Advances in the Research Application of Ultrasound Non-Invasive Stress-Strain Loop Technology in Cardiovascular Diseases

The ultrasound pressure-strain loop (PSL) technique is a non-invasive method of examining myocardial work, which takes into account the effect of cardiac afterload on deformation and combines the overall longitudinal strain force of the left ventricle with the changes in the left ventricular pressure, allowing earlier detection of possible subclinical cardiac damage in patients, and a more accurate and non-invasive assessment of the patient’s myocardial work performance. In this article, we will discuss the progress of PSL applications in cardiovascular diseases.

Progress in Preparation and Application of Gel-Emulsions

Compared to conventional emulsions, gel-emulsions have a higher internal phase volume fraction, unique structures and properties, higher viscosity, and tunable internal structures. These advantages make them widely applicable in the cosmetics industry, food industry, aerospace, and biomedicine, with significant potential in the development of new materials and high-performance products. The factors affecting the stability of gel-emulsions, as well as the types of stabilizers required for their preparation (including solid particles, surfactants, and small molecule gelators), and the corresponding preparation methods (including the one-step method, two-step method, and phase inversion method) are reviewed in this article. The applications of gel-emulsions in porous materials, food, cosmetics, and stimuli-responsive materials are introduced, and future research directions are also discussed.

C_(6)H自由基B^(2)Π-X^(2)Π的O_(0)^(0)带光谱的Λ型双重分裂和寿命展宽

本文利用狭缝超声射流等离子体结合高灵敏腔衰荡光谱在18990 cm^(-1)附近研究了C6H碳链自由基B^(2)Π-X^(2)Π电子跃迀000带谱带的高分辨光谱.通过采用一套自研的窄线宽纳秒脉冲激光光源,首次在实验上观测到了该电子跃迁谱带的A型转动线分裂,获得了B^(2)Π态精确的A型双重分裂光谱常数p’=-1.16(9)×10^(-3)cm^(-1)和q’=-1.22(7)×10^(-4)cm^(-1),并更精确地确定了考虑A型分裂后修正的B、D、γ等光谱常数.基于谱线线形展宽,获得了B^(2)Π的能级寿命~100±20 ps,并分析了其可能的来源机理.

咪唑鎓盐基材料电催化二氧化碳还原研究进展

随着化石能源的使用日益增加,大气中CO_(2)的浓度不断上升,给环境带来了挑战。通过催化将CO_(2)转化为高附加值化学品为解决这些问题提供了一个机会,并为燃料合成开辟了一条新的途径,最终有助于减少CO_(2)排放并实现碳中和。在众多的方法中,利用可再生清洁能源进行CO_(2)电还原反应(CO_(2)RR)以其反应条件温和、反应进度可控、环境友好以及可以产生大量的附加值产品而受到重视。在此背景下,咪唑鎓基材料及其衍生物已成为CO_(2)RR的有潜力的候选材料。这些材料对CO_(2)有很强的亲和力,并且在CO_(2)RR系统中作为电解质和电催化剂都有应用。所以它们的主要优点之一是能够在催化体系中富集CO_(2),有效地抑制析氢副反应(HER),并提高CO_(2)RR产物的选择性。了解电催化条件下咪唑鎓基离子液体(Im-ILs)与CO_(2)分子之间的相互作用机制对于从分子角度深入了解为什么添加Im-ILs可以改善CO_(2)RR性能至关重要。此外在非均相电催化剂中,Im-ILs作为表面修饰基团和捕集剂,可以显著改变催化剂的表面环境和疏水性,从而促进CO_(2)RR。值得注意的是,Lehn型和金属卟啉分子催化剂中的咪唑鎓基团已被发现对这些催化剂在CO_(2)RR中的性能有影响。N-杂环卡宾(NHC)基电催化剂作为咪唑鎓与CO_(2)相互作用的活性形式之一,表现出优异的CO_(2)RR性能。将NHC基电催化剂引入多孔多相催化剂和分子催化剂中,可以稳定金属纳米颗粒,提高捕获CO_(2)的能力,从而提高CO_(2)RR活性。总之,在CO_(2)RR中使用咪唑鎓基材料对于推进CO_(2)转化,实现可持续、有效合成高附加值化学品具有巨大的前景。

