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Marginal zone lymphoma with severe rashes: A case report
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作者 Si-Jun Bai Ye Geng +7 位作者 Yi-Nan Gao Cai-Xia Zhang qian mi Chen Zhang Jia-Ling Yang Si-Jie He Zhen-YingYan Jian-Xia He 《World Journal of Clinical Cases》 SCIE 2024年第3期565-574,共10页
BACKGROUND Marginal zone lymphoma(MZL)is an indolent subtype of non-Hodgkin lymphoma(NHL),which is rare clinically with severe rashes as the initial symptom.CASE SUMMARY This study reports a case of MZL with generaliz... BACKGROUND Marginal zone lymphoma(MZL)is an indolent subtype of non-Hodgkin lymphoma(NHL),which is rare clinically with severe rashes as the initial symptom.CASE SUMMARY This study reports a case of MZL with generalized skin rashes accompanied by pruritus and purulent discharge.First-line treatment with rituximab combined with zanubrutinib had poor effects.However,after switching to obinutuzumab combined with zanubrutinib,the case was alleviated,and the rashes disappeared.CONCLUSION For patients with advanced stage MZL not benefiting from type I anti-CD20 monoclonal antibody(mAb)combination therapy,switching to a type II anti-CD20 mAb combination regimen may be considered.This approach may provide a new perspective in the treatment of MZL. 展开更多
关键词 Marginal zone lymphoma Mucosa-associated lymphoid tissue Extranodal marginal zone lymphoma Primary cutaneous marginal zone lymphoma Rituximab Obinutuzumab Zanubrutinib Case report
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液压快换接头压力降-流量特性试验台的设计及不确定度分析
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作者 郑智剑 钱婷婷 +1 位作者 钱咪 贺梁 《机床与液压》 北大核心 2024年第6期47-51,共5页
为测试不同流体介质、流量等工况下液压快换接头的流通能力,设计一套液压快换接头压力降-流量特性试验台,完成配套测试处理软件的开发。该试验台可采用46号液压油或水作为试验介质,其流量测试范围为40~1000 L/min,被测快换接头的进、出... 为测试不同流体介质、流量等工况下液压快换接头的流通能力,设计一套液压快换接头压力降-流量特性试验台,完成配套测试处理软件的开发。该试验台可采用46号液压油或水作为试验介质,其流量测试范围为40~1000 L/min,被测快换接头的进、出口压力降测量范围为0~5.0 MPa,被测快换接头的适用公称通径范围为12.5~51 mm。在此基础上,依据ISO 9110-1:2020和ISO 9110-2:2020标准,建立被测快换接头压降值测量的数学模型,并分别计算得到了使用46号液压油或水作为试验介质时的合成不确定度。该试验台的技术参数符合GB/T 5861—2003,也可用于测量快换接头的流量系数和流阻系数。 展开更多
关键词 液压快换接头 压力降-流量特性 流通能力 不确定度
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Electrospinning of Flexible Poly(vinyl alcohol)/MXene Nanofiber-Based Humidity Sensor Self-Powered by Monolayer Molybdenum Diselenide Piezoelectric Nanogenerator 被引量:16
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作者 Dongyue Wang Dongzhi Zhang +3 位作者 Peng Li Zhimin Yang qian mi Liandong Yu 《Nano-Micro Letters》 SCIE EI CAS CSCD 2021年第4期30-42,共13页
Two-dimensional material has been widely investigated for potential applications in sensor and flexible electronics.In this work,a self-powered flexible humidity sensing device based on poly(vinyl alcohol)/Ti_(3)C_(2)... Two-dimensional material has been widely investigated for potential applications in sensor and flexible electronics.In this work,a self-powered flexible humidity sensing device based on poly(vinyl alcohol)/Ti_(3)C_(2)Tx(PVA/MXene)nanofibers film and monolayer molybdenum diselenide(MoSe2)piezoelectric nanogenerator(PENG)was reported for the first time.The monolayer MoSe_(2)-based PENG was fabricated by atmospheric pressure chemical vapor deposition techniques,which can generate a peak output of 35 mV and a power density of42 mW m^(-2).The flexible PENG integrated on polyethylene terephthalate(PET)substrate can harvest energy generated by different parts of human body and exhibit great application prospects in wearable devices.The electrospinned PVA/MXene nanofiber-based humidity sensor with flexible PET substrate under the driven of monolayer MoSe_(2) PENG,shows high response of~40,fast response/recovery time of 0.9/6.3 s,low hysteresis of 1.8%and excellent repeatability.The self-powered flexible humidity sensor yields the capability of detecting human skin moisture and ambient humidity.This work provides a pathway to explore the high-performance humidity sensor integrated with PENG for the self-powered flexible electronic devices. 展开更多
