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急性单侧外周前庭病变病因初步探究
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作者 朱艳含 钱果 +4 位作者 秦文静 方毅 徐姣 周涛 常丽英 《神经损伤与功能重建》 2024年第2期81-85,共5页
目的:通过分析急性单侧外周前庭病变(acute unilateral peripheral vestibular dysfunction,AUPVD)患者的基本信息、前庭功能、影像学检查、治疗效果等指标,探究AUPVD的可能病因、累及部位。方法:收集2022年2月~4月我科收治的符合纳入... 目的:通过分析急性单侧外周前庭病变(acute unilateral peripheral vestibular dysfunction,AUPVD)患者的基本信息、前庭功能、影像学检查、治疗效果等指标,探究AUPVD的可能病因、累及部位。方法:收集2022年2月~4月我科收治的符合纳入标准的AUPVD患者36例的临床资料,其中30例接受视频头脉冲(v HIT)检查,26例接受激素治疗,3例行迷路钆造影增强扫描。分析、比较患者的检查结果及脑血管病危险因素。结果:30例行v HIT检查的患者中,结果异常25例,其中12例(48%)水平半规管vHIT异常,但前管正常;部分迷路钆造影增强检查的患者可见病变侧前庭迷路强化信号,未观察到前庭神经的强化信号;26例使用激素治疗的患者中,17例(65.4%)效果较好,9例(34.6%)效果欠佳,后者平均年龄及至少合并1项脑血管病危险因素占比明显高于前者(P<0.05)。结论:AUPVD的病因可能包括炎性、缺血等多种机制;可能累及前庭神经、前庭迷路等多处部位。 展开更多
关键词 急性单侧外周前庭病变 双温检查 视频头脉冲试验 钆造影 激素治疗
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武汉市青少年吸烟影响因素的路径分析 被引量:4
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作者 周敦金 龚洁 +6 位作者 曾晶 qian guo 夏江 Ping Sun 柳春红 Chihping Chou Carl Anderson Johnson 《中国公共卫生》 CAS CSCD 北大核心 2006年第10期1171-1172,共2页
目的研究青少年吸烟的危险因素及其对吸烟的影响。方法采用分层随机整群抽样的方法,从武汉市3个城区中抽取普通和职业高中的高一和高二学生共1 168人,1 077人完成了调查问卷。采用探索性因子分析和路径分析方法进行分析。结果过去30 d... 目的研究青少年吸烟的危险因素及其对吸烟的影响。方法采用分层随机整群抽样的方法,从武汉市3个城区中抽取普通和职业高中的高一和高二学生共1 168人,1 077人完成了调查问卷。采用探索性因子分析和路径分析方法进行分析。结果过去30 d的吸烟率为10.3%,其中男生为21.0%,女生为1.8%,30 d平均吸烟量为91.3支。结果显示,影响青少年吸烟量的直接因素有4个:饮酒、社会规范、初始吸烟年龄和吸烟朋友数,其他因素都是通过这几个因素间接影响青少年吸烟量。影响吸烟的前4位因素标准回归系数估计值为饮酒(0.354 3)、朋友吸烟(0.305 0)、性别(0.182 0)、多动(0.127 5)。结论今后干预措施应着重考虑预防青少年饮酒、减少吸烟朋友数以及改变青少年对吸烟社会规范的认识,重点人群为男生和具有多动特质的儿童。 展开更多
关键词 青少年 吸烟量 路径分析
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Vaginal endoscopy combined with gonadotropin-releasing hormone agonist successfully treated a patient with cervical endometriosis:a case report
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作者 Ying Lin Pei-Fang Chen +2 位作者 qian guo De-Ye Zeng Xiu-Shan Feng 《Clinical Research Communications》 2024年第4期29-32,共4页
A 36-year-old unmarried woman with no sexual history presented with 12 days of uncontrollable yellowish vaginal discharge,bloating,lower back pain,frequent urination,and urgency.Her menstrual cycles were regular with ... A 36-year-old unmarried woman with no sexual history presented with 12 days of uncontrollable yellowish vaginal discharge,bloating,lower back pain,frequent urination,and urgency.Her menstrual cycles were regular with moderate flow and worsening dysmenorrhea.Ultrasound and magnetic resonance imaging identified uterine and cervical masses.Laparoscopic surgery and postoperative gonadotropin-releasing hormone agonist injections led to significant lesion reduction.The patient is currently on oral dienogest acetate with ongoing follow-up. 展开更多
关键词 ENDOMETRIOSIS cervical endometriosis ruptured cyst vaginal discharge pelvic pain
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智慧工地中低分辨率的安全帽状态识别 被引量:6
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作者 王秋茗 孙广玲 +2 位作者 陆小锋 钱国 刘学锋 《电子测量技术》 2020年第15期63-67,共5页
在工地施工过程中,安全帽正确佩戴在保障工人人身安全方面起到至关重要的作用,利用无人机巡检的方式可对工人安全帽佩戴状态进行监督。针对拍摄图像中目标头部的分辨率过低,存在漏检的问题,设计了一种基于深度学习的低分辨率的安全帽状... 在工地施工过程中,安全帽正确佩戴在保障工人人身安全方面起到至关重要的作用,利用无人机巡检的方式可对工人安全帽佩戴状态进行监督。针对拍摄图像中目标头部的分辨率过低,存在漏检的问题,设计了一种基于深度学习的低分辨率的安全帽状态识别算法,首先通过目标检测网络获取图像中的人体区域,根据先验信息获取头部位置图像,然后使用超分辨率重建技术,对头部图像进行像素恢复,将头部图像输入到目标分类网络中进行判别,最终得到了88.28%的识别正确率。结果表明,该算法可以有效改善漏检问题,符合工地对工人安全帽佩戴识别的要求。 展开更多
关键词 低分辨率 安全帽佩戴识别 超分辨率重建 深度学习
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Correlation Between the Clinical Severity, Bacterial Load, and Inflammatory Reaction in Children with Mycoplasma Pneumoniae Pneumonia 被引量:24
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作者 Chen ZHANG Qiao ZHANG +7 位作者 Jie-lin DU Dan DENG Ye-lei GAO Cheng-lin WANG Hong-jie ZHAO qian guo Zhou FU Dai-yin TIAN 《Current Medical Science》 SCIE CAS 2020年第5期822-828,共7页
Given the lack of defining features in the clinical manifestations and radiographic findings for children with mycoplasma pneumoniae pneumonia(MPP),quantitative polymerase chain reaction(qPCR)has become a useful diagn... Given the lack of defining features in the clinical manifestations and radiographic findings for children with mycoplasma pneumoniae pneumonia(MPP),quantitative polymerase chain reaction(qPCR)has become a useful diagnostic method.This study was performed to explore the relationship between the qPCR findings,clinical symptoms,and inflammatory markers in children with MPP.Four hundred children with MPP have been enrolled in this retrospective analysis.All clinical and analytical information,including mycoplasma pneumoniae(MP)PCR results,has been collected.Based