料及其衍生物在析氧催化中的研究进展进行了总结与讨论,重点分析了该类材料的设计策略和催化机理。最后对该领域目前所面临的主要挑战以及未来的发展趋势进行了总结与展望。

Feedback regulation between phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 and transforming growth factor β1 and prognostic value in gastric cancer

BACKGROUND Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1(PREX1)was reported to be overexpressed in some cancers and involved in cancer development,but its expression and significance in gastric cancer remain unclear.AIM To evaluate the expression of PREX1 in gastric cancer and its significance in the development of gastric cancer,especially to evaluate the potential mechanism of PREX1 in gastric cancer.METHODS Bioinformatic analysis was performed in order to examine the expression of PREX1 in gastric cancer.The relationship between the survival rate of gastric cancer patients and PREX1 expression was assessed by Kaplan Meier portal.The Gene Set Enrichment Analysis and the correlation between PREX1 and transforming growth factor(TGF)β1 pathway-related mediators were evaluated by cBioPortal for Cancer Genomics.Western blotting and reverse transcriptase polymerase chain reaction assay were used to test the role of TGFβ1 on the expression of PREX1.Western blotting and dual-luciferase reporter system was used to evaluate the effect of PREX1 on the activation of TGFβ1 pathway.Wound healing and Transwell assay were used to assess the effect of PREX1 on the metastasis activity of gastric cancer cells.RESULTS PREX1 was overexpressed in the gastric tumors,and the expression levels were positively associated with the development of gastric cancer.Also,the high expression of PREX1 revealed poor prognosis,especially for those advanced and specific intestinal gastric cancer patients.PREX1 was closely involved in the positive regulation of cell adhesion and positively correlated with TGFβ1-related mediators.Furthermore,TGFβ1 could induce the expression of PREX1 at both the protein and mRNA level.Also,PREX1 could activate the TGFβ1 pathway.The induced PREX1 could increase the migration and invasion activity of gastric cancer cells.CONCLUSION PREX1 is overexpressed in gastric cancer,and the high level of PREX1 predicts poor prognosis.PREX1 is closely associated with TGFβsignaling and promotes the metastasis of gastric cancer cells.

Bias correction of sea surface temperature retrospective forecasts in the South China Sea

Offline bias correction of numerical marine forecast products is an effective post-processing means to improve forecast accuracy. Two offline bias correction methods for sea surface temperature(SST) forecasts have been developed in this study: a backpropagation neural network(BPNN) algorithm, and a hybrid algorithm of empirical orthogonal function(EOF) analysis and BPNN(named EOF-BPNN). The performances of these two methods are validated using bias correction experiments implemented in the South China Sea(SCS), in which the target dataset is a six-year(2003–2008) daily mean time series of SST retrospective forecasts for one-day in advance, obtained from a regional ocean forecast and analysis system called the China Ocean Reanalysis(CORA),and the reference time series is the gridded satellite-based SST. The bias-correction results show that the two methods have similar good skills;however, the EOF-BPNN method is more than five times faster than the BPNN method. Before applying the bias correction, the basin-wide climatological error of the daily mean CORA SST retrospective forecasts in the SCS is up to-3°C;now, it is minimized substantially, falling within the error range(±0.5°C) of the satellite SST data.

Temporal-spatial oceanic variation in relation with the three typical Kuroshio paths south of Japan

Empirical orthogonal function(EOF)analysis was applied to a 50-year long time series of monthly mean positions of the Kuroshio path south of Japan from a regional reanalysis.Three leading EOF modes characterize the contributions from three typical paths of the Kuroshio meander:the typical large meander path,the offshore nonlarge meander path,and the nearshore non-large meander path,respectively.Accordingly,the spatial variation characteristics of oceanic anomaly fields can be depicted by their regression fields upon the associated three leading principal components(PCs),which are well-matched with the results of composite analysis corresponding to each period of the three typical Kuroshio paths.A new index for the typical large meander is defined by using the second leading PC,which is highly correlated with the Kushimoto-Uragami index.Spectral analysis of this new index series shows variability of the Kuroshio path south of Japan at time scales of about 7–8 years and 20 years.

What does it mean to be a macronutritional generalist? A five-year case study in wild rhesus macaques(Macaca mulatta)

DEAR EDITOR,Dietary generalism is widely associated with ecological flexibility,but the mechanisms of this relationship remain poorly understood.A recently developed body of theory on the relationship between generalism/specialism at the levels of foods selected vs.nutrients ingested,termed multi-level dietary niche theory,offers a powerful opportunity to deepen our understanding of the dietary generalist-specialist spectrum and its ecological significance.

