跨地域采供血联动在新型冠状病毒肺炎疫情期间血液保障的实践与探讨

目的探讨采供血机构在新型冠状病毒肺炎疫情期间如何保障血液的有效供应。方法对新型冠状病毒肺炎疫情期间武汉地区血液联动和临床供血保障的措施进行回顾性分析。结果本中心在新型冠状病毒肺炎疫情期间采取了有力的应急预案,通过跨地域采供血联动,合理调配血液资源,满足了临床用血需求。结论“武汉跨地域采供血联动血液保障模式”具有较强的可实践性,为各地区血站应对类似突发的传染性公共卫生事件提供经验,有重要借鉴意义。

重度高胆红素血症患儿HDN血清学检查结果及相关因素分析~﹡

目的探讨HDN血清学检查在重度高胆红素血症并行换血治疗患儿诊疗中的作用,为临床诊疗提供依据。方法对行换血治疗的重度高胆红素血症患儿标本进行ABO、Rh血型、溶血3项试验,产妇标本进行ABO血型、Rh血型、意外抗体筛查和抗体鉴定试验,分析HDN检查结果与血清总胆红素、日龄之间的关系。结果 372例标本中,共确诊ABO以外HDN 30例(8.06%)、ABO-HDN 172例(46.24%),非HDN 170例(45.70%),3组血清总胆红素及日龄差异均具有统计学意义(P<0.01);母婴血型O/A型与O/B型HDN检出率差异无统计学意义(P>0.05);HDN检出率随新生儿日龄增长呈下降趋势,其中日龄1—6 d呈快速下降趋势,6—9 d呈平稳趋势,9 d以上呈缓慢下降趋势;血清总胆红素随日龄增长呈先上升后下降趋势,于8.5 d达到峰值,约为518μmol/L。结论 HDN检查对重度高胆红素血症患儿病因的早期识别与诊断有较大临床意义,对重度高胆红素血症需换血治疗的患儿,不论是否错过最佳检查时机,仍应尽快检查。

Immune formulation-assisted conventional therapy on anti-infective effectness of multidrug-resistant Mycobacterium tuberculosis infection mice

Objective:To study the effect of immune formulation-assisted conventional therapy on antiinfective ability of multidrug-resistant Mycobacterium tuberculous infection mice.Methods:BALB/c mice were used as experimental animals,multidrug-resistant Mycobacterium tuberculosis infection models were built,randomly divided into model group,moxifloxacin group,thymopentin group and combined treatment group and given corresponding drug intervention,and then colony numbers in the spleen and lung,T lymphocyte subset contents and programmed death-1(PD-1) expression levels in peripheral blood were detected.Results:Colony numbers in lung and spleen of moxifloxacin group and thymopentin group were significantly lower than those of model group and colony numbers in lung and spleen of combined treatment group were significantly lower than those of moxifloxacin group and thymopentin group:contents of CD3^+CD4^+T cells,Thl and Thl7 in peripheral blood of moxifloxacin group and thymopentin group were higher than dtose of model group,and contents of CD3^+CD8^+T cells.Th2 and Treg were lower than those of model group;contents of CD3^+CD4^+T cells.Th 1 and Th 17 in peripheral blood of combined treatment group were higher than those of moxifloxacin group and thymopentin group,and contents of CD3^+CD8^+T cells.Th2 and Treg were lower than those of moxifloxacin group and thymopentin group:PD-I expression levels on T lymphocyte,B lymphocyte and monocyte surface in peripheral blood of moxifloxacin group and thymopentin group were lower than those of model group,and PD-I expression levels on T lymphocyte.B lymphocyte and monocyte surface in peripheral blood of combined treatment group were lower than those of moxifloxacin group and thymopentin group.Conclusions:Immune formulation thymopentin can enhance the anti-infective ability of multidrug-resistant Mycobacterium tuberculosis infection mice,decrease bacterial load in lung and spleen,and enhance immune function.