on the PCR results,the patients were divided into groups with load values(copy number)<105(54 cases),2105 and<106(71 cases),2106 and<107(112 cases),>107 and<108(114 cases),and>108(49 cases).The clinical features(including symptoms and signs)and inflammatory indicators were compared among the groups.The incidence of high fever(above 39℃),thermal peak during the entire hospitalization period,fever duration,days of hospitalization,and plasma lactate dehydrogenase(LDH)levels were statistically correlated with the MP PCR load value in children with MPP.The analysis of relevance degree showed the correlative order as a thermal peak of hospitalization>duration of fever>period of hospitalization>LDH value>C-reactive protein value.The host immune response was significantly greater in the complication group than in the non-complication group. 展开更多
关键词 mycoplasma pneumonia quantitative polymerase chain reaction bacterial load
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KL-6 mucin expression in carcinoma of the ampulla of Vater: Association with cancer progression 被引量:10
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作者 Wei Tang Yoshinori Inagaki +7 位作者 Norihiro Kokudo qian guo Yasuji Seyama Munehiro Nakata Hiroshi Imamura Keiji Sano Yasuhiko Sugawara Masatoshi Makuuchi 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第35期5450-5454,共5页
AIM: To assess histochemical expression of KL-6 and its clinicopathological significance in carcinoma of the ampulla of Vater. METHODS: Ampullary carcinoma tissues were collected from 38 patients who underwent pancr... AIM: To assess histochemical expression of KL-6 and its clinicopathological significance in carcinoma of the ampulla of Vater. METHODS: Ampullary carcinoma tissues were collected from 38 patients who underwent pancreatoduodenectomy or local resection. Tissues were subjected to immunohistochemical analysis using KL-6 antibody. RESULTS: Positive staining of ampullary carcinoma cells was observed in 26 (68.4%) cases. Staining was not found in the surrounding non-cancer regions of the ampullary tissues. Remarkable KL-6 expression was observed in invasive carcinoma cells in pancreatic and duodenal tissues and in metastatic carcinoma cells in lymph nodes. Positive KL-6 expression was related to lymph node metastasis (P = 0.020), pancreatic invasion (P = 0.016), duodenal invasion (P = 0.034), and advanced stage of TNM clinical classification (P = 0.010). Survival analysis showed that positive expression of KL-6 was related to a poorer prognosis (P = 0.029). CONCLUSION: The aberrant expression of KL-6 mucin is significantly related to unfavorable behaviors of cardnoma of the ampulla of Vater. 展开更多
关键词 KL-6 mucin Carcinoma of the ampulla of Vater Invasion METASTASIS PROGNOSIS
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Rapid screening of Zr-containing particles from Chang’e-5 lunar soil samples for isotope geochronology:Technical roadmap for future study 被引量:5
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作者 Jin-Hua Li Qiu-Li Li +16 位作者 Liang Zhao Jin-Hai Zhang Xu Tang Li-Xin Gu qian guo Hong-Xia Ma Qin Zhou Yan Liu Pei-Yu Liu Hao Qiu Gang Li Lin Gu Shun guo Chun-Lai Li Xian-Hua Li Fu-Yuan Wu Yong-Xin Pan 《Geoscience Frontiers》 SCIE CAS CSCD 2022年第3期68-78,共11页
New samples returned by China Chang’e-5(CE-5)mission offer an opportunity for studying the lunar geologic longevity,space weathering,and regolith evolution.The age determination of the CE-5 samples was among the firs... New samples returned by China Chang’e-5(CE-5)mission offer an opportunity for studying the lunar geologic longevity,space weathering,and regolith evolution.The age determination of the CE-5 samples was among the first scientific questions to be answered.However,the precious samples,most in the micrometer size range,challenge many traditional analyses on large single crystals of zircon developed for massive bulk samples.Here,we developed a non-destructive rapid screening of individual zirconium-containing particle for isotope geochronology based on a Micro X-ray fluorescence analysis(μXRF).The selected particles were verified via scanning electron microscopy(SEM),3D X-ray microscopy(XRM),and focused ion beam scanning electron microscopy(FIB-SEM)techniques,which showed that zirconium-bearing minerals with several microns were precisely positioned and readily suitable for site-specific isotopic dating by second ion mass spectrometry(SIMS).Such protocol could be also appli-cable in non-destructively screening other types of particles for different scientific purposes.We there-fore proposed