A two-year field experiment was conducted to measure the effects of densification methods on photosynthesis and yield of densely planted wheat.Inter-plant and inter-row distances were used to define ratefixed pattern(...A two-year field experiment was conducted to measure the effects of densification methods on photosynthesis and yield of densely planted wheat.Inter-plant and inter-row distances were used to define ratefixed pattern(RR)and row-fixed pattern(RS)density treatments.Meanwhile,four nitrogen(N)rates(0,144,192,and 240 kg N ha-1,termed N0,N144,N192,and N240)were applied with three densities(225,292.5,and 360×10^(4)plants ha^(-1),termed D225,D292.5,and D360).The wheat canopy was clipped into three equal vertical layers(top,middle,and bottom layers),and their chlorophyll density(Ch D)and photosynthetically active radiation interception(FIPAR)were measured.Results showed that the response of Ch D and FIPAR to N rate,density,and pattern varied with different layers.N rate,density,and pattern had significant interaction effects on Ch D.The maximum values of whole-canopy Ch D in the two seasons appeared in N240 combined with D292.5 and D360 under RR,respectively.Across two growing seasons,FIPAR values of RR were higher than those of RS by 29.37%for the top layer and 5.68%for the middle layer,while lower than those of RS by 20.62%for the bottom layer on average.With a low N supply(N0),grain yield was not significantly affected by density for both patterns.At N240,increasing density significantly increased yield under RR,but D360 of RS significantly decreased yield by 3.72%and 9.00%versus D225 in two seasons,respectively.With an appropriate and sufficient N application,RR increased the yield of densely planted wheat more than RS.Additionally,the maximum yield in two seasons appeared in the combination of D360 with N144 or N192 rather than of D225 with N240 under both patterns,suggesting that dense planting combined with an appropriate N-reduction application is feasible to increase photosynthesis capacity and yield.展开更多
Wheat cultivar Zhongmai 895 was earlier found to carry YR86 in an 11.6 Mb recombination-suppressed region on chromosome 2AL when crossed with Yangmai 16.To fine-map the YR86 locus,we developed two large F2 populations...Wheat cultivar Zhongmai 895 was earlier found to carry YR86 in an 11.6 Mb recombination-suppressed region on chromosome 2AL when crossed with Yangmai 16.To fine-map the YR86 locus,we developed two large F2 populations from crosses Emai 580/Zhongmai 895 and Avocet S/Zhongmai 895.Remarkably,both populations exhibited suppressed recombination in the same 2AL region.Collinearity analysis across Chinese Spring,Aikang 58,and 10+wheat genomes revealed a 4.1 Mb chromosomal inversion spanning 708.5-712.6 Mb in the Chinese Spring reference genome.Molecular markers were developed in the breakpoint and were used to assess a wheat cultivar panel,revealing that Chinese Spring,Zhongmai 895,and Jimai 22 shared a common sequence named InvCS,whereas Aikang 58,Yangmai 16,Emai 580,and Avocet S shared the sequence named InvAK58.The inverted configuration explained the suppressed recombination observed in all three bi-parental populations.Normal recombination was observed in a Jimai 22/Zhongmai 895 F2 population,facilitating mapping of YR86 to a genetic interval of 0.15 cM corresponding to 710.27-712.56 Mb falling within the inverted region.Thirty-three high-confidence genes were annotated in the interval using the Chinese Spring reference genome,with six identified as potential candidates for YR86 based on genome and transcriptome analyses.These results will accelerate map-based cloning of YR86 and its deployment in wheat breeding.展开更多
A single stage Stifling pulse tube cryocooler was designed based on REGEN 3.2 and fabricated for testing. The experimental results show that the cooler can provide a cooling capacity of 5.0 W at 79.1 K, and produce a ...A single stage Stifling pulse tube cryocooler was designed based on REGEN 3.2 and fabricated for testing. The experimental results show that the cooler can provide a cooling capacity of 5.0 W at 79.1 K, and produce a no-load temperature of 57.0 K, operating with an average pressure of 2.50 MPa and a frequency of 60 Hz, performance results that are very close to the calculated values. The cryocooler can be cooled from room temperature to 80 K in 8.5 min. The fast cooldown time is a result of the small regenerator.展开更多
The hypoxia-inducible factor-1α(HIF-1α) plays an important role in regulating angiogenesis, which is essential for tumor growth and metastasis. Genetic variations of HIFIA (coding HIF-1α) have been shown to inf...The hypoxia-inducible factor-1α(HIF-1α) plays an important role in regulating angiogenesis, which is essential for tumor growth and metastasis. Genetic variations of HIFIA (coding HIF-1α) have been shown to influence an individual's susceptibility to many human tumors; however, evidence on associations between HIFIA single-nucleotide polymorphisms (SNPs) and prostate cancer (PCa) risk is conflicting. We genotyped three potentially functional polymorphisms in HIFIA (rs11549465, rs11549467 and rs2057482) using the TaqMan method and assessed their associations with PCa risk in a case-control study of 662 PCa patients and 716 controls in a Chinese Hart population. Compared with rs 11549467 GG genotype, the variant genotypes GA +AA had a significantly increased PCa risk (adjusted odds ratio (OR)= 1.70; 95% confidence interval (C1)= 1.06-2.72), particularly among older patients (0R=2.01; 95%C1 = 1.05-3.86), smokers (0R=2.06; 95%C1 = 1.07-3.99), never drinkers (OR=2.16; 95%C1 = 1.20-3.86) and patients without a family history of cancer (OR= 1.71; 95%C1= 1.02-2.89). Furthermore, patients with rs11549467 variant genotypes were associated with a higher Gleason score (OR=2.14; 95%CI = 1.22-3.75). No altered PCa risk was associated with the rs 11549465 and rs2057482 polymorphism. However, the combined variant genotypes of rs2057482 and rs 11549467 were associated with increased PCa risk (0R=2.10; 95%C1= 1.23-3.57 among subjects carrying three or more risk alleles). These results suggest that HIFIA polymorphisms may impact PCa susceptibility and progression in the Chinese Han population.展开更多
