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Effects of Spring Biomass Burning in the Indochina Peninsula on May Precipitation in South China
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作者 qianqian mao Shuyu Liu Yu Huang 《Journal of Water Resource and Protection》 CAS 2023年第5期179-193,共15页
Each year, during the dry season that precedes the summer wind and rainfall Indo-China Peninsula (ICP), significant biomass burning occurs and reaches its peak from March to April. This biomass burning generates large... Each year, during the dry season that precedes the summer wind and rainfall Indo-China Peninsula (ICP), significant biomass burning occurs and reaches its peak from March to April. This biomass burning generates large amounts of aerosols that impact East Asia and surrounding areas through the Asian monsoon. This study aims to investigate the potential connection between biomass burning over the ICP and precipitation in South China during May, along with the physical processes involved. The analysis is based on GLDAS soil moisture reanalysis data and CPC (NOAA) precipitation data covering the period from 1980 to 2021. The research findings indicate a negative (positive) correlation between biomass burning in the ICP region during spring and precipitation in the same region (South China) during May. The circulation patterns corresponding to years with biomass-burning emission anomalies are further investigated, and the impact of biomass-burning emissions in spring on soil moisture and temperature is examined. The results suggest that biomass-burning emissions can significantly affect atmospheric circulation and precipitation, ultimately leading to anomalous precipitation in South China. 展开更多
关键词 Indo-China Peninsula Biomass-Burning Aerosols Atmospheric Circulation PRECIPITATION
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Noradrenergic, glutamatergic and dopaminergic systems are implicated in antidepressant-like effect of flavonoids extracted from okra (Abelmoschus esculentus [L.] Moench.) fruit in the forced swimming test
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作者 Fuyuan Li Xiaozhuo Zhang +3 位作者 qianqian mao Bo Wu Ying Jia Tingxu Yan 《Journal of Polyphenols》 2022年第1期17-31,共15页
Okra(Abelmoschus esculentus[L.]Moench.)is one of the most frequently used herbals in East or West Africa,and its various biological activities have been widely studied.Flavonoids extracted from many plants are reporte... Okra(Abelmoschus esculentus[L.]Moench.)is one of the most frequently used herbals in East or West Africa,and its various biological activities have been widely studied.Flavonoids extracted from many plants are reported to have neurological properties,e.g antidepressant and antifatigue.However,its neurological protect in antidepressant-like effect of flavonoids extracted from okra have not yet been demonstrated.The present study was aimed at investigating the antidepressant-like eff ect of the flavonoids extracted from okra fruit(FOF)using the forced swimming test(FST)pattern and preliminary exploration its potential mechanism.We also used the open fi eld test(OFT)to estimate the spontaneous locomotor activity.We found that oral administration(p.o.)of FOF(300 mg/kg)alone signifi cantly reduced the immobility time in the FST without changes in locomotor activity in the OPT.The experimental data indicated the antidepressant-like eff ect of FOF involved in noradrenergic,glutamatergic and dopaminergic systems. 展开更多
关键词 OKRA ANTIDEPRESSANT forced swimming test(FST) mechanism flavonoid compound
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Low-dose immune tolerance induction for severe hemophilia A inhibitor patients:Immunosuppressants are generally not necessary for inhibitor-titer below 200 BU/mL