Height prediction of water-flowing fracture zone with a geneticalgorithm support-vector-machine method

Prediction of the height of a water-flowing fracture zone(WFFZ)is the foundation for evaluating water bursting conditions on roof coal.By taking the Binchang mining area as the study area and conducting an in-depth study of the influence of coal seam thickness,burial depth,working face length,and roof category on the height of a WFFZ,we proposed that the proportion of hard rock in different roof ranges should be used to characterise the influence of roof category on WFFZ height.Based on data of WFFZ height and its influence index obtained from field observations,a prediction model is established for WFFZ height using a combination of a genetic algorithm and a support-vector machine.The reliability and superiority of the prediction model were verified by a comparative study and an engineering application.The results show that the main factors affecting WFFZ height in the study area are coal seam thickness,burial depth,working face length,and roof category.Compared with multiple-linear-regression and back-propagation neural-network approaches,the height-prediction model of the WFFZ based on a genetic-algorithm support-vector-machine method has higher training and prediction accuracy and is more suitable for WFFZ prediction in the mining area.

基于改进深度强化学习算法的电力市场监测模型研究

针对典型深度强化学习算法若干显性固有弊端,提出了一种改进深度强化学习算法,设计了基于改进深度强化学习算法的电力市场监测模型。引入智能体(agent)机制,Agent执行动作(action)并把当前收益(reward)和未来收益反馈给环境(environment)模拟策略网络,在有限马尔科夫决策过程中引入多重Q网络机制实现深度估值网络。以国家电网某电力公司为效能评价载体,基于谷歌的Tensorflow 1.2.1和OpenAI的Gym 0.9.2环境开发了验证环境并对模型进行了实证分析,仿真验证结果表明所提模型可以在较短的时间内处理多维波动非线性电力市场监预测模型,在稳定性、监测自主性、预测准确性、对抗环境下的模型性能等方面具有明显优势。

Ten-year retrospective analysis of multiple trauma complicated by pulmonary contusion

Background: This study reports a 10-year retrospective analysis of multiple trauma complicated by pulmonary contusion. The purpose of this study is to ascertain the risk factors for mortality due to trauma in patients with pulmonary contusion, the impact of various treatment options for prognosis, and the risk factors for concurrent Acute Respiratory Distress Syndrome(ARDS). Methods: We retrospectively analyzed 252 trauma patients with lung contusion admitted to the General Hospital of Guangzhou Military Command from January 2000 to June 2011 by using the statistical processing system SPSS 17.0 for Windows. Results: We included 252 patients in our study, including 214 males and 38 females. The average age was 37.1±14.9 years. There were 110 cases admitted to the ICU, of which 26 cases with ARDS. Nine of the 252 patients died. We compared those who survived with those who died by gender and age, the difference was not statistically significant(P=0.199, P=0.200). Separate univariate analysis of those who died and those who survived found that shock on admission(P=0.000), coagulation disorders(P=0.000), gastrointestinal bleeding(P=0.02), the need for emergency surgery on admission(P=0.000), pre-hospital intubation(P=0.000), blood transfusion within 24 hours(P=0.006), the use of mechanical ventilation(P=0.000), and concurrent ARDS(P=0.000) are poor prognosis risk factors. Further logistic analysis, including the admission GCS score(OR=0.708, 95%CI 0.516-0.971, P=0.032), ISS score(OR 1.135, 95%CI 1.006-1.280, P=0.039), and concurrent ARDS(OR=15.814, 95%CI 1.819-137.480, P=0.012), identified the GCS score, ISS score and concurrent ARDS as independent risk factors of poor prognosis. Shock(OR=9.121, 95%CI 0.857-97.060, P=0.067) was also related to poor prognosis. Patients with injury factors such as road accident, falling injury, blunt injury and crush injury, et al.(P=0.039), infection(P=0.005), shock(P=0.004), coagulation disorders(P=0.006), emergency surgery(P=0.01), pre-hospital intubation(P=0.000), chest tube insertion(P=0.004), blood transfusion(P=0.000), usage of hormones(P=0.002), phlegm(P=0.000), ventilation(P=0.000) were at a significantly increased risk for ARDS complications. Conclusions: Those patients with multiple trauma and pulmonary contusion admitted to the hospital with shock, coagulopathy, a need for emergency surgery, pre-hospital intubation, and a need for mechanical ventilation could have a significantly increased risk of mortality and ARDS incidence. A risk for poor prognosis was associated with gastrointestinal bleeding. A high ISS score, high APACHE Ⅱ, and low GCS score were independent risk factors for poor prognosis. If patients developed an infection or were given drainage, hormones, and phlegm treatment, they were at higher risk of ARDS. Pre-hospital intubation and drainage were independent risk factors for ARDS. In patients with ARDS, the ICU stay, total length of stay, and hospital costs might increase significantly. A GCS score【5.5, APACHE Ⅱ score】16.5, and ISS score】20.5 could be considered indicators of poor prognosis for patients with multiple trauma and lung contusion.