Intermittent disturbance mechanical behavior and fractional deterioration mechanical model of rock under complex true triaxial stress paths

Mechanical excavation,blasting,adjacent rockburst and fracture slip that occur during mining excavation impose dynamic loads on the rock mass,leading to further fracture of damaged surrounding rock in three-dimensional high-stress and even causing disasters.Therefore,a novel complex true triaxial static-dynamic combined loading method reflecting underground excavation damage and then frequent intermittent disturbance failure is proposed.True triaxial static compression and intermittent disturbance tests are carried out on monzogabbro.The effects of intermediate principal stress and amplitude on the strength characteristics,deformation characteristics,failure characteristics,and precursors of monzogabbro are analyzed,intermediate principal stress and amplitude increase monzogabbro strength and tensile fracture mechanism.Rapid increases in microseismic parameters during rock loading can be precursors for intermittent rock disturbance.Based on the experimental result,the new damage fractional elements and method with considering crack initiation stress and crack unstable stress as initiation and acceleration condition of intermittent disturbance irreversible deformation are proposed.A novel three-dimensional disturbance fractional deterioration model considering the intermediate principal stress effect and intermittent disturbance damage effect is established,and the model predicted results align well with the experimental results.The sensitivity of stress states and model parameters is further explored,and the intermittent disturbance behaviors at different f are predicted.This study provides valuable theoretical bases for the stability analysis of deep mining engineering under dynamic loads.

Soft,body conformable electronics for thermoregulation enabled by kirigami

The application of thermoelectric devices(TEDs)for personalized thermoregulation is attractive for saving energy while balancing the quality of life.TEDs that directly attach to human skin remarkably minimized the energy wasted for cooling the entire environment.However,facing the extreme dynamic geometry change and strain of human skin,conventional TEDs cannot align with the contour of our bodies for the best thermoregulation effect.Hence,we designed a kirigami-based wearable TED with excellent water vapor permeability,flexibility,and conformability.Numerical analysis and experimental results reveal that our product can withstand various types of large mechanical deformation without circuit rupture.The stated outcome and proposed facile approach not only reinforce the development of wearable TEDs but also offer an innovative opportunity for different electronics that require high conformability.

Research progress on the water vapor channel within the Yarlung Zsangbo Grand Canyon, China

The Second Tibetan Plateau Scientific Expedition and Research Program tasked a research team with the“Investigation of the water vapor channel of the Yarlung Zsangbo Grand Canyon(INVC)”in the southeastern Tibetan Plateau(TP).This paper summarizes the scientific achievements obtained from the data collected by the INVC observation network and highlights the progress in investigating the development of heavy rainfall events associated with water vapor changes.The rain gauge network of the INVC can represent the impacts of the Yarlung Zsangbo Grand Canyon(YGC)topography on precipitation at the hourly scale.The microphysical characteristics of the precipitation in the YGC are different than those in the lowland area.The GPM-IMERG(Integrated MultisatellitE Retrievals for Global Precipitation Measurement)satellite precipitation data for the YGC region should be calibrated before they are used.The meridional water vapor flux through the YGC is more important than the zonal flux for the precipitation over the southeastern TP.The decreased precipitation around the YGC region is partly due to the decreased meridional water vapor flux passing through the YGC.High-resolution numerical models can benefit precipitation forecasting in this region by using a combination of specific schemes that capture the valley wind and water vapor flux along the valley floor.