关键词 Self-powered sensing Monolayer molybdenum diselenide Piezoelectric nanogenerator Humidity sensor Flexible electronics
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低速大转矩液压马达标准化现状与对策研究 被引量:1
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作者 郑智剑 王洋定 +1 位作者 钱咪 贺梁 《液压气动与密封》 2023年第12期1-8,共8页
分析了低速大扭矩液压马达的国内外产业现状,明确了该产品在最大工作压力、最大输出扭矩、转速范围、使用寿命等重要性能指标存在的国内外技术差距;梳理了现行有效的低速大扭矩液压马达的国家和行业标准,提出了产品的基础性指标、核心... 分析了低速大扭矩液压马达的国内外产业现状,明确了该产品在最大工作压力、最大输出扭矩、转速范围、使用寿命等重要性能指标存在的国内外技术差距;梳理了现行有效的低速大扭矩液压马达的国家和行业标准,提出了产品的基础性指标、核心指标和先进性指标,并对比分析了在机械行业标准和船舶行业标准中产品核心指标的检测方法的技术差异。指出现有行业标准在适用范围、试验方法和技术指标方面存在的问题,提出标准化工作建议,为后续行业标准的制修订工作提供参考和借鉴。 展开更多
关键词 低速大转矩液压马达 标准化 产品质量 核心指标
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液压轴向柱塞泵空载排量的测定方法研究
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作者 王洋定 李亦鸣 +2 位作者 郑智剑 钱咪 贺梁 《机床与液压》 北大核心 2023年第2期64-68,共5页
采用具有A级测试精度的液压泵综合性能试验台,按液压轴向柱塞泵的型式试验要求,分别测试在不同进出口压差、转速下泵的出口流量。基于测试数据,分别采用零压力截取法、一步TOET法和两步TOET法计算泵的空载排量,并进行对比分析。结果表明... 采用具有A级测试精度的液压泵综合性能试验台,按液压轴向柱塞泵的型式试验要求,分别测试在不同进出口压差、转速下泵的出口流量。基于测试数据,分别采用零压力截取法、一步TOET法和两步TOET法计算泵的空载排量,并进行对比分析。结果表明:采用零压力截取法计算得到的泵的空载排量受转速的影响较大,特别是在低速测试工况下,与泵的公称排量存在较大差异;而采用TOET法计算得到泵的空载排量更接近其公称排量。超过被测泵额定压力或额定转速下测得的数据可能会导致较大的数据偏差。 展开更多
关键词 空载排量 柱塞泵 零压力截取法 一步TOET法 两步TOET法
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论结合“两学一做”开展“微党课”的意义 被引量:1
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作者 钱蜜 蒋诚钢 《教育教学论坛》 2017年第15期82-83,共2页
"两学一做"——学党章党规,学系列讲话,做合格党员。就当代大学生而言,该如何"学"呢?做,又该怎么体现呢?开展"微党课",实现"学"与"做"相结合,突破传统党课的局限,让学员学到了党的... "两学一做"——学党章党规,学系列讲话,做合格党员。就当代大学生而言,该如何"学"呢?做,又该怎么体现呢?开展"微党课",实现"学"与"做"相结合,突破传统党课的局限,让学员学到了党的理论知识,更是对"做"的创新诠释。 展开更多
关键词 高校 “两学一做” “微党课”
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全媒体时代高校思想政治教育创新路径浅析
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作者 钱蜜 彭科 苏玲 《湖北开放职业学院学报》 2022年第14期14-15,共2页
现阶段,人们已全面步入全媒体时代,这一时代背景下,大学生所能接受的信息越发丰富,而思维意识受之影响也发生了潜在变化,此时高校思想政治教师必须在工作中积极渗透创新理念,以便能更好地适应全媒体时代的变革趋势。文章重点针对全媒体... 现阶段,人们已全面步入全媒体时代,这一时代背景下,大学生所能接受的信息越发丰富,而思维意识受之影响也发生了潜在变化,此时高校思想政治教师必须在工作中积极渗透创新理念,以便能更好地适应全媒体时代的变革趋势。文章重点针对全媒体时代高校思想政治教育创新路径进行分析,给出了相应的建议。 展开更多
关键词 全媒体时代 高校 思想政治教育 创新
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阀杆倾角对角座阀流量特性影响的数值研究 被引量:4
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作者 王洋定 郑智剑 +1 位作者 钱咪 贺梁 《液压与气动》 北大核心 2018年第11期43-48,共6页
采用计算流体动力学方法研究阀杆倾角对角座阀流量特性的影响。分别采用数值模拟和实验测试,获得了在不同阀门进出口压差条件下,阀杆倾角为45°,55°和60°时阀内介质体积流量,对比验证了数值计算的准确性。在此基础上,对... 采用计算流体动力学方法研究阀杆倾角对角座阀流量特性的影响。分别采用数值模拟和实验测试,获得了在不同阀门进出口压差条件下,阀杆倾角为45°,55°和60°时阀内介质体积流量,对比验证了数值计算的准确性。在此基础上,对不同阀杆倾角条件下阀内的流场和阀门的通流能力进行分析。结果表明阀内的最高流速及速度场分布对阀门的通流能力具有重要影响:当阀杆倾角为45°时,阀内介质的流速最高,流量系数最大,流阻系数最小;阀杆倾角处于45°~60°范围时,随着角度的增加,角座阀的流量系数随之降低,流阻系数相应增加。对于该流道结构的角座阀,阀杆倾角推荐采用45°~50°的设计范围。 展开更多
关键词 角座阀 阀杆倾角 流量特性 数值计算 流量试验
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Heparin Sodium Was Prepared from Pig Intestinal Mucosa by Dialysis and Spray Drying
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作者 Shunshun Shu qian mi +3 位作者 Caixia Yang Chonghuan Bao Zhaoyang Wang Jun Niu 《Journal of Biosciences and Medicines》 2018年第10期5-11,共7页
