期刊文献+
共找到81篇文章
< 1 2 5 >
每页显示 20 50 100
Layered manganese phosphorus trisulfides for high-performance lithium-ion batteries and the storage mechanism 被引量:2
1
作者 Hailin Shen Yueling Cai +8 位作者 Zhongtao Ma Peng Wang Bingkun Guo Jipeng Cheng qianqian li Hongtao Wang Zhongyuan liu Anmin Nie Jinsong Wu 《Carbon Energy》 SCIE CSCD 2023年第3期160-169,170,171,共12页
Although advanced anode materials for the lithium-ion battery have been investigated for decades,a reliable,high-capacity,and durable material that can enable a fast charge remains elusive.Herein,we report that a meta... Although advanced anode materials for the lithium-ion battery have been investigated for decades,a reliable,high-capacity,and durable material that can enable a fast charge remains elusive.Herein,we report that a metal phosphorous trichalcogenide of MnPS_(3)(manganese phosphorus trisulfide),endowed with a unique and layered van der Waals structure,is highly beneficial for the fast insertion/extraction of alkali metal ions and can facilitate changes in the buffer volume during cycles with robust structural stability.The few-layered MnPS_(3)anodes displayed the desirable specific capacity and excellent rate chargeability owing to their good electronic and ionic conductivities.When assembled as a half-cell lithium-ion battery,a high reversible capacity of 380 mA h g^(−1)was maintained by the MnPS_(3)after 3000 cycles at a high current density of 4 A g^(−1),with a capacity retention of close to or above 100%.In full-cell testing,a reversible capacity of 450 mA h g^(−1)after 200 cycles was maintained as well.The results of in-situ TEM revealed that MnPS_(3)nanoflakes maintained a high structural integrity without exhibiting any pulverization after undergoing large volumetric expansion for the insertion of a large number of lithium ions.Their kinetics of lithium-ion diffusion,stable structure,and high pseudocapacitance contributed to their comprehensive performance,for example,a high specific capacity,rapid charge-discharge,and long cyclability.MnPS_(3)is thus an efficient anode for the next generation of batteries with a fast charge/discharge capability. 展开更多
关键词 cyclic stability in‐situ TEM MnPS3 PSEUDOCAPACITANCE rate performance
下载PDF
Unraveling the reaction reversibility and structure stability of nickel sulfide anodes for lithium ion batteries
2
作者 Yu Huang Chunyuan liang +10 位作者 Yueling Cai Yi Zhou Bingkun Guo Jipeng Cheng Heguang liu Peng Wang qianqian li Anmin Nie Hongtao Wang Jinsong Wu Tongyi Zhang 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2023年第5期392-401,I0010,共11页
The electrochemical performance of lithium-ion batteries,i.e.specific capacity and cyclability,is primarily determined by chemical reversibility and structural stability of the electrodes in cycling.Here we have inves... The electrochemical performance of lithium-ion batteries,i.e.specific capacity and cyclability,is primarily determined by chemical reversibility and structural stability of the electrodes in cycling.Here we have investigated the fundamental reaction behaviors of nickel sulfide(NixSy)as lithium-ion battery anodes by in-situ TEM.We find that Ni_(3)S_(2)is the electrochemically stable phase,which appears in the first cycle of the NixSyanode.From the second cycle,conversion between Ni_(3)S_(2)and Li_(2)S/Ni is the dominant electrochemical reaction.In lithiation,the NixSynanoparticles evolve into a mixture of Ni nanocrystals embedded in Li_(2)S matrix,which form a porous structure upon full lithiation,and with the recrystallization of the Ni_(3)S_(2)phase in delithiation,a compact and interconnected network is built.Structural stability in cycles is susceptible to particle size and substrate restraint.Carbon substrate can certainly improve the tolerance for size-dependent pulverization of NixSynanoparticles.When NixSynanoparticle exceeds the critical size value,the morphology of the particle is no longer well maintained even under the constraints of the carbon substrate.This work deepens the understanding of electrochemical reaction behavior of conversiontype materials and helps to rational design of high-energy density battery anodes. 展开更多
关键词 Nickel sulfide anodes Reaction reversility Structure rebuilding In-situ TEM Lithium-ion battery
下载PDF
An improved algorithm based on equivalent sound velocity profile method at large incident angle
3
作者 qianqian li Qian Tong +3 位作者 Fanlin Yang Qi li Zhihao Juan Yu Luo 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2024年第2期161-167,共7页