Degradable magnesium alloy suture promotes fibrocartilaginous interface regeneration in a rat rotator cuff transosseous repair model

Despite transosseous rotator cuff tear repair using sutures is widely accepted for tendon-bone fixation,the fibrocartilaginous enthesis regeneration is still hardly achieved with the traditional sutures.In the present work,degradable magnesium(Mg)alloy wire was applied to suture supraspinatus tendon in a rat acute rotator cuff tear model with Vicryl Plus 4±0 absorbable suture as control.The shoulder joint humerus-supraspinatus tendon complex specimens were retrieved at 4,8,and 12 weeks after operation.The Mg alloy suture groups showed better biomechanical properties in terms of ultimate load to failure.Gross observation showed that hyperplastic response of the scar tissue at the tendon-bone interface is progressively alleviated over time in the both Mg alloy suture and Vicryl suture groups.In the histological analysis,for Mg alloy suture groups,chondrocytes appear to proliferate at 4 weeks postoperatively,and the tendon-bone interface showed an orderly structural transition zone at 8 weeks postoperatively.The collagenous fiber tended to be aligned and the tendon-bone interlocking structures apparently formed,where transitional structure from unmineralized fibrocartilage to mineralized fibrocartilage was closer to the native fibrocartilaginous enthesis.In vivo degradation of the magnesium alloy wire was completed within 12 weeks.The results indicated that Mg alloy wire was promising as degradable suture with the potential to promotes fibrocartilaginous interface regeneration in rotator cuff repair.

Amitriptyline inhibits NLRP3 inflammasome activation via the ASM/CE pathway in a cell model of NAFLD

Background:Nonalcoholic fatty liver disease(NAFLD)is a global health concern with the acid sphingomyelinase(ASM)/ceramide(CE)pathway and the NOD-like receptor family,pyrin domain-containing protein 3(NLRP3)inflammasome identified as pivotal players in lipid disorders and inflammation.This study explores the interaction mechanism between the ASM/CE pathway and NLRP3 in NAFLD cell models,aiming to understand the impact of amitriptyline(Ami),an ASM inhibitor,on lipid deposition and hepatocyte injury by regulating the ASM/CE-NLRP3 pathway.Methods:HepG2 and HL-7702 cells were exposed to free fatty acids(FFAs)to establish the NAFLD model.The cells were divided into 5 groups:control group,model group,Ami group,tumor necrosis factoralpha(TNF-α)group,and Ami+TNF-αgroup.Intracellular lipid droplets were visualized using Oil Red O staining,and Western blot analysis quantified ASM,NLRP3,and caspase 1 protein expression.Enzyme linked immunosorbent assay(ELISA)was measured CE and ASM levels,while qRT-PCR assessed mRNA expression.The apoptotic rate was evaluated by flow cytometry(FCM).Results:Following FFAs incubation,significant increases in ASM and CE levels were observed in HepG2 and HL-7702 cells,accompanied by elevated expression of NLRP3,and caspase 1,and IL-1β.TNF-αtreatment further amplified these indicators.Ami demonstrated a reduction in lipid deposition,suppressed ASM/CE pathway activation,downregulated NLRP3 and caspase 1 expression,and improved apoptosis.Additionally,MCC950,a selective inhibitor of the NLRP3,mitigated NLRP3,caspase 1,and IL-1βexpression,alleviating lipid deposition and apoptosis in the NAFLD cell model.Conclusion:The ASM/CE-NLRP3 pathway in NAFLD cells promotes hepatocyte steatosis,inflammation,and cell damage.Ami emerges as a promising therapeutic agent by inhibiting the ASM/CE-NLRP3 pathway,underscoring its potential as a key target for NAFLD treatment.