Nerve growth factor protects against palmitic acid- induced injury in retinal ganglion cells

Accumulating evidence supports an important role for nerve growth factor （NGF） in diabetic retinopathy. We hypothesized that NGF has a protective effect on rat retinal ganglion RGC-5 cells injured by palmitic acid （PA）, a metabolic factor implicated in the development of dia- betes and its complications. Our results show that PA exposure caused apoptosis of RGC-5 cells, while NGF protected against PA insult in a concentration-dependent manner. Additionally, NGF significantly attenuated the levels of reactive oxygen species （ROS） and malondialde- hyde （MDA） in RGC-5 cells. Pathway inhibitor tests showed that the protective effect of NGF was completely reversed by LY294002 （PI3K inhibitor）, Akt VIII inhibitor, and PD98059 （ERK1/2 inhibitor）. Western blot analysis revealed that NGF induced the phosphorylation of Akt/FoxO1 and ERK1/2 and reversed the PA-evoked reduction in the levels of these proteins. These results indicate that NGF protects RGC-5 cells against PA-induced injury through anti-oxidation and inhibition of apoptosis by modulation of the PI3K/Akt and ERK1/2 signaling pathways.

Specific effects of c-Jun NH2-terminal kinaseinteracting protein 1 in neuronal axons

c-Jun NH2-terminal kinase（JNK）-interacting protein 3 plays an important role in brain-derived neurotrophic factor/tropomyosin-related kinase B（Trk B） anterograde axonal transport. It remains unclear whether JNK-interacting protein 1 mediates similar effects, or whether JNK-interacting protein 1 affects the regulation of Trk B anterograde axonal transport. In this study, we isolated rat embryonic hippocampus and cultured hippocampal neurons in vitro. Coimmunoprecipitation results demonstrated that JNK-interacting protein 1 formed Trk B complexes in vitro and in vivo. Immunocytochemistry results showed that when JNK-interacting protein 1 was highly expressed, the distribution of Trk B gradually increased in axon terminals. However, the distribution of Trk B reduced in axon terminals after knocking out JNK-interacting protein 1. In addition, there were differences in distribution of Trk B after JNK-interacting protein 1 was knocked out compared with not. However, knockout of JNK-interacting protein 1 did not affect the distribution of Trk B in dendrites. These findings confirm that JNK-interacting protein 1 can interact with Trk B in neuronal cells, and can regulate the transport of Trk B in axons, but not in dendrites.