a correlative workflow for comprehensively studying the CE-5 lunar samples from single particles on nanometer to atomic scales.Linking various microscopic and spectromicroscopic instru-ments together,this workflow consists of six steps:(1)single-particle selection with non-destructive μXRF technique,(2)2D/3D morphological and structural characterization with a correlative submicron 3D XRM and nanoscale resolution FIB-SEM imaging methods,(3)SEM analysis of the surface morphology and chemistry of the selected particle,(4)a series of microscopic and microbeam analyses(e.g.,SEM,electron probe microanalysis,and SIMS)on the cross-section of the selected particle to obtain structural,mineralogical,chemical,and isotopic features from the micron to nanometer scale,(5)advanced 2D/3D characterization and site-specific sample preparation of thin foil/tip specimens on a microregion of inter-est in the selected particle with FIB-SEM technique,and(6)comprehensive analyses on the FIB-milled specimens at nanometer to atomic scale with synchrotron-based scanning transmission X-ray micro-scopy,analytic transmission electron microscopy,and atom probe tomography.Following this technical roadmap,one can integrate multiple modalities into a uniform frame of multimodal and multiscale cor-related datasets to acquire high-throughput information on the limited or precious terrestrial and extraterrestrial samples. 展开更多
关键词 Chang’e-5 lunar samples Zr-containing particles mXRF Correlative workflow Technical roadmap Extraterrestrial samples
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Clinical significance of subcellular localization of KL-6 mucin in primary colorectal adenocarcinoma and metastatic tissues 被引量:5
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作者 qian guo Wei Tang +7 位作者 Yoshinori Inagaki Yutaka Midorikawa Norihiro Kokudo Yasuhiko Sugawara MunehiroNakata Toshiro Konishi Hirokazu Nagawa Masatoshi Makuuchi 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第1期54-59,共6页
AIM: To assess subcellular localization of KL-6 mucin and its clinicopathological significance in colorectal carcinoma as well as metastatic lymph node and liver tissues. METHODS: Colorectal carcinoma tissues as wel... AIM: To assess subcellular localization of KL-6 mucin and its clinicopathological significance in colorectal carcinoma as well as metastatic lymph node and liver tissues. METHODS: Colorectal carcinoma tissues as well as metastatic lymph node and liver tissues were collected from 82 patients who underwent colorectomy or hepatectomy. Tissues were subjected to immunohistochemical analysis using KL-6 antibody. RESULTS: Of the 82 colorectal carcinoma patients, 6 showed no staining, 29 showed positive staining only in the apical membrane, and 47 showed positive staining in the circumferential membrane and/or cytoplasm. Positive staining was not observed in non-cancerous colorectal epithelial cells surrounding the tumor tissues. The five-year survival rate was significantly lower in cases showing positive staining in the circumferential membrane and/or cytoplasm (63.0%) than those showing positive staining only in the apical membrane (85.7%) and those showing no staining (100%). Statistical analysis between clinicopathological factors and subcellular localization of KL-6 mucin showed that KL-6 localization in the circumferential membrane and/or cytoplasm was significantly associated with the presence of venous invasion (P = 0.0003), lymphatic invasion (P 〈 0.0001), lymph node metastasis (P〈0.0001), liver metastasis (P = 0.058), and advanced histological stage (P〈 0.0001). Positive staining was observed in all metastatic lesions tested as well as in the primary colorectal carcinoma tissues. CONCLUSION: The subcellular staining pattern of KL-6 in colorectal adenocarcinoma may be an important indicator for unfavorable behaviors such as lymph node and liver metastasis, as well as for the prognosis of patients. 展开更多
关键词 KL-6 mucin Colorectal carcinoma Metasta-sis Prognosis IMMUNOHISTOCHEMISTRY
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还原氧化石墨烯@泡沫镍载CoO纳米花电极制备及催化CO_(2)性能 被引量:6
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作者 郭茜 富佳龙 +5 位作者 张成燕 蔡超越 王城 周丽华 许瑞波 王明艳 《电化学》 CAS CSCD 北大核心 2021年第4期449-455,共7页
本文以氧化石墨烯包覆泡沫镍电极(GO@NF)作为基底,采用水热法在GO@NF基底上原位生长CoO纳米花,同时GO在水热过程中被同步热还原为还原氧化石墨烯(RGO),从而一步制得还原氧化石墨烯包覆泡沫镍负载CoO纳米花电极(CoO/RGO@NF)。使用XRD和SE... 本文以氧化石墨烯包覆泡沫镍电极(GO@NF)作为基底,采用水热法在GO@NF基底上原位生长CoO纳米花,同时GO在水热过程中被同步热还原为还原氧化石墨烯(RGO),从而一步制得还原氧化石墨烯包覆泡沫镍负载CoO纳米花电极(CoO/RGO@NF)。使用XRD和SEM对CoO/RGO@NF电极进行表征,发现CoO纳米花均匀生长在泡沫镍三维网络结构上,CoO纳米花为大量针状纳米棒围绕一个中心而成的花状结构,纳米棒的长度约为10~15μm,直径约为100~200 nm。使用循环伏安和线性扫描法测试了CoO/RGO@NF电极电催化CO_(2)的还原性能,在-0.76 V(vs.SHE)电位下,CoO/RGO@NF电极电催化CO_(2)还原的电流效率达到70.9%,产甲酸法拉第效率达到65.2%,甲酸产率为59.8μmol·h^(-1)·cm^(-2),且电极可持续稳定电催化还原CO_(2)4 h,表明CoO/RGO@NF电极对CO_(2)电还原有着优良的催化活性、选择性和稳定性。 展开更多