A trace of Pt can significantly boost RuO_(2) for acidic water splitting

The development of highly potential electrocatalysts for acidic water electrolysis is particularly desirable for many energy‐related processes.Herein,we demonstrated a versatile strategy to activate and stabilize RuO_(2)‐based electrocatalyst for acidic water splitting by a trace of Pt,where Pt plays an essential role in promoting oxygen evolution reaction(OER),and can simultaneously act as the active site for hydrogen evolution reaction(HER).Compared with pure Ru oxide nanosheet assemblies(Ru ONAs),the“5%Pt‐containing”Ru ONAs(5%Pt‐Ru ONAs)achieve much enhanced OER activity in 0.5 and 0.05 mol/L H_(2)SO_(4),with much lower overpotentials of 227 and 234 mV at 10 mA cm^(‒2),respectively.Experimental and theoretical analyses reveal that the atomically dispersed Pt incorporating into RuO_(2)lattice is conducive to increasing the concentration of O vacancies,which effectively enhances the interaction with reaction intermediate and thus lowers the energy barrier for the formation of OOH*.Moreover,benefited from the presence of Pt,the formation of RuO_(2)is more achievable when proper annealing is applied.In addition to OER,due to the presence of active Pt,the HER performance of 5%Pt‐Ru ONAs can also be ensured,thereby realizing efficient acidic overall water splitting.Finally,the excellent activity can also be achieved without sacrificing stability.This work highlights an attractive strategy for designing active and stable RuO_(2)‐based electrocatalysts for acidic overall water splitting.

An application of the A-4DEnVar to coupled parameter optimization

In variational methods,coupled parameter optimization(CPO) often needs a long minimization time window(MTW) to fully incorporate observational information,but the optimal MTW somehow depends on the model nonlinearity.The analytical four-dimensional ensemble-variational(A-4DEnVar) considers model nonlinearity well and avoids adjoint model.It can theoretically be applied to CPO.To verify the feasibility and the ability of the A-4DEnVar in CPO,“twin” experiments based on A-4DEnVar CPO are conducted for the first time with the comparison of four-dimensional variational(4D-Var).Two algorithms use the same background error covariance matrix and optimization algorithm to control variates.The experiments are based on a simple coupled oceanatmosphere model,in which the atmospheric part is the highly nonlinear Lorenz-63 model,and the oceanic part is a slab ocean model.The results show that both A-4DEnVar and 4D-Var can effectively reduce the error of state variables through CPO.Besides,two methods produce almost the same results in most cases when the MTW is less than 560 time steps.The results are similar when the MTW is larger than 560 time steps and less than 880 time steps.The largest MTW of 4 D-Var and A-4DEnVar are 1 200 time steps.Moreover,A-4DEnVar is not sensitive to ensemble size when the MTW is less than 720 time steps.A-4DEnVar obtains satisfactory results in the case of highly nonlinear model and long MTW,suggesting that it has the potential to be widely applied to realistic CPO.

A Novel System for Recognizing Recording Devices from Recorded Speech Signals

The field of digital audio forensics aims to detect threats and fraud in audio signals.Contemporary audio forensic techniques use digital signal processing to detect the authenticity of recorded speech,recognize speakers,and recognize recording devices.User-generated audio recordings from mobile phones are very helpful in a number of forensic applications.This article proposed a novel method for recognizing recording devices based on recorded audio signals.First,a database of the features of various recording devices was constructed using 32 recording devices(20 mobile phones of different brands and 12 kinds of recording pens)in various environments.Second,the audio features of each recording device,such as the Mel-frequency cepstral coefficients(MFCC),were extracted from the audio signals and used as model inputs.Finally,support vector machines(SVM)with fractional Gaussian kernel were used to recognize the recording devices from their audio features.Experiments demonstrated that the proposed method had a 93.4%accuracy in recognizing recording devices.