区块链在电力双边协商交易中的应用研究

针对双边协商效率低下、违约责任不清等问题,文章根据陕西电力在双边交易中的区块链项目经验,结合中心化和去中心化各自优势,设计了基于区块链的电力双边协商交易社区。在保证区块链网络安全和市场主体隐私安全的前提下,通过节点优化和账户模式创新,大幅提升用户体验。使用区块链解决双边协商交易的业务痛点,将双边协商交易业务由线下转移到线上开展,建立公平、公正、公开的交易社区,有效提升双边协商交易效率,降低社会成本。

遗址的魅力

前段时间,三星堆遗址重大考古发现震惊世界,也让考古再成热门话题。其实巴蜀大地上的古代遗址何其多,除了三星堆遗址,还有泸州宋墓遗址、金沙遗址等,早已被列为国家重点文保单位。遗址背后,一方一土一窟一佛,无不在与古老文明的各种关联中衍射出非凡的意义。故此,近年来,一些考古爱好者、作家,以更为私人的立场、角度走进这些古代密码场,以自己的方式理解、写作、推广认知。尤其是将考古、遗址、博物馆、文物结合起来,以作家视野来串联、地理情结来铺陈,则具备了旅游、探秘、大众考古、钩沉方志的综合魅力。

Spontaneous Infection and Periodic Evolving of Domain in a Diffusive SIS Epidemic Model

In this paper, we consider a susceptible-infective-susceptible(SIS) reaction-diffusion epidemic model with spontaneous infection and logistic source in a periodically evolving domain. Using the iterative technique,the uniform boundedness of solution is established. In addition, the spatial-temporal risk index R0(ρ) depending on the domain evolution rate ρ(t) as well as its analytical properties are discussed. The monotonicity of R0(ρ)with respect to the diffusion coefficients of the infected dI, the spontaneous infection rate η(ρ(t)y) and interval length L is investigated under appropriate conditions. Further, the existence and asymptotic behavior of periodic endemic equilibria are explored by upper and lower solution method. Finally, some numerical simulations are presented to illustrate our analytical results. Our results provide valuable information for disease control and prevention.

新生儿溶血病检查在重度高胆红素血症患儿诊疗中的意义

目的:探讨新生儿溶血病(HDN)在重度高胆红素血症患儿诊断治疗中的临床意义。方法:对300例重度高胆红素血症患儿进行HDN血型血清学检查,回顾性分析HDN结果与血清总胆红素(TSB)、日龄之间的关系。结果:300例重度高胆红素血症新生儿标本中,共检出ABO-HDN 134例(44.67%)、ABO以外HDN 20例(6.67%)、未检出HDN 146例(48.67%),3组日龄差异有统计学意义(P<0.01),TSB差异无统计学意义(P>0.05);母婴血型O/A型与O/B型其HDN检出率差异无统计学意义(P>0.05);重度、极重度、危险性高胆红素血症HDN检出率差异无统计学意义(P>0.05),TSB及日龄差异均有统计学意义(均P<0.01);HDN检出率随日龄增长呈下降趋势,其中日龄1～5 d呈快速下降趋势,5～9 d呈平稳趋势,9 d以上呈缓慢下降趋势,TSB随日龄增长呈先上升后下降趋势,于9.5 d龄处达到峰值,约为516μmol/L。结论:HDN结果与新生儿日龄密切相关,对重度高胆红素血症患儿病因的早期识别与诊断有较大临床意义,临床标本应尽快送检,以免错过最佳检测时机。

RhD--缺失型患者的血型血清学特征及临床意义分析

目的探讨RhD--缺失型患者的血型血清学特征,分析抗-Rh17抗体产生及其临床意义。方法采用直接/间接凝集和吸收放散试验检测患者红细胞Rh抗原及血清中抗体,结合生育史和输血史进行分析。结果患者为B型RhD阳性,缺失C/c、E/e抗原,抗体鉴定强阳性,特异性为抗-Rh17抗体。结论RhD--缺失型个体妊娠或输血极易产生抗-Rh17高频抗体,输血前进行RhCcEe抗原鉴定,为患者制定合适的输血方案,对保障临床输血安全,提高救治率有重要意义。