关键词 CO_(2)电催化 水热法 泡沫镍 CoO纳米花
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The advanced development of molecular targeted therapy for hepatocellular carcinoma 被引量:4
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作者 Tao Yan Lingxiang Yu +9 位作者 Ning Zhang Caiyun Peng guodong Su Yi Jing Linzhi Zhang Tong Wu Jiamin Cheng qian guo Xiaoliang Shi Yinying Lu 《Cancer Biology & Medicine》 SCIE CAS CSCD 2022年第6期802-817,共16页
Hepatocellular carcinoma(HCC),one of the most common malignant tumors in China,severely threatens the life and health of patients.In recent years,precision medicine,clinical diagnoses,treatments,and innovative researc... Hepatocellular carcinoma(HCC),one of the most common malignant tumors in China,severely threatens the life and health of patients.In recent years,precision medicine,clinical diagnoses,treatments,and innovative research have led to important breakthroughs in HCC care.The discovery of new biomarkers and the promotion of liquid biopsy technologies have greatly facilitated the early diagnosis and treatment of HCC.Progress in targeted therapy and immunotherapy has provided more choices for precise HCC treatment.Multiomics technologies,such as genomics,transcriptomics,and metabolomics,have enabled deeper understanding of the occurrence and development mechanisms,heterogeneity,and genetic mutation characteristics of HCC.The continued promotion and accurate typing of HCC,accurate guidance of treatment,and accurate prognostication have provided more treatment opportunities and prolonged survival timelines for patients with HCC.Innovative HCC research providing an in-depth understanding of the biological characteristics of HCC will be translated into accurate clinical practices for the diagnosis and treatment of HCC. 展开更多
关键词 Hepatocellular carci no ma precision medicine liquid biopsy targeted therapy IMMUNOTHERAPY
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Detecting and monitoring of water inrush in tunnels and coal mines using direct current resistivity method:A review 被引量:13
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作者 Shucai Li Bin Liu +5 位作者 Lichao Nie Zhengyu Liu Mingzhen Tian Shirui Wang Maoxin Su qian guo 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2015年第4期469-478,共10页
Detecting, real-time monitoring and early warning of underground water-bearing structures are critically important issues in prevention and mitigation of water inrush hazards in underground engineering. Direct current... Detecting, real-time monitoring and early warning of underground water-bearing structures are critically important issues in prevention and mitigation of water inrush hazards in underground engineering. Direct current (DC) resistivity method is a widely used method for routine detection, advanced detection and real-time monitoring of water-bearing structures, due to its high sensitivity to groundwater. In this study, the DC resistivity method applied to underground engineering is reviewed and discussed, including the observation mode, multiple inversions, and real-time monitoring. It is shown that a priori information constrained inversion is desirable to reduce the non-uniqueness of inversion, with which the accuracy of detection can be significantly improved. The focused resistivity method is prospective for advanced detection;with this method, the flanking interference can be reduced and the detection dis-tance is increased subsequently. The time-lapse resistivity inversion method is suitable for the regions with continuous conductivity changes, and it can be used to monitor water inrush in those regions. Based on above-mentioned features of various methods in terms of benefits and limitations, we propose a three-dimensional (3D) induced polarization method characterized with multi-electrode array, and introduce it into tunnels and mines combining with real-time monitoring with time-lapse inversion and cross-hole resistivity method. At last, the prospective applications of DC resistivity method are discussed as follows: (1) available advanced detection technology and instrument in tunnel excavated by tunnel boring machine (TBM), (2) high-resolution detection method in holes, (3) four-dimensional (4D) monitoring technology for water inrush sources, and (4) estimation of water volume in water-bearing structures. 展开更多