A method to extract crude heparin sodium from pig intestinal mucosa by dialysis and spray drying was established. The pig intestinal mucosa was treated in the following steps: enzymolysis, resin exchange adsorption-wa... A method to extract crude heparin sodium from pig intestinal mucosa by dialysis and spray drying was established. The pig intestinal mucosa was treated in the following steps: enzymolysis, resin exchange adsorption-washing, elution, pressure filtration, dialysis, spray drying. Activity of the product was measured using a heparin anti-IIa factor assay kit. The yield of crude heparin obtained by this method was 2.79% higher than that of oven drying method;the production of 1 kg crude heparin sodium saved 43.4 pigs small intestine. The activity was 98.48 ± 2.49 IU/mg (n = 5), 15.18 IU/mg higher than that obtained by oven drying method. The product is pale white powder, attractive color and easy to dissolve. 展开更多
关键词 HEPARIN Sodium DIALYSIS and Spray DRYING OVEN DRYING Method The Production Process
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Current Status for Oral Platinum (IV) Anticancer Drug Development
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作者 qian mi Shunshun Shu +6 位作者 Caixia Yang Chuan Gao Xian Zhang Xiao Luo Chonghuan Bao Xia Zhang Jun Niu 《International Journal of Medical Physics, Clinical Engineering and Radiation Oncology》 2018年第2期231-247,共17页
Platinum-based chemotherapeutic drugs such as cisplatin, carboplatin and oxaliplatin are widely applied for the treatment of various types of tumors. However, poor solubility, serious side effects, and more importantl... Platinum-based chemotherapeutic drugs such as cisplatin, carboplatin and oxaliplatin are widely applied for the treatment of various types of tumors. However, poor solubility, serious side effects, and more importantly, the intrinsic and acquired resistance limit their clinical applications. These factors motivate scientists to design and synthesize novel and more potent analogues lacking disadvantages of clinical platinum drugs. Platinum (IV) complexes are one of representatives. In this review, we summarized the investigations undertaken into Platinum (IV) antitumor compounds since Rosenberg first noted their antitumor activity. The synthesis method and mechanism of action of Platinum (IV) complexes are outlined, as well as their chemical and pharmacological properties. Recent advances in Platinum (IV) anticancer agents that have been in clinical trials and photoactivatable Platinum (IV) complexes are also summarized, and the purpose here is to provide insight into the requirements for the antitumor activity of Platinum (IV) complexes and a basis for progressing in a new platinum compound. 展开更多
关键词 PLATINUM (IV) COMPLEXES Properties Mechanism ANTITUMOR Activity Cancer THERAPY Photoactivatable
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Disparities in hepatitis B virus healthcare Check for updates service access among marginalised poor populations: a mixed-method systematic review
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作者 Caixia Li Dejina Thapa +2 位作者 qian mi Yuanxiu Gao Xia Fu 《Infectious Diseases of Poverty》 SCIE CAS 2024年第4期95-95,共1页
Background Marginalised poor populations,characterised by poverty and social exclusion,suffer disproportionately from hepatitis B virus(HBV)infections and encounter substantial disparities in access to healthcare.This... Background Marginalised poor populations,characterised by poverty and social exclusion,suffer disproportionately from hepatitis B virus(HBV)infections and encounter substantial disparities in access to healthcare.This has further exacerbated the global HBV burden and precluded progress towards HBV elimination.This mixed-method systematic review aimed to synthesise their utilisation and influencing factors in HBV healthcare services,including screening,vaccination,treatment,and linkage-to-care.Methods Eleven databases were searched from their inception to May 4,2023.Quantitative and qualitative stud-ies examining the factors influencing HBV healthcare access among marginalised poor populations were included.A meta-analysis was conducted to synthesise the pooled rates of HBV healthcare utilisation.The