^(131)I治疗对早期甲状腺乳头状癌女性患者健康相关生存质量的影响

目的探讨早期甲状腺乳头状癌(PTC)女性患者接受^(131)I治疗与否对健康相关生存质量(HRQOL)的影响。方法回顾性分析2015年6月至2016年6月于吉林大学中日联谊医院接受双侧甲状腺全切的PTC女性患者356例(患者组),年龄21~65(41.00±9.64)岁。应用欧洲癌症研究与治疗组织(EORTC)开发的生存质量核心量表30(QLQ-C30)(简称EORTC QLQ-C30)进行HRQOL评估,分别比较400名与上述患者年龄相匹配[21~65(41.70±9.38)岁]的健康女性体检者(对照组)与患者组在EORTC QLQ-C30各领域得分[包括5个功能领域、9个症状领域以及独立的总体生活质量(GQOL)]。根据是否接受过^(131)I治疗将所有患者分为2组:^(131)I治疗组(205例)和未治疗组(151例),分别比较2组患者术前及术后(1、3、6个月)的促甲状腺激素(TSH)和甲状腺球蛋白(Tg)水平、EORTC QLQ-C30各领域得分。数据的组间比较采用Mann-Whitney U秩和检验。结果患者组术前的GQOL得分(59.11±21.12)明显低于对照组(83.08±14.62),除了身体功能以外的其他功能领域的得分均低于对照组,除了疼痛以外的其他症状领域的得分均高于对照组,且差异均有统计学意义(Z=−6.958~−4.673,均P<0.05)。术后6个月,患者组的GQOL得分(73.88±18.04)虽然仍低于对照组,但与术前相比有明显提升,除了身体功能、认知功能、社会功能以外的其他功能领域的得分均比术前升高,除了乏力、疼痛、气短以外的其他症状领域的得分均比术前降低,且差异均有统计学意义(Z=−5.790~−2.876,均P<0.05)。术前^(131)I治疗组与未治疗组的GQOL及其他所有领域的得分的差异均无统计学意义(Z=−0.876~−0.001,均P>0.05)。术后1个月,^(131)I治疗组的TSH和Tg水平明显高于未治疗组,且差异均有统计学意义(Z=−6.159、−10.061,均P<0.01);^(131)I治疗组的GQOL得分(50.57±17.72)低于未治疗组(55.74±18.82),功能领域的得分均低于未治疗组,除了疼痛、腹泻、经济困难以外的其他症状领域的得分均高于未治疗组,且差异均有统计学意义(Z=−5.512~−2.550,均P<0.05)。术后3个月,^(131)I治疗组的GQOL得分(64.43±32.12)仍低于未治疗组(72.68±17.29),但^(131)I治疗组功能领域仅有角色功能、情绪功能、社会功能的得分低于未治疗组,症状领域仅有失眠、食欲下降的得分高于未治疗组,且差异均有统计学意义(Z=−2.939~−0.984,均P<0.05)。术后6个月,^(131)I治疗组的GQOL得分及其他所有领域的得分的差异均无统计学意义(Z=−2.550~−0.008,均P>0.05)。结论^(131)I治疗不影响早期PTC女性患者术后6个月及以后的HRQOL。

房子还是儿子?——房价与出生性别比

本文考察房价对出生性别比的影响及机制。基于2010年人口普查资料,发现当房价收入比上升1个单位,城乡地区出生性别比将显著下降0.2%,其中房价上涨显著降低农村地区的出生性别比,对城镇地区出生性别比没有显著影响。为克服潜在内生性问题,本文使用刀切法工具变量回归进行分析,研究结论稳健。进一步分析发现,房价上涨不仅通过性别替代机制直接降低各胎次出生性别比,而且通过生育数量机制降低各胎次生育率进而间接降低出生性别比。