关键词 Direct current (DC) resistivity methodTechnical statusLatest progressUnderground engineeringWater inrushRoutine detectionAdvanced detectionReal-time monitoring
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Glycogen Synthase Kinase-3β,NLRP3 Inflammasome,and Alzheimer's Disease 被引量:2
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作者 Yue-ran JIA Zi-qing guo +1 位作者 qian guo Xiao-chuan WANG 《Current Medical Science》 SCIE CAS 2023年第5期847-854,共8页
Alzheimer’s disease (AD) is the most prevalent cause of dementia worldwide. Because of the progressive neurodegeneration, individual cognitive and behavioral functions are impaired, affecting the quality of life of m... Alzheimer’s disease (AD) is the most prevalent cause of dementia worldwide. Because of the progressive neurodegeneration, individual cognitive and behavioral functions are impaired, affecting the quality of life of millions of people. Although the exact pathogenesis of AD has not been fully elucidated, amyloid plaques, neurofibrillary tangles (NFTs), and sustaining neuroinflammation dominate its characteristics. As one of the major tau kinases leading to hyperphosphorylation and aggregation of tau, glycogen synthase kinase-3β (GSK-3β) has been drawing great attention in various AD studies. Another research focus of AD in recent years is the inflammasome, a multiprotein complex acting as a regulator in immunological reactions to exogenous and endogenous danger signals, of which the Nod-like receptor (NLR) family, pyrin domain-containing 3 (NLRP3) inflammasome has been studied mostly in AD and proven to play a significant role in AD development by its activation and downstream effects such as caspase-1 maturation and interleukin (IL)-1β release. Studies have shown that the NLRP3 inflammasome is activated in a GSK-3β-dependent way and that inhibition of the NLRP3 inflammasome downregulates GSK-3β, suggesting that these two important proteins are closely related. This article reviews the respective roles of GSK-3β and the NLRP3 inflammasome in AD as well as their relationship and interaction. 展开更多
关键词 glycogen synthase kinase-3β NLRP3 inflammasome Alzheimer's disease
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Optical multi-color monitoring of OJ 287 from 2006 to 2012 被引量:1
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作者 qian guo Ding-Rong Xiong +2 位作者 Jin-Ming Bai Xu-Liang Fan Wei-Min Yi 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2017年第8期57-68,共12页
We present our optical multi-color monitoring of the BL Lac object OJ 287 from January 2006to December 2012 in the V,R and I bands.A relatively active state in OJ 287 has been found over all monitored epochs,among whi... We present our optical multi-color monitoring of the BL Lac object OJ 287 from January 2006to December 2012 in the V,R and I bands.A relatively active state in OJ 287 has been found over all monitored epochs,among which the variations of average magnitude in V/R/I bands were measured with ?V=1.956 mag,?R=2.067 mag and ?I=2.115 mag,respectively.No reliable intraday variability is detected,but possible variability is detected on 16 nights.Their relative variation amplitudes fall into the range between 1% and 8%,with the majority between 2% and 4%.No time lags have been detected,but strong correlations exist among light curves in the three wavebands.The bluer-when-brighter trend is dominant over intraday timescales,which supports the shock-in-jet model.When combining with additional V/R band data obtained from SMARTS and the Steward Observatory,we also find a bluer-when-brighter trend over a long-term timescale.Some possible periods of 513,176,36,30,26,17 and 14 d are found in all time-series data sets from 2006 to 2017.Possible explanations about these periods are given. 展开更多
关键词 BL Lacertae objects individual(OJ 287)—galaxies active—galaxies PHOTOMETRY
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Different patterns of association between white matter microstructure and plasma unsaturated fatty acids in those with high risk for psychosis and healthy participants 被引量:1
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作者 Wenjun Su Zhixing Li +7 位作者 Lihua Xu Jiahui Zeng Yingying Tang Xiaochen Tang Yanyan Wei qian guo Tianhong Zhang Jijun Wang 《General Psychiatry》 CAS CSCD 2022年第2期109-118,共10页