With the development of ultra-wide coverage technology,multibeam echo-sounder(MBES)system has put forward higher requirements for localization accuracy and computational efficiency of ray tracing method.The classical ... With the development of ultra-wide coverage technology,multibeam echo-sounder(MBES)system has put forward higher requirements for localization accuracy and computational efficiency of ray tracing method.The classical equivalent sound speed profile(ESSP)method replaces the measured sound velocity profile(SVP)with a simple constant gradient SVP,reducing the computational workload of beam positioning.However,in deep-sea environment,the depth measurement error of this method rapidly increases from the central beam to the edge beam.By analyzing the positioning error of the ESSP method at edge beam,it is discovered that the positioning error increases monotonically with the incident angle,and the relationship between them could be expressed by polynomial function.Therefore,an error correction algorithm based on polynomial fitting is obtained.The simulation experiment conducted on an inclined seafloor shows that the proposed algorithm exhibits comparable efficiency to the original ESSP method,while significantly improving bathymetry accuracy by nearly eight times in the edge beam. 展开更多
关键词 equivalent sound speed profile ray tracing method large incident angle edge beam deep sea error correction multibeam echo-sounder system
下载PDF
An improved positioning model of deep-seafloor datum point at large incidence angle
4
作者 qianqian li Shoulian CAO +2 位作者 Fanlin YANG Yu LUO Qian TONG 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2024年第1期90-100,共11页
The inhomogeneous sound speed in seawater causes refraction of sound waves,and the elimination of the refraction effect is essential to the accuracy of underwater acoustic positioning.The raytracing method is an indis... The inhomogeneous sound speed in seawater causes refraction of sound waves,and the elimination of the refraction effect is essential to the accuracy of underwater acoustic positioning.The raytracing method is an indispensable tool for effectively handling problems.However,this method has a conflict between localization accuracy and computational quantity.The equivalent sound speed profile(ESSP)method uses a simple sound speed profile(SSP)instead of the actual complex SSP,which can improve positioning precision but with residual error.The residual error is especially non-negligible in deep water and at large beam incidence angles.By analyzing the residual error of the ESSP method through a simulation,an empirical formula of error is presented.The data collected in the sailing circle mode(large incidence angle)of the South China Sea are used for verification.The experiments show that compared to the ESSP method,the improved algorithm has higher positioning precision and is more efficient than the ray-tracing method. 展开更多
关键词 underwater acoustic positioning seafloor datum points large incident angle equivalent sound speed profile(ESSP) deep water
下载PDF
iTRAQ-based proteomics reveals the mechanism of action of Yinlai decoction in treating pneumonia in mice consuming a high-calorie diet
5
作者 qianqian li Tiegang liu +7 位作者 Chen Bai Xueyan Ma Hui liu Zi’an Zheng Yuxiang Wan He Yu Yuling Ma Xiaohong Gu 《Journal of Traditional Chinese Medical Sciences》 CAS 2024年第1期21-32,共12页
Objective:To uncover the underlying mechanisms of action of the Yinlai decoction on high-calorie dietinduced pneumonia through proteomics analysis.Methods:Based on the Gene Expression Omnibus(GEO)database,lung tissue ... Objective:To uncover the underlying mechanisms of action of the Yinlai decoction on high-calorie dietinduced pneumonia through proteomics analysis.Methods:Based on the Gene Expression Omnibus(GEO)database,lung tissue samples from normal and high-fat diet(HFD)fed mice in the GSE16377 dataset were selected as test cohorts to identify differentially expressed genes and conduct bioinformatics analyses.In the animal experiments,mice were randomly divided into the control(N),high-calorie diet pneumonia(M),and Yinlai decoction treatment(Y)groups.Mice in the M group received high-calorie feed and a 0.5 mg/mL lipopolysaccharide solution spray for 30 min for 3 d.The mice in the Y group were intragastrically administered 2 mL/10 g Yinlai decoction twice daily for 3 d.Pathological evaluation of the lung tissue was performed.Differentially expressed proteins(DEPs)in the lung tissue were identified using quantitative proteomics and bioinformatics analyses.The drug-target relationships between Yinlai decoction and core DEPs in the lung tissue were verified using AutoDock Vina and