Effects of Tongluo Jiedu prescription on immune function and oxidative stress in patients with oral cancer

BACKGROUND Oral cancer,which is caused by mucous membrane variation,represents a prevalent malignant tumor in the oral and maxillofacial region,posing a significant threat to patients’lives and safety.While surgical intervention stands as a cornerstone treatment for oral cancer patients,it carries the risk of incomplete treatment or high rates of postoperative recurrence.Hence,a multifaceted approach incorporating diverse treatment modalities is essential to enhance patient prognosis.AIM To analyze the application effect of Tongluo Jiedu prescription as adjuvant therapy and its influence on patient prognosis in patients with oral cancer.METHODS Eighty oral cancer patients in our hospital were selected and divided into the observation group and control group by a random number table.The control group was treated with continuous arterial infusion chemotherapy of cisplatin and 5-fluorouracil.The observation group was additionally given Tongluo Jiadu prescription.The inflammatory stress level,peripheral blood T-cell subsets,and immune function of the two groups were subsequently observed.SPSS 21.0 was used for data analysis.RESULTS The observation group demonstrated lower levels of interleukin-6 and C-reactive protein,and a higher level of tumor necrosis factor in comparison to the control group.After treatment,the immune function in the observation group was significantly better than in the control group.CONCLUSION Tongluo Jiedu prescription can improve the immune function and oxidative stress level of patients with oral cancer and accelerate the recovery process.

Cross-layer all-interface defect passivation with pre-buried additive toward efficient all-inorganic perovskite solar cells

The buried interface in the perovskite solar cell(PSC)has been regarded as a breakthrough to boost the power conversion efficiency and stability.However,a comprehensive manipulation of the buried interface in terms of the transport layer,buried interlayer,and perovskite layer has been largely overlooked.Herein,we propose the use of a volatile heterocyclic compound called 2-thiopheneacetic acid(TPA)as a pre-buried additive in the buried interface to achieve cross-layer all-interface defect passivation through an in situ bottom-up infiltration diffusion strategy.TPA not only suppresses the serious interfacial nonradiative recombination losses by precisely healing the interfacial and underlying defects but also effectively enhances the quality of perovskite film and releases the residual strain of perovskite film.Owing to this versatility,TPA-tailored CsPbBr3 PSCs deliver a record efficiency of 11.23% with enhanced long-term stability.This breakthrough in manipulating the buried interface using TPA opens new avenues for further improving the performance and reliability of PSC.

Effect of the anionic composition of sulfolane based electrolytes on the performances of lithium-sulfur batteries

In lithium-sulfur batteries,cell design,specifically electrolyte design,has a key impact on the battery performance.The effect of lithium salt anion donor number(DN)(DN[PF_(6)]^(-)=2.5,DN[N(SO_(2)CF_(3))_(2)]^(-)=5.4,DN[ClO_(4)]^(-)=8.4,DN[SO_(3)CF_(3)]^(-)=16.9,and DN[NO_(3)]^(-)=21.1)on the patterns of lithium-sulfur batteries and lithium metal electrode performances with sulfola ne-based electrolytes is investigated.An increase in DN of lithium salt anions leads to an increase in the depth and rate of electrochemical reduction of sulfur and long-chain lithium polysulfides and to a decrease in those for medium-and short-chain lithium polysulfides.DN of lithium salt anions has weak effect on the discharge capacity of lithium-sulfur batteries and the Coulomb efficiency during cycling,with the exception of LiSO_(3)CF_(3)and LiNO_(3).An increase in DN of lithium salt anions leads to an increase in the cycling duration of lithium metal anodes and to a decrease in the presence of lithium polysulfides.In sulfolane solutions of LiNO_(3)and LiSO_(3)CF_(3),lithium polysulfides do not affect the cycling duration of lithium metal anodes.

