BACKGROUND Marginal zone lymphoma(MZL)is an indolent subtype of non-Hodgkin lymphoma(NHL),which is rare clinically with severe rashes as the initial symptom.CASE SUMMARY This study reports a case of MZL with generaliz...BACKGROUND Marginal zone lymphoma(MZL)is an indolent subtype of non-Hodgkin lymphoma(NHL),which is rare clinically with severe rashes as the initial symptom.CASE SUMMARY This study reports a case of MZL with generalized skin rashes accompanied by pruritus and purulent discharge.First-line treatment with rituximab combined with zanubrutinib had poor effects.However,after switching to obinutuzumab combined with zanubrutinib,the case was alleviated,and the rashes disappeared.CONCLUSION For patients with advanced stage MZL not benefiting from type I anti-CD20 monoclonal antibody(mAb)combination therapy,switching to a type II anti-CD20 mAb combination regimen may be considered.This approach may provide a new perspective in the treatment of MZL.展开更多
Two-dimensional material has been widely investigated for potential applications in sensor and flexible electronics.In this work,a self-powered flexible humidity sensing device based on poly(vinyl alcohol)/Ti_(3)C_(2)...Two-dimensional material has been widely investigated for potential applications in sensor and flexible electronics.In this work,a self-powered flexible humidity sensing device based on poly(vinyl alcohol)/Ti_(3)C_(2)Tx(PVA/MXene)nanofibers film and monolayer molybdenum diselenide(MoSe2)piezoelectric nanogenerator(PENG)was reported for the first time.The monolayer MoSe_(2)-based PENG was fabricated by atmospheric pressure chemical vapor deposition techniques,which can generate a peak output of 35 mV and a power density of42 mW m^(-2).The flexible PENG integrated on polyethylene terephthalate(PET)substrate can harvest energy generated by different parts of human body and exhibit great application prospects in wearable devices.The electrospinned PVA/MXene nanofiber-based humidity sensor with flexible PET substrate under the driven of monolayer MoSe_(2) PENG,shows high response of~40,fast response/recovery time of 0.9/6.3 s,low hysteresis of 1.8%and excellent repeatability.The self-powered flexible humidity sensor yields the capability of detecting human skin moisture and ambient humidity.This work provides a pathway to explore the high-performance humidity sensor integrated with PENG for the self-powered flexible electronic devices.展开更多
A method to extract crude heparin sodium from pig intestinal mucosa by dialysis and spray drying was established. The pig intestinal mucosa was treated in the following steps: enzymolysis, resin exchange adsorption-wa...A method to extract crude heparin sodium from pig intestinal mucosa by dialysis and spray drying was established. The pig intestinal mucosa was treated in the following steps: enzymolysis, resin exchange adsorption-washing, elution, pressure filtration, dialysis, spray drying. Activity of the product was measured using a heparin anti-IIa factor assay kit. The yield of crude heparin obtained by this method was 2.79% higher than that of oven drying method;the production of 1 kg crude heparin sodium saved 43.4 pigs small intestine. The activity was 98.48 ± 2.49 IU/mg (n = 5), 15.18 IU/mg higher than that obtained by oven drying method. The product is pale white powder, attractive color and easy to dissolve.展开更多
Platinum-based chemotherapeutic drugs such as cisplatin, carboplatin and oxaliplatin are widely applied for the treatment of various types of tumors. However, poor solubility, serious side effects, and more importantl...Platinum-based chemotherapeutic drugs such as cisplatin, carboplatin and oxaliplatin are widely applied for the treatment of various types of tumors. However, poor solubility, serious side effects, and more importantly, the intrinsic and acquired resistance limit their clinical applications. These factors motivate scientists to design and synthesize novel and more potent analogues lacking disadvantages of clinical platinum drugs. Platinum (IV) complexes are one of representatives. In this review, we summarized the investigations undertaken into Platinum (IV) antitumor compounds since Rosenberg first noted their antitumor activity. The synthesis method and mechanism of action of Platinum (IV) complexes are outlined, as well as their chemical and pharmacological properties. Recent advances in Platinum (IV) anticancer agents that have been in clinical trials and photoactivatable Platinum (IV) complexes are also summarized, and the purpose here is to provide insight into the requirements for the antitumor activity of Platinum (IV) complexes and a basis for progressing in a new platinum compound.展开更多
Background Marginalised poor populations,characterised by poverty and social exclusion,suffer disproportionately from hepatitis B virus(HBV)infections and encounter substantial disparities in access to healthcare.This...Background Marginalised poor populations,characterised by poverty and social exclusion,suffer disproportionately from hepatitis B virus(HBV)infections and encounter substantial disparities in access to healthcare.This has further exacerbated the global HBV burden and precluded progress towards HBV elimination.This mixed-method systematic review aimed to synthesise their utilisation and influencing factors in HBV healthcare services,including screening,vaccination,treatment,and linkage-to-care.Methods Eleven databases were searched from their inception to May 4,2023.Quantitative and qualitative stud-ies examining the factors influencing HBV