PEGA:probabilistic environmental gradient-driven genetic algorithm considering epigenetic traits to balance global and local optimizations

Epigenetics’flexibility in terms of finer manipulation of genes renders unprecedented levels of refined and diverse evolutionary mechanisms possible.From the epigenetic perspective,the main limitations to improving the stability and accuracy of genetic algorithms are as follows:(1)the unchangeable nature of the external environment,which leads to excessive disorders in the changed phenotype after mutation and crossover;(2)the premature convergence due to the limited types of epigenetic operators.In this paper,a probabilistic environmental gradientdriven genetic algorithm(PEGA)considering epigenetic traits is proposed.To enhance the local convergence efficiency and acquire stable local search,a probabilistic environmental gradient(PEG)descent strategy together with a multi-dimensional heterogeneous exponential environmental vector tendentiously generates more offsprings along the gradient in the solution space.Moreover,to balance exploration and exploitation at different evolutionary stages,a variable nucleosome reorganization(VNR)operator is realized by dynamically adjusting the number of genes involved in mutation and crossover.Based on the above-mentioned operators,three epigenetic operators are further introduced to weaken the possible premature problem by enriching genetic diversity.The experimental results on the open Congress on Evolutionary Computation-2017(CEC’17)benchmark over 10-,30-,50-,and 100-dimensional tests indicate that the proposed method outperforms 10 state-of-the-art evolutionary and swarm algorithms in terms of accuracy and stability on comprehensive performance.The ablation analysis demonstrates that for accuracy and stability,the fusion strategy of PEG and VNR are effective on 96.55%of the test functions and can improve the indicators by up to four orders of magnitude.Furthermore,the performance of PEGA on the real-world spacecraft trajectory optimization problem is the best in terms of quality of the solution.

Effects of flue gas desulfurization gypsum and clover planting on qualities of soil and winter jujube in coastal saline-alkali orchard of north China

Flue gas desulfurization gypsum and clover planting alleviated the soil salinization stress.Soil pH and total phosphorus affected the bacterial communi-ties.Total phosphorus affected the fungal communities.Flue gas desulfurization gypsum and clover planting improved jujube quality.The coastal area of Shandong Province,characterized by coastal saline tidal soil,is one of the main production areas of winter jujube in China.However,the low soil fertility and poor soil structure in jujube orchard restricted the development of the jujube industry.The objectives of this study were to 1)evaluate the effect of application of flue gas desulfurization(FGD)gypsum and clover planting on soil quality improvement and soil microbial community structure of jujube orchard;2)investigate the effects of two measures on the nutrition and quality of winter jujube.The results showed that FGD gypsum reduced the soil total salt content by 65.6%,and clover planting increased the soil organic matter content by 30.7%,which effectively alleviated the soil salinization stress and improved the soil structure.Soil pH and total phosphorus(TP)were the main determinants influencing bacterial community composition,and TP was the dominant factor of the fungal community composition in the saline-alkali soils.Meanwhile,FGD gypsum addition and clover planting significantly increased the sugar degree and Vc content of winter jujube,thus improved jujube quality,and further contributed to the ecological sustainable development of winter jujube industry.

Single-Site Cu-Doped PdSn Wavy Nanowires for Highly Active,Stable,and CO-Tolerant Ethanol Oxidation Electrocatalysis

Developing a catalyst to break the tradeoff relation-ship between the catalytic activity and antipoisoning property toward the ethanol oxidation reaction(EOR)is of critical importance to the development of direct ethanol fuel cells(DEFCs),but remains challenging.Here,we developed a unique class of single-site Cu-doped PdSn wavy nanowires(denoted as SS Cu−PdSn WNWs)with promoted activity and durability toward alkaline EOR.Detailed characterizations reveal the atomic isolation of Cu species dispersed on the surface of the PdSn WNWs with distinct wavy structure and grain boundaries.The created SS Cu−PdSn WNWs exhibit an enhanced EOR performance in terms of mass activity,which is higher than those of PdSn WNWs,commercial Pd black,and commercial Pd/C,respectively.Moreover,the SS Cu−PdSn WNWs can also show improved stability as compared to other catalysts due to the improved antipoisoning property from the unique surface anchoring structure.Further investigations demonstrate that the doped SS Cu can strongly inhibit the adsorption of CO and promote the reaction process of EOR.DFT results reveal that the doped Cu shifts down the d-band center of PdSn,thereby modifying the adsorption of intermediates and reducing the reaction barrier of EOR.This work maps a pathway for optimally boosting EOR performance with surface engineering via atomic doping.