This study was designed to evaluate whether the revised 2010 Tumour Node Metastasis (TNM) staging system could lead to a more accurate prediction of the prognosis of renal cell carcinoma (RCC) patients. A total of...This study was designed to evaluate whether the revised 2010 Tumour Node Metastasis (TNM) staging system could lead to a more accurate prediction of the prognosis of renal cell carcinoma (RCC) patients. A total of 1216 patients who had undergone radical nephrectomy or partial nephrectomy for RCC from 2003 to 2011 were enrolled. All of the patients had pathologically confirmed clear cell RCC (ccRCC). All cases were staged by both the 2002 and 2010 TNM staging systems after pathological review, and survival data were collected. Univariate and multivariate Cox regression models were used to evaluate cancer-specific survival (CSS) and progression-free survival (PFS) after surgery. Continuous variables, such as age and tumour diameter, were calculated as mean values and standard deviations (s.d.) or as median values. Survival was calculated by the Kaplan-Meier method, and the log-rank test assessed differences between groups. Statistically significant differences in CSS and PFS were noted among patients in T3 subgroups using the new 2010 staging system. Therefore, the revised 2010 TNM staging system can lead to a more accurate prediction of the prognosis of ccRCC patients. However, when using the revised 2010 staging system, we found that more than 92% of patients (288/313) with T3 tumours were staged in the T3a subgroup, and their survival data were not significantly different from those of patients with T2b tumours. In addition, T2 subclassification failed to independently predict survival in RCC patients.展开更多
Erythropoietin(EPO) is a circulating glycosylated protein hormone and has been implicated in the development and progression of non-hematopoietic tissue tumors.The objective of the present study was to determine if ...Erythropoietin(EPO) is a circulating glycosylated protein hormone and has been implicated in the development and progression of non-hematopoietic tissue tumors.The objective of the present study was to determine if the EPO rs576236 polymorphism was associated with the risk of adrenal tumors.We genotyped the EPO rs576236 polymorphism in a case-control study of 288 adrenal tumor patients and 456 cancer-free controls by using the TaqMan method,and assessed the association between the polymorphism and the adrenal tumor risk by logistic regression.Furthermore,95%confidence interval(CI) was used to assess the genetic association between the polymorphism and the risk of adrenal tumor.Compared with the TT genotype,the TC genotype had a significantly increased risk of adrenal tumor[adjusted odds ratio(OR) = 1.24,95%CI = 1.12-2.22].Furthermore a significantly increased risk of adrenal tumor was found in the combined variant genotypes TC+CC compared with the TT genotype(adjusted OR = 1.17,95%CI = 1.12-2.21).Our present study suggests that the rs576236 polymorphism of EPO confers susceptibility to adrenal tumor in the Chinese population.展开更多
Over the past half a century, considerable research activities have been directing towards the development of magnetic semiconductors that can work at room temperature. These efforts were aimed at seeking room tempera...Over the past half a century, considerable research activities have been directing towards the development of magnetic semiconductors that can work at room temperature. These efforts were aimed at seeking room temperature magnetic semiconductors with strong and controllable s, p-d exchange interaction. With this s, p-d exchange interaction, one can utilize the spin degree of freedom to design applicable spintronics devices with very attractive functions that are not available in conventional semiconductors. Here, we first review the progress in understanding of this particular material and the dilemma to prepare a room temperature magnetic semiconductor. Then we discuss recent experimental progresses to pursue strong s, p-d interaction to realize room temperature magnetic semiconductors, which are achieved by introducing a very high concentration of magnetic atoms by means of low-temperature nonequilibrium growth.展开更多
Commercially pure titanium (CP Ti) sheets show typical planar anisotropy due to the inherently crys- tallographic texture and manufacturing process. To char- acterize the planar anisotropic behaviors of CP Ti sheets...Commercially pure titanium (CP Ti) sheets show typical planar anisotropy due to the inherently crys- tallographic texture and manufacturing process. To char- acterize the planar anisotropic behaviors of CP Ti sheets in the forming process, uniaxial tensile tests of TA0 sheets were performed along rolling, transverse, and diagonal directions at room temperature; corresponding stress-strain curves and Lankford coefficients were obtained. Based on Hi11'48 and Barlat'89 yield functions, the planar anisotropy of TA0 sheets was investigated. In order to verify the accuracy of two models, we compared the experimental and predicted values of yield stress and Lankford coeffi- cients. It reveals that Barlat'89 criterion with M = 10 is good agreement with experimental data, and the obtained function can be used in simulation of forming process.展开更多
