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急性冠脉综合征患者原研与“带量采购”阿托伐他汀钙片疗效和安全性的回顾性比较 被引量:3
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作者 彭倩雯 徐斌 张伟霞 《药物流行病学杂志》 CAS 2023年第4期361-366,共6页
目的比较国产带量采购和原研阿托伐他汀钙片治疗急性冠脉综合征患者的疗效和安全性。方法回顾性分析2020年4月—2021年3月上海交通大学医学院附属瑞金医院心内科使用原研(辉瑞制药有限公司,立普妥)和带量采购中标(乐普制药科技有限公司... 目的比较国产带量采购和原研阿托伐他汀钙片治疗急性冠脉综合征患者的疗效和安全性。方法回顾性分析2020年4月—2021年3月上海交通大学医学院附属瑞金医院心内科使用原研(辉瑞制药有限公司,立普妥)和带量采购中标(乐普制药科技有限公司,优力平)阿托伐他汀钙片的急性冠脉综合征患者资料,以用药4~6周后低密度脂蛋白胆固醇(LDL-C)达标率、血脂水平变化以及不良事件为评价指标。结果纳入73例有效患者,其中立普妥组37例,优力平组36例,立普妥组患者LDL-C达标率为43.2%,优力平组LDL-C达标率为50.0%,差异无统计学意义(P>0.05)。两组患者治疗后各项血脂水平均较治疗前明显改善(P<0.05);且两组间各项指标的变化幅度绝对值和百分比差异无统计学意义(P>0.05)。两组药品不良事件也未见明显差异(P>0.05)。结论我院使用带量采购中标和原研的阿托伐他汀钙片治疗急性冠脉综合征的疗效和安全性具有一致性。 展开更多
关键词 阿托伐他汀钙片 急性冠脉综合征 队列研究 真实世界研究 带量采购
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Influence of childhood trauma on adolescent internet addiction: The mediating roles of loneliness and negative coping styles
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作者 Wang-Lin Dong Yuan-Yuan Li +3 位作者 Yi-Ming Zhang qian-wen peng Guang-Li Lu Chao-Ran Chen 《World Journal of Psychiatry》 SCIE 2023年第12期1133-1144,共12页
BACKGROUND In the information age,the use of the internet and multimedia tools has large effects on the life of middle school students.Improper use of the internet may result in internet addiction(IA).Thus,actively ex... BACKGROUND In the information age,the use of the internet and multimedia tools has large effects on the life of middle school students.Improper use of the internet may result in internet addiction(IA).Thus,actively exploring the factors influencing adolescent and the mechanism of addiction as well as promoting adolescent physical and mental health and academic development are priorities that families,schools,and society urgently need to address.AIM To explore the effect of childhood trauma on adolescent IA and to consider the roles of loneliness and negative coping styles.METHODS A total of 11310 students from six junior high schools in Henan,China,completed the child trauma questionnaire,IA test,loneliness scale,and simple coping style questionnaire.In addition,data were collected from 1044 adolescents with child-hood trauma for analysis with IBM SPSS 26.0 and AMOS 28.0;we examined the relationships among childhood trauma,IA,loneliness,and negative coping styles.RESULTS We found that childhood trauma not only directly affected adolescents’IA but also affected IA through loneliness and negative coping styles.CONCLUSION Therefore,this study has theoretical implications regarding adolescent mental health and may inform interventions for IA. 展开更多
关键词 Addictive behavior Mental health Coping styles TRAUMA LONELINESS
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