Plasmonic anisotropic gold nanorods:Preparation and biomedical applications

Gold nanorods(AuNRs)have attracted tremendous interest in biomedical fields due to their unique optical properties,tunable surface plasmon,and excellent biocompatibility.Their biomedical applications are mainly influenced by near-infrared(NIR)light,which can guarantee deep penetration into human tissues with minimal loss.However,traditional single AuNRs are unable to carry medicine into the lesion regions.Furthermore,it is difficult for AuNR nanoparticles to be implemented in multimodal imagingguided synergetic therapy,which has limited the application of AuNRs in the field of theranostics.In recent years,researchers have made great strides in modifying gold nanorods into nanomaterials for the integration of diagnosis and treatment.After modifying different functionalized shells on the outsides of AuNRs,heterostructure AuNRs known as anisotropic gold nanorod(AAuNR)nanoparticles possessed bioimaging and cancer therapy abilities,as well as a variety of other amazing biomedical applications.In addition,AAuNR nanoparticles can combine biomedical imaging and therapy into one system to achieve multimodal bioimaging guided synergetic therapy.In this study,we presented a current review of the latest progress of different types of AAuNRs nanoparticles and their biomedical applications.Furthermore,the challenges and future development trends of AAuNR nanoparticles in the biomedical fields are discussed.

The TripleSat constellation:a new geospatial data service model

With the increase of different sensors,applications and customers,the demand from data providers and users is for a new geospatial data service model,which supports low cost,high dexterity,and which would provide a comprehensive service.Based on such requirements and demands,the 21AT TripleSat constellation terminal and data delivery and management system has been developed by a Beijing based high-tech enterprise,Twenty First Century Aerospace Technology Co.,Ltd.(21AT).The company is the first commercial Earth observation satellite operator and service provider in China.This new geospatial data service model allows the user to directly access multi-source satellite data,manage the data order,and carry out automatic massive data production and delivery.The solution also implements safe and hierarchical user management,statistical data analysis,and automatic information reports.In addition,a mobile application is also available for users to easily access system functions.This new geospatial solution has already been successfully applied and installed in many customer sites in China,and is now available globally for international clients interested in fast geospatial solutions.It enables the success of customers’operational services.Besides providing TripleSat Constellation images,the multi-source data access system also allows the users to access other satellite data sources,based on customized agreement.This paper describes and discusses this new geospatial data service model.

A Triptycene-Based Porous Organic Polymer that Exhibited High Hydrogen and Carbon Dioxide Storage Capacities and Excellent CO_(2)/N_(2) Selectivity

A novel porous organic polymer(POP)has been constructed through the condensation of triptycene tricatechol and 1,3,5-benzenetris(4-phenylboronic acid).This triptycene-based POP exhibited high H2 uptake(up to 1.84 wt%at 77 K,1 bar),large CO_(2) adsorption capacity(up to 18.1 wt%at 273K,1 bar),and excellent CO_(2)/N_(2) adsorption selectivity(up to 120/1).The influence of solvent on the gas adsorption performance of the POP has also been investigated.

基于贝叶斯网络的电价自动监测设备数据校正方法

传统数据校正方法在计算节点状态量过程中,约束条件不够全面,状态量运行范围较大,导致节点过失误差的识别存在偏差。为此,提出基于贝叶斯网络的电价自动监测设备数据校正方法。利用贝叶斯网络进行概率推理,计算数据节点状态量,检测超出约束条件的异常节点,选取随机二叉树数据结构,对异常节点进行孤立隔离,模拟异常节点的动态数据,在模拟数据中加入随机误差和过失误差,输出设备数据校正值。将提出方法与两种传统方法进行对比实验,模拟小区居民用电基本负荷数据,共检测10个数据异常节点,对监测电价序列进行校正,结果表明,在两种分解层数中,提出方法的过失误差偏差值,都要小于两种传统方法,使校正值与电价实际值更加接近。

Chongqing ice jelly: An essential treat in summer

In midsummer,just after the cicadas make their first chirps,ice jelly stalls appear everywhere in Chongqing—on the streets,in alleyways,up and down the slopes of stairs,on mountain paths and on riverside wharves.There are too many iced treats in the summer—ice creams,popsicles.