Molecular Graphics Laboratory(MGL)Tools.DEPs were verified by western blot.Results:GEO data mining showed that an HFD altered oxidative phosphorylation in mouse lung tissue.The Yinlai decoction alleviated pathological damage to lung tissue and pneumonia in mice that were fed a high-calorie diet.A total of 47 DEPs were identified between the Y and M groups.Enrichment analysis revealed their association with energy metabolism pathways such as the tricarboxylic acid cycle(TCA)and oxidative phosphorylation.The protein-protein interaction network revealed that Atp5a1,Pdha1,and Sdha were the target proteins mediating the therapeutic effects of Yinlai decoction.Molecular docking results suggested that the mechanism of the therapeutic effect of Yinlai decoction involves the binding of brassinolide,praeruptorin B,chrysoeriol,and other components in Yinlai decoction to Atp5a1.Conclusion:The Yinlai decoction alleviated lung tissue damage and pneumonia in mice that were fed a high-calorie diet by regulating the TCA and oxidative phosphorylation.Our study highlights the importance of a healthy diet for patients with pneumonia and provides a scientific basis for the prevention and treatment of pneumonia through dietary adjustments. 展开更多
关键词 Yinlai decoction High-calorie diet PNEUMONIA iTRAQ proteomics Energy metabolism
下载PDF
Comparison of labeling methods and time course of traumatic brain injury-induced cell death in mice 被引量:6
6
作者 Chengliang Luo Xiping Chen +5 位作者 Hong Ni qianqian li Rui Yang Yuxia Sun Guangyou Zhu Luyang Tao 《Neural Regeneration Research》 SCIE CAS CSCD 2010年第9期706-709,共4页
BACKGROUND:Various molecular mechanisms of cell death following traumatic brain injury have been previously described.However,the time course of cell death remains unclear.TUNEL and Fluoro-Jade B labeling have been w... BACKGROUND:Various molecular mechanisms of cell death following traumatic brain injury have been previously described.However,the time course of cell death remains unclear.TUNEL and Fluoro-Jade B labeling have been widely used to label apoptotic cells and neuronal degeneration.Propidium iodide (PI) functions as a biomarker of cell death in vivo.OBJECTIVE:To explore the role of PI labeling compared to TUNEL and Fluoro-Jade B staining for detecting neural cell death,and to observe time course of traumatic brain injury-induced cell death in mice.DESIGN,TIME AND SETTING:A randomized,controlled,animal experiment was performed at the Laboratory of Aging and Nervous Diseases,Soochow University from September 2007 to December 2008.MATERIALS:PI (B1221) was purchased from Sigma,USA.TUNEL kit was purchased from Roche Molecular Biochemicals,USA.Fluoro-Jade B was purchased from Chemicon,USA.METHODS:A total of 70 healthy,male,Kunming mice were randomly assigned to sham-surgery (n = 5) and model (n = 65) groups.Traumatic brain injury was established using the controlled cortical impact method.PI was intraperitoneally injected at 1 hour prior to animal sacrifice.MAIN OUTCOME MEASURES:TUNEL,Fluoro-Jade B,and Pl-positive cells were quantified using a double-labeling method to determine the time course of traumatic brain injury-induced cell death.RESULTS:PI labeled cells in an earlier phase of cell death than TUNEL and Fluoro-Jade B labeling.Pl-positive cells were observed immediately following injury,and the numbers rapidly increased in injured brain areas at 1 hour,peaked at 24-48 hours,and subsequently decreased at 3-21 days post-injury.TUNEL-labeled cells were significantly increased at 12 hours,while Fluoro-Jade B-labeled cells were increased at 6 hours after injury,with cells still visible at 6-48 hours post-injury.Moreover,a greater number of Pl-positive cells were observed compared to TUNEL- and Fluoro-Jade B-labeled cells.CONCLUSION:PI labeling is more sensitive and reliable than TUNEL and Fluoro-Jade B staining for detecting cell death following traumatic brain injury.Moreover,PI labeling can function as a reliable marker to estimate the entire time course of cell death. 展开更多
关键词 propidium iodide cell death traumatic brain injury neural regeneration
下载PDF
Effects of 1-MCP on proline,polyamine,and nitric oxide metabolism in postharvest peach fruit under chilling stress 被引量:5
7
作者 Chunlu Qian Zhengjie Ji +8 位作者 Qin Zhu Xiaohua Qi qianqian li Jiandong Yin Jun liu Juan Kan Man Zhang Changhai Jin lixia Xiao 《Horticultural Plant Journal》 SCIE CSCD 2021年第3期188-196,共9页