healthcare access among marginalised poor populations were included.A meta-analysis was conducted to synthesise the pooled rates of HBV healthcare utilisation.The factors influencing utilisation were integrated and visualised using a health disparity research framework.Results Twenty-one studies were included involving 13,171 marginalised poor individuals:sex workers,rural migrant workers,irregular immigrants,homeless adults,and underprivileged individuals.Their utilisation of HBV healthcare ranged from 1.5%to 27.5%.Meta-analysis showed that the pooled rate of at least one dose of the HBV vaccine barely reached 37%(95%confidence interval:0.26-0.49).Fifty-one influencing factors were identifed,with sociocultural factors(n=19)being the most frequently reported,followed by behavioural(n=14)and healthcare system fac-tors(n=11).Socio-cultural barriers included immigration status,prison history,illegal work,and HBV discrimination.Behavioural domain factors,including previous testing for sexually transmitted diseases,residential drug treatment,and problem-solving coping,facilitated HBV healthcare access,whereas hostility coping exerted negative influences.Healthcare system facilitators comprised HBV health literacy,beliefs,and physician recommendations,whereas barriers included service inaccessibility and insurance inadequacies.The biological and physical/built environments were the least studied domains,highlighting that geographical mobility,shelter capacity,and access to humanitarian health centres affect HBV healthcare for marginalised poor populations.Conclusions Marginalised poor populations encounter substantial disparities in accessing HBV healthcare,highlight-ing the need for a synergistic management approach,including deploying health education initiatives to debunk HBV misperceptions,developing integrated HBV management systems for continuous tracking,conducting tailored com-munity outreach programmes,and establishing a human rights-based policy framework to guarantee the unfettered access of marginalised poor populations to essential HBV services.展开更多
Two-dimensional(2D)nanomaterials have been widely used in gas sensing due to their large specific surface area,high surface reactivity,and excellent gas adsorption properties.This paper reviews the typical synthesis m...Two-dimensional(2D)nanomaterials have been widely used in gas sensing due to their large specific surface area,high surface reactivity,and excellent gas adsorption properties.This paper reviews the typical synthesis methods of various types of 2D nanomaterials and summarizes the recent progress in gas sensors based on 2D materials,such as noble metal nanoparticles(NPs),metal oxides(MOS),conductive polymers,other new 2D materials.The methods of doping,modification,and photoexcitation can effectively improve the gas-sensing properties of 2D materials.The sensitive mechanisms of heterojunction,Schottky junction,and photoexcitation in 2D material sensors are discussed in detail.This paper discusses the application prospects of 2D materials in wearable gas sensors,food safety,and self-powered sensing,and provides ideas for further applications in environmental quality monitoring and disease diagnosis.In addition,the opportunities and challenges for gas sensors based on 2D materials are also discussed.展开更多
文摘BACKGROUND Marginal zone lymphoma(MZL)is an indolent subtype of non-Hodgkin lymphoma(NHL),which is rare clinically with severe rashes as the initial symptom.CASE SUMMARY This study reports a case of MZL with generalized skin rashes accompanied by pruritus and purulent discharge.First-line treatment with rituximab combined with zanubrutinib had poor effects.However,after switching to obinutuzumab combined with zanubrutinib,the case was alleviated,and the rashes disappeared.CONCLUSION For patients with advanced stage MZL not benefiting from type I anti-CD20 monoclonal antibody(mAb)combination therapy,switching to a type II anti-CD20 mAb combination regimen may be considered.This approach may provide a new perspective in the treatment of MZL.
基金supported by the National Natural Science Foundation of China(51777215)National Natural Science Foundation of China(51775306)+1 种基金Beijing Municipal Natural Science Foundation(4192027)the Graduate Innovation Fund of China University of Petroleum(YCX2020097)。
文摘Two-dimensional material has been widely investigated for potential applications in sensor and flexible electronics.In this work,a self-powered flexible humidity sensing device based on poly(vinyl alcohol)/Ti_(3)C_(2)Tx(PVA/MXene)nanofibers film and monolayer molybdenum diselenide(MoSe2)piezoelectric nanogenerator(PENG)was reported for the first time.The monolayer MoSe_(2)-based PENG was fabricated by atmospheric pressure chemical vapor deposition techniques,which can generate a peak output of 35 mV and a power density of42 mW m^(-2).The flexible PENG integrated on polyethylene terephthalate(PET)substrate can harvest energy generated by different parts of human body and exhibit great application prospects in wearable devices.The electrospinned PVA/MXene nanofiber-based humidity sensor with flexible PET substrate under the driven of monolayer MoSe_(2) PENG,shows high response of~40,fast response/recovery time of 0.9/6.3 s,low hysteresis of 1.8%and excellent repeatability.The self-powered flexible humidity sensor yields the capability of detecting human skin moisture and ambient humidity.This work provides a pathway to explore the high-performance humidity sensor integrated with PENG for the self-powered flexible electronic devices.