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作者 Zhengping Li Jie Sun +11 位作者 Zekun Li Zhenping Chen Guoqing Liu Wanru Yao Xiaoling Cheng Gang Li Yingzi Zhen Di Ai Yaohan Zhou qianqian mao Man-Chiu Poon Runhui Wu 《Pediatric Investigation》 CAS CSCD 2024年第2期91-100,共10页
Importance:It remained unclear that the efficacy comparison between low-dose immune tolerance induction(LD-ITI)incorporating immunosuppressants(IS)when severe hemophilia A(SHA)patients had inhibitor-titer≥200 Bethesd... Importance:It remained unclear that the efficacy comparison between low-dose immune tolerance induction(LD-ITI)incorporating immunosuppressants(IS)when severe hemophilia A(SHA)patients had inhibitor-titer≥200 Bethesda Units(BU)/mL(LD-ITI-IS^(200) regimen)and LD-ITI combining with IS when SHA patients had inhibitor-titer≥40 BU/mL(LD-ITI-IS^(40) regimen).Objective:To compare the efficacy of the LD-ITI-IS^(200) regimen with that of the LD-ITI-IS^(40) regimen for SHA patients with high-titer inhibitors.Methods:A prospective cohort study on patients receiving LD-ITI-IS^(200) compared to those receiving LD-ITI-IS^(40) from January 2021 to December 2023.Both received LD-ITI[FVIII 50 IU/kg every other day].IS(rituximab+prednisone)was added when peak inhibitor tier≥200 BU/mL in the LD-ITI-IS^(200) regimen and≥40 BU/mL in the LD-ITI-IS^(40) regimen.Success is defined as a negative inhibitor plus FVIII recovery≥66%of the expected.Results:We enrolled 30 patients on LD-ITI-IS^(200) and 64 patients on LD-ITI-IS^(40),with similar baseline clinical characteristics.A lower IS-use rate was discovered in the LD-ITI-IS^(200) regimen compared to the LD-ITI-IS^(40) regimen(30.0%vs.62.5%).The two regimens(LD-ITI-IS^(200) vs.LD-ITI-IS^(40))had similar success rate(70.0%vs.79.7%),median time to success(9.4 vs.10.6 months),and annualized bleeding rate during ITI(3.7 vs.2.8).The cost to success was lower for LD-ITI-IS^(200) than for LD-ITI-IS^(40)(2107 vs.3256 US Dollar/kg).Among patients with peak inhibitor-titer 40-199 BU/mL,10 non-IS-using(on LD-ITI-IS^(200) regimen)and 28 IS-using(on LD-ITI-IS^(40) regimen)had similar success rates(70.0%vs.78.6%)and time to success(9.0 vs.8.8 months).Interpretation:In LD-ITI,IS are not necessary for inhibitor titer<200 BU/mL. 展开更多
关键词 Hemophilia A High-titer inhibitor Immune tolerance induction IMMUNOSUPPRESSANT LOW-DOSE
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一种基于度量优化的深度网络SAR自聚焦方法
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作者 毛倩倩 詹梦洋 李银伟 《运筹与模糊学》 2024年第3期653-664,共12页
相位误差是引起合成孔径雷达图像散焦的主要原因,受到目标场景与算法参数的影响,基于度量优化的传统自聚焦方法迭代次数多,计算量大。鉴于卷积神经网络在图像特征提取与特征分类方面的优越性,本文提出了一种基于度量优化的深度网络SAR... 相位误差是引起合成孔径雷达图像散焦的主要原因,受到目标场景与算法参数的影响,基于度量优化的传统自聚焦方法迭代次数多,计算量大。鉴于卷积神经网络在图像特征提取与特征分类方面的优越性,本文提出了一种基于度量优化的深度网络SAR自聚焦方法。首先,利用卷积神经网络的特征提取能力,将不同程度的离焦图像通过特征分类来实现离焦图像到相位误差系数的映射。其次,网络估计的相位误差系数被建模成相应的相位误差多项式,构成相应的误差向量来补偿离焦图像。通过使用度量函数作为损失函数进行网络训练,实现SAR离焦图像的误差更新和补偿。相比于传统自聚焦方法,基于深度网络的方法,训练完成后,不需要进行反复迭代,且不依赖于场景强散射点,具有更快的聚焦速度和稳定的聚焦性能。 展开更多
关键词 深度网络 特征提取 自聚焦 度量优化
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多孔有机笼的合成及衍生化
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作者 毛倩倩 章金金 刘明 《中国科学:化学》 CAS CSCD 北大核心 2023年第12期2378-2401,共24页
多孔有机笼(porous organic cages,POCs)作为一类具有永久空腔的三维有机分子,具有孔道结构有序、加工性良好、模块化等优点,已在气体吸附、分子分离、催化等领域展现了巨大应用潜力,成为多孔材料科学的前沿研究方向之一.近年来,利用动... 多孔有机笼(porous organic cages,POCs)作为一类具有永久空腔的三维有机分子,具有孔道结构有序、加工性良好、模块化等优点,已在气体吸附、分子分离、催化等领域展现了巨大应用潜力,成为多孔材料科学的前沿研究方向之一.近年来,利用动态共价化学,许多拓扑结构新颖和功能丰富的POCs被成功合成报道.然而,与多孔框架材料不同,全封闭结构的POCs需要构建块间有更精确的匹配性,导致了POCs自下而上设计合成相对困难,难以系统地进行功能化.为解决上述瓶颈问题,近年来领域的研究者们发展了一系列合成后修饰策略来扩展POCs的结构与功能.此外,POCs结构中丰富的有机官能团赋予了材料被进一步拓展为高级结构的可能性,如将POCs转化为多孔框架材料如金属有机框架、共价有机框架、氢键有机框架等,这些研究将有利于整合多种材料的优势并推动多孔材料领域的发展.基于此,本文从POCs的合成、合成后修饰以及结构转化等方面对多孔有机笼的合成及衍生化进行综述. 展开更多
关键词 多孔有机笼 多孔材料 拓扑结构 合成后修饰 结构转化
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