Background Disrupted white matter(WM)microstructure has been commonly identified in youth at clinical high risk(CHR)for psychosis.Several lines of evidence suggest that fatty acids,especially unsaturated fatty acids(U... Background Disrupted white matter(WM)microstructure has been commonly identified in youth at clinical high risk(CHR)for psychosis.Several lines of evidence suggest that fatty acids,especially unsaturated fatty acids(UFAs),might play a crucial role in the WM pathology of early onset psychosis.However,evidence linking UFA and WM microstructure in CHR is quite sparse.Aims We investigated the relationship between the plasma UFA level and WM microstructure in CHR participants and healthy controls(HC).Methods Plasma fatty acids were assessed and diffusion tensor imaging(DTI)data were performed with tract-based spatial statistics(TBSS)analysis for 66 individuals at CHR for psychosis and 70 HC.Results Both the global and regional diffusion measures showed significant between-group differences,with decreased fractional anisotropy(FA)but increased mean diffusivity(MD)and radial diffusivity(RD)found in the CHR group compared with the HC group.On top of that,we found that in the HC group,plasma arachidic acid showed obvious trend-level associations with higher global FA,lower global MD and lower global RD,which regionally spread over the corpus callosum,right anterior and superior corona radiata,bilateral anterior and posterior limb of the internal capsule,and bilateral superior longitudinal fasciculus.However,there were no associations between global WM measures and any UFA in the CHR group.Conversely,we even found negative associations between arachidic acid levels and regional FA values in the right superior longitudinal fasciculus and right retrolenticular part of the internal capsule in the CHR group.Conclusions Compared with the HC group,CHR subjects exhibited a different pattern of association between WM microstructure and plasma UFA,with a neuroprotective effect found in the HC group but not in the CHR group.Such discrepancy could be due to the excessively upregulated UFAs accumulated in the plasma of the CHR group,highlighting the role of balanced plasma-membrane fatty acids homeostasis in WM development. 展开更多
关键词 UNSATURATED diffusion LINKING
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Relationships between selfreflectiveness and clinical symptoms in individuals during pre-morbid and early clinical stages of psychosis 被引量:1
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作者 Lihua Xu Huiru Cui +9 位作者 Yanyan Wei Zhenying qian Xiaochen Tang Yegang Hu Yingchan Wang Hao Hu qian guo Yingying Tang Tianhong Zhang Jijun Wang 《General Psychiatry》 CAS CSCD 2022年第3期163-172,共10页
Background Self-reflectiveness,one dimension of cognitive insight,plays a protective role in an individual’s mental state.Both high and low levels of self-reflectiveness have been reported in patients with schizophre... Background Self-reflectiveness,one dimension of cognitive insight,plays a protective role in an individual’s mental state.Both high and low levels of self-reflectiveness have been reported in patients with schizophrenia and individuals at clinical high risk for the illness.Aims This study aimed to explore the relationship patterns between self-reflectiveness and clinical symptoms in individuals during the pre-morbid and early clinical stages of psychosis.Methods A total of 181 subjects,including individuals with attenuated positive symptoms(APS,n=122)and patients with first-episode psychosis(FEP,n=59),completed the Beck Cognitive Insight Scale and were evaluated using the Schedule of Assessment of Insight and Positive and Negative Syndrome Scale.All subjects were classified into three groups according to their level of selfreflectiveness:low level(LSR,n=59),medium level(MSR,n=67)and high level(HSR,n=55).Both linear and nonlinear relationships between self-reflectiveness and clinical symptoms were explored.Results More individuals with APS were classified into the MSR group,while more patients with FEP were classified into the LSR group.The LSR group demonstrated less awareness of illness than the MSR and HSR groups,more stereotyped thinking and poorer impulse control but less anxiety than the MSR group,and lower levels of blunted affect and guilt feelings than the HSR group.The MSR group demonstrated lower stereotyped thinking than the HSR group.Compared to the LSR group,the MSR group had increased selfreflectiveness,improved awareness of illness,decreased stereotyped thinking,and better impulse control,but increased feelings of guilt.The HSR group showed increased stereotyped thinking when compared to the MSR group,but the other variables did not change significantly between these two groups.Overall,self-reflectiveness demonstrated an approximately inverse S-shaped relationship with the awareness of illness,a U-shaped relationship with stereotyped thinking and poor impulse control,and an almost linear relationship with anxiety and guilt feelings.Conclusions Self-reflectiveness demonstrates complex relationships with clinical symptoms and fails to exert significant positive effects when reaching a certain high level. 展开更多