Peach(Prunus persica Batsch‘Yuhualu’)fruit are sensitive to chilling injury(CI).Proline,polyamine(PA),and nitric oxide(NO)are important small regulators of various metabolic pathways under chilling stress that mitig... Peach(Prunus persica Batsch‘Yuhualu’)fruit are sensitive to chilling injury(CI).Proline,polyamine(PA),and nitric oxide(NO)are important small regulators of various metabolic pathways under chilling stress that mitigate CI.Ethylene is known to promote senescence and CI,while 1-methylcyclopropene(1-MCP)is an antagonist that inhibits the effects of ethylene.However,how1-MCP and ethylene affect proline,PA,and NO levels under chilling stress remains unclear.To address these questions,1-MCP(1μL·L^(−1))and ethylene(1μL·L^(−1))treatments were applied to peach fruit.Fruit were stored at 4°C for 28 d,then moved to 25°C for 3 d immediately after cold storage.Peach fruit exhibited CI symptoms after 7 d of cold storage with enhanced electrolyte leakage and malondialdehyde contents.The 1-MCP treatment significantly(P<0.05)restrained peach CI,and fruit did not exhibit CI symptoms until 14 d of cold storage.Proline and PAs in peach under chilling stress weremostly synthesized from glutamate and arginine,which were catalyzed by1-pyrroline-5-carboxylate synthetase and arginine decarboxylase,respectively.1-MCPtreated fruit exhibited higher proline and PA contents and enhanced chilling tolerance compared to the control,while ethylene-treated fruit had lower proline and PA contents and reduced chilling tolerance.Ethylene-treated fruit,which exhibited more severe CI symptoms compared to the control,had significantly(P<0.05)lower NO contents and NO synthase activities.However,NOmay not be a direct acting factor in 1-MCPinduced chilling tolerance,as 1-MCP-treated fruit had lower NO contents and NO synthase activities compared to the control.In conclusion,proline and PA clearly played direct and important roles in 1-MCP-induced peach chilling tolerance,while NO may not be actively involved. 展开更多
关键词 Peach fruit Chilling injury PROLINE Polyamines Nitric oxide 1-MCP ETHYLENE
下载PDF
Dynamic Resource Pricing and Allocation in Multilayer Satellite Network 被引量:1
8
作者 Yuan li Jiaxuan Xie +4 位作者 Mu Xia qianqian li Meng li Lei Guo Zhen Zhang 《Computers, Materials & Continua》 SCIE EI 2021年第12期3619-3628,共10页
The goal of delivering high-quality service has spurred research of 6G satellite communication networks.The limited resource-allocation problem has been addressed by next-generation satellite communication networks,es... The goal of delivering high-quality service has spurred research of 6G satellite communication networks.The limited resource-allocation problem has been addressed by next-generation satellite communication networks,especially multilayer networks with multiple low-Earth-orbit(LEO)and nonlow-Earth-orbit(NLEO)satellites.In this study,the resource-allocation problem of a multilayer satellite network consisting of one NLEO and multiple LEO satellites is solved.The NLEO satellite is the authorized user of spectrum resources and the LEO satellites are unauthorized users.The resource allocation and dynamic pricing problems are combined,and a dynamic gamebased resource pricing and allocation model is proposed to maximize the market advantage of LEO satellites and reduce interference between LEO and NLEO satellites.In the proposed model,the resource price is formulated as the dynamic state of the LEO satellites,using the resource allocation strategy as the control variable.Based on the proposed dynamic game model,an openloop Nash equilibrium is analyzed,and an algorithm is proposed for the resource pricing and allocation problem.Numerical simulations validate the model and algorithm. 展开更多
关键词 Resource pricing resource allocation satellite network LEO dynamic game Nash equilibrium
下载PDF
Icosahedral quasicrystal structure of the Mg_(40)Zn_(55)Nd_(5) phase and its thermodynamic stability 被引量:1
9
作者 Shuai Zhang qianqian li +2 位作者 Hongcan Chen Qun Luo Qian li 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2022年第8期1543-1550,共8页
The quasicrystal phase is beneficial to increasing the strength of magnesium alloys.However,its complicated structure and unclear phase relations impede the design of alloys with good mechanical properties.In this pap... The quasicrystal phase is beneficial to increasing the strength of magnesium alloys.However,its complicated structure and unclear phase relations impede the design of alloys with good mechanical properties.In this paper,the Mg_(40)Zn_(55)Nd_(5) icosahedral quasicrystal(I-phase)structure is discovered in an as-cast Mg-58Zn-4Nd alloy by atomic resolution high-angle annular dark-field scanning transmission electron microscopy(HAADF-STEM).A cloud-like morphology is observed with Mg_(41.6)Zn_(55.0)Nd_(3.4) composition.The selected area electronic diffrac-tion(SAED)analysis shows that the icosahedral quasicrystal structure has 5-fold,4-fold,3-fold,and 2-fold symmetry zone axes.The thermo-dynamic stability of the icosahedral quasicrystal is investigated by differential scanning calorimetry(DSC)in the annealed alloys.When an-nealed above 300℃,the Mg_(40)Zn_(55)Nd_(5) quasicrystal is found to decompose into a stable ternary phase Mg_(35)Zn_(60)Nd_(5),a binary phase MgZn,andα-Mg,suggesting that the quasicrystal is a metastable phase in the Mg-Zn-Nd system. 展开更多