Commercially pure titanium( CP Ti) sheets show typical planar anisotropy due to inherently crystallographic texture and rolling process. To characterize the initial,planar,plastic anisotropy of CP Ti sheets in forming...Commercially pure titanium( CP Ti) sheets show typical planar anisotropy due to inherently crystallographic texture and rolling process. To characterize the initial,planar,plastic anisotropy of CP Ti sheets in forming process,uniaxial tensile tests of cold-rolled TA1 sheets at 0°,45° and 90° to the rolling direction were performed at room temperature,corresponding stress-strain curves and Lankford coefficient( r value) were obtained. Based on Hill'48 and Barlat'89 yield criteria,the anisotropic behavior of TA1 sheets was investigated. In order to verify the accuracy of two models,the experimental values of yield stress and r were compared with predicted ones. It revealed that Barlat '89 criterion with M = 6 is the best agreement with experimental data,and the obtained model can be used in the simulation of forming process.展开更多
2x (FeNi/CoZnO)/ZnO/(CoZnO/Co) x2 spin-inJection devices were prepared by sputtering and photo-lithography. In the devices, two composite magnetic layers 2x(FeNi/CoZnO) and (CoZnO/Co)x2 with different coercivi...2x (FeNi/CoZnO)/ZnO/(CoZnO/Co) x2 spin-inJection devices were prepared by sputtering and photo-lithography. In the devices, two composite magnetic layers 2x(FeNi/CoZnO) and (CoZnO/Co)x2 with different coercivities were used to fabricate the ZnO-based semiconductor spin valve. Since the CoZnO ferromagnetic semiconductor layers touched the ZnO space layer directly, the significant spin injection from CoZnO into ZnO was observed by measuring the magnetoresistance of the spin-injection devices. The magnetoresistance reduced linearly with increasing temperature, from 1.12% at 90 K to 0.35% at room temperature.展开更多
Chaluhe Basin is in Jilin Province of China with a cumulative sedimentary rock thickness of about 6000 meters and has four subdivisions: Wanchang Structural High, Bo-Tai Sag, Xinanpu Sag, Liangjia Structure High and t...Chaluhe Basin is in Jilin Province of China with a cumulative sedimentary rock thickness of about 6000 meters and has four subdivisions: Wanchang Structural High, Bo-Tai Sag, Xinanpu Sag, Liangjia Structure High and the Gudian Slope. The basin with its better source rock distribution and more favorable maturation indicators than the adjacent Moliqing and Luxiang Basins is expected to be a potential hydrocarbon-producing basin. Four (4) wells were used in determining the maturation hydrocarbon generating potential of the mudstone beds present in the Eocene Formations (Shuangyang, Sheling and Yongji). Obtained result revealed heat flow average of 71.8 mW/m<sup>2</sup>, oil generation between 3.15 mg/g TOC and 39.49 mg/g TOC with gas generation of 6.98 mg/g TOC to 92.83 mg/g TOC. In conclusion the Eocene Shuangyang mudstone is the main petroleum source rock.展开更多
The Lynedoch field is located on the west flank of the Calder Graben in the north-eastern Bonaparte Basin, Australia. The data from the wells Lynedoch 1 and Lynedoch 2 and Seismic Line N11809 were used to reconstruct ...The Lynedoch field is located on the west flank of the Calder Graben in the north-eastern Bonaparte Basin, Australia. The data from the wells Lynedoch 1 and Lynedoch 2 and Seismic Line N11809 were used to reconstruct the burial and thermal histories and evaluate the hydrocarbon generated and expelled from the Jurassic to Early Cretaceous source rocks of the study area. Basin Mod 1-D and 2-D softwares were used for modeling. The Upper Jurassic Cleia (Lower Frigate) and Lower Cretaceous Echuca Shoals formations source rocks in the well Lynedoch 1 were a fair-to-good source richness with poor hydrocarbon generating potential, showing kerogen type III and gas prone. The Middle Jurassic Plover Formation source rock in the well Lynedoch 2 was a good organic matter richness with poor hydrocarbon generative potential, the late Middle Jurassic (Callovian) Elang Formation source rock in the same well was a fair source rock with poor hydrocarbon generation potential, and the Lower Cretaceous Echuca Shoals Formation source rock in the same well was a fair-to-very good organic richness with poor-to-fair hydrocarbon generating potential, gas prone with kerogen type III, and reaching wet gas window at present day. These previous formations of the both wells generated oil at the Late Cretaceous and gas at the Early Neogene. But, only Echuca Shoals Formation source rock in the well Lynedoch 2 was able to expelled hydrocarbon at the Middle Paleogene and continued up to present day. This Formation represents fair to slightly good potential source rock in the Lynedoch field.展开更多
The Sahul Platform where the Sunset-Loxton Shoals and Chuditch gas fields were discovered is located between the Timor Trough to the north and the Malita Graben to the south. These areas are located respectively 440 k...The Sahul Platform where the Sunset-Loxton Shoals and Chuditch gas fields were discovered is located between the Timor Trough to the north and the Malita Graben to the south. These areas are located respectively 440 km and 380 km northwest of Darwin in the northern Bonaparte Basin, Australia. Based on the structural evolution of the northern Bonaparte Basin, data from the wells Loxton Shoals 1, Sunset 1 and Chuditch 1 in the Sahul Platform and Heron 1 in the Malita Graben depocentre, and the Seismic Line N11606 were used to clarify the geological conditions and reconstruct the hydrocarbon accumulation processes in the study area. BasinMod 1-D, 2-D, and 3-D software was used for modeling. The Plover Formation source rock was a poor-to-good hydrocarbon generative potential and reached the middle to late mature oil window in the Sunset-Loxton Shoals field whereas in the Chuditch field, it was an overall fair-to-good hydrocarbon generative