关键词 CLINICAL SYMPTOMS MORBID
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Altered attentive bias towards interpersonal communication information across phases of schizophrenia: an eye-tracking study 被引量:1
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作者 Yikang Zhu Lihua Xu +5 位作者 qian guo Tianhong Zhang Xiaochen Hu Paul Enck Jijun Wang Chunbo Li 《General Psychiatry》 CAS CSCD 2022年第2期119-126,共8页
Background Eye movement abnormality in schizophrenia has been studied for several decades.However,patient differences in eye movements across phases of schizophrenia from eye-tracking studies have not been well docume... Background Eye movement abnormality in schizophrenia has been studied for several decades.However,patient differences in eye movements across phases of schizophrenia from eye-tracking studies have not been well documented.Aims This pilot study used eye-tracking technology to investigate attentive bias towards interpersonal communication information across different clinical phases of schizophrenia.Methods This study included 78 persons at clinical high risk(CHR)for schizophrenia,68 first-episode(FEZ)patients,and 39 chronically ill patients from the Shanghai At Risk for Psychosis Extending Project(SHARP Extending cohort)as well as 74 healthy controls(HCs).The experiment was an unguided-viewing task composed of 24 trials showing three types of pictures which varied in the degree of interpersonal communication.Type 1 was a scenery picture without people,type 2 was a picture with four people not communicating,and type 3 was a picture with four people communicating.We used two measures:(1)initial fixation duration and(2)total fixation duration.Results A ratio for both measures was calculated between measures for pictures with more or less interpersonal communication.The ratio of initial fixation duration for pictures with people communicating versus pictures with people not communicating was lowest in chronically ill patients(0.13(0.34))compared with HCs(0.31(0.36)),FEZ patients(0.31(0.46)),and CHR patients(0.36(0.42)).The difference in the ratios of initial fixation duration for type 2 and type 3 pictures was also significant for female participants(HCs vs chronically ill patients,t=2.706,p=0.009;CHR patients vs chronically ill patients,t=4.079,p<0.001).In addition,the ratio of initial fixation duration on pictures with people not communicating versus pictures without people negatively correlated with participants’high-risk symptoms(r=−0.35,p=0.002)among the CHR group and also correlated with the negative symptom subscore on the Positive and Negative Syndrome Scale(PANSS)among chronically ill patients(r=−0.33,p=0.037).The ratio of initial fixation duration between type 1 and type 3 pictures was associated with PANSS negative symptoms only in female patients with schizophrenia(r=−0.46,p=0.004).Conclusions These findings suggest an altered attentive bias towards pictures with a high degree of interpersonal communication information across different clinical phases in schizophrenia.The ratio of initial attentive orienting was associated with negative symptoms in female patients. 展开更多
关键词 SCHIZOPHRENIA communication measures
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Abnormal neural oscillations in clinical high risk for psychosis:a magnetoencephalography method study 被引量:1
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作者 Yegang Hu Jun Wu +10 位作者 Yujiao Cao Xiaochen Tang Guisen Wu qian guo Lihua Xu Zhenying qian Yanyan Wei Yingying Tang Chunbo Li Tianhong Zhang Jijun Wang 《General Psychiatry》 CAS CSCD 2022年第2期148-153,共6页