关键词 icosahedral quasicrystal crystal structure thermodynamic stability Mg-Zn-Nd alloys
下载PDF
A Data-Semantic-Conflict-Based Multi-Truth Discovery Algorithm for a Programming Site 被引量:1
10
作者 Haitao Xu Haiwang Zhang +2 位作者 qianqian li Tao Qin Zhen Zhang 《Computers, Materials & Continua》 SCIE EI 2021年第8期2681-2691,共11页
With the extensive application of software collaborative development technology,the processing of code data generated in programming scenes has become a research hotspot.In the collaborative programming process,differ... With the extensive application of software collaborative development technology,the processing of code data generated in programming scenes has become a research hotspot.In the collaborative programming process,different users can submit code in a distributed way.The consistency of code grammar can be achieved by syntax constraints.However,when different users work on the same code in semantic development programming practices,the development factors of different users will inevitably lead to the problem of data semantic conflict.In this paper,the characteristics of code segment data in a programming scene are considered.The code sequence can be obtained by disassembling the code segment using lexical analysis technology.Combined with a traditional solution of a data conflict problem,the code sequence can be taken as the declared value object in the data conflict resolution problem.Through the similarity analysis of code sequence objects,the concept of the deviation degree between the declared value object and the truth value object is proposed.A multi-truth discovery algorithm,called the multiple truth discovery algorithm based on deviation(MTDD),is proposed.The basic methods,such as Conflict Resolution on Heterogeneous Data,Voting-K,and MTRuths_Greedy,are compared to verify the performance and precision of the proposed MTDD algorithm. 展开更多
关键词 Data semantic conflict multi-truth discovery programming site
下载PDF
Random Forests Algorithm Based Duplicate Detection in On-Site Programming Big Data Environment 被引量:1
11
作者 qianqian li Meng li +1 位作者 Lei Guo Zhen Zhang 《Journal of Information Hiding and Privacy Protection》 2020年第4期199-205,共7页
On-site programming big data refers to the massive data generated in the process of software development with the characteristics of real-time,complexity and high-difficulty for processing.Therefore,data cleaning is e... On-site programming big data refers to the massive data generated in the process of software development with the characteristics of real-time,complexity and high-difficulty for processing.Therefore,data cleaning is essential for on-site programming big data.Duplicate data detection is an important step in data cleaning,which can save storage resources and enhance data consistency.Due to the insufficiency in traditional Sorted Neighborhood Method(SNM)and the difficulty of high-dimensional data detection,an optimized algorithm based on random forests with the dynamic and adaptive window size is proposed.The efficiency of the algorithm can be elevated by improving the method of the key-selection,reducing dimension of data set and using an adaptive variable size sliding window.Experimental results show that the improved SNM algorithm exhibits better performance and achieve higher accuracy. 展开更多
关键词 On-site programming big data duplicate record detection random forests adaptive sliding window
下载PDF
Genome-Wide Characterization of the Cellulose Synthase Gene Superfamily in Tea Plants(Camellia sinensis)
12
作者 qianqian li Qi Zhao +2 位作者 Xinzhuan Yao Baohui Zhang litang Lu 《Phyton-International Journal of Experimental Botany》 SCIE 2022年第10期2163-2189,共27页