potential, and attained the Late mature oil window. The Flamingo, and the Echuca Shoals formations source rocks in the same field were a fair and good hydrocarbon generation potential respectively, and both reached mid-mature oil window. In the Malita Graben depocentre, the Petrel (Frigate) and the Echuca Shoals formations source rocks were a poor-to-very good hydrocarbon generating potential, and had attained wet gas window at the present day. The analyses of organic matter showed that the source rocks in the study area and Malita Graben were gas prone with kerogen types II2 & III and III predominantly. The Middle Jurassic Plover Formation sandstone reservoir in the Sunset-Loxton field was a poor-to-very good quality and potential for gas beds, and it was a very poor-to-very good quality and potential for gas beds in the Chuditch field. The intensities of gas generation and expulsion were more than of oil ones either in the Sahul Platform or in the Malita Graben. The Plover, Petrel (Frigate) and Echuca Shoals formations source rocks in the wells Chuditch 1 and Heron 1, except for the Flamingo Formation in the well Chuditch 1, had higher gas and oil expelling efficiencies than the Plover Formation source rock of the wells in the Sunset-Loxton Shoals field. The hydrocarbon migrated mainly from the Upper Jurassic Frigate Shale source rock in the Malita Graben depocentre (structurally lower) to the Plover Formation sandstone reservoir in the Sunset-Loxton Shoals field during the Late Cretaceous at 66 Ma. In the Chuditch field, the hydrocarbon migration to the Plover Formation sandstone reservoir was initiated during the Late Miocene at 7.5 Ma from the Middle Jurassic Plover Formation source rock in the well Chuditch 1. Nowadays, the main migration pathways are from the southeastward and southward of the Sunset-Loxton Shoals field, and from southward and eastward of the Chuditch field, precisely from the hydrocarbon source kitchens of the Malita Graben depocentre. The traps in the Sahul Platform have been effective to receive the migrated hydrocarbon.展开更多
Effective probing current-induced magnetization switching is highly required in the study of emerging spin-orbit torque(SOT)effect.However,the measurement of in-plane magnetization switching typically relies on the gi...Effective probing current-induced magnetization switching is highly required in the study of emerging spin-orbit torque(SOT)effect.However,the measurement of in-plane magnetization switching typically relies on the giant/tunneling magnetoresistance measurement in a spin valve structure calling for complicated fabrication process,or the non-electric approach of Kerr imaging technique.Here,we present a reliable and convenient method to electrically probe the SOT-induced in-plane magnetization switching in a simple Hall bar device through analyzing the MR signal modified by a magnetic field.In this case,the symmetry of MR is broken,resulting in a resistance difference for opposite magnetization orientations.Moreover,the feasibility of our method is widely evidenced in heavy metal/ferromagnet(Pt/Ni_(20)Fe_(80) and W/Co_(20)Fe_(60)B_(20))and the topological insulator/ferromagnet(Bi_(2)Se_(3)/Ni_(20)Fe_(80)).Our work simplifies the characterization process of the in-plane magnetization switching,which can promote the development of SOT-based devices.展开更多
Yitong Graben in Jilin Province of China, hosts three basins, namely: Chaluhe, Luxiang and Moliqing basins. The Chaluhe basin, as the focal point of this study has five subdivisions, thus, Bo-Tai sag, Wanchang Structu...Yitong Graben in Jilin Province of China, hosts three basins, namely: Chaluhe, Luxiang and Moliqing basins. The Chaluhe basin, as the focal point of this study has five subdivisions, thus, Bo-Tai sag, Wanchang Structural high, Liangjia Structure high Xinanpu sag, and the Gudian slope, with a cumulative sedimentary rock thickness of about 6000 metres. The basin is supposed to be a potential hydrocarbon-producing basin with its better source rock distribution and more favorable maturation indicators than the adjacent Luxiang and Moliqing Basin. Determining whether the mudstone beds present in the Eocene Formations are matured enough to generate hydrocarbons, three (3) wells with Seismic Lines (clh02, clh05 and clh07) were used for the study. It is observed that the entire region from NW to SE in the source rocks is mature to produce oil and gas. At depths of about 2400 m and below show good maturity with vitrinite reflectance values averaging 1.02% Ro. The Eocene Shuangyang mudstone is the main petroleum source rock.展开更多
Moliqing basin is a continental sedimentary basin in the northeast of China, between Changchun and Jilin. The source rocks characterization was done using the data of three wells to define the generative potential, ke...Moliqing basin is a continental sedimentary basin in the northeast of China, between Changchun and Jilin. The source rocks characterization was done using the data of three wells to define the generative potential, kerogen type and thermal maturity. Basin Mod software was used for the models. The three Eocene source rock formations in the basin are Shuangyang, Sheling and Yongji. Shuangyang is the most important due to its quantity and maturity levels of kerogen with very good generative potential (TOC between 2% - 4%) towards the southern region of the basin. According to the Tmax values, all three source rocks reached the mature stage, and the levels increased from early mature for the Yongji formation, to late mature for some locations of the Shuangyang formation. The 1D and 2D modeling reconstructed shows that the heat flow developed in the basin laid between 64 and 78.1 mW/m2 and had maximum heat flow location towards the center of the basin.展开更多