Extending homogeneous fluidization flow regime of Geldart-A particles by exerting axial uniform and steady magnetic field

The homogeneous/particulate fluidization flow regime is particularly suitable for handling the various gas–solid contact processes encountered in the chemical and energy industry.This work aimed to extend such a regime of Geldart-A particles by exerting the axial uniform and steady magnetic field.Under the action of the magnetic field,the overall homogeneous fluidization regime of Geldart-A magnetizable particles became composed of two parts:inherent homogeneous fluidization and newly-created magnetic stabilization.Since the former remained almost unchanged whereas the latter became broader as the magnetic field intensity increased,the overall homogeneous fluidization regime could be extended remarkably.As for Geldart-A nonmagnetizable particles,certain amount of magnetizable particles had to be premixed to transmit the magnetic stabilization.Among others,the mere addition of magnetizable particles could broaden the homogeneous fluidization regime.The added content of magnetizable particles had an optimal value with smaller/lighter ones working better.The added magnetizable particles might raise the ratio between the interparticle force and the particle gravity.After the magnetic field was exerted,the homogeneous fluidization regime was further expanded due to the formation of magnetic stabilization flow regime.The more the added magnetizable particles,the better the magnetic performance and the broader the overall homogeneous fluidization regime.Smaller/lighter magnetizable particles were preferred to maximize the magnetic performance and extend the overall homogeneous fluidization regime.This phenomenon could be ascribed to that the added magnetizable particles themselves became more Geldart-A than-B type as their density or size decreased.

Influences of polymorphism of packed particles on bulk characterizations in fluidization realm

The characterization of a particle ensemble(rather than a single particle) is of paramount significance to various particle technologies and has long been a fundamental subject in the fluidization realm. However, many of such bulk characterizations as loosely-packed density(ρbl), minimum fluidization velocity(Umf), sphericity(φ), discharge rate through orifice(q), angle of repose(β), and segregation index(S),were found to be poorly reproducible, making the reported results seldom comparable. Since these bulk characterizations started from the packed state of particles, such poor reproducibility was ascribed to the polymorphism of packed particles in this work. We observed that in the fluidized bed, the settled/packed state of particles varied monotonously with the settling rate(a) from complete fluidization to zero. This phenomenon confirmed the polymorphic characteristic of packed particles and further enabled us to systematically disclose/clarify its influences on the aforementioned bulk characterizations. Such influences could be comprehensively and intuitively reflected by the impacts induced by a. With the decrease of a, ρbl, φ and q first increased, then decreased, and finally leveled off while Umfand β showed an opposite trend. On the other hand, S first increased and then remained invariant. As per these findings and definitions of these bulk characterizations, benchmarks were indicated to unify the selection of settled state among future scholars and further make their outcomes become fairly comparable. Additionally, most packed states of the particle ensemble were proved to be metastable with their formation and behavior being identical to those of the amorphous state.

Effects of different energy levels in low-protein diet on liver lipid metabolism in the late-phase laying hens through the gut-liver axis

Background The energy/protein imbalance in a low-protein diet induces lipid metabolism disorders in late-phase laying hens.Reducing energy levels in the low-protein diet to adjust the energy-to-protein ratio may improve fat deposition,but this also decreases the laying performance of hens.This study investigated the mechanism by which different energy levels in the low-protein diet influences liver lipid metabolism in late-phase laying hens through the enterohepatic axis to guide feed optimization and nutrition strategies.A total of 288 laying hens were randomly allocated to the normal-energy and normal-protein diet group(positive control:CK)or 1 of 3 groups:lowenergy and low-protein diet(LL),normal-energy and low-protein diet(NL),and high-energy and low-protein diet(HL)groups.The energy-to-protein ratios of the CK,LL,NL,and HL diets were 0.67,0.74,0.77,and 0.80,respectively.Results Compared with the CK group,egg quality deteriorated with increasing energy intake in late-phase laying hens fed low-protein diet.Hens fed LL,NL,and HL diets had significantly higher triglyceride,total cholesterol,acetylCo A carboxylase,and fatty acid synthase levels,but significantly lower hepatic lipase levels compared with the CK group.Liver transcriptome sequencing revealed that genes involved in fatty acid beta-oxidation(ACOX1,HADHA,EHHADH,and ACAA1)were downregulated,whereas genes related to fatty acid synthesis(SCD,FASN,and ACACA)were upregulated in LL group compared with the CK group.Comparison of the cecal microbiome showed that in hens fed an LL diet,Lactobacillus and Desulfovibrio were enriched,whereas riboflavin metabolism was suppressed.Cecal metabolites that were most significantly affected by the LL diet included several vitamins,such as riboflavin(vitamin B2),pantethine(vitamin B5 derivative),pyridoxine(vitamin B6),and 4-pyridoxic acid.Conclusion A lipid metabolism disorder due to deficiencies of vitamin B2 and pantethine originating from the metabolism of the cecal microbiome may be the underlying reason for fat accumulation in the liver of late-phase laying hens fed an LL diet.Based on the present study,we propose that targeting vitamin B2 and pantethine(vitamin B5 derivative)might be an effective strategy for improving lipid metabolism in late-phase laying hens fed a low-protein diet.