The cellulose synthase gene superfamily,including Cellulose synthase A(CesA)and cellulose synthase-like(Csl)gene families,is responsible for the synthesis of cellulose and hemicellulose,respectively.The CesA/Csl genes... The cellulose synthase gene superfamily,including Cellulose synthase A(CesA)and cellulose synthase-like(Csl)gene families,is responsible for the synthesis of cellulose and hemicellulose,respectively.The CesA/Csl genes are vital for abiotic stress resistance and shoot tenderness regulation of tea plants(Camellia sinensis).However,the CesA/Csl gene family has not been extensively studied in tea plants.Here,we identified 53 CsCesA/Csl genes in tea plants.These genes were grouped into five subfamilies(CsCesA,CsCslB,CsCslD,CsCslE,CsCslG)based on the phylogenetic relationships with Arabidopsis and rice.The analysis of chromosome distribution,gene structure,protein domain and motif revealed that most genes in CsCesA,CsCslD and CsCslE subfamilies were conserved,whereas CsCslB and CsCslG subfamily members are highly diverged.The transcriptome analysis showed that most CsCesA/Csl genes displayed tissue-specific expression pattern.In addition,members of CsCslB4,CsCesA1/3/6,CsCslB3/4,CsCslD3,CsCslE1 and CsCslG2/3 subfamilies were up-regulated under drought and cold stresses,indicating their potential roles in regulating stress tolerance in tea plants.Furthermore,the expression levels of CsCslG2_6 and CsCslD3_5 in different tissues and cultivars,respectively,were positively correlated with the cellulose content that is negatively related with shoot tenderness.Thus,these two genes were speculated to be involved in the regulation of shoot tenderness in tea plants.Our findings may help elucidate the evolutionary relationships and expression patterns of the CsCesA/Csl genes in tea plants,and provide more candidate genes responsible for stress tolerance and tenderness regulation in tea plants for future functional research. 展开更多
关键词 Tea plant(Camellia sinensis) cellulose synthase superfamily PHYLOGENY stress resistance shoot tenderness regulation
下载PDF
Basis functions for shallow-water temperature profiles based on the internal-wave eigenmodes
13
作者 qianqian li Shoulian Cao +2 位作者 Yu Luo Kai Zhang Fanlin Yang 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2023年第2期56-64,共9页
The shallow-water temperature profile is typically parameterized using a few empirical orthogonal function(EOF)coefficients.However,when the experimental area is poorly known or highly variable,the adaptability of the... The shallow-water temperature profile is typically parameterized using a few empirical orthogonal function(EOF)coefficients.However,when the experimental area is poorly known or highly variable,the adaptability of the EOFs will be significantly reduced.In this study,a new set of basis functions,generated by combining the internal-wave eigenmodes with the average temperature gradient,is developed for characterizing the temperature perturbations.Temperature profiles recorded by a thermistor chain in the South China Sea in 2015 are processed and analyzed.Compared to the EOFs,the new set of basis functions has higher reconstruction accuracy and adaptability;it is also more stable in ocean regions that have internal waves. 展开更多
关键词 temperature profile basis function internal-wave eigenmode EOF sound speed profile
下载PDF
Washed microbiota transplantation stopped the deterioration of amyotrophic lateral sclerosis:The first case report and narrative review
14
作者 Gaochen Lu Quan Wen +2 位作者 Bota Cui qianqian li Faming Zhang 《The Journal of Biomedical Research》 CAS CSCD 2023年第1期69-76,共8页
Amyotrophic lateral sclerosis(ALS) is known as a progressive paralysis disorder characterized by degeneration of upper and lower motor neurons, and has an average survival time of three to five years. Growing evidence... Amyotrophic lateral sclerosis(ALS) is known as a progressive paralysis disorder characterized by degeneration of upper and lower motor neurons, and has an average survival time of three to five years. Growing evidence has suggested a bidirectional link between gut microbiota and neurodegeneration. Here we aimed to report one female case with ALS, who benefited from washed microbiota transplantation(WMT), an improved fecal microbiota transplantation(FMT), through a transendoscopic enteral tube during a 12-month follow-up. Notedly, the accidental scalp trauma the patient suffered later was treated with prescribed antibiotics that caused ALS deterioration. The subsequent rescue WMTs successfully stopped the progression of the disease with a quick improvement. The plateaus and reversals occurred during the whole course of WMT. The stool and blood samples from the first WMT to the last were collected for dynamic microbial and metabolomic analysis. We observed the microbial and metabolomic changing trend consistent with the disease status. This case report for the first time shows the direct clinical evidence on using WMT for treating ALS, indicating that WMT may be the novel treatment strategy for controlling this so-called incurable disease. 展开更多