Waste polyolefin plastics, accounting for 50% of all plastic waste, represent a tremendously unexploited carbon source. Efficiently upcycling polyolefin waste into value-added carbon materials for waste water treatmen...Waste polyolefin plastics, accounting for 50% of all plastic waste, represent a tremendously unexploited carbon source. Efficiently upcycling polyolefin waste into value-added carbon materials for waste water treatment avoiding using noble metals is challenging but economically and environmentally sustainable. In this work, MAX-Ti_(3)AlC_(2) supported Fe selectively catalyzes polyolefin into few-layered graphene in 5 min under microwave treatment. Graphene and MAX supported Fe(Fe@MLC) can completely(99.9%)degrade chloramphenicol(CAP) within 60 min, retain robust after 10 cycles and work efficiently at a wide p H range(3.87–13.03), avoiding the usage of noble metal. Moreover, the electrochemical active surface area(ECSA) of Fe@MLC is 2.7 times higher than that of commercial Pt/C. This work provides a cheap and efficient catalyst that promotes deconstruction of plastic wastes and indirectly degrades antibiotics thereby realizes the treatment of waste water with waste plastic.展开更多
基金supported by the National Key Research and Development Program of China(2022YFD2301402)the National Natural Science Foundation of China(32071903)+2 种基金the Jiangsu Provincial Key Technologies R&D Program of China(BE2019386)the Guidance Foundation of the Sanya Institute of Nanjing Agricultural University,China(NAUSY2D01)the Earmarked Fund for Jiangsu Agricultural Industry Technology System(JATS(2022)468,JATS(2022)168)。
文摘A two-year field experiment was conducted to measure the effects of densification methods on photosynthesis and yield of densely planted wheat.Inter-plant and inter-row distances were used to define ratefixed pattern(RR)and row-fixed pattern(RS)density treatments.Meanwhile,four nitrogen(N)rates(0,144,192,and 240 kg N ha-1,termed N0,N144,N192,and N240)were applied with three densities(225,292.5,and 360×10^(4)plants ha^(-1),termed D225,D292.5,and D360).The wheat canopy was clipped into three equal vertical layers(top,middle,and bottom layers),and their chlorophyll density(Ch D)and photosynthetically active radiation interception(FIPAR)were measured.Results showed that the response of Ch D and FIPAR to N rate,density,and pattern varied with different layers.N rate,density,and pattern had significant interaction effects on Ch D.The maximum values of whole-canopy Ch D in the two seasons appeared in N240 combined with D292.5 and D360 under RR,respectively.Across two growing seasons,FIPAR values of RR were higher than those of RS by 29.37%for the top layer and 5.68%for the middle layer,while lower than those of RS by 20.62%for the bottom layer on average.With a low N supply(N0),grain yield was not significantly affected by density for both patterns.At N240,increasing density significantly increased yield under RR,but D360 of RS significantly decreased yield by 3.72%and 9.00%versus D225 in two seasons,respectively.With an appropriate and sufficient N application,RR increased the yield of densely planted wheat more than RS.Additionally,the maximum yield in two seasons appeared in the combination of D360 with N144 or N192 rather than of D225 with N240 under both patterns,suggesting that dense planting combined with an appropriate N-reduction application is feasible to increase photosynthesis capacity and yield.
基金financially supported by the National Key Research and Development Program of China (2022YFD1200900 and 2022YFD1200904)the Agricultural Science and Technology Innovation Program+1 种基金Fundamental Research Funds for Central NonProfit of Institute of Crop Sciences, CAASShijiazhuang S&T Project (232490022A and 232490432A)
文摘Wheat cultivar Zhongmai 895 was earlier found to carry YR86 in an 11.6 Mb recombination-suppressed region on chromosome 2AL when crossed with Yangmai 16.To fine-map the YR86 locus,we developed two large F2 populations from crosses Emai 580/Zhongmai 895 and Avocet S/Zhongmai 895.Remarkably,both populations exhibited suppressed recombination in the same 2AL region.Collinearity analysis across Chinese Spring,Aikang 58,and 10+wheat genomes revealed a 4.1 Mb chromosomal inversion spanning 708.5-712.6 Mb in the Chinese Spring reference genome.Molecular markers were developed in the breakpoint and were used to assess a wheat cultivar panel,revealing that Chinese Spring,Zhongmai 895,and Jimai 22 shared a common sequence named InvCS,whereas Aikang 58,Yangmai 16,Emai 580,and Avocet S shared the sequence named InvAK58.The inverted configuration explained the suppressed recombination observed in all three bi-parental populations.Normal recombination was observed in a Jimai 22/Zhongmai 895 F2 population,facilitating mapping of YR86 to a genetic interval of 0.15 cM corresponding to 710.27-712.56 Mb falling within the inverted region.Thirty-three high-confidence genes were annotated in the interval using the Chinese Spring reference genome,with six identified as potential candidates for YR86 based on genome and transcriptome analyses.These results will accelerate map-based cloning of YR86 and its deployment in wheat breeding.
基金the National Natural Science Foundation of China (No. 50676081)the Science and Technology Department of Zhejiang Province (No. 2007C30063), China
文摘A single stage Stifling pulse tube cryocooler was designed based on REGEN 3.2 and fabricated for testing. The experimental results show that the cooler can provide a cooling capacity of 5.0 W at 79.1 K, and produce a no-load temperature of 57.0 K, operating with an average pressure of 2.50 MPa and a frequency of 60 Hz, performance results that are very close to the calculated values. The cryocooler can be cooled from room temperature to 80 K in 8.5 min. The fast cooldown time is a result of the small regenerator.