factors influencing utilisation were integrated and visualised using a health disparity research framework.Results Twenty-one studies were included involving 13,171 marginalised poor individuals:sex workers,rural migrant workers,irregular immigrants,homeless adults,and underprivileged individuals.Their utilisation of HBV healthcare ranged from 1.5%to 27.5%.Meta-analysis showed that the pooled rate of at least one dose of the HBV vaccine barely reached 37%(95%confidence interval:0.26-0.49).Fifty-one influencing factors were identifed,with sociocultural factors(n=19)being the most frequently reported,followed by behavioural(n=14)and healthcare system fac-tors(n=11).Socio-cultural barriers included immigration status,prison history,illegal work,and HBV discrimination.Behavioural domain factors,including previous testing for sexually transmitted diseases,residential drug treatment,and problem-solving coping,facilitated HBV healthcare access,whereas hostility coping exerted negative influences.Healthcare system facilitators comprised HBV health literacy,beliefs,and physician recommendations,whereas barriers included service inaccessibility and insurance inadequacies.The biological and physical/built environments were the least studied domains,highlighting that geographical mobility,shelter capacity,and access to humanitarian health centres affect HBV healthcare for marginalised poor populations.Conclusions Marginalised poor populations encounter substantial disparities in accessing HBV healthcare,highlight-ing the need for a synergistic management approach,including deploying health education initiatives to debunk HBV misperceptions,developing integrated HBV management systems for continuous tracking,conducting tailored com-munity outreach programmes,and establishing a human rights-based policy framework to guarantee the unfettered access of marginalised poor populations to essential HBV services. 展开更多
关键词 Hepatitis B virus Health disparity Marginalised poor Poverty Systematic review
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Diversiform gas sensors based on two-dimensional nanomaterials
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作者 Dongzhi Zhang Wenjing Pan +5 位作者 mingcong Tang Dongyue Wang Sujing Yu qian mi qiannan Pan andYaqing Hu 《Nano Research》 SCIE EI CSCD 2023年第10期11959-11991,共33页
Two-dimensional(2D)nanomaterials have been widely used in gas sensing due to their large specific surface area,high surface reactivity,and excellent gas adsorption properties.This paper reviews the typical synthesis m... Two-dimensional(2D)nanomaterials have been widely used in gas sensing due to their large specific surface area,high surface reactivity,and excellent gas adsorption properties.This paper reviews the typical synthesis methods of various types of 2D nanomaterials and summarizes the recent progress in gas sensors based on 2D materials,such as noble metal nanoparticles(NPs),metal oxides(MOS),conductive polymers,other new 2D materials.The methods of doping,modification,and photoexcitation can effectively improve the gas-sensing properties of 2D materials.The sensitive mechanisms of heterojunction,Schottky junction,and photoexcitation in 2D material sensors are discussed in detail.This paper discusses the application prospects of 2D materials in wearable gas sensors,food safety,and self-powered sensing,and provides ideas for further applications in environmental quality monitoring and disease diagnosis.In addition,the opportunities and challenges for gas sensors based on 2D materials are also discussed. 展开更多
关键词 gas sensor two-dimensional materials synthesis methods doping and modification light excitation enhanced sensitization mechanism
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