关键词 fecal microbiota transplant MICROBIOME efficacy NEURODEGENERATION amyotrophic lateral sclerosis
下载PDF
An incompressible flow solver on a GPU/CPU heterogeneous architecture parallel computing platform
15
作者 qianqian li Rong li Zixuan Yang 《Theoretical & Applied Mechanics Letters》 CSCD 2023年第5期387-393,共7页
A computational fluid dynamics(CFD)solver for a GPU/CPU heterogeneous architecture parallel computing platform is developed to simulate incompressible flows on billion-level grid points.To solve the Poisson equation,t... A computational fluid dynamics(CFD)solver for a GPU/CPU heterogeneous architecture parallel computing platform is developed to simulate incompressible flows on billion-level grid points.To solve the Poisson equation,the conjugate gradient method is used as a basic solver,and a Chebyshev method in combination with a Jacobi sub-preconditioner is used as a preconditioner.The developed CFD solver shows good performance on parallel efficiency,which exceeds 90%in the weak-scalability test when the number of grid points allocated to each GPU card is greater than 2083.In the acceleration test,it is found that running a simulation with 10403 grid points on 125 GPU cards accelerates by 203.6x over the same number of CPU cores.The developed solver is then tested in the context of a two-dimensional lid-driven cavity flow and three-dimensional Taylor-Green vortex flow.The results are consistent with previous results in the literature. 展开更多
关键词 GPU Acceleration Parallel computing Poisson equation PRECONDITIONER
下载PDF
The parallel biosynthesis routes of hyperoside from naringenin in Hypericum monogynum
16
作者 Yingying Wang Zhirong Cui +5 位作者 qianqian li Shuai Zhang Yongyi li Xueyan li lingyi Kong Jun Luo 《Horticulture Research》 SCIE CSCD 2023年第9期247-259,共13页
Hyperoside is a bioactive flavonoid galactoside in both medicinal and edible plants.It plays an important physiological role in the growth of flower buds.However,the hyperoside biosynthesis pathway has not been system... Hyperoside is a bioactive flavonoid galactoside in both medicinal and edible plants.It plays an important physiological role in the growth of flower buds.However,the hyperoside biosynthesis pathway has not been systematically elucidated in plants,including its original source,Hypericaceae.Our group found abundant hyperoside in the flower buds of Hypericum monogynum,and we sequenced its transcriptome to study the biosynthetic mechanism of hyperoside.After gene screening and functional verification,four kinds of key enzymes were identified.Specifically,HmF3Hs(flavanone 3-hydroxylases)and HmFLSs(flavonol synthases)could catalyze flavanones into dihydroflavonols,as well as catalyzing dihydroflavonols into flavonols.HmFLSs could also convert flavanones into flavonols and flavones with varying efficiencies.HmF3′H(flavonoid 3′-hydroxylase)was found to act broadly on 4′-hydroxyl flavonoids to produce 3′,4′-diydroxylated flavanones,dihydroflavonols,flavonols,and flavones.HmGAT(flavonoid 3-O-galactosyltransferase)would transform flavonols into the corresponding 3-O-galactosides,including hyperoside.The parallel hyperoside biosynthesis routes were thus depicted,one of which was successfully reconstructed in Escherichia coli BL21(DE3)by feeding naringenin,resulting in a hyperoside yield of 25 mg/l.Overall,this research not only helped us understand the interior catalytic mechanism of hyperoside in H.monogynum concerning flower development and bioactivity,but also provided valuable insights into these enzyme families. 展开更多
关键词 INTERIOR concerning HYPER
下载PDF
Research Progress in Surface and Marine Gravimetry
17
作者 Heping SUN lifeng BAO +13 位作者 Shi CHEN Xiaoming CUI qianqian li Lulu JIA Jianqiao XU Jiangcun ZHOU Minzhang HU Yiqing ZHU Xiaodong CHEN lin WU Jiancheng HAN Honglei li Miaomiao ZHANG linhai WANG 《Journal of Geodesy and Geoinformation Science》 CSCD 2023年第3期19-32,共14页