文摘The hypoxia-inducible factor-1α(HIF-1α) plays an important role in regulating angiogenesis, which is essential for tumor growth and metastasis. Genetic variations of HIFIA (coding HIF-1α) have been shown to influence an individual's susceptibility to many human tumors; however, evidence on associations between HIFIA single-nucleotide polymorphisms (SNPs) and prostate cancer (PCa) risk is conflicting. We genotyped three potentially functional polymorphisms in HIFIA (rs11549465, rs11549467 and rs2057482) using the TaqMan method and assessed their associations with PCa risk in a case-control study of 662 PCa patients and 716 controls in a Chinese Hart population. Compared with rs 11549467 GG genotype, the variant genotypes GA +AA had a significantly increased PCa risk (adjusted odds ratio (OR)= 1.70; 95% confidence interval (C1)= 1.06-2.72), particularly among older patients (0R=2.01; 95%C1 = 1.05-3.86), smokers (0R=2.06; 95%C1 = 1.07-3.99), never drinkers (OR=2.16; 95%C1 = 1.20-3.86) and patients without a family history of cancer (OR= 1.71; 95%C1= 1.02-2.89). Furthermore, patients with rs11549467 variant genotypes were associated with a higher Gleason score (OR=2.14; 95%CI = 1.22-3.75). No altered PCa risk was associated with the rs 11549465 and rs2057482 polymorphism. However, the combined variant genotypes of rs2057482 and rs 11549467 were associated with increased PCa risk (0R=2.10; 95%C1= 1.23-3.57 among subjects carrying three or more risk alleles). These results suggest that HIFIA polymorphisms may impact PCa susceptibility and progression in the Chinese Han population.
文摘This study was designed to evaluate whether the revised 2010 Tumour Node Metastasis (TNM) staging system could lead to a more accurate prediction of the prognosis of renal cell carcinoma (RCC) patients. A total of 1216 patients who had undergone radical nephrectomy or partial nephrectomy for RCC from 2003 to 2011 were enrolled. All of the patients had pathologically confirmed clear cell RCC (ccRCC). All cases were staged by both the 2002 and 2010 TNM staging systems after pathological review, and survival data were collected. Univariate and multivariate Cox regression models were used to evaluate cancer-specific survival (CSS) and progression-free survival (PFS) after surgery. Continuous variables, such as age and tumour diameter, were calculated as mean values and standard deviations (s.d.) or as median values. Survival was calculated by the Kaplan-Meier method, and the log-rank test assessed differences between groups. Statistically significant differences in CSS and PFS were noted among patients in T3 subgroups using the new 2010 staging system. Therefore, the revised 2010 TNM staging system can lead to a more accurate prediction of the prognosis of ccRCC patients. However, when using the revised 2010 staging system, we found that more than 92% of patients (288/313) with T3 tumours were staged in the T3a subgroup, and their survival data were not significantly different from those of patients with T2b tumours. In addition, T2 subclassification failed to independently predict survival in RCC patients.
基金supported by the Program for Development of Innovative Research Team in the First Affiliated Hospital of Nanjing Medical University,Provincial Initiative Program for Excellency Disciplines of Jiangsu Province,by the National Natural Science Foundation of China(No.81171963,81102089,and 81201998)the Natural Science Foundation of Jiangsu Province(No.BK2011773)
文摘Erythropoietin(EPO) is a circulating glycosylated protein hormone and has been implicated in the development and progression of non-hematopoietic tissue tumors.The objective of the present study was to determine if the EPO rs576236 polymorphism was associated with the risk of adrenal tumors.We genotyped the EPO rs576236 polymorphism in a case-control study of 288 adrenal tumor patients and 456 cancer-free controls by using the TaqMan method,and assessed the association between the polymorphism and the adrenal tumor risk by logistic regression.Furthermore,95%confidence interval(CI) was used to assess the genetic association between the polymorphism and the risk of adrenal tumor.Compared with the TT genotype,the TC genotype had a significantly increased risk of adrenal tumor[adjusted odds ratio(OR) = 1.24,95%CI = 1.12-2.22].Furthermore a significantly increased risk of adrenal tumor was found in the combined variant genotypes TC+CC compared with the TT genotype(adjusted OR = 1.17,95%CI = 1.12-2.21).Our present study suggests that the rs576236 polymorphism of EPO confers susceptibility to adrenal tumor in the Chinese population.
基金supported by the National Natural Science Foundation of China (Grant Nos. 11434006, and 51871112)the National Basic Research Program of China (Grant No. 2015CB921502)+1 种基金the 111 Project (Grant No. B13029)Shandong Provincial Natural Science Foundation (Grant No. ZR2018MA035)
文摘Over the past half a century, considerable research activities have been directing towards the development of magnetic semiconductors that can work at room temperature. These efforts were aimed at seeking room temperature magnetic semiconductors with strong and controllable s, p-d exchange interaction. With this s, p-d exchange interaction, one can utilize the spin degree of freedom to design applicable spintronics devices with very attractive functions that are not available in conventional semiconductors. Here, we first review the progress in understanding of this particular material and the dilemma to prepare a room temperature magnetic semiconductor. Then we discuss recent experimental progresses to pursue strong s, p-d interaction to realize room temperature magnetic semiconductors, which are achieved by introducing a very high concentration of magnetic atoms by means of low-temperature nonequilibrium growth.
基金financially supported by the National Natural Science Foundation of China (No. 51075031,50831008)
文摘Commercially pure titanium (CP Ti) sheets show typical planar anisotropy due to the inherently crys- tallographic texture and manufacturing process. To char- acterize the planar anisotropic behaviors of CP Ti sheets in the forming process, uniaxial tensile tests of TA0 sheets were performed along rolling, transverse, and diagonal directions at room temperature; corresponding stress-strain curves and Lankford coefficients were obtained. Based on Hi11'48 and Barlat'89 yield functions, the planar anisotropy of TA0 sheets was investigated. In order to verify the accuracy of two models, we compared the experimental and predicted values of yield stress and Lankford coeffi- cients. It reveals that Barlat'89 criterion with M = 10 is good agreement with experimental data, and the obtained function can be used in simulation of forming process.