数字经济、税收管辖与增值税改革

数字经济的出现和快速发展,凸显了国内跨区域交易的增值税税收管辖和税收分配矛盾,也衍生出国与国之间增值税税收管辖新问题。本文在案例分析和理论分析的基础上,对数字经济背景下不同商业模式面临的增值税管辖问题进行探讨,通过梳理经济合作与发展组织(OECD)、欧盟(EU)、南非、美国等相关做法,提出适应数字经济发展需要的增值税改革建议,主要包括加强国内增值税的区域管辖、区分跨境增值税管辖认定标准、改进增值税征管方式、加强增值税国际征管合作与信息交换等。

Highly porous Pt-Pb nanostructures as active and ultrastable catalysts for polyhydric alcohol electrooxidations

Highly porous materials have attracted intensive attention in the past decades due to their unique geometrical configuration, unusual structural features, and outstanding physicochemical properties, but the facile creation of porous metal nanomaterias remains a formidable challenge. Most reports focused on using hard templates to create porous metal nanomaterials via sacrificing the templates. Herein, we have created a new class of porous PtPb/Pt nanocrystals(NCs)with well-defined morphology, composition and porosity through a facile chemical etching approach. Due to the highly open three-dimensional(3D) structure and alloy effect, the porous PtPb/Pt NCs exhibit enhanced performances towards polyhydric alcohol electrooxidations with the optimized porous Pt3Pb nanoplates exhibiting superior activities of 1.75 mA cm-2 and 1.19 A mgPt-1 for ethylene glycol oxidation reaction(EGOR) and of 1.46 m A cm-2 and 1.00 A mg-1Pt for glycerol oxidation reaction(GOR) that are much higher than the commercial Pt/C(0.34 mA cm-2 and 0.22 A mgPt-1 for EGOR, 0.30 mA cm-2 and 0.20 A mgPt-1for GOR). In addition, the porous Pt3Pb nanoplates can endure the long-term stability in EG and glycerol oxidation reactions with limited activity and structure change after 20,000 and 5,000 cycles,respectively, showing a highly promising class of porous Ptbased electrocatalysts for direct polyhydric alcohol fuel cells and beyond.

Myt1L Promotes Differentiation of Oligodendrocyte Precursor Cells and is Necessary for Remyelination After Lysolecithin-Induced Demyelination

The differentiation and maturation of oligodendrocyte precursor cells(OPCs) is essential for myelination and remyelination in the CNS. The failure of OPCs to achieve terminal differentiation in demyelinating lesions often results in unsuccessful remyelination in a variety of human demyelinating diseases. However, the molecular mechanisms controlling OPC differentiation under pathological conditions remain largely unknown. Myt1 L(myelin transcription factor 1-like), mainly expressed in neurons,has been associated with intellectual disability, schizophrenia, and depression. In the present study, we found that Myt1 L was expressed in oligodendrocyte lineage cells during myelination and remyelination. The expression level of Myt1 L in neuron/glia antigen 2-positive(NG2+)OPCs was significantly higher than that in mature CC1+oligodendrocytes. In primary cultured OPCs,overexpression of Myt1 L promoted, while knockdown inhibited OPC differentiation. Moreover, Myt1 L was potently involved in promoting remyelination after lysolecithin-induced demyelination in vivo. Ch IP assays showed that Myt1 L bound to the promoter of Olig1 and transcriptionally regulated Olig1 expression. Taken together, our findings demonstrate that Myt1 L is an essential regulator of OPC differentiation, thereby supporting Myt1 L as a potential therapeutic target for demyelinating diseases.

Shikimic Acid Promotes Oligodendrocyte Precursor Cell Differentiation and Accelerates Remyelination in Mice

The obstacle to successful remyelination in demyelinating diseases, such as multiple sclerosis, mainly lies in the inability of oligodendrocyte precursor cells(OPCs) to differentiate, since OPCs and oligodendrocytelineage cells that are unable to fully differentiate are found in the areas of demyelination. Thus, promoting the differentiation of OPCs is vital for the treatment of demyelinating diseases. Shikimic acid(SA) is mainly derived from star anise, and is reported to have antiinfluenza, anti-oxidation, and anti-tumor effects. In the present study, we found that SA significantly promoted the differentiation of cultured rat OPCs without affecting their proliferation and apoptosis. In mice, SA exerted therapeutic effects on experimental autoimmune encephalomyelitis(EAE), such as alleviating clinical EAE scores, inhibiting inflammation, and reducing demyelination in the CNS. SA also promoted the differentiation of OPCs as well as their remyelination after lysolecithin-induced demyelination.Furthermore, we showed that the promotion effect of SA on OPC differentiation was associated with the up-regulation of phosphorylated m TOR. Taken together, our resultsdemonstrated that SA could act as a potential drug candidate for the treatment of demyelinating diseases.