文摘A method to extract crude heparin sodium from pig intestinal mucosa by dialysis and spray drying was established. The pig intestinal mucosa was treated in the following steps: enzymolysis, resin exchange adsorption-washing, elution, pressure filtration, dialysis, spray drying. Activity of the product was measured using a heparin anti-IIa factor assay kit. The yield of crude heparin obtained by this method was 2.79% higher than that of oven drying method;the production of 1 kg crude heparin sodium saved 43.4 pigs small intestine. The activity was 98.48 ± 2.49 IU/mg (n = 5), 15.18 IU/mg higher than that obtained by oven drying method. The product is pale white powder, attractive color and easy to dissolve.
文摘Platinum-based chemotherapeutic drugs such as cisplatin, carboplatin and oxaliplatin are widely applied for the treatment of various types of tumors. However, poor solubility, serious side effects, and more importantly, the intrinsic and acquired resistance limit their clinical applications. These factors motivate scientists to design and synthesize novel and more potent analogues lacking disadvantages of clinical platinum drugs. Platinum (IV) complexes are one of representatives. In this review, we summarized the investigations undertaken into Platinum (IV) antitumor compounds since Rosenberg first noted their antitumor activity. The synthesis method and mechanism of action of Platinum (IV) complexes are outlined, as well as their chemical and pharmacological properties. Recent advances in Platinum (IV) anticancer agents that have been in clinical trials and photoactivatable Platinum (IV) complexes are also summarized, and the purpose here is to provide insight into the requirements for the antitumor activity of Platinum (IV) complexes and a basis for progressing in a new platinum compound.
文摘Background Marginalised poor populations,characterised by poverty and social exclusion,suffer disproportionately from hepatitis B virus(HBV)infections and encounter substantial disparities in access to healthcare.This has further exacerbated the global HBV burden and precluded progress towards HBV elimination.This mixed-method systematic review aimed to synthesise their utilisation and influencing factors in HBV healthcare services,including screening,vaccination,treatment,and linkage-to-care.Methods Eleven databases were searched from their inception to May 4,2023.Quantitative and qualitative stud-ies examining the factors influencing HBV healthcare access among marginalised poor populations were included.A meta-analysis was conducted to synthesise the pooled rates of HBV healthcare utilisation.The factors influencing utilisation were integrated and visualised using a health disparity research framework.Results Twenty-one studies were included involving 13,171 marginalised poor individuals:sex workers,rural migrant workers,irregular immigrants,homeless adults,and underprivileged individuals.Their utilisation of HBV healthcare ranged from 1.5%to 27.5%.Meta-analysis showed that the pooled rate of at least one dose of the HBV vaccine barely reached 37%(95%confidence interval:0.26-0.49).Fifty-one influencing factors were identifed,with sociocultural factors(n=19)being the most frequently reported,followed by behavioural(n=14)and healthcare system fac-tors(n=11).Socio-cultural barriers included immigration status,prison history,illegal work,and HBV discrimination.Behavioural domain factors,including previous testing for sexually transmitted diseases,residential drug treatment,and problem-solving coping,facilitated HBV healthcare access,whereas hostility coping exerted negative influences.Healthcare system facilitators comprised HBV health literacy,beliefs,and physician recommendations,whereas barriers included service inaccessibility and insurance inadequacies.The biological and physical/built environments were the least studied domains,highlighting that geographical mobility,shelter capacity,and access to humanitarian health centres affect HBV healthcare for marginalised poor populations.Conclusions Marginalised poor populations encounter substantial disparities in accessing HBV healthcare,highlight-ing the need for a synergistic management approach,including deploying health education initiatives to debunk HBV misperceptions,developing integrated HBV management systems for continuous tracking,conducting tailored com-munity outreach programmes,and establishing a human rights-based policy framework to guarantee the unfettered access of marginalised poor populations to essential HBV services.
基金the National Natural Science Foundation of China(No.51777215)the Original Innovation Special Project of Science and Technology Plan of Qingdao West Coast New Area(No.2020-85)the Special Foundation of the Taishan Scholar Project.
文摘Two-dimensional(2D)nanomaterials have been widely used in gas sensing due to their large specific surface area,high surface reactivity,and excellent gas adsorption properties.This paper reviews the typical synthesis methods of various types of 2D nanomaterials and summarizes the recent progress in gas sensors based on 2D materials,such as noble metal nanoparticles(NPs),metal oxides(MOS),conductive polymers,other new 2D materials.The methods of doping,modification,and photoexcitation can effectively improve the gas-sensing properties of 2D materials.The sensitive mechanisms of heterojunction,Schottky junction,and photoexcitation in 2D material sensors are discussed in detail.This paper discusses the application prospects of 2D materials in wearable gas sensors,food safety,and self-powered sensing,and provides ideas for further applications in environmental quality monitoring and disease diagnosis.In addition,the opportunities and challenges for gas sensors based on 2D materials are also discussed.