基金Sponsored by the Key Technologies R&D Program(Grant No.2011BAE13B05)the National Natural Science Foundation of China(Grant No.51075031)
文摘Commercially pure titanium( CP Ti) sheets show typical planar anisotropy due to inherently crystallographic texture and rolling process. To characterize the initial,planar,plastic anisotropy of CP Ti sheets in forming process,uniaxial tensile tests of cold-rolled TA1 sheets at 0°,45° and 90° to the rolling direction were performed at room temperature,corresponding stress-strain curves and Lankford coefficient( r value) were obtained. Based on Hill'48 and Barlat'89 yield criteria,the anisotropic behavior of TA1 sheets was investigated. In order to verify the accuracy of two models,the experimental values of yield stress and r were compared with predicted ones. It revealed that Barlat '89 criterion with M = 6 is the best agreement with experimental data,and the obtained model can be used in the simulation of forming process.
基金This work was supported by the National Natural Science Foundation of China under grant No. 50102019 and 50572053New Century Fund for Outstanding Scholars (Grant No. 040634).
文摘2x (FeNi/CoZnO)/ZnO/(CoZnO/Co) x2 spin-inJection devices were prepared by sputtering and photo-lithography. In the devices, two composite magnetic layers 2x(FeNi/CoZnO) and (CoZnO/Co)x2 with different coercivities were used to fabricate the ZnO-based semiconductor spin valve. Since the CoZnO ferromagnetic semiconductor layers touched the ZnO space layer directly, the significant spin injection from CoZnO into ZnO was observed by measuring the magnetoresistance of the spin-injection devices. The magnetoresistance reduced linearly with increasing temperature, from 1.12% at 90 K to 0.35% at room temperature.
文摘Chaluhe Basin is in Jilin Province of China with a cumulative sedimentary rock thickness of about 6000 meters and has four subdivisions: Wanchang Structural High, Bo-Tai Sag, Xinanpu Sag, Liangjia Structure High and the Gudian Slope. The basin with its better source rock distribution and more favorable maturation indicators than the adjacent Moliqing and Luxiang Basins is expected to be a potential hydrocarbon-producing basin. Four (4) wells were used in determining the maturation hydrocarbon generating potential of the mudstone beds present in the Eocene Formations (Shuangyang, Sheling and Yongji). Obtained result revealed heat flow average of 71.8 mW/m<sup>2</sup>, oil generation between 3.15 mg/g TOC and 39.49 mg/g TOC with gas generation of 6.98 mg/g TOC to 92.83 mg/g TOC. In conclusion the Eocene Shuangyang mudstone is the main petroleum source rock.
文摘The Lynedoch field is located on the west flank of the Calder Graben in the north-eastern Bonaparte Basin, Australia. The data from the wells Lynedoch 1 and Lynedoch 2 and Seismic Line N11809 were used to reconstruct the burial and thermal histories and evaluate the hydrocarbon generated and expelled from the Jurassic to Early Cretaceous source rocks of the study area. Basin Mod 1-D and 2-D softwares were used for modeling. The Upper Jurassic Cleia (Lower Frigate) and Lower Cretaceous Echuca Shoals formations source rocks in the well Lynedoch 1 were a fair-to-good source richness with poor hydrocarbon generating potential, showing kerogen type III and gas prone. The Middle Jurassic Plover Formation source rock in the well Lynedoch 2 was a good organic matter richness with poor hydrocarbon generative potential, the late Middle Jurassic (Callovian) Elang Formation source rock in the same well was a fair source rock with poor hydrocarbon generation potential, and the Lower Cretaceous Echuca Shoals Formation source rock in the same well was a fair-to-very good organic richness with poor-to-fair hydrocarbon generating potential, gas prone with kerogen type III, and reaching wet gas window at present day. These previous formations of the both wells generated oil at the Late Cretaceous and gas at the Early Neogene. But, only Echuca Shoals Formation source rock in the well Lynedoch 2 was able to expelled hydrocarbon at the Middle Paleogene and continued up to present day. This Formation represents fair to slightly good potential source rock in the Lynedoch field.
文摘The Sahul Platform where the Sunset-Loxton Shoals and Chuditch gas fields were discovered is located between the Timor Trough to the north and the Malita Graben to the south. These areas are located respectively 440 km and 380 km northwest of Darwin in the northern Bonaparte Basin, Australia. Based on the structural evolution of the northern Bonaparte Basin, data from the wells Loxton Shoals 1, Sunset 1 and Chuditch 1 in the Sahul Platform and Heron 1 in the Malita Graben depocentre, and the Seismic Line N11606 were used to clarify the geological conditions and reconstruct the hydrocarbon accumulation processes in the study area. BasinMod 1-D, 2-D, and 3-D software was used for modeling. The Plover Formation source rock was a poor-to-good hydrocarbon generative potential and reached the middle to late mature oil window in the Sunset-Loxton Shoals field whereas in the Chuditch field, it was an overall fair-to-good hydrocarbon generative potential, and attained the Late mature oil window. The Flamingo, and the Echuca Shoals formations source rocks in the same field were a fair and good hydrocarbon generation potential respectively, and both reached mid-mature oil window. In the Malita Graben depocentre, the Petrel (Frigate) and the Echuca Shoals formations source rocks were a poor-to-very good hydrocarbon generating potential, and had attained wet gas window at the present day. The analyses of organic matter showed that the source rocks in the study area and Malita Graben were gas prone with kerogen types II2 & III and III predominantly. The Middle Jurassic Plover Formation sandstone reservoir in the Sunset-Loxton field was a poor-to-very good quality and potential for gas beds, and it was a very poor-to-very good quality and potential for gas beds in the Chuditch field. The intensities of gas generation and expulsion were more than of oil ones either in the Sahul Platform or in the Malita Graben. The Plover, Petrel (Frigate) and Echuca Shoals formations source rocks in the wells Chuditch 1 and Heron 1, except for the Flamingo Formation in the well Chuditch 1, had higher gas and oil expelling efficiencies than the Plover Formation source rock of the wells in the Sunset-Loxton Shoals field. The hydrocarbon migrated mainly from the Upper Jurassic Frigate Shale source rock in the Malita Graben depocentre (structurally lower) to the Plover Formation sandstone reservoir in the Sunset-Loxton Shoals field during the Late Cretaceous at 66 Ma. In the Chuditch field, the hydrocarbon migration to the Plover Formation sandstone reservoir was initiated during the Late Miocene at 7.5 Ma from the Middle Jurassic Plover Formation source rock in the well Chuditch 1. Nowadays, the main migration pathways are from the southeastward and southward of the Sunset-Loxton Shoals field, and from southward and eastward of the Chuditch field, precisely from the hydrocarbon source kitchens of the Malita Graben depocentre. The traps in the Sahul Platform have been effective to receive the migrated hydrocarbon.