Fatigue properties and damage constitutive model of salt rock based on CT scanning

To investigate the macroscopic fatigue properties and the mesoscopic pore evolution characteristics of salt rock under cyclic loading,fatigue tests under different upper-limit stresses were carried out on salt rock,and the mesoscopic pore structures of salt rock before and after fatigue tests and under different cycle numbers were measured using CT scanning instrument.Based on the test results,the effects of the cycle number and the upper-limit stress on the evolution of cracks,pore morphology,pore number,pore volume,pore size,plane porosity,and volume porosity of salt rock were analyzed.The failure path of salt rock specimens under cyclic loading was analyzed using the distribution law of plane porosity.The damage variable of salt rock under cyclic loading was defined on basis of the variation of volume porosity with cycle number.In order to describe the fatigue deformation behavior of salt rock under cyclic loading,the nonlinear Burgers damage constitutive model was further established.The results show that the model established can better reflect the whole development process of fatigue deformation of salt rock under cyclic loading.

Giant and controllable Goos—Hänchen shift of a reflective beam off a hyperbolic metasurface of polar crystals

We conduct a theoretical analysis of the massive and tunable Goos–Hänchen(GH) shift on a polar crystal covered with periodical black phosphorus(BP)-patches in the THz range. The surface plasmon phonon polaritons(SPPPs), which are coupled by the surface phonon polaritons(SPh Ps) and surface plasmon polaritons(SPPs), can greatly increase GH shifts.Based on the in-plane anisotropy of BP, two typical metasurface models are designed and investigated. An enormous GH shift of about-7565.58 λ_(0) is achieved by adjusting the physical parameters of the BP-patches. In the designed metasurface structure, the maximum sensitivity accompanying large GH shifts can reach about 6.43 × 10^(8) λ_(0)/RIU, which is extremely sensitive to the size, carrier density, and layer number of BP. Compared with a traditional surface plasmon resonance sensor, the sensitivity is increased by at least two orders of magnitude. We believe that investigating metasurface-based SPPPs sensors could lead to high-sensitivity biochemical detection applications.

Molecular Mechanisms of Intracellular Delivery of Nanoparticles Monitored by an Enzyme‑Induced Proximity Labeling