Gravity field is the most basic physical field generated by the material properties of the Earth system.It reflects the spatial distribution,movement and change of materials determined by the interaction and dynamic p... Gravity field is the most basic physical field generated by the material properties of the Earth system.It reflects the spatial distribution,movement and change of materials determined by the interaction and dynamic process inside the Earth.Over the years,a variety of technical means have been used to detect the Earth’s gravity field and supported numerous studies on the global change,resource detection,geological structure movement,water resources change and other related fields of research.Here is part of the progress in surface and marine gravimetry obtained by Chinese geodesy scientists from 2019 to 2023 from the following aspects,including:①Continuous gravity network in Chinese mainland;②Application of superconducting gravity measurement;③Network adjustment for continental-scale gravity survey campaign and data quality control;④Regional time-variable gravity field and its application;⑤Research progress on novel technologies for gravity inversion;⑥Research progress on marine gravity field determination;⑦Application research on marine gravity field. 展开更多
关键词 surface and marine gravimetry time-variable gravity field GEODYNAMICS gravity inversion
下载PDF
Source apportionment and suitability evaluation of seasonal VOCs contaminants in the soil around a typical refining-chemical integration park in China
18
作者 Xu Zhao Jing Meng +5 位作者 qianqian li Guijin Su Qifan Zhang Bin Shi lingwen Dai Yong Yu 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2024年第3期651-663,共13页
Accurate source apportionment of volatile organic compounds(VOCs)in soil nearby petrochemical industries prevailing globally,is critical for preventing pollution.However,in the process,seasonal effect on contamination... Accurate source apportionment of volatile organic compounds(VOCs)in soil nearby petrochemical industries prevailing globally,is critical for preventing pollution.However,in the process,seasonal effect on contamination pathways and accumulation of soil VOCs is often neglected.Herein,Yanshan Refining-Chemical Integration Park,including a carpet,refining,synthetic rubber,and two synthetic resin zones,was selected for traceability.Season variations resulted in a gradual decrease of 31 VOCs in soil from winter to summer.A method of dry deposition resistance model coupling partitioning coefficient model was created,revealing that dry deposition by gas phase was the primary pathway for VOCs to enter soil in winter and spring,with 100 times higher fux than by particle phase.Source profiles for five zones were built by gas sampling with distinct substance indicators screened,which were used for positive matrix factorization factors determination.Contributions of the five zones were 14.9%,20.8%,13.6%,22.1%,and 28.6%in winter and 33.4%,12.5%,10.7%,24.9%,and 18.5%in spring,respectively.The variation in the soil sorption capacity of VOCs causes inter-seasonal differences in contribution.The better correlation between dry deposition capacity and soil storage of VOCs made root mean square and mean absolute errors decrease averagely by 8.8%and 5.5%in winter compared to spring.This study provides new perspectives and methods for the source apportionment of soil VOCs contamination in industrial sites. 展开更多
关键词 Dry deposition resistance model Positive matrix factorization model Partitioning coefficient model Contamination pathway Source profile
原文传递
重度AECOPD患者接受机械通气期间实施早期康复治疗的临床效果观察 被引量:1
19
作者 李倩倩 施惠 +1 位作者 卞红 嵇丹丹 《国际感染病学(电子版)》 CAS 2019年第4期126-127,共2页
目的探索重度AECOPD患者接受机械通气期间实施早期康复治疗的临床效果.方法40例重度AECOPD患者为试验对象,采用数据库随机分组式,各20例,分别进行机械通气治疗、机械通气联合早期康复治疗.结果观察组并发症、VAP发生率、CAT评分低于对照... 目的探索重度AECOPD患者接受机械通气期间实施早期康复治疗的临床效果.方法40例重度AECOPD患者为试验对象,采用数据库随机分组式,各20例,分别进行机械通气治疗、机械通气联合早期康复治疗.结果观察组并发症、VAP发生率、CAT评分低于对照组,住院时间、总机械通气时间、有创机械通气时间、无创机械通气时间短于对照组,FEV1、PaO2、拔管成功率高于对照组(P<0.05).结论重度AECOPD患者机械通气期间联合早期康复治疗可显著改善临床疗效. 展开更多
关键词 重度AECOPD 机械通气 早期康复
下载PDF
lncRNA TCONS00815878对猪骨骼肌卫星细胞分化的影响 被引量:4
20
作者 黄子莹 李龙 +2 位作者 李倩倩 刘向东 李长春 《遗传》 CAS CSCD 北大核心 2019年第12期1119-1128,I0002,I0003,共12页
猪骨骼肌发育是一个复杂的生物学过程,其中骨骼肌卫星细胞分化是影响骨骼肌发育的重要环节。近年来发现长链非编码RNA(long non-coding RNA,lncRNA)在骨骼肌卫星细胞分化中具有重要作用。为探究lncRNA TCONS00815878对猪骨骼肌卫星细胞... 猪骨骼肌发育是一个复杂的生物学过程,其中骨骼肌卫星细胞分化是影响骨骼肌发育的重要环节。近年来发现长链非编码RNA(long non-coding RNA,lncRNA)在骨骼肌卫星细胞分化中具有重要作用。为探究lncRNA TCONS00815878对猪骨骼肌卫星细胞分化的影响,本研究利用qRT-PCR技术检测出生7 d内大白仔猪6种组织(心脏、脾脏、肺脏、肾脏、背肌和腿肌)及从胚胎期到出生后5个不同时间点(35 d、45 d、55 d胚胎及产后第7 d和第200 d后腿肌肉组织)TCONS00815878的表达情况;利用反义核苷酸(antisense oligonucleotides,ASO)在猪骨骼肌卫星细胞中敲低TCONS00815878,检验分化标记基因MyoD、MyoG和MyHC表达情况;通过生物信息学分析预测TCONS00815878靶基因,并利用DAVID软件在线预测其靶基因的功能与通路。结果表明:TCONS00815878在猪心肌和腿肌中高表达;仔猪出生后7 d内,TCONS00815878在猪肌肉组织中表达量不断升高,第7 d达到高峰;在猪骨骼肌卫星细胞增殖和分化过程中,TCONS00815878在分化期表达量不断上升,且在分化30 h表达量达到峰值;敲低TCONS00815878后,MyoD、MyoG和MyHC基因表达量降低,其中MyoD表达量显著下降(P<0.05)。此外,功能预测结果发现,其靶基因富集到糖酵解和丙酮酸代谢等与骨骼肌卫星细胞分化相关的多个生物学过程。本研究推测,lncRNA TCONS00815878可能对猪骨骼肌卫星细胞的分化起促进作用。 展开更多
关键词 lncRNA TCONS00815878 猪骨骼肌卫星细胞 分化 敲低 靶基因
下载PDF
上一页 1 2 5 下一页 到第
使用帮助 返回顶部