基金Project supported by the National Natural Science Foundation of China (Grant Nos. 11904017, 11974145, 51901008, and 12004024)Shandong Provincial Natural Science Foundation, China (Grant No. ZR2020ZD28)+1 种基金platform from Qingdao Science and Technology Commissionthe Fundamental Research Funds for the Central Universities of China
文摘Effective probing current-induced magnetization switching is highly required in the study of emerging spin-orbit torque(SOT)effect.However,the measurement of in-plane magnetization switching typically relies on the giant/tunneling magnetoresistance measurement in a spin valve structure calling for complicated fabrication process,or the non-electric approach of Kerr imaging technique.Here,we present a reliable and convenient method to electrically probe the SOT-induced in-plane magnetization switching in a simple Hall bar device through analyzing the MR signal modified by a magnetic field.In this case,the symmetry of MR is broken,resulting in a resistance difference for opposite magnetization orientations.Moreover,the feasibility of our method is widely evidenced in heavy metal/ferromagnet(Pt/Ni_(20)Fe_(80) and W/Co_(20)Fe_(60)B_(20))and the topological insulator/ferromagnet(Bi_(2)Se_(3)/Ni_(20)Fe_(80)).Our work simplifies the characterization process of the in-plane magnetization switching,which can promote the development of SOT-based devices.
文摘Yitong Graben in Jilin Province of China, hosts three basins, namely: Chaluhe, Luxiang and Moliqing basins. The Chaluhe basin, as the focal point of this study has five subdivisions, thus, Bo-Tai sag, Wanchang Structural high, Liangjia Structure high Xinanpu sag, and the Gudian slope, with a cumulative sedimentary rock thickness of about 6000 metres. The basin is supposed to be a potential hydrocarbon-producing basin with its better source rock distribution and more favorable maturation indicators than the adjacent Luxiang and Moliqing Basin. Determining whether the mudstone beds present in the Eocene Formations are matured enough to generate hydrocarbons, three (3) wells with Seismic Lines (clh02, clh05 and clh07) were used for the study. It is observed that the entire region from NW to SE in the source rocks is mature to produce oil and gas. At depths of about 2400 m and below show good maturity with vitrinite reflectance values averaging 1.02% Ro. The Eocene Shuangyang mudstone is the main petroleum source rock.
文摘Moliqing basin is a continental sedimentary basin in the northeast of China, between Changchun and Jilin. The source rocks characterization was done using the data of three wells to define the generative potential, kerogen type and thermal maturity. Basin Mod software was used for the models. The three Eocene source rock formations in the basin are Shuangyang, Sheling and Yongji. Shuangyang is the most important due to its quantity and maturity levels of kerogen with very good generative potential (TOC between 2% - 4%) towards the southern region of the basin. According to the Tmax values, all three source rocks reached the mature stage, and the levels increased from early mature for the Yongji formation, to late mature for some locations of the Shuangyang formation. The 1D and 2D modeling reconstructed shows that the heat flow developed in the basin laid between 64 and 78.1 mW/m2 and had maximum heat flow location towards the center of the basin.
基金the financial support provided by the National Key R&D Program of China (Nos.2020YFC1808401 and 2020YFC1808403)National Natural Science Foundation of China (Nos.22078213, 21938006 and 51973148)+3 种基金Basic Research Project of Cutting-Edge Technology in Jiangsu Province (No.BK20202012)Prospective Application Research Project of Suzhou (No.SYC2022042)Water Research and Technology Project of Suzhou (No.2022006)the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)。
文摘Waste polyolefin plastics, accounting for 50% of all plastic waste, represent a tremendously unexploited carbon source. Efficiently upcycling polyolefin waste into value-added carbon materials for waste water treatment avoiding using noble metals is challenging but economically and environmentally sustainable. In this work, MAX-Ti_(3)AlC_(2) supported Fe selectively catalyzes polyolefin into few-layered graphene in 5 min under microwave treatment. Graphene and MAX supported Fe(Fe@MLC) can completely(99.9%)degrade chloramphenicol(CAP) within 60 min, retain robust after 10 cycles and work efficiently at a wide p H range(3.87–13.03), avoiding the usage of noble metal. Moreover, the electrochemical active surface area(ECSA) of Fe@MLC is 2.7 times higher than that of commercial Pt/C. This work provides a cheap and efficient catalyst that promotes deconstruction of plastic wastes and indirectly degrades antibiotics thereby realizes the treatment of waste water with waste plastic.