Achieving increasingly finely targeted drug delivery to organs,tissues,cells,and even to intracellular biomacromolecules is one of the core goals of nanomedicines.As the delivery destination is refined to cellular and subcellular targets,it is essential to explore the delivery of nanomedicines at the molecular level.However,due to the lack of technical methods,the molecular mechanism of the intracellular delivery of nanomedicines remains unclear to date.Here,we develop an enzyme-induced proximity labeling technology in nanoparticles(nano-EPL)for the real-time monitoring of proteins that interact with intracellular nanomedicines.Poly(lactic-co-glycolic acid)nanoparticles coupled with horseradish peroxidase(HRP)were fabricated as a model(HRP(+)-PNPs)to evaluate the molecular mechanism of nano delivery in macrophages.By adding the labeling probe biotin-phenol and the catalytic substrate H_(2)O_(2)at different time points in cellular delivery,nano-EPL technology was validated for the real-time in situ labeling of proteins interacting with nanoparticles.Nano-EPL achieves the dynamic molecular profiling of 740 proteins to map the intracellular delivery of HRP(+)-PNPs in macrophages over time.Based on dynamic clustering analysis of these proteins,we further discovered that different organelles,including endosomes,lysosomes,the endoplasmic reticulum,and the Golgi apparatus,are involved in delivery with distinct participation timelines.More importantly,the engagement of these organelles differentially affects the drug delivery efficiency,reflecting the spatial–temporal heterogeneity of nano delivery in cells.In summary,these findings highlight a significant methodological advance toward understanding the molecular mechanisms involved in the intracellular delivery of nanomedicines.

Understanding Simulated Causes of Damaging Surface Winds in a Derecho-Producing Mesoscale Convective System near the East China Coast Based on Convection-Permitting Simulations

A mesoscale convective system(MCS) occurred over the East China coastal provinces and the East China Sea on 30April 2021, producing damaging surface winds near the coastal city Nantong with observed speeds reaching 45 m s^(–1). A simulation using the Weather Research and Forecasting model with a 1.5-km grid spacing generally reproduces the development and subsequent organization of this convective system into an MCS, with an eastward protruding bow segment over the sea. In the simulation, an east-west-oriented high wind swath is generated behind the gust front of the MCS. Descending dry rear-to-front inflows behind the bow and trailing gust front are found to feed the downdrafts in the main precipitation regions. The inflows help to establish spreading cold outflows and enhance the downdrafts through evaporative cooling. Meanwhile, front-to-rear inflows from the south are present, associated with severely rearward-tilted updrafts initially forming over the gust front. Such inflows descend behind(north of) the gust front, significantly enhancing downdrafts and near-surface winds within the cold pool. Consistently, calculated trajectories show that these parcels that contribute to the derecho originate primarily from the region ahead(south) of the east-west-oriented gust front, and dry southwesterly flows in the low-to-middle levels contribute to strong downdrafts within the MCS. Moreover, momentum budget analyses reveal that a large westward-directed horizontal pressure gradient force within the simulated cold pool produced rapid flow acceleration towards Nantong. The analyses enrich the understanding of damaging wind characteristics over coastal East China and will prove helpful to operational forecasters.

Synergistic defect passivation and strain compensation toward efficient and stable perovskite solar cells

Rational interface engineering is essential for minimizing interfacial nonradiative recombination losses and enhancing device performance.Herein,we report the use of bidentate diphenoxybenzene(DPOB)isomers as surface modifiers for perovskite films.The DPOB molecules,which contain two oxygen(O)atoms,chemically bond with undercoordinated Pb^(2+) on the surface of perovskite films,resulting in compression of the perovskite lattice.This chemical interaction,along with physical regulations,leads to the formation of high-quality perovskite films with compressive strain and fewer defects.This compressive strain-induced band bending promotes hole extraction and transport,while inhibiting charge recombination at the interfaces.Furthermore,the addition of DPOB will reduce the zero-dimensional(OD) Cs_4PbBr_6 phase and produce the two-dimensional(2D) CsPb_(2)Br_5 phase,which is also conducive to the improvement of device performance.Ultimately,the resulting perovskite films,which are strain-released and defect-passivated,exhibit exceptional device efficiency,reaching 10.87% for carbon-based CsPbBr_(3) device,14.86% for carbon-based CsPbI_(2)Br device,22,02% for FA_(0.97)Cs_(0.03)PbI_(3) device,respectively.Moreover,the unencapsulated CsPbBr_(3) PSC exhibits excellent stability under persistent exposure to humidity(80%) and heat(80℃) for over 50 days.