Background Neural oscillations directly reflect the rhythmic changes of brain activities during the resting state or while performing specific tasks.Abnormal neural oscillations have been discovered in patients with s... Background Neural oscillations directly reflect the rhythmic changes of brain activities during the resting state or while performing specific tasks.Abnormal neural oscillations have been discovered in patients with schizophrenia.However,there is limited evidence available on abnormal spontaneous neural oscillations in clinical high risk for psychosis(CHR-P).The brain signals recorded by the magnetoencephalography(MEG)technique are not to be disrupted by the skull and scalp.Methods In this study,we applied the MEG technique to record the resting-state neural activities in CHR-P.This was followed by a detailed MEG analysis method including three steps:(1)preprocessing,which was band-pass filtering based on the 0.5-60Hz frequency range,removal of 50Hz power frequency interference,and removal of electrocardiography(ECG)and electrooculography(EOG)artefacts by independent component analysis;(2)time-frequency analysis,a multitaper time-frequency transformation based on the Hanning window,and(3)source localisation.an exact low-resolution brain electromagnetic tomography.The method was verified by comparing aparticipant with CHR-P with a healthy control during the MEG recordings with an eyes-closed resting state.Results Experimental results show that the neural oscillations in CHR-P were significantly abnormal in the theta frequency band(4-7Hz)and the delta frequency band(1-3Hz).Also,relevant brain regions were located in the left occipital lobe and left temporo-occipital junction for the theta band and in the right dorsolateral prefrontal lobe and near orbitofrontal gyrus for the delta band.Conclusions Abnormal neural oscillations based on specific frequency bands and corresponding brain sources may become biomarkers for high-risk groups.Further work will validate these characteristics in CHR-P cohorts. 展开更多
关键词 STEPS BANDS EXACT
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Pathological complete response to neoadjuvant alectinib in unresectable anaplastic lymphoma kinase positive non-small cell lung cancer:A case report 被引量:1
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作者 Lu-Ming Wang Peng Zhao +2 位作者 Xu-Qi Sun Feng Yan qian guo 《World Journal of Clinical Cases》 SCIE 2023年第22期5322-5328,共7页
BACKGROUND The development of anaplastic lymphoma kinase(ALK)-tyrosine kinase inhibitors(TKIs)has remarkably improved the prognosis of patients with ALK-positive advanced non-small cell lung cancer(NSCLC).Alectinib,th... BACKGROUND The development of anaplastic lymphoma kinase(ALK)-tyrosine kinase inhibitors(TKIs)has remarkably improved the prognosis of patients with ALK-positive advanced non-small cell lung cancer(NSCLC).Alectinib,the second-generation ALK-TKI,has been approved as first-line treatment for advanced or metastatic NSCLC patients with ALK rearrangement.Neoadjuvant therapy can achieve tumor downstaging and eradicate occult lesions in patients with potentially resectable disease.Whether neoadjuvant alectinib can be a conversion therapy in ALK-positive advanced NSCLC patients remains unclear.CASE SUMMARY A 41-year-old man was pathologically diagnosed with locally advanced ALKpositive stage IIIB NSCLC.Alectinib was prescribed to induce tumor downstaging and facilitate the subsequent surgical resection.The tumor was successfully downstaged and pathological complete response was achieved.Left upper lobectomy with mediastinal lymphadenectomy was performed after tumor downstaging.The patient has continued to receive alectinib as adjuvant therapy during postoperative follow-up with a recurrence-free survival of 29 mo as of writing this report.CONCLUSION This case sheds light on the feasibility and safety of alectinib as a neoadjuvant treatment for stage IIIB NSCLC patients with ALK rearrangement.Its efficacy needs to be validated in prospective clinical trials. 展开更多
关键词 Alectinib Anaplastic lymphoma kinase Non-small cell lung cancer Neoadjuvant therapy Case report
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腺苷负荷心肌核素显像对冠心病的诊断价值研究 被引量:2
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作者 郭倩 文鑫 +2 位作者 姜果 黄娇 蒲涛 《心血管外科杂志(电子版)》 2018年第1期67-68,共2页
目的探讨在诊断冠心病的过程中使用腺苷负荷心肌核素显像的效果分析。方法收集2015年-2017年我院收治的冠心病患者86例,随机分为两组,对照组采用心脏彩超的诊断方法,研究组采用腺苷负荷心肌核素显像的诊断方法,分析两组的诊断准确率以... 目的探讨在诊断冠心病的过程中使用腺苷负荷心肌核素显像的效果分析。方法收集2015年-2017年我院收治的冠心病患者86例,随机分为两组,对照组采用心脏彩超的诊断方法,研究组采用腺苷负荷心肌核素显像的诊断方法,分析两组的诊断准确率以及对前降支病变、回旋支病变以及右冠病变病变的诊断率。结果采用腺苷负荷心肌核素显像的诊断准确率高于心脏彩超,且结果具有统计学意义(P<0.05)。结论腺苷负荷心肌核素显像诊断准确率高,可在临床上推广应用。 展开更多
关键词 冠心病 腺苷负荷心肌核素显像 心脏彩超 诊断
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电气盘柜智能巡检镜像展示系统设计与实现
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作者 钱国 施琦 陆小锋 《工业控制计算机》 2022年第1期57-59,共3页
智慧屏等显示器终端常作为工业设备智能监管的载体,针对电气室盘柜的巡检,设计了一套基于Unity3D引擎的镜像展示系统,采用三维建模技术、可视化场景技术和C#脚本语言,建立起与巡检机器人的数据交互,在显示载体上完成电气室巡检场景的镜... 智慧屏等显示器终端常作为工业设备智能监管的载体,针对电气室盘柜的巡检,设计了一套基于Unity3D引擎的镜像展示系统,采用三维建模技术、可视化场景技术和C#脚本语言,建立起与巡检机器人的数据交互,在显示载体上完成电气室巡检场景的镜像复刻,实现了指令控制与巡检信息多维展示的核心功能。测试表明系统具有良好的操作性、稳定性和交互实时性,为工厂电气盘柜的巡检提供了一种智能化方式。 展开更多
关键词 智能巡检 镜像展示 